Yini iMacitentan neTadalafil: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Macitentan ne-tadalafil iyinhlanganisela yemithi esiza ukwelapha i-pulmonary arterial hypertension (PAH), isimo esibucayi lapho umfutho wegazi emaphashini akho uba phezulu ngendlela eyingozi. Le ndlela yokwelapha ephindwe kabili ihlanganisa imithi emibili ehlukene esebenza ngokubambisana ukuvula imithambo yegazi yamaphaphu akho futhi ithuthukise ukugeleza kwegazi.

Uma une-PAH, imithambo emincane emaphashini akho iba mncane futhi iqine, okwenza inhliziyo yakho isebenze kanzima kakhulu ukuze ipompe igazi ngayo. Le nhlanganisela yemithi ibhekana nenkinga evela ezinhlangothini ezimbili, ikunikeza indlela yokwelapha ebanzi kakhulu kunokusebenzisa noma iyiphi imithi yodwa.

Yini iMacitentan neTadalafil?

Le mithi ihlanganisa izithako ezimbili ezisebenzayo ezihlose izindlela ezihlukene emzimbeni wakho ukwelapha i-pulmonary arterial hypertension. I-Macitentan ivimba ama-receptor athile abangela ukuthi imithambo yegazi inciphe, kuyilapho i-tadalafil isiza ukuphumuza imisipha ebushelelezi ezindongeni zemithambo yakho yegazi.

Le nhlanganisela iza ngamaphilisi omlomo owathatha ngomlomo, ngokuvamile kanye ngosuku. Udokotela wakho ukunika lokhu uma ukwelashwa ngomuthi owodwa kungahlinzeki inzuzo eyanele, noma uma isimo sakho sidinga indlela yokwelapha enobudlova kusukela ekuqaleni.

Zombili izithako ziye zafundwa kabanzi zodwa futhi ndawonye, zibonisa ukuthi le nhlanganisela ingasebenza ngempumelelo kakhulu kunoma iyiphi imithi esetshenziswa yodwa ekuphatheni izimpawu ze-PAH nokunciphisa ukuqhubeka kwesifo.

Yini iMacitentan neTadalafil Esetshenziselwa Yona?

Le nhlanganisela yemithi yenzelwe ngokuqondile ukwelapha i-pulmonary arterial hypertension, isimo esingavamile kodwa esibucayi esithinta imithambo emaphashini akho. I-PAH yenza kube nzima ukuthi igazi ligeleze ngamaphaphu akho, okubeka ingcindezi ohlangothini olungakwesokudla lwenhliziyo yakho.

Udktela wakho angase akunike le nhlanganisela uma uhlangabezana nezimpawu ezinjengokuphefumula kanzima ngesikhathi semisebenzi yansuku zonke, ubuhlungu besifuba, ukukhathala, noma ukuvuvukala emilenzeni yakho nasezingxenyeni zezinyawo. Lezi zimpawu zenzeka ngoba inhliziyo yakho isebenza ngokweqile ukuze ipompe igazi ngemithambo yamaphaphu enciphile.

Umuthi usiza ukuthuthukisa amandla akho okuzivocavoca, okusho ukuthi ungahamba ibanga elide futhi wenze imisebenzi eminingi ngaphandle kokuphefumula kanzima. Futhi kusiza ukunciphisa ukuqhubeka kwe-PAH, okungenzeka kunciphise ingozi yakho yokulaliswa esibhedlela nezinye izinkinga ezingathi sína.

Isebenza Kanjani i-Macitentan ne-Tadalafil?

Lo muthi ohlanganisiwe usebenza ngezindlela ezimbili ezihlukene ukuhlinzeka ngemithi ephelele ye-pulmonary arterial hypertension yakho. Cabanga ngayo njengokubhekana nenkinga evela ezinhlangothini eziningi ukukunikeza imiphumela engcono.

I-Macitentan ivimba ama-endothelin receptors emithanjeni yakho yegazi. I-Endothelin iyinto eyenza imithambo yegazi iqine futhi inciphise, ngakho-ke ngokuvimba la ma-receptors, i-macitentan isiza ukugcina imithambo yakho yamaphaphu ivulekile futhi iphumule.

I-Tadalafil isebenza ngokuvimbela i-enzyme ebizwa nge-PDE5, okuholela emazingeni anda ento esiza imithambo yegazi ukuthi iphumule. Lokhu kudala ukugeleza okubushelelezi kwegazi ngemithambo yakho yamaphaphu futhi kunciphisa ingcindezi inhliziyo yakho ebhekene nayo.

Ngokubambisana, le mithi idala umphumela we-synergistic, okusho ukuthi isebenza kangcono ndawonye kunalokho ezingakwenza ngokwehlukana. Le ndlela yokuhlanganisa ithathwa njengeqine ngokulinganisela futhi ngokuvamile igcinelwe iziguli ezidinga ukwelashwa okubanzi.

Kufanele Ngiyithathe Kanjani i-Macitentan ne-Tadalafil?

Thatha lo muthi ngendlela eqondile udokotela wakho ayala ngayo, ngokuvamile kanye ngosuku ngaphandle kokudla noma ngemva kokudla. Ungayithatha ngamanzi, futhi akukhathazi ukuthi uyadla ngaphambi noma ngemva kokuthatha umthamo wakho.

Zama ukuthatha imithi yakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo egazini lakho. Lokhu kusiza ekuqinisekiseni ukwelashwa okuqhubekayo komfutho wegazi ophezulu wamaphaphu usuku lonke.

Gwinya ithebhulethi yonke ngaphandle kokuyichoboza, ukuyiqhekeza, noma ukuyihlafuna. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho ngezinketho ezingezinye noma amasu angase akusize.

Ungayeki ukuthatha lo muthi kungazelelwe, ngisho noma uzizwa ungcono. I-PAH yisimo esingamahlalakhona esidinga ukwelashwa okuqhubekayo, futhi ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho zibe zimbi ngokushesha.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Macitentan ne-Tadalafil?

Lokhu ngokuvamile ukwelashwa kwesikhathi eside okuzodingeka uqhubeke nakho uma nje kusiza ekuphatheni umfutho wegazi ophezulu wamaphaphu ngempumelelo. I-PAH yisimo esingamahlalakhona esinganyamalali sodwa, ngakho-ke imithi eqhubekayo ivame ukudingeka.

Udokotela wakho uzoqapha ukusabela kwakho ekwelashweni ngokuhlolwa okuvamile, okuhlanganisa nokuhlolwa kokukala amandla akho okuzivocavoca kanye nomsebenzi wenhliziyo. Lokhu kuqokwa kusiza ukunquma ukuthi imithi iyasebenza yini kuwe nokuthi ngabe kudingeka yini ukulungiswa.

Ezinye iziguli zingase zidingeke ukuthi zithathe le nhlanganisela iminyaka, kanti ezinye zingase zigcine zishintshela kweminye imithi ngokusekelwe ekutheni isimo sazo siphendula kanjani. Uhlelo lwakho lokwelashwa luzokwenziwa ngawodwana ngokusekelwe ezidingweni zakho ezithile nokuthi uyayibekezelela kangakanani imithi.

Yiziphi Imiphumela Eceleni Ye-Macitentan ne-Tadalafil?

Njengayo yonke imithi, le nhlanganisela ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi iyalawuleka futhi ivame ukuthuthuka njengoba umzimba wakho uzivumela emithini.

Nawa amanye imiphumela emibi ejwayelekile ongase uyithole njengoba umzimba wakho uzivumela kulokhu kwelashwa:

• Ukuba nobuhlungu bekhanda, okuvame ukuthuthuka ngemva kwamasonto ambalwa okuqala
• Ukubomvu noma ukuzwa ufudumele ebusweni nasentanyeni yakho
• Ukuvuvukala emilenzeni yakho, emaqakaleni, noma ezinyaweni
• Ukuvaleka kwamakhala noma amakhala avalekile
• Isisu esibuhlungu noma isicanucanu
• Isiyezi, ikakhulukazi uma usukuma ngokushesha
• Ubuhlungu emhlane noma ubuhlungu bemisipha

Le miphumela emibi ejwayelekile ivame ukuba ngaphansi kokukhathaza ngokuhamba kwesikhathi, kodwa yazisa udokotela wakho uma iqhubeka noma iphazamisa imisebenzi yakho yansuku zonke.

Ezinye izimpawu ezinzima zidinga ukunakekelwa kwezempilo ngokushesha, nakuba zingavamile. Xhumana nodokotela wakho ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ezikhathazayo:

• Ushintsho olungazelelwe embonweni noma ukulahlekelwa umbono
• Ukulahlekelwa ukuzwa okungazelelwe noma ukukhala ezindlebeni zakho
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile
• Isiyezi esikhulu noma ukuquleka
• Izimpawu zezinkinga zesibindi njengokuphuzi kwesikhumba noma amehlo
• Ukuphefumula okungajwayelekile noma ukuba kubi kokuphefumula
• Ukuvuka okubuhlungu okuhlala ngaphezu kwamahora angu-4 (kwabesilisa)

Le miphumela emibi emibi ayivamile, kodwa kubalulekile ukuyibona kusenesikhathi ukuze uthole ukunakekelwa kwezempilo okufanele uma kudingeka.

Ubani Ongafanele Athole i-Macitentan ne-Tadalafil?

Le mithi ehlanganisiwe ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo eziningana nemithi ingenza lokhu kwelashwa kungaphephile noma kungasebenzi kahle.

Akufanele uthathe lo muthi uma njengamanje usebenzisa imithi ye-nitrate yobuhlungu besifuba, njengoba le nhlanganisela ingabangela ukwehla okuyingozi kwengcindezi yegazi. Lokhu kuhlanganisa ama-nitrate kadokotela afana ne-nitroglycerin kanye nemithi yokuzilibazisa ebizwa ngokuthi "ama-poppers."

Abesifazane abakhulelwe noma abazama ukukhulelwa kufanele bagweme lo muthi, njengoba ungabangela ukukhubazeka okukhulu kokuzalwa. Uma ukhulelwa ngenkathi uthatha lo muthi, xhumana nodokotela wakho ngokushesha ukuze nixoxe ngezindlela eziphephile.

Abantu abanezifo zesibindi ezinzima noma izimo ezithile zenhliziyo kungenzeka bangabi ngabakhethekile kulolu hlobo lokwelashwa. Udokotela wakho uzohlola ukusebenza kwesibindi sakho nempilo yenhliziyo ngaphambi kokuqala ukukwelapha ngalo muthi.

Uma unomlando wezinkinga zokubona, ukulahlekelwa ukuzwa, noma umfutho wegazi ophansi, udokotela wakho uzodinga ukulinganisa izinzuzo nezingozi ngokucophelela ngaphambi kokukuchazela le nhlanganisela.

Amagama e-Macitentan kanye ne-Tadalafil Brand

Lo muthi ohlanganisiwe utholakala ngaphansi kwegama lomkhiqizo elithi Opsynvi, okuyisithako esiyinhloko sezohwebo esivunyelwe ukwelapha umfutho wegazi ophezulu wamaphaphu. Igama lomkhiqizo lisiza ukulihlukanisa neminye imithi equkethe lezi zithako ngokwehlukana.

Ungase futhi uhlangane nezingxenye ngazinye ezithengiswa ngokwehlukana ngaphansi kwamagama ahlukene omkhiqizo. I-Macitentan itholakala njenge-Opsumit, kanti i-tadalafil yaziwa ngamagama amaningi omkhiqizo okuhlanganisa i-Cialis ne-Adcirca.

Njalo sebenzisa umkhiqizo othile kanye nesithako esichazwe udokotela wakho, njengoba izithako ezihlukene zingase zibe namandla ahlukene noma amaphethini okukhishwa okuthinta ukuthi umuthi usebenza kahle kangakanani esimweni sakho.

Ezinye izindlela ze-Macitentan kanye ne-Tadalafil

Kukhona ezinye izindlela zokwelapha umfutho wegazi ophezulu wamaphaphu uma le nhlanganisela ingakulungele noma inganikezi ukulawulwa kwezimpawu okwanele. Udokotela wakho angasiza ekunqumeni ukuthi iyiphi inketho engasebenza kangcono esimweni sakho esithile.

Eminye imithi yomlomo ye-PAH ihlanganisa i-bosentan, i-ambrisentan, i-sildenafil, ne-riociguat. Ngamunye walaba usebenza ngezindlela ezihlukene zokusiza ukuvula imithambo yegazi yamaphaphu akho futhi kunciphise umfutho wamaphaphu.

Ezimweni ezinzima kakhulu, udokotela wakho angase acabange ngemithi ephefumulwayo noma eyenziwa ngemithambo efana ne-epoprostenol, i-treprostinil, noma i-iloprost. Lokhu kwelashwa kuvame ukugcinwa ezigulini ezinokugula okuthuthukile noma labo abangaphenduli kahle emithini yomlomo.

Ezinye iziguli ziyazuza ekwelashweni okuhlanganisiwe kusetshenziswa izigaba ezihlukene zemithi ndawonye, ​​kanti ezinye zenza kahle ngokwelashwa okulandelanayo lapho imithi ingezwa ngakunye ngesikhathi esisodwa ngokususelwa ekuphenduleni.

Ingabe i-Macitentan ne-Tadalafil ingcono kune-Sildenafil?

Zombili izindlela zemithi zinamandla azo, futhi ukukhetha phakathi kwazo kuncike esimweni sakho sezokwelapha kanye nemigomo yokwelashwa. Inhlanganisela ye-Macitentan ne-tadalafil inikeza ukwelashwa okumbili, kuyilapho i-sildenafil isebenza ngendlela eyodwa efana ne-tadalafil.

Indlela yokuhlanganisa ingahlinzeka ngemithi ebanzi ngoba ibhekana nezindlela eziningi ezihilelekile ku-PAH. Ezinye izifundo zikhomba ukuthi ukwelashwa okumbili kungasebenza kahle kakhulu kunokwelashwa ngomuthi owodwa ezigulini ezithile.

Nokho, i-sildenafil isetshenziswe isikhathi eside ekwelashweni kwe-PAH futhi inemininingwane ebanzi yokuphepha. Kungase kukhethwe ezigulini ezidinga indlela yokwelashwa elula noma ezinemibandela ethile yezokwelapha eyenza ukwelashwa okuhlanganisiwe kungafaneleki.

Udokotela wakho uzocabangela izinto ezinjengobunzima besifo sakho, ezinye izimo zezokwelapha, imithi yamanje, kanye nemigomo yokwelashwa lapho enquma ukuthi iyiphi inketho engcono kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Macitentan ne-Tadalafil

Ingabe i-Macitentan ne-Tadalafil iphephile ezigulini ezinokugula kwenhliziyo?

Le nhlanganisela ingasetshenziswa kubantu abanezinhlobo ezithile zokugula kwenhliziyo, kodwa idinga ukuqapha nokuhlolwa ngokucophelela ngudokotela wakho. Njengoba i-PAH ngokwayo ithinta inhliziyo, ukwelapha isimo esiyisisekelo ngokuvamile kusiza ukuthuthukisa ukusebenza kwenhliziyo.

Nokho, uma unesifo senhliziyo esibi kakhulu, ukuhlaselwa yinhliziyo kwakamuva, noma izinkinga ezithile zesigqi senhliziyo, udokotela wakho angase adinge ukulungisa uhlelo lwakho lokwelashwa noma acabange ezinye izindlela zokwelapha. Umuthi ungase uthinte umfutho wegazi nesigqi senhliziyo, ngakho ukuqapha njalo kwenhliziyo kubalulekile.

Udokotela wakho wenhliziyo kanye nochwepheshe be-PAH bazosebenzisana ukuqinisekisa ukuthi uhlelo lwakho lokwelapha lubhekana kokubili nomfutho wegazi ophezulu emaphashini kanye nanoma yiziphi izimo zenhliziyo ezingaphansi ngendlela ephephile.

Kufanele ngenzeni uma ngiphuzile i-Macitentan ne-Tadalafil eningi ngengozi?

Uma ngengozi uthatha ngaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukweqisa kungabangela ukwehla okuyingozi komfutho wegazi nezinye izinkinga ezingathi sína.

Izimpawu zokuthatha okuningi zingabandakanya isiyezi esikhulu, ukuquleka, isicanucanu, noma izinguquko embonweni. Ungazami ukuzelapha lezi zimpawu ngokwakho, futhi ungalindi ukubona ukuthi ziyathuthuka yini zodwa.

Uma ushayela ucingo ukuze uthole usizo, yiba nebhodlela lakho lemithi elitholakalayo ukuze ukwazi ukunikeza imininingwane ethile ngalokho okuthathile nokuthi kungakanani. Lokhu kusiza ochwepheshe bezokwelapha ukuthi bakunikeze iseluleko esifanele kakhulu.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Macitentan ne-Tadalafil?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho lokulinganisa olujwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, njengoba lokhu kungandisa ingozi yakho yemiphumela emibi nezinkinga. Ukulinganisa kabili kungabangela ukwehla okuyingozi komfutho wegazi.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni nohlelo lwakho lokwelapha.

Ngingayeka nini ukuthatha i-Macitentan ne-Tadalafil?

Kufanele uyeke kuphela ukuthatha lo muthi ngaphansi kokuqondisa okuqondile kukadokotela wakho, njengoba i-PAH iyisimo esingamahlalakhona esidinga ukwelashwa okuqhubekayo. Ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho zibuye noma zibe zimbi ngokushesha.

Udkt wakho angase acabange ukunciphisa noma ukuyeka imithi uma uhlangabezana nemiphumela emibi engalawuleki, noma uma isimo sakho sishintsha kakhulu. Noma yiziphi izinguquko ohlelweni lwakho lokwelashwa kufanele zenziwe kancane kancane futhi ngokuqapha eduze.

Noma ngabe uzizwa ungcono kakhulu, qhubeka nokuthatha imithi yakho njengoba kunqunyiwe. Ukuthuthuka kwezimpawu zakho kubonisa ukuthi ukwelashwa kuyasebenza, hhayi ukuthi awusadingi.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Macitentan ne-Tadalafil?

Kufanele ukhawulele ukusetshenziswa kotshwala ngenkathi uthatha lo muthi, njengoba kokubili utshwala nomuthi kunganciphisa umfutho wegazi. Ukuhlanganisa lezi zinto kungakhuphula ingozi yakho yokuba nesiyezi, ukuquleka, noma eminye imiphumela emibi.

Uma ukhetha ukuphuza ngezikhathi ezithile, yenza kanjalo ngokulinganisela futhi unake indlela ozizwa ngayo. Qala ngamanani amancane ukuze ubone ukuthi umzimba wakho usabela kanjani, futhi gwema ukuphuza uma usuvele uzwa isiyezi noma umfutho wegazi ophansi.

Xoxa nodokotela wakho ngalokho okulingana nokusetshenziswa kotshwala, uma bukhona, okuphephile kuwe ngokusekelwe empilweni yakho yonke nokusabela ekwelashweni.