Yini i-Lorcaserin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Lorcaserin yayiyimithi yokunciphisa umzimba eyayitholakala ngemvume kadokotela eyayisiza abantu ukuthi banciphise umzimba ngokubenza bazizwe begcwele ngokushesha ngesikhathi sokudla. Kodwa-ke, i-FDA yakhipha lo muthi emakethe yase-U.S. ngoFebhuwari 2020 ngenxa yokukhathazeka ngokuphepha mayelana nokwanda kwengozi yomdlavuza. Uma njengamanje usebenzisa i-lorcaserin noma ucabangela izinketho zokunciphisa umzimba, kubalulekile ukuqonda okwenzekile nokuhlola ezinye izindlela eziphephe kakhulu nodokotela wakho.

Yini i-Lorcaserin?

I-Lorcaserin yayiyimithi yokucindezela ukudla eyenzelwe ukusiza abantu abadala ukuthi banciphise umzimba uma ihlanganiswe nokudla nokuzivocavoca. Yayisebenza ngokugxila kuma-serotonin receptors ebuchosheni bakho alawula imizwa yendlala nokugcwala. Lo muthi wawuthengiswa ngaphansi kwegama lomkhiqizo elithi Belviq kanye ne-Belviq XR.

Lo muthi wawungowesigaba semithi ebizwa ngokuthi serotonin 2C receptor agonists. Cabanga ngayo njengomthunywa wamakhemikhali owayetshela ubuchopho bakho ukuthi wanelisekile ngokudla okuncane. Lokhu kwasiza abantu ukuthi badle izingxenye ezincane futhi bazizwe begcwele isikhathi eside ngemva kokudla.

I-Lorcaserin yayigunyazwe kuphela kubantu abadala abanenkomba yobuningi bomzimba (BMI) engama-30 noma ngaphezulu, noma labo abane-BMI engama-27 noma ngaphezulu abanezinye izimo zempilo ezihlobene nesisindo njengohlobo lwesifo sikashukela noma umfutho wegazi ophezulu.

Yayisetshenziselwani i-Lorcaserin?

I-Lorcaserin yayinikezwa ngokuqondile ukuze kulawulwe isisindo esingapheli kubantu abadala abahlupheka ngokukhuluphala. Kwakungeyona indlela esheshayo noma iphilisi lokudla, kodwa ithuluzi lokusekela imizamo yokunciphisa umzimba yesikhathi eside kanye nokudla okunempilo kanye nomsebenzi womzimba ovamile.

Odokotela ngokuvamile babenikeza i-lorcaserin kubantu ababezamile izindlela zokunciphisa umzimba zendabuko ngaphandle kwempumelelo. Lo muthi wawuhloselwe ukusiza ukuqeda umjikelezo wokudla ngokweqile ngokunciphisa ukudla kanye nokulangazelela ukudla. Iziguli eziningi zathola ukuthi kulula ukunamathela emigomweni yazo yama-calorie lapho zithatha lo muthi.

Umuthi wawusetshenziselwa nabantu abanezimo zezokwelapha ezihlobene nesisindo. Lokhu kwakuhlanganisa isifo sikashukela sohlobo 2, umfutho wegazi ophezulu, i-cholesterol ephezulu, kanye ne-sleep apnea. Ukuncipha kwesisindo kwavame ukusiza ukuthuthukisa lezi zimo, okwenza i-lorcaserin ibe yindlela yokwelapha ebalulekile ngaphambi kokuhoxiswa kwayo.

I-Lorcaserin yayisebenza kanjani?

I-Lorcaserin yayisebenza ngokuvula ama-receptor athile e-serotonin esikhungweni sakho sokulawula ukudla kobuchopho. Lawa ma-receptor, abizwa ngokuthi ama-receptor e-5-HT2C, adlala indima ebalulekile ekutsheleni umzimba wakho ukuthi sekwanele ukudla. Uma esevuliwe, athumela izimpawu zokuthi wanelisekile futhi ugcwele.

Umuthi wawuthathwa njengosebenza kahle ngokulinganisela kunokuba umuthi oqinile wokunciphisa umzimba. Abantu abaningi abathatha i-lorcaserin balahlekelwa cishe amaphesenti amahlanu kuya kwayi-10 wesisindo somzimba wabo phakathi nonyaka. Ngenkathi lokhu kungase kungazwakali kakhulu, ngisho nokuncipha kwesisindo okuncane kungathuthukisa kakhulu imiphumela yezempilo kubantu abakhuluphele ngokweqile.

Ngokungafani nezinye izinto ezicindezela ukudla, i-lorcaserin yayenzelwe ukuba ikhetheke esenzweni sayo. Ngokuyinhloko yayiqondise kuma-receptor abambe iqhaza ekulawuleni ukudla kunokuthinta ezinye izinhlelo emzimbeni wakho. Lokhu kukhetha kwakuhloswe ukunciphisa imiphumela emibi uma kuqhathaniswa nemithi yokunciphisa umzimba endala.

I-Lorcaserin yayithathwa kanjani?

I-Lorcaserin yayivame ukuthathwa kabili ngosuku ngaphandle kokudla. Inguqulo ejwayelekile yokukhishwa ngokushesha yayidinga imithamo emibili engu-10mg ngosuku, kanti inguqulo yokukhishwa isikhathi eside (Belviq XR) yayithathwa kanye ngosuku njengomthamo ongu-20mg. Udokotela wakho wayezonquma uhlelo olungcono kakhulu lokulinganisa olususelwe ezidingweni zakho.

Umuthi wawungathathwa ngamanzi, ubisi, noma ijusi. Kwakungekho imikhawulo ethile yokudla, nakuba ukuwuthatha nokudla kwesinye isikhathi kwakusiza ukunciphisa isisu esibuhlungu kubantu abazwelayo. Odokotela abaningi batusa ukuthatha umuthi ngezikhathi ezifanayo nsuku zonke ukuze kugcinwe amazinga aqhubekayo ohlelweni lwakho.

Kwakubalulekile ukuqhubeka nokulandela ukudla okunciphisa ama-calories kanye nohlelo lokuzivivinya ngenkathi uthatha i-lorcaserin. Umuthi usebenza kahle kakhulu uma uhlanganiswe nezinguquko zokuphila, hhayi njengendlela yokushintsha imikhuba enempilo. Udokotela wakho wayezobe ekunikeze imihlahlandlela ethile yokudla eyenzelwe izinhloso zakho zokunciphisa umzimba.

Kufanele I-Lorcaserin Ithathwe Isikhathi Eside Kangakanani?

I-Lorcaserin yayenzelwe ukusetshenziswa isikhathi eside, kodwa odokotela ngokuvamile babevivinya ukusebenza kwayo ngemuva kwamasonto angu-12 okwelashwa. Uma ubungazange ulahlekelwe okungenani amaphesenti angu-5 obunzima bomzimba wakho bokuqala ngalesi sikhathi, udokotela wakho wayezomisa umuthi ngoba wawunganikezi inzuzo ebalulekile.

Kulabo abasabela kahle, i-lorcaserin ingaqhubeka isikhathi eside ngaphansi kokuqashwa kwezokwelapha. Abanye abantu bayithatha iminyaka eminingi njengengxenye yohlelo lwabo oluqhubekayo lokuphatha isisindo. Ukuhlolwa njalo kwakubalulekile ukuqapha kokubili ukusebenza kahle nemiphumela engemihle engaba khona.

Isinqumo sokuyeka ukuthatha i-lorcaserin sasiyohlala senziwa ngokubonisana nomhlinzeki wakho wezempilo. Ukuyeka kungazelelwe akuzange kubangele izimpawu zokuhoxisa, kodwa abantu abaningi bathola ukuthi isifiso sabo sokudla sabuyela emazingeni angaphambilini ngokushesha ngemuva kokuyeka.

Zaziyini Imiphumela Emiqoka Ye-Lorcaserin?

Njengayo yonke imithi, i-lorcaserin ingabangela imiphumela emibi, nakuba abantu abaningi bayibekezelela kahle. Imiphumela emibi evame kakhulu yayivame ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Nokho, ukukhathazeka okukhulu okwaholela ekuhoxisweni kwayo kwakuwukwanda kwengozi yomdlavuza.

Nansi imiphumela emibi ebikwa kaningi abantu abayithola ngenkathi bethatha i-lorcaserin:

• Ikhanda elibuhlungu nesiyezi
• Isicanucanu nesisu esibuhlungu
• Ukukhathala nobuthakathaka
• Umlomo owomile
• Ukuqunjelwa
• Ubuhlungu emhlane
• Ukukhwehlela nezifo eziphezulu zokuphefumula

Lezi zimo ezivamile ezibangelwa imithi zazivame ukulawuleka futhi zihambela phambili. Abantu abaningi bathola ukuthi ukuphuza amanzi amaningi, ukudla ukudla okuvamile, nokuthola ukuphumula okwanele kwakusiza ekunciphiseni lezi zimpawu.

Imiphumela emibi kakhulu kodwa engavamile yayihlanganisa i-serotonin syndrome, ikakhulukazi uma ihlanganiswe neminye imithi ethinta amazinga e-serotonin. Lesi simo sabangela izimpawu ezinjengokudideka, ukushaya kwenhliziyo okusheshayo, umfutho wegazi ophezulu, nokuqina kwemisipha. Ngaphezu kwalokho, abanye abantu babenezinkinga zamavalvu enhliziyo, nakuba lokhu kwakungavamile.

Okutholwe okukhathazayo kakhulu kwaba ukwanda kwengozi yomdlavuza, ikakhulukazi umdlavuza wamaphaphu, we-pancreatic, kanye ne-colorectal. Lokhu kutholakele ngesikhathi sokutadisha ukuphepha kwesikhathi eside okwaholela esinqumweni se-FDA sokukhipha i-lorcaserin emakethe ngoFebhuwari 2020.

Obani okungafanele basebenzise i-Lorcaserin?

Amaqembu amaningana abantu anconywa ukuthi angasebenzisi i-lorcaserin ngenxa yezingozi ezengeziwe noma ukusebenza kahle okuncishisiwe. Abesifazane abakhulelwe nabancelisayo babenqatshelwe ngokuphelele ukusebenzisa lo muthi ngoba ukulahlekelwa isisindo ngesikhathi esinjalo kungalimaza umama nomntwana.

Abantu abanezimo ezithile zezokwelapha babedinga ukugwema i-lorcaserin ngokuphelele. Lokhu kwakuhlanganisa abantu abanezifo ezinzima zezinso noma zesibindi, njengoba lezi zitho zaziphethe ukucubungula umuthi. Labo abanomlando wezinkinga zamavalvu enhliziyo nabo banconywa ukuthi bangasebenzisi i-lorcaserin ngenxa yezinkinga zenhliziyo ezingase zibe khona.

Ngaphezu kwalokho, abantu abasebenzisa imithi ethile abakwazanga ukusebenzisa i-lorcaserin ngokuphepha. Lokhu kwakuhlanganisa labo abasebenzisa ama-MAO inhibitors, ezinye izidambisi zokucindezeleka, imithi ye-migraine, neminye imithi ethinta amazinga e-serotonin. Inhlanganisela ingaholela ku-serotonin syndrome eyingozi.

Amagama Omkhiqizo we-Lorcaserin

I-Lorcaserin yayithengiswa ngaphansi kwamagama amabili amakhulu e-brand e-United States. I-Belviq yayiyinguqulo yokukhishwa ngokushesha eyayidinga ukuthathwa kabili ngosuku, kanti i-Belviq XR yayiyindlela yokukhishwa isikhathi eside eyayithathwa kanye ngosuku. Zombili lezi zinguqulo ziqukethe isithako esifanayo esisebenzayo kodwa zazenzelwe izinhlelo ezihlukene zokulinganisa.

Umuthi wawenziwa yi-Arena Pharmaceuticals futhi kamuva wathengiswa yi-Eisai Inc. Ezinye izindawo zingase zibe namagama e-brand ahlukene, kodwa isithako esisebenzayo sahlala singu-lorcaserin hydrochloride kungakhathaliseki ukuthi ngubani owenza noma igama le-brand.

Selokhu kwakhishwa yi-FDA ngo-2020, lawa magama e-brand awasatholakali e-United States. Noma yiziphi izinto ezisele kwakudingeka zisuswe emakhemisi futhi zibuyiselwe kubakhiqizi.

Ezinye izindlela ze-Lorcaserin

Imithi eminingana yokulahlekelwa isisindo evunywe yi-FDA iyatholakala njengezinye izindlela ze-lorcaserin. Lezi zinketho zisebenza ngezindlela ezihlukene futhi zingase zifaneleke kuye ngesimo sakho sempilo kanye nemigomo yokulahlekelwa isisindo. Udokotela wakho angasiza ekutholeni ukuthi iyiphi enye indlela engasebenza kahle kuwe.

Imithi yamanje yokulahlekelwa isisindo kadokotela ihlanganisa i-orlistat (Xenical), i-phentermine-topiramate (Qsymia), i-naltrexone-bupropion (Contrave), kanye ne-liraglutide (Saxenda). Ngayinye inezinzuzo zayo kanye nemiphumela engemihle engaba khona, ngakho ukuhlola ngokucophelela nodokotela wakho kubalulekile.

Ezinye izindlela ezingezona imithi zihlanganisa izinhlelo zokulahlekelwa isisindo ezihlelekile, izinhlelo zokushintsha ukudla, kanye nokuhlinzwa kwe-bariatric kulabo abafanelekayo. Abantu abaningi baphumelela ngezinhlelo ezibanzi zokushintsha indlela yokuphila ezihlanganisa ukwelulekwa ngokudla, isiqondiso sokuzivocavoca, kanye nokusekelwa kokuziphatha.

Ingabe i-Lorcaserin yayingcono kunezinye izindlela zokulahlekelwa isisindo?

Ukuphumelela kwe-Lorcaserin kwakufana neminye imithi yokunciphisa umzimba ebekwe ngudokotela eyayitholakala ngaleso sikhathi. Abantu abaningi balahlekelwa cishe amaphesenti amahlanu kuya kwayishumi obunzima bomzimba babo ngonyaka, okwakufana nezinye izinketho ezivunyelwe yi-FDA. Inzuzo enkulu kwaba ukuthi yayinezinkinga ezincane uma iqhathaniswa nezinye izindlela.

Kodwa-ke, ingozi yomdlavuza etholwe ocwaningweni lwesikhathi eside ekugcineni yaba nkulu kunoma yiziphi izinzuzo i-lorcaserin ebingase izinikeze. Yingakho i-FDA yaphetha ngokuthi izingozi zedlula izinzuzo futhi yacela ukuthi ikhishwe emakethe. Eminye imithi yokunciphisa umzimba iyaqhubeka nokutholakala ngoba amaphrofayili abo ezinzuzo nezingozi ahlala elungile.

Umuthi ngamunye wokunciphisa umzimba unezici eziyingqayizivele ezingenza ukuthi ilungele kakhulu noma ingafaneleki kubantu abahlukene. Okubaluleke kakhulu ukuthola inketho ephephile, esebenzayo esebenza nezimo zakho zempilo kanye nendlela yokuphila ngaphansi kokuqondiswa okufanele kwezokwelapha.

Imibuzo Evame Ukubuzwa Mayelana ne-Lorcaserin

Ingabe i-Lorcaserin iphephile kubantu abanesifo sikashukela?

I-Lorcaserin ekuqaleni yayibhekwa njengephephile kubantu abanesifo sikashukela sohlobo 2 futhi yayivame ukunqunywa ukusiza ekuphathweni kwesisindo ezigulini ezinomdlavuza. Umuthi empeleni ungasiza ekuthuthukiseni ukulawulwa kukashukela egazini ngokunciphisa umzimba. Kodwa-ke, ingozi eyanda yomdlavuza eholele ekuhoxisweni kwayo ithinta wonke umuntu, okuhlanganisa nalabo abanesifo sikashukela.

Uma unesifo sikashukela futhi ubuthatha i-lorcaserin, udokotela wakho cishe wakushintshela komunye umuthi wokunciphisa umzimba noma indlela. Eminye imithi yesifo sikashukela efana ne-liraglutide (Saxenda) kanye ne-semaglutide (Wegovy) manje inikeza izinzuzo zokunciphisa umzimba kanye nokulawulwa kukashukela egazini.

Ngingenzani uma ngisebenzise i-Lorcaserin eningi ngengozi?

Uma ngabe uthathe i-lorcaserin eningi ngengozi, bekufanele uxhumane nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Izimpawu zokweqisa umthamo zingabandakanya isicanucanu, ukuhlanza, isiyezi, ukozela, kanye nemiphumela engase ibe yingozi kakhulu ezingeni lokushaya kwenhliziyo yakho nomfutho wegazi.

Njengoba i-lorcaserin ingasatholakali, ukweqisa umthamo akusakhathazi. Kodwa-ke, uma unamayeza amadala asele, kufanele alahlwe ngendlela efanele ngohlelo lokubuyisa amakhemisi noma kulandela imihlahlandlela ye-FDA yokulahla imithi ngokuphepha.

Kufanele ngabe ngenzeni uma ngiphuthelwe umthamo we-Lorcaserin?

Uma uphuthelwe umthamo we-lorcaserin, isincomo esivamile sasiwukuthi uwuthathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo. Kulokho, ubuzodlula umthamo ophuthelwe bese uqhubeka nesheduli yakho yokulinganisa ejwayelekile. Ukuthatha imithamo emibili ngesikhathi esisodwa akuzange kunconywe.

Nge-version yokukhishwa okwandisiwe (Belviq XR), isikhathi sasibaluleke kakhulu ngoba yayenzelwe ukuhlala amahora angama-24. Ukuphuthelwa imithamo kungathinta ukusebenza kahle komuthi ekulawuleni ukudla usuku lonke.

Ngingayeka nini ukuthatha i-Lorcaserin?

Ungayeka ukuthatha i-lorcaserin nganoma yisiphi isikhathi ngaphandle kokuzwa izimpawu zokuhoxiswa, kodwa isinqumo kufanele ngaso sonke isikhathi senziwe ngesiqondiso sikadokotela wakho. Odokotela abaningi bancoma ukuyeka uma ungazange ulahlekelwe okungenani amaphesenti ama-5 wesisindo sakho somzimba ngemuva kwamasonto ayi-12 okwelashwa.

Njengoba ukuhoxiswa kwe-FDA ngo-2020, wonke umuntu owayethatha i-lorcaserin welulekwa ukuthi ayeke ngokushesha futhi axhumane nomhlinzeki wabo wezempilo mayelana namasu okuphatha isisindo esikhundleni. Ukushintshela ekuyekeni kwakuvamile ukuthi kuhambe kahle, yize amazinga okudla ngokuvamile abuyela emazingeni angaphambi kokwelashwa ngokushesha.

Ingabe zikhona izinkinga zempilo zesikhathi eside ezivela ekuthathweni kwe-Lorcaserin?

Into enkulu yesikhathi eside evela ekuthathweni kwe-lorcaserin yingozi eyanda yomdlavuza eholele ekuhoxisweni kwayo. Uma ngabe uke wathatha i-lorcaserin ngaphambili, kubalulekile ukuxoxa ngalomlando nodokotela wakho futhi uhlale unolwazi lwakamuva ngezivivinyo ezinconywayo zokuhlolwa komdlavuza. Kodwa-ke, ukuthatha imithi akuqinisekisi ukuthi uzothola umdlavuza.

Umhlinzeki wakho wezempilo angakusiza ukuthi uqonde izici zakho eziyingozi ngamanye futhi uthuthukise uhlelo olufanele lokuqapha. Abantu abaningi abathatha i-lorcaserin ukunciphisa isisindo bashintshe ngempumelelo kwezinye izindlela zokuphatha isisindo ngaphandle kokuba nezinkinga zesikhathi eside.