Yini i-Linagliptin ne-Metformin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Linagliptin ne-metformin iyinhlanganisela yemithi esiza abantu abanesifo sikashukela sohlobo 2 ukulawula amazinga kashukela egazini labo ngempumelelo enkulu. Le mithi esebenza kabili ihlanganisa ukwelashwa okubili okufakazelwe kwesifo sikashukela epilini elilodwa elilula, okwenza kube lula kuwe ukuthi unamathele ohlelweni lwakho lokwelashwa ngenkathi uthola ukulawulwa okungcono kukashukela wegazi kunanoma iyiphi imithi engase inikeze yodwa.

Yini i-Linagliptin ne-Metformin?

Le mithi ehlanganisiwe iqukethe imithi emibili ehlukene yesifo sikashukela esebenza ndawonye ukwehlisa ushukela wakho wegazi. I-Linagliptin ingeyeqembu elibizwa ngokuthi ama-DPP-4 inhibitors, kanti i-metformin ivela emndenini wemithi yesifo sikashukela i-biguanide.

Cabanga ngale mithi emibili njengozakwethu abanamandla ahlukene. I-Metformin isiza umzimba wakho ukuthi usebenzise i-insulin kangcono futhi inciphisa inani likashukela isibindi sakho esikwenzayo. I-Linagliptin isebenza ngokusiza i-pancreas yakho ukuthi ikhiphe i-insulin eningi lapho ushukela wakho wegazi uphakeme futhi inciphisa amahomoni akhuphula ushukela wegazi.

Udokotela wakho angase akubhalele le nhlanganisela uma i-metformin yodwa ingawugcini ushukela wakho wegazi ebangeni eliqondiwe. Indlela yokuhlanganisa ivame ukusebenza kangcono kunokuthatha noma iyiphi imithi yodwa, ikunikeza ukuphathwa okubanzi kukashukela wegazi.

Isetshenziselwani i-Linagliptin ne-Metformin?

Le mithi yenzelwe ngokuqondile ukwelapha isifo sikashukela sohlobo 2 kubantu abadala. Ibhalwa lapho ukudla nokuzivocavoca kuphela kunganele ukugcina amazinga kashukela wakho wegazi ebangeni elinempilo.

Udokotela wakho angase ancome le nhlanganisela uma usuvele uthatha i-metformin kodwa udinga ukulawulwa okwengeziwe kukashukela wegazi. Isetshenziswa futhi lapho kuqala ukwelashwa kwesifo sikashukela kubantu abangazuza emithini yomibili kusukela ekuqaleni.

Inhloso

Inhloso ukusiza ukugcina i-hemoglobin A1C yakho (isilinganiso sikashukela wegazi ovamile ezingxenyeni zama-2-3 izinyanga) ngaphansi kuka-7% kubantu abadala abaningi. Le nhlanganisela ingasiza ikakhulukazi uma ubulokhu ulwela ukufinyelela imigomo yakho kashukela wegazi ngezinguquko zokuphila kanye nemithi eyodwa.

Isebenza Kanjani I-Linagliptin ne-Metformin?

Le mithi ehlanganisiwe isebenza ngezindlela ezimbili ezihlukene ukukunika ukulawula okungcono kukashukela wegazi. Ithathwa njengokwelashwa okunamandla okuphakathi nendawo yesifo sikashukela esibhekana nezici eziningi zokuphathwa kukashukela wegazi.

I-Metformin isebenza ikakhulukazi ngokwenza amaseli emisipha yakho azwele kakhulu i-insulin, ukuze akwazi ukusebenzisa i-glucose ngempumelelo. Futhi itshela isibindi sakho ukuthi sikhiqize i-glucose encane, ikakhulukazi phakathi kokudla kanye nobusuku lapho ungaqedi ukudla.

I-Linagliptin isebenza nesistimu yakho yamahomoni yemvelo yomzimba. Lapho ushukela wakho wegazi ukhuphuka ngemva kokudla, isiza amanyikwe akho ukuthi akhiphe i-insulin eningi. Ngesikhathi esifanayo, inciphisa ukukhishwa kwe-glucagon, i-hormone ekhuphula ushukela wegazi uma ungasidingi.

Ngokuhlangene, lezi zindlela zinikeza ukulawula okubanzi kukashukela wegazi kunanoma iyiphi imithi yodwa. Le nhlanganisela isebenza ngempumelelo ikakhulukazi ngoba ibhekana nezinkinga zokumelana ne-insulin kanye nokukhiqizwa kwe-insulin ezivamile kuhlobo 2 lwesifo sikashukela.

Kufanele Ngiyithathe Kanjani I-Linagliptin ne-Metformin?

Thatha le mithi ngendlela eqondile udokotela wakho ayiyalayo, ngokuvamile kabili ngosuku ngokudla. Ukuyithatha nokudla kusiza ukunciphisa isisu esicasulayo futhi kusiza umzimba wakho ukuba umunce imithi kahle.

Gwinya amaphilisi wonke ngengilazi yamanzi egcwele. Ungachobozi, uhlafune, noma uqhekeze amaphilisi, ngoba lokhu kungathinta indlela imithi ekhululwa ngayo emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinye izindlela.

Zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke, njengokudla kwasekuseni nakusihlwa. Lokhu kusiza ukugcina amazinga aqhubekayo omuthi emzimbeni wakho futhi kwenza kube lula ukukhumbula imithamo yakho.

Qhubeka udla ukudla okunempilo futhi uzivocavoce njengoba kunconywe ithimba lakho lokunakekelwa kwezempilo. Umuthi usebenza kahle uma uhlanganiswe nalezi zindlela zokuphila, hhayi njengendlela yokuzithatha esikhundleni sazo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Linagliptin ne-Metformin?

Lokhu ngokuvamile kuwumuthi wesikhathi eside ozowuthatha uma nje ulawula ngempumelelo isifo sakho sikashukela. Uhlobo 2 lwesifo sikashukela yisimo esingamahlala-khona esivame ukudinga ukwelashwa okuqhubekayo ukuze kugcinwe amazinga kashukela egazi anempilo.

Udokotela wakho uzoqapha ukulawulwa kukashukela wakho njalo ngezivivinyo ze-A1C, ngokuvamile njalo emavikini angu-3-6. Uma umuthi usebenza kahle futhi ungaqali ukuba nemiphumela emibi, cishe uzoqhubeka ukuwuthatha unomphela.

Abanye abantu bangase badinge ukulungiswa komthamo noma imithi eyengeziwe ngokuhamba kwesikhathi njengoba isifo sabo sikashukela siqhubeka. Lokhu kujwayelekile futhi akusho ukuthi umuthi awusebenzi. Ithimba lakho lokunakekelwa kwezempilo lizosebenza nawe ukulungisa uhlelo lwakho lokwelashwa njengoba kudingeka.

Ungayeki ukuthatha lo muthi ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka kungazelelwe kungabangela ukuthi ushukela wakho wegazi unyuke uze ufinyelele emazingeni ayingozi, ngisho noma uzizwa kahle.

Yiziphi Imiphumela Eceleni ye-Linagliptin ne-Metformin?

Abantu abaningi bayawuthatha kahle lo muthi ohlanganisiwe, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela eminingi emibi ithambile futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Imiphumela ejwayelekile ongase uyithole ihlanganisa izinkinga ezihlobene nesisu ezivame ukulawuleka ngesikhathi esifanele nokudla:

• Ukugula kwesisu noma isisu esibuhlungu, ikakhulukazi uma uqala ukusithatha
• Ukuphuma isisu noma izitulo ezixekile
• Umgomo noma ukuqunjelwa
• Ukunambitheka kwensimbi emlonyeni wakho
• Ukuncipha kwesifiso sokudla
• Ukukhathazeka ikhanda

Le miphumela emibi yokugaya ngokuvamile iyathuthuka emasontweni ambalwa njengoba umzimba wakho ujwayela umuthi. Ukuthatha umuthi nokudla nokuqala ngomthamo ophansi kungasiza ekunciphiseni le miphumela.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Le miphumela emibi engavamile kodwa ebalulekile ihlanganisa:

• I-lactic acidosis (isimo esingavamile kodwa esibi esibangela ubuhlungu bemisipha, ubuthakathaka, ubunzima bokuphefumula, nokukhathala okungavamile)
• Ukungezwani okukhulu komzimba okunezinduna, ukuluma, ukuvuvukala, noma ubunzima bokuphefumula
• I-Pancreatitis (ubuhlungu obukhulu besisu obungase buye emhlane wakho)
• Izimpawu zikashukela ophansi uma kuhlanganiswe neminye imithi yesifo sikashukela

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína, njengoba zingase zidinge ukwelashwa ngokushesha noma ukulungiswa komuthi.

Ubani Ongafanele Athathwe I-Linagliptin ne-Metformin?

Lo muthi awulungele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwubhala. Kunezimo eziningana ezibalulekile ezingenza lo muthi ungaphephile kuwe.

Abantu abanezinkinga zezinso akufanele bathathe lo muthi, njengoba i-metformin ingakha emazingeni ayingozi uma izinso zakho zingasebenzi kahle. Udokotela wakho uzohlola ukusebenza kwezinso zakho ngaphambi kokuqala ukwelashwa futhi njalo ngenkathi uwuthatha.

Kufanele futhi ugweme lo muthi uma unesifo esibi sesibindi, ukuhluleka kwenhliziyo, noma izimo ezikhuphula ingozi yakho ye-lactic acidosis. Abantu abanesifo sikashukela sohlobo 1 noma i-diabetic ketoacidosis akufanele basebenzise le nhlanganisela.

Uma uhlela ukuhlinzwa noma ezinye izinqubo zezokwelapha, kungase kudingeke ukuthi uyeke lesi sithako ngesikhashana. Hlala utshela abahlinzeki bakho bezempilo ngayo yonke imithi oyithathayo, okuhlanganisa nale.

Abesifazane abakhulelwe nabancelisayo kufanele baxoxe ngezindlela zokwelapha ezingezinye nodokotela babo, njengoba ukuphepha kwalolu hlobo lokuhlanganisa ngesikhathi sokukhulelwa kungakahlolisiswa ngokugcwele.

Amagama Omkhiqizo we-Linagliptin kanye ne-Metformin

Le mithi ehlanganisiwe itholakala ngaphansi kwegama lomkhiqizo elithi Jentadueto e-United States. Inguqulo yokukhishwa okwandisiwe ibizwa ngokuthi Jentadueto XR, evumela ukuthi kuthathwe kanye ngosuku esikhundleni sokuthatha kabili ngosuku.

Izinhlobo ezivamile zalolu hlobo lokuhlanganisa nazo ziyatholakala, eziqukethe izithako ezifanayo ezisebenzayo kodwa zingabiza ngaphansi kwezinhlobo zamagama omkhiqizo. Umuthi wakho wemithi angakusiza ukuthi uqonde ukuthi ngabe inguqulo ejwayelekile iyatholakala futhi ilungele wena.

Noma ngabe uthatha igama lomkhiqizo noma inguqulo ejwayelekile, umuthi usebenza ngendlela efanayo. Udokotela wakho uzoqoka inguqulo engcono kakhulu esimweni sakho esithile kanye nomshwalense wakho.

Ezinye izindlela ze-Linagliptin kanye ne-Metformin

Uma lokhu kuhlanganiswa kungasebenzi kahle kuwe, ezinye izinketho zokwelapha ziyatholakala. Udokotela wakho angakusiza ukuthi uthole enye indlela evumelana kangcono nezidingo zakho kanye nesimo sakho sezokwelapha.

