Yini i-Maprotiline: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Maprotiline iyisidakamizwa esibhalwe ngudokotela esilwa nokucindezeleka esingaphansi kohlobo lwemithi ebizwa ngokuthi ama-tetracyclic antidepressants. Isebenza ngokusiza ukubuyisela ibhalansi yamakhemikhali athile emvelo ebuchosheni bakho, ikakhulukazi i-norepinephrine, engathuthukisa imizwa yakho nemizwa yokuzizwa kahle.

Lo muthi ubelokhu usiza abantu ukulawula ukucindezeleka amashumi eminyaka, futhi ngenkathi kungenzeka ukuthi awubhalwa njalo njengama-antidepressants amasha, usahlala uyindlela yokwelapha ephumelelayo kubantu abaningi. Ukuqonda ukuthi i-maprotiline isebenza kanjani nokuthi yini ongayilindela kungakusiza ukuthi uzizwe uqiniseka ngokwengeziwe ngohambo lwakho lokwelashwa.

Yini i-Maprotiline?

I-Maprotiline iyi-tetracyclic antidepressant engase ibhalwe udokotela wakho ukwelapha i-major depressive disorder. Ngokungafani nama-antidepressants amasha, iqondise ngqo i-norepinephrine, ikhemikhali yobuchopho edlala indima ebalulekile ekulawuleni imizwa.

Lo muthi wathuthukiswa ngeminyaka yawo-1960 futhi unomlando omude wokusiza abantu ukunqoba ukucindezeleka. Ithathwa njenge-antidepressant yesizukulwane sesibili, okusho ukuthi yathuthukiswa ngemuva kwama-tricyclic antidepressants okuqala kodwa ngaphambi kwama-selective serotonin reuptake inhibitors (SSRIs) anamuhla.

Udokotela wakho angase acabangele i-maprotiline uma amanye ama-antidepressants engasebenzi kahle kuwe noma uma izimpawu zakho ezithile zikwenza ukuthi ilungele uhlelo lwakho lokwelashwa. Itholakala kuphela ngemiyalelo kadokotela futhi iza ngesimo samaphilisi okusetshenziswa ngomlomo.

Yini i-Maprotiline Esizenzelwe Yona?

I-Maprotiline ikakhulukazi ibhalwe ukwelapha i-major depressive disorder, isimo sempilo yengqondo esibi esithinta indlela ozizwa ngayo, ocabanga ngayo, nokuphatha imisebenzi yansuku zonke. Ingasiza ukuphakamisa usizi oluqhubekayo, ukungabi nathemba, nokuntula amandla okubonisa ukucindezeleka.

Udktela wakho angase futhi acabangele i-maprotiline kwezinye izimo, nakuba lezi zivamile kakhulu. Ngesinye isikhathi inikezwa ngezifo zokukhathazeka ezenzeka kanye nokucindezeleka, noma ngezinhlobo ezithile zezimo zobuhlungu obungapheli lapho ukucindezeleka kuyisici esibangela.

Umuthi ulusizo ikakhulukazi kubantu abahlangabezana nokucindezeleka ngezimpawu ezinjengamandla aphansi, ubunzima bokugxila, nokuphazamiseka kokulala. Kungase kuthathe amasonto amaningana ukuzwa izinzuzo ezigcwele, ngakho ukubekezela kubalulekile njengoba umzimba wakho uzivumela ekwelashweni.

Isebenza Kanjani I-Maprotiline?

I-Maprotiline isebenza ngokuvimba ukuthathwa kabusha kwe-norepinephrine ebuchosheni bakho. Lokhu kusho ukuthi ivimbela amaseli akho obuchopho ukuthi angamunci ngokushesha le neurotransmitter ebalulekile, ivumela okuningi kwayo ukuthi kuhlale kutholakala ukuze kusize ukulawula imizwa yakho.

