Yini i-Liothyronine (Indlela Yokungenisa Ngemithambo): Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Liothyronine intravenous iyifomu elenziwe ngamachweba le-T3 hormone yegilo enikezwa ngqo egazini lakho ngomugqa we-IV. Lo muthi ugcinelwe izimo ezingathi sína, ezisongela impilo lapho amazinga akho egilo ephansi ngendlela eyingozi futhi edinga ukulungiswa ngokushesha.

Ngokungafani namathebulethi omlomo ongase uwajwayele, i-IV liothyronine isebenza emahoreni kunasezinsukwini. Ivame ukusetshenziswa ezindaweni zomtholampilo lapho ukusebenza komgogodla womuntu kwehla kakhulu kangangokuthi ukulinda umuthi womlomo ukuthi usebenze kungaba yingozi.

Yini i-Liothyronine?

I-Liothyronine iyinguqulo eyenziwe ngabantu ye-triiodothyronine (T3), enye yama-hormone amabili amakhulu i-gland yakho yegilo ekhiqiza ngokwemvelo. I-T3 iyifomu elisebenzayo le-hormone yegilo elithinta ngokuqondile ukuthi amaseli akho asebenzisa kanjani amandla.

Uma inikezwa ngemithambo, i-liothyronine idlula ngokuphelele uhlelo lwakho lokugaya ukudla futhi ingena ngokushesha egazini lakho. Lokhu kuyenza isheshe ukusebenza kunezithako zomlomo zegilo, yingakho odokotela beyigcinela izimo eziphuthumayo.

Ifomu le-IV lifana ngamakhemikhali ne-hormone ye-T3 umzimba wakho oyenzayo, ngakho-ke lingangena futhi lenze umsebenzi ofanayo lapho igilo lakho lingakwazi ukukhiqiza okwanele ngokwalo.

Isetshenziselwani i-Liothyronine?

I-IV liothyronine isetshenziswa ikakhulukazi ukwelapha i-myxedema coma, isimo esingavamile kodwa esisongela impilo lapho amazinga e-hormone yegilo ehla kakhulu kangangokuthi ithinta ukusebenza kobuchopho bakho nezitho ezibalulekile. Lesi simo esiphuthumayo sezokwelapha sidinga ukushintshwa kwe-hormone ngokushesha ukuvimbela ukwehluleka kwezitho.

Odokotela bayisebenzisa futhi nge-hypothyroidism eqinile lapho umuntu engakwazi ukuthatha imithi yomlomo ngenxa yezinkinga zokugaya ukudla noma lapho bengazi lutho futhi bengakwazi ukugwinya. Ngezikhathi ezithile isetshenziswa ngaphambi kokuhlinzwa okukhulu kwenhliziyo ezigulini ezinazo izinkinga eziqashelwayo zegilo.

Ezimweni ezingavamile kakhulu, kungenzeka ukuthi inikezwe kumuntu okhishwe ngaphandle kwegland yakhe ye-thyroid futhi othola izimpawu ezinzima ngaphambi kokuba imithi yomlomo iqale ukusebenza. Umgomo uhlala ukuzinzisa isiguli ngokushesha bese ushintshela ekushintsheni ama-hormone e-thyroid ngomlomo.

Isebenza Kanjani I-Liothyronine?

I-Liothyronine isebenza ngokushintsha i-hormone ye-T3 i-gland yakho ye-thyroid ejwayele ukuyikhiqiza. I-T3 ithathwa njenge-hormone ye-thyroid "esebenzayo" ngoba itshela ngqo amaseli akho ukuthi asheshe kangakanani ukushisa amandla nokwenza imisebenzi yawo.

Lena imithi enamandla esebenza ngokushesha kakhulu kunezinye izinhlobo zama-hormone e-thyroid. Ngenkathi i-T4 (levothyroxine) idinga ukuguqulwa ibe yi-T3 emzimbeni wakho, i-liothyronine isivele isesimweni sayo esisebenzayo futhi iqala ukusebenza kungakapheli amahora ambalwa.

Indlela ye-IV yenza ibe namandla nakakhulu ngoba iletha i-hormone ngqo emjondolo wakho wegazi ngaphandle kokubambezeleka ekugayeni ukudla. Inhliziyo yakho, ubuchopho, nezinye izitho zingaqala ukusabela ku-hormone cishe ngokushesha, okubalulekile ezimweni eziphuthumayo.

Kufanele Ngiyithathe Kanjani I-Liothyronine?

Ngeke uzithathele wena i-IV liothyronine - le mithi inikezwa kuphela ochwepheshe bezempilo esibhedlela noma endaweni yezokwelapha. Umhlengikazi noma udokotela uzoyiphatha ngomugqa we-IV osusetshenzisiwe emthanjeni wakho.

Umuthi uza njengesixazululo esicacile esixutshwe namanzi ahlanzekile ngaphambi nje kokuba unikezwe. Ithimba lakho lezokwelapha lizokuqapha eduze ngesikhathi nangemva kokufakwa ukuze libheke noma yiziphi izinguquko ekushayeni kwenhliziyo yakho, umfutho wegazi, noma ezinye izimpawu ezibalulekile.

Uma uqaphela ngesikhathi sokwelashwa, akudingeki ukuthi ugweme ukudla noma iziphuzo, kodwa ithimba lakho lezokwelapha lizokunikeza imiyalelo ethile ngokusekelwe esimweni sakho esiphelele nanoma yiziphi ezinye izindlela zokwelapha ozitholayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Liothyronine?

I-liothyronine ye-IV ivamise ukunikezwa izinsuku ezimbalwa nje, ngokuvamile izinsuku eziyi-1-3 ubuningi. Yenzelwe ukuba ibe yindlela yokwelapha yesikhashana esiphuthumayo ukuze kuzinziswe amazinga akho e-hormone yegilo ngokushesha.

Uma isimo sakho sithuthuka futhi uzinzile, udokotela wakho cishe uzokushintshela emithini yegilo yomlomo efana namathebulethi e-levothyroxine. Ushintsho ngokuvamile lwenzeka kancane kancane ukuze kuqinisekiswe ukuthi amazinga akho e-hormone ahlala ezinzile.

Isikhathi esiqondile sincike ekutheni isimo sakho sasinzima kangakanani nokuthi usabela ngokushesha kangakanani ekwelashweni. Ithimba lakho lezokwelapha lizobe lihlole amazinga akho e-hormone yegilo njalo ukuze linqume ukuthi kuphephile nini ukuyeka umuthi we-IV.

Yiziphi Izimo Ezingezinhle Ze-Liothyronine?

Imiphumela emibi evame kakhulu ihlobene nomzimba wakho osabela ngokushesha kakhulu ekwenyukeni okungazelelwe kwe-hormone yegilo. Ungase uzwe ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, ubuhlungu besifuba, noma ukujuluka njengoba umzimba wakho usheshisa.

Abanye abantu bazizwa bekhathazekile, bengazinzi, noma benenkinga yokulala lapho amazinga abo egilo enyuka ngokushesha. Ungase futhi uqaphele ukuthuthumela ezandleni zakho, ukucindezeleka, noma uzizwe ufudumele ngokungavamile noma ukhanya.

Imiphumela emibi engathi sína ingabandakanya izinguquko eziyingozi zesigqi senhliziyo, ikakhulukazi uma unezinkinga zenhliziyo ezikhona. Ithimba lakho lezokwelapha lizobe liqapha inhliziyo yakho ngokuqhubekayo ukuze libambe noma yiziphi izinguquko ezikhathazayo ekuqaleni.

Nansi imiphumela emibi ongase uyithole, ihlelwe ngokuthi ivame kangakanani:

Imiphumela emibi evamile abantu abaningi abayitholayo:

• Ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• Ubuhlungu besifuba noma ukuqina
• Ukujuluka okuningi kunokujwayelekile
• Ukuzizwa ukhathazekile noma ungazinzi
• Izandla ezithuthumelayo
• Ukucindezeleka
• Inkinga yokulala
• Ukuzizwa ufudumele noma ukhanya

Imiphumela emibi engavamile kodwa engathi sína:

• Ubuhlungu obukhulu besifuba
• Ushintsho oluyingozi lwesigqi senhliziyo
• Umfutho wegazi ophezulu kakhulu
• Ukuphefumula kanzima kakhulu
• Ukudideka noma ukucasuka
• Ukushaywa yisithuthwane (akuvamile)

Khumbula ukuthi uzoqashwa eduze ngaso sonke isikhathi sokwelashwa kwakho, ngakho-ke ithimba lakho lezokwelapha lingakwazi ukubhekana ngokushesha nanoma yimaphi imiphumela emibi evelayo. Imiphumela eminingi emibi iyalawuleka futhi iyathuthuka njengoba umzimba wakho ujwayela imithi.

Ubani Ongafanele Athathe I-Liothyronine?

Abantu abanezimo ezithile zenhliziyo badinga ukuqapha okwengeziwe nge-IV liothyronine ngoba ingacindezela uhlelo lwe-cardiovascular. Uma unesifo esibi semithambo yenhliziyo, ukuhlaselwa yinhliziyo kwakamuva, noma izinkinga eziyingozi zesigqi senhliziyo, udokotela wakho uzohlola izingozi ngokucophelela.

Labo abanokunganele kwamadlala e-adrenal okungelashwa (lapho amadlala akho e-adrenal engenzi amahomoni anele) ngokuvamile abakwazi ukuthola amahomoni e-thyroid ngokuphepha kuze kube yilapho isimo sabo se-adrenal selashwa kuqala. Inhlanganisela ingaba yingozi.

Uma unokungezwani ne-liothyronine noma yiziphi izithako ezixazululweni ze-IV, ithimba lakho lezokwelapha lizodinga ukuthola ezinye izindlela zokwelapha. Bazophinda baqaphele uma unomfutho wegazi ophezulu ongathuthukisiwe kahle.

Nazi izimo eziyinhloko lapho i-IV liothyronine ingase ingafaneleki khona:

Izimo ezidinga ukuqapha okwengeziwe:

• Isifo senhliziyo esibi noma ukuhlaselwa yinhliziyo kwakamuva
• Ukunganele kwamadlala e-adrenal okungelashwa
• Ukuphazamiseka okuyingozi kwesigqi senhliziyo
• Umfutho wegazi ophezulu ongathuthukisiwe kakhulu
• I-thyrotoxicosis esebenzayo (i-thyroid esebenza ngokweqile)
• Ukungezwani okwaziwayo ne-liothyronine

Abantu abakhethekile abadinga ukuqashwa ngokucophelela:

• Iziguli ezigugile (ezizwela kakhulu emiphumeleni emibi)
• Abantu abanesifo sikashukela (bangase badinge ukulungiswa kwemithi)
• Labo abathatha izinciphisi zegazi
• Iziguli ezinzima zezinso noma zesibindi

Iqembu lakho lezokwelapha lizobukeza ngokucophelela umlando wakho wezokwelapha kanye nesimo sakho samanje ngaphambi kokunquma ukuthi i-IV liothyronine ikulungele yini. Ezimweni eziphuthumayo, bangase basebenzise ngisho nangokuqapha okwengeziwe uma izinzuzo zidlula izingozi.

Amagama Omkhiqizo we-Liothyronine

Igama elivamile lomkhiqizo we-IV liothyronine yi-Triostat, eyenzelwe ngqo ukusetshenziswa ngemithambo. Lokhu kwehluke ezinhlotsheni ze-liothyronine yomlomo ongase uzazi, njengamaphilisi e-Cytomel.

I-Triostat iza njengempushana enezinto ezingcolisiwe abafaka imithi esibhedlela abayixuba namanzi ahlanzekile ngaphambi kokuthi inikezwe kuwe. Yenziwe ngqo ukusetshenziswa esibhedlela futhi ayitholakali ukuze isetshenziswe ekhaya.

Ezinye izibhedlela zingase futhi zisebenzise izinguqulo ezivamile ze-IV liothyronine, kodwa zonke ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngendlela efanayo. Ithimba lakho lezokwelapha lizosebenzisa noma iyiphi inguqulo etholakalayo endaweni yabo.

Ezinye Izindlela ze-Liothyronine

Ezimweni ezingagqamile ze-hypothyroidism, i-levothyroxine yomlomo (Synthroid, Levoxyl) iyindlela ejwayelekile yokwelapha. Iphephile ukusetshenziswa isikhathi eside futhi ingathathwa ekhaya, kodwa kuthatha amasonto ukufinyelela ekusebenzeni okugcwele.

Ezimweni eziphuthumayo lapho i-IV liothyronine ingatholakali, ezinye izinyanga zingase zisebenzise i-IV levothyroxine (i-Synthroid injection), nakuba isebenza kancane. Ezimweni ezingavamile, ama-extracts emvelo e-thyroid angase acabangwe, kodwa lawa awatholakali ngesimo se-IV.

Ukukhetha kuncike ekutheni ukwelashwa kudingeka ngokushesha kangakanani nokuthi yini etholakalayo. I-IV liothyronine ihlala iyindlela esebenza ngokushesha kakhulu ezimweni eziphuthumayo ze-thyroid zangempela, kuyilapho imithi yomlomo ingcono ekwelashweni okuzinzile, kwesikhathi eside.

Ingabe i-Liothyronine Ingcono Kune-Levothyroxine?

I-IV liothyronine ne-levothyroxine zisebenzela izinjongo ezihlukene, ngakho ukuziqhathanisa akufani nokufanisa ama-apula nama-apula. I-Liothyronine isebenza ngokushesha okukhulu kodwa futhi inamandla kakhulu futhi ingaba yingozi.

Ezimweni eziphuthumayo njenge-myxedema coma, i-IV liothyronine ingcono ngoba ingasindisa impilo lapho isivinini sibalulekile. Kodwa-ke, ekushintsheni ama-hormone e-thyroid nsuku zonke, i-oral levothyroxine iphephile futhi ilindeleke kakhulu.

Cabanga nge-IV liothyronine njengomuthi wokusiza ophuthumayo, kuyilapho i-levothyroxine injengokwelashwa kwansuku zonke okuzinzile, okuthembekile. Abantu abaningi abathola i-IV liothyronine ekugcineni bazoshintshela ku-oral levothyroxine ukuze balawulwe isikhathi eside.

Ukukhetha okuthi "kungcono" kuncike ngokuphelele esimweni sakho sezokwelapha. Esimweni esiphuthumayo esisongela impilo, i-IV liothyronine ngokusobala ingcono. Ukuphatha i-hypothyroidism engapheli ekhaya, i-levothyroxine iyindlela ephephile.

Imibuzo Evame Ukubuzwa Nge-Liothyronine

Q1. Ingabe i-Liothyronine iphephile kubantu abanezifo zenhliziyo?

I-IV liothyronine idinga ukuqapha okwengeziwe kubantu abanezifo zenhliziyo ngoba ingakhuphula izinga lokushaya kwenhliziyo nomfutho wegazi. Kodwa-ke, ezimweni ezisongela impilo, odokotela bangase basebenzise ngokuqapha okukhulu kwenhliziyo.

Uma unezinkinga zenhliziyo, ithimba lakho lezokwelapha lizoqala ngemithamo ephansi futhi liqaphe ukushaya kwenhliziyo yakho ngokuqhubekayo. Bangase futhi bakunikeze imithi yokuvikela inhliziyo yakho ngesikhathi sokwelashwa. Isinqumo sincike ekutheni ukuphuthuma kwe-thyroid kuyingozi kakhulu yini kunezinkinga zenhliziyo.

Q2. Kufanele ngenzeni uma ngithola i-Liothyronine eningi ngengozi?

Njengoba i-IV liothyronine inikezwa kuphela ochwepheshe bezempilo emitholampilo, ukweqisa ngengozi akuvamile futhi kungaphathwa ngokushesha yithimba lakho lezokwelapha. Izimpawu ze-hormone ye-thyroid eningi zihlanganisa ukushaya kwenhliziyo okusheshayo kakhulu, ubuhlungu obukhulu besifuba, noma ukucasuka okukhulu.

Uma kwenzeka ukweqisa, ithimba lakho lezokwelapha lizoyeka ukufakwa ngokushesha futhi linikeze ukunakekelwa okusekelayo. Bangase bakunikeze imithi yokunciphisa izinga lokushaya kwenhliziyo yakho futhi bakuqaphe eduze kuze kube yilapho imiphumela iphela. Izindaba ezinhle ukuthi i-IV liothyronine inesikhathi esifushane sokusebenza.

Q3. Kwenzekani Uma Ngingaphuthelwa Umthamo We-Liothyronine?

Njengoba i-liothyronine ye-IV inikezwa endaweni yasesibhedlela ochwepheshe bezempilo, ngeke uphuthelwe imithamo uqobo. Ithimba lakho lezokwelapha lilandela isimiso esiqinile futhi likuqapha ngokuqhubekayo.

Uma kukhona ukubambezeleka emthomeni wakho ohleliwe ngezizathu zezokwelapha, odokotela bakho bazolungisa isikhathi ngokuya ngesimo sakho samanje kanye namahomoni. Bangase bahlole umsebenzi wegazi lakho ngaphambi kokuqhubeka nomthamo olandelayo.

Q4. Ngingayeka Nini Ukuthatha I-Liothyronine?

Ithimba lakho lezokwelapha lizinqumela ukuthi lingayeka nini i-liothyronine ye-IV ngokusekelwe emazingeni akho e-hormone yegilo nokuthuthuka okuphelele. Lokhu kuvame ukwenzeka ezinsukwini ezimbalwa njengoba isimo sakho sizinzile.

Ushintsho ngokuvamile luhlanganisa ukushintshela emithini yegilo yomlomo kunokuyeka ngokuphelele ukufaka esikhundleni se-hormone yegilo. Odokotela bakho bazohlola umsebenzi wegazi lakho njalo ukuze baqinisekise ukuthi amazinga akho e-hormone ahlala ezinzile ngalesi sikhathi sokushintsha.

Q5. Ngingathatha Eminye Imithi Ngesikhathi Ngithola I-Liothyronine Ye-IV?

Imithi eminingi ingathathwa ngokuphepha ne-liothyronine ye-IV, kodwa eminye ingase idinge ukulungiswa komthamo. Izinciphisi zegazi, imithi yesifo sikashukela, nemithi yenhliziyo ngokuvamile idinga ukuqapha nezinguquko ezingenzeka.

Ithimba lakho lezokwelapha lizobuyekeza yonke imithi yakho futhi lenze noma yikuphi ukulungiswa okudingekayo. Bazophinda baqaphele ukusebenzisana okungase kuthinte ukuthi i-liothyronine isebenza kahle kangakanani noma ikhulise ingozi yakho yemiphumela emibi. Hlala utshela ithimba lakho lezempilo ngayo yonke imithi nezithasiselo ozithathayo.