Eminye imithi ehlanganisiwe ihlanganisa i-metformin neminye imithi yesifo sikashukela, njenge-glipizide (Metaglip), i-glyburide (Glucovance), noma i-pioglitazone (Actoplus Met). Ukuhlanganiswa ngakunye kunenzuzo ehlukene kanye namaphrofayili emiphumela emibi.

Ungase futhi uthathe imithi ngayinye ngamanye, okuvumela ukuthi uthathe imithi eguquguqukayo kodwa kudingeka ukuthi uthathe amaphilisi amaningi. Abanye abantu bakhetha le ndlela uma bedinga imithamo ehlukene yesithako ngasinye.

Imithi emisha yesifo sikashukela efana ne-GLP-1 agonists noma i-SGLT-2 inhibitors ingase ibe yizinketho, ikakhulukazi uma unesifo senhliziyo noma udinga ukunciphisa umzimba. Udokotela wakho uzocabangela isithombe sakho sempilo esiphelele lapho encoma ezinye izindlela.

Ingabe i-Linagliptin ne-Metformin ingcono kune-Metformin yodwa?

Kubantu abaningi, le nhlanganisela inikeza ukulawulwa okungcono ushukela wegazi kune-metformin yodwa. Ucwaningo lubonisa ukuthi ukwengeza i-linagliptin ku-metformin kunganciphisa amazinga e-A1C ngama-0.5-0.7% engeziwe uma kuqhathaniswa ne-metformin yodwa.

Indlela yokuhlanganisa ibhekana nesifo sikashukela emazingeni amaningi, okuvame ukuholela ekuphathweni okungcono kukashukela wegazi. Uthola imiphumela yokuzwela i-insulin ye-metformin kanye nemiphumela yokukhulisa i-insulin nokunciphisa i-glucagon ye-linagliptin.

Kodwa-ke, "kungcono" kuncike esimweni sakho ngasinye. Abanye abantu benza kahle kakhulu nge-metformin yodwa, kanti abanye badinga usizo olwengeziwe olunikezwa ukwelashwa okuhlanganisiwe. Udokotela wakho uzoqoka ukuthi yini engcono kakhulu ngokusekelwe emazingeni akho kashukela wegazi, imiphumela emibi, nempilo yonke.

Inzuzo enkulu yokwelashwa okuhlanganisiwe ukulula - ukuthatha iphilisi elilodwa esikhundleni semithi emibili ehlukene kungenza kube lula ukunamathela ohlelweni lwakho lokwelashwa. Ukunamathela okungcono emithini kuvame ukuholela ekulawulweni okungcono kukashukela wegazi ngokuhamba kwesikhathi.

Imibuzo Evame Ukubuzwa Mayelana ne-Linagliptin ne-Metformin

Ingabe i-Linagliptin ne-Metformin iphephile kubantu abanesifo senhliziyo?

Le nhlanganisela ngokuvamile ithathwa njengephephile kubantu abanesifo senhliziyo, futhi ingase inikeze nezinzuzo ezithile zenhliziyo nemithambo yegazi. I-Metformin iboniswe ukunciphisa ingozi yezinkinga zenhliziyo kubantu abanesifo sikashukela, kuyilapho i-linagliptin ibonakala ingathathi hlangothi mayelana nengozi yesifo senhliziyo.

Noma kunjalo, kufanele utshele udokotela wakho nganoma yiziphi izimo zenhliziyo ngaphambi kokuqala lo muthi. Abantu abanenhliziyo ehlulekayo enkulu bangase badinge ukuqapha okukhethekile noma ezinye izindlela zokwelapha, njengoba i-metformin ngezinye izikhathi ingase iqhubeke nokwenza lesi simo sibe sibi.

Udktela wakho uzoqaphela izinzuzo zokulawula kangcono ushukela wegazi uma kuqhathaniswa nanoma yiziphi izingozi ezingaba khona ngokusekelwe esimweni sakho senhliziyo esithile kanye nesimo sempilo esiphelele.

Kufanele Ngenzeni Uma Ngiphuzile Kakhulu I-Linagliptin ne-Metformin Ngengozi?

Uma ngengozi uphuza ngaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuphuza okuningi kungakhuphula ingozi yakho yemiphumela emibi, ikakhulukazi i-lactic acidosis evela engxenyeni ye-metformin.

Qaphela izimpawu ezinjengobuhlungu obungavamile bemisipha, ubuthakathaka, ubunzima bokuphefumula, ubuhlungu besisu, isicanucanu, noma ukuzizwa ukhathele noma kubanda ngokungavamile. Lokhu kungaba yizimpawu ze-lactic acidosis, edinga ukunakekelwa kwezempilo ngokushesha.

Ungalindi ukubona ukuthi izimpawu ziyavela yini - funa iseluleko sezokwelapha ngokushesha ngemuva kwanoma yikuphi ukweqisa. Letha ibhodlela lemithi nawe ukusiza abahlinzeki bezempilo baqonde kahle ukuthi yini nokuthi ungakanani oyiphuzile.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Linagliptin ne-Metformin?

Uma uphuthelwa umthamo, uwuphuze ngokushesha lapho ukhumbula, inqobo nje uma kungesona isikhathi esicishe sibe sesikhathini somthamo wakho olandelayo ohleliwe. Uma sekuseduze nesikhathi somthamo wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uphuze imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kwandisa ingozi yakho yemiphumela emibi. Esikhundleni salokho, buyela emuva emgwaqeni ngeshejuli yakho yokulinganisa ejwayelekile.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi. Ukulinganisa kwansuku zonke okuqhubekayo kubalulekile ekugcineni ukulawula ushukela wegazi okuzinzile.

Ngingayeka Nini Ukuphuza I-Linagliptin ne-Metformin?

Kufanele uyeke kuphela ukuphuza lo muthi ngaphansi kokuqondisa kukadokotela wakho. Noma ngabe amazinga akho kashukela egazi athuthuka kakhulu, ukuyeka umuthi cishe kuzobenza baphinde banyuke, ngoba isifo sikashukela sohlobo 2 siyisimo esingamahlalakhona.

Abanye abantu bangakwazi ukunciphisa umthamo wemithi yabo uma benza izinguquko ezinkulu zokuphila, njengokunciphisa isisindo noma ukwandisa ukuzivivinya. Kodwa-ke, lokhu kufanele kwenziwe kancane kancane futhi ngaphansi kokuqondisa kwezokwelapha.

Udokotela wakho uzobuyekeza njalo uhlelo lwakho lokwelashwa futhi angase alungise noma ashintshe imithi yakho ngokusekelwe ekulawulweni kukashukela wegazi lakho, imiphumela emibi, kanye nempilo yakho yonke. Ungalokothi wenze lezi zinqumo uwedwa.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Linagliptin ne-Metformin?

Ungaphuza utshwala ngokulinganisela ngenkathi uthatha lo muthi, kodwa udinga ukuqaphela kakhulu amazinga kashukela wegazi lakho. Utshwala bungakhuphula ingozi yakho yokuba noshukela ophansi negazi elinobuthi, ikakhulukazi uma kuhlangene ne-metformin.

Uma ukhetha ukuphuza, kwenze ngokudla futhi uqaphele ushukela wakho wegazi kaningi. Ukuhlanganiswa kotshwala nemithi yesifo sikashukela kungabangela ushukela ophansi obambezelekile, ngezinye izikhathi ngemva kwamahora okuphuza.

Xoxa nodokotela wakho mayelana nemikhawulo yokusetshenziswa kotshwala ephephile esimweni sakho esithile. Bangase batusa ukugwema utshwala ngokuphelele uma unezimo ezithile zempilo noma uthatha eminye imithi esebenzisana notshwala.