Cabanga ngayo njengokulungisa ivolumu kumsakazo - ngokugcina i-norepinephrine eningi isebenza ebuchosheni bakho, i-maprotiline isiza ukukhulisa amasignali anegalelo emizweni emihle nokulinganisela kwemizwa. Le nqubo ayenzeki ngobusuku obubodwa, yingakho ngokuvamile kuthatha amasonto angu-2-4 ukuqaphela ukuthuthuka okukhulu.

I-Maprotiline ithathwa njenge-antidepressant enamandla ngokulinganisela. Ayinamandla njengeminye imithi emidala efana ne-MAOIs, kodwa ngokuvamile isebenza kahle kunezithasiselo zemithi enobumnene. Amandla ayenza ilungele ukucindezeleka okuphakathi nendawo kuya kokukhulu, kodwa futhi kusho ukuthi uzodinga ukuqashwa ngokucophelela okuvela kumhlinzeki wakho wezempilo.

Ngingayithatha Kanjani I-Maprotiline?

Thatha i-maprotiline ngendlela udokotela wakho ayala ngayo, ngokuvamile kanye ngosuku noma ihlukaniswe ngemithamo emincane usuku lonke. Ungayithatha ngokudla noma ngaphandle kokudla, kodwa ukuyithatha ngokudla kungasiza ukunciphisa isisu uma uhlangabezana nanoma yikuphi ukuphazamiseka kokugaya ukudla.

Kungcono ukuthatha i-maprotiline ngesikhathi esifanayo nsuku zonke ukuze kugcinwe amazinga aqhubekayo emzimbeni wakho. Abantu abaningi bakuthola kuwusizo ukuyithatha kusihlwa ngoba ingabangela ukozela, okungase kube usizo ekulaleni uma ukucindezeleka bekuthinta ukuphumula kwakho.

Gwinya amaphilisi wonke ngengilazi yamanzi egcwele - ungaqobi, uhlafune, noma uwaphule. Uma udinga ukuhlukanisa umthamo, yenza lokho kuphela uma udokotela wakho ekuyala ngqo, futhi usebenzise umgundi wamaphilisi ukuze uqinisekise ukulinganisa okunembile.

Njengoba ngishilo lokho, gwema ukuphuza utshwala ngenkathi uthatha i-maprotiline, njengoba ingakhuphula ukozela neminye imiphumela emibi. Futhi, qaphela ngemisebenzi edinga ukuqapha, ikakhulukazi uma uqala umuthi noma uma umthamo wakho ulungiswa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Maprotiline?

Abantu abaningi badinga ukuthatha i-maprotiline okungenani izinyanga eziyi-6-12 ngemuva kokuthi izimpawu zabo zokucindezeleka zithuthuke ukuze basize ekuvimbeleni ukuphindeka. Udokotela wakho uzosebenza nawe ukunquma ubude obufanele ngokuya ngesimo sakho ngasinye nokuthi usabela kanjani ekwelashweni.

Ngemuva kwamasonto ambalwa okuqala, ungase ungaboni ukuthuthuka okuningi - lokhu kujwayelekile ngokuphelele. Ama-antidepressants afana ne-maprotiline ngokuvamile kuthatha amasonto ama-2-4 ukuqala ukusebenza, futhi kungathatha amasonto angama-6-8 ukuzwa izinzuzo ezigcwele.

Abanye abantu bangase badinge ukwelashwa kwesikhathi eside, ikakhulukazi uma beke baba neziqephu eziningi zokucindezeleka noma uma benezinye izimo zempilo yengqondo. Udokotela wakho uzohlala ekuhlolisisile ukuthi wenza kanjani nokuthi ngabe kudingeka yini ukulungiswa ohlelweni lwakho lokwelashwa.

Ungayeki ukuthatha i-maprotiline ngokuzumayo, noma ngabe uzizwa ungcono. Udokotela wakho uzokusiza ukuthi unciphise kancane umthamo lapho sekuyisikhathi sokuyeka umuthi ukuze ugweme izimpawu zokuhoxisa.

Yiziphi Imiphumela Emