Ukuhlinzeka nge-intravenous (indlela ye-intravenous)
Imikhiqizo etholakalayo
Ukuphila
Mayelana naleli khambi
I-Lovotibeglogene autotemcel injection iyilokhu-kanye kuphela i-gene therapy esetshenziswa ekwelapheni isifo se-sickle cell (isifo sama-red blood cell) kubantu abake baba ne-vaso-occlusive events. I-Sickle cell disease yisifo esidluliselwa nge-genetic, esiyifa, esiphila ubomi bonke esibangelwa ukuguqulwa kwenye ye-genes kuma-red blood cell, i-beta-globin gene ebangela ama-red cells ajwayelekile ane-disc shape ukuba abe yi-shape yesikhova, ebangela i-anemia ne-vaso-occlusive events, njengokucindezeleka kobuhlungu. Lona umuthi kufanele unikezwe kuphela ngudokotela wakho noma ngaphansi kokunakekelwa kwakhe. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma ukhetha ukusebenzisa le mishini, kufanele kuqhathaniswe ingozi yokusebenzisa le mishini nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Ngale mishini, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqhelile noma oluhambisana nokwaleka kule mishini noma kwezinye izidakamizwa. Tshela futhi ochwepheshe bakho bezempilo uma unanoma yiluphi olunye uhlobo lwezinto ozaleka kuzo, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenaso iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Akwenziwanga ucwaningo olufanele mayelana nobudlelwano bobudala nemiphumela yokubeka i-lovotibeglogene autotemcel kubantwana abaneminyaka engaphansi kwengu-12. Ukuphepha nokuphumelela akukaqiniswa. Akwenziwanga ucwaningo olufanele mayelana nobudlelwano bobudala nemiphumela yokubeka i-lovotibeglogene autotemcel kubantu abadala. Ayikho izifundo ezanele zabesifazane zokunquma ingozi yengane uma usebenzisa le mishini ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokusebenzisa le mishini ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswanga ndawonye, kwezinye izimo imishini emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthola le mishini, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma usebenzisa noma yimiphi imishini ehlaliswe ngezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mishini nanoma yimiphi imishini elandelayo ngokuvamile akunconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imishini ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imishini. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba kungenzeka kube khona ukusebenzisana. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusebenzisa imishini yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mishini. Qiniseka ukuthi utshela udokotela wakho uma unanoma yiziphi ezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Udokotela noma omunye ochwepheshe bezempilo oqeqeshwe ngokufanele uzakukunika le miyekezo esibhedlela. Inikezwa ngenhlanzi ebekwe esithanjeni. Le miyekezo kufanele inikezwe kancane, ngakho-ke ipayipi lakho le-IV kuzodingeka lihlale endaweni okungenani imizuzu engama-30. Le miyekezo iza ne-Medication Guide. Funda bese ulandela lezi zinkomba ngokucophelela. Buza udokotela wakho noma umthengisi wemithi uma unemibuzo. Le miyekezo yenziwe ngokukhethekile kumuntu ngamunye, usebenzisa amangqamuzana egazi lomuntu. Udokotela wakho uzoqoqa igazi lakho ngenqubo ebizwa ngokuthi yi-mobilization ne-apheresis. Khuluma nodokotela wakho uma ukhathazekile ngalokhu. Ungasebenzisi i-crizanlizumab, i-hydroxyurea, i-L-glutamine, ne-voxelotor okungenani izinyanga ezimbili, imithi yokwelapha i-HIV okungenani inyanga eyodwa, kanye ne-iron chelator okungenani izinsuku eziyisikhombisa ngaphambi kokuba ube nenqubo yokuqoqa igazi lakho.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.