Macitentan ne-tadalafil (indlela yokwelapha ngomlomo)
Imikhiqizo etholakalayo
Opsynvi
Mayelana naleli khambi
Ukuhlanganiswa kweMacitentan neTadalafil kusetshenziswa ekwelapheni i-pulmonary arterial hypertension (PAH), okuyisibindisi esiphezulu segazi elivela emithanjeni emikhulu ethwala igazi evela ngakwesokudla senhliziyo (iventrikele) liye emaphashini. Uma imithambo emincane yegazi emaphashini ihlala inamandla okuphikisa ukugeleza kwegazi, iventrikele yokudla kufanele isebenze nzima ukuze iphonse igazi elanele emaphashini. Ukuhlanganiswa kweMacitentan neTadalafil kusebenza ngokukhulula le mithambo yegazi nokukhulisa ukunikezwa kwegazi emaphashini, okunciphisa umsebenzi wenhliziyo. Lona umuthi uyatholakala kuphela kubantu besifazane ngaphansi kohlelo lokusabalalisa oluqediwe oluthi Macitentan-Containing Products REMS (Risk Evaluation and Mitigation Strategy) program. Asikho isidingo sokuba amadoda abhalise ohlelweni lwe-REMS. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma kunquma ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokusebenzisa imithi nezinzuzo ezizoletha. Lo ngumqulu ozowenza wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma iyiphi impendulo engaqondakali noma ebangelwa ukungezwani nale mithi noma eminye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokungezwani, njengokudla, izibenge, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubuhlobo bobudala nemiphumela yokuhlanganiswa kwe-macitentan ne-tadalafil kubantu abancane. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalinda ukusetshenziswa kokuxuba kwe-macitentan ne-tadalafil kubantu abadala. Ayikho izifundo ezifanele kwabesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokusebenzisa le mithi ngesikhathi sokuncelisa. Nakuba ezinye izimithi kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthatha le mithi, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlaliswe ngezansi. Ukuhlangana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi noma ashintshe ezinye izimithi ozithathayo. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akuyona into enconywayo, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyisebenzisa kangaki enye noma kokubili imithi. Ezinye izimithi akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla njengoba kungenzeka ukuhlangana. Ukusebenzisa utshwala noma utshaba nezinye izimithi kungabangela ukuhlangana. Ukuhlangana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ngokuvamile akuyona into enconywayo, kodwa kungagwenyeki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyisebenzisa kangaki le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukusebenzisa le mithi nanoma yini elandelayo kungabangela ukwanda kengozi yezinye izingozi ezibuhlungu kodwa kungagwenyeki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyisebenzisa kangaki le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli leyeza kuphela njengoba kunqunyiwe udokotela wakho. Ungathathi okuningi kwalokhu, ungathathi kaningi, futhi ungathathi isikhathi eside kunalokho udokotela wakho akuqondile. Umthamo wakho ungase udinga ukushintshwa izikhathi eziningi ukuze uthole ukuthi yini ehambisana nawe kangcono. Kubalulekile kakhulu ukuthi uqonde izidingo ze-Macitentan-Containing Products REMS program kanye ne-Medication Guide. Funda futhi ulandele lezi zinkomba ngokucophelela. Buza udokotela wakho uma unemibuzo. Cela umthengisi wezidakamizwa i-medication guide uma ungenayo. Ungathatha leli leyeza ngokudla noma ngaphandle kokudla. Gwinya ithebulethi yonke ngamanzi. Ungasiki, ungawuphululi, noma ungawugibe. Ungadli i-grapefruit noma uphuze ijusi le-grapefruit ngenkathi usebenzisa leli leyeza. I-grapefruit nejusi le-grapefruit zingashintsha inani laleli leyeza elithathwa emzimbeni. Umthamo waleli leyeza uzobahlukile kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemthethweni. Ulwazi olulandelayo luhlanganisa kuphela imithamo yaleli leyeza. Uma umthamo wakho uhlukile, ungawushintshi ngaphandle kokuthi udokotela wakho akuqondile. Inani leyeza olithathayo lixhomeke emandleni leyeza. Futhi, inani lemithamo oyithathayo nsuku zonke, isikhathi esivunyelwe phakathi kwemithamo, nobude besikhathi olithatha leli leyeza kuya ngenkinga yezokwelapha oyisebenzisela leli leyeza. Uma uphuthelwa umthamo waleli leyeza, uthathe ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi somthamo wakho olandelayo, skip umthamo ophuthelwe bese ubuyela esikhathini sakho sokuthatha imithi. Ungawandisi imithamo. Gcina leli leyeza esitsheni esivaliwe ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungawumisisi. Gcina ungafinyeleleki ezinganeni. Ungagcini imithi esele iphelile noma imithi engasasetshenziswa. Buza ochwepheshe bakho bezempilo ukuthi kufanele ulahle kanjani noma iyiphi imithi ongayisebenzisi.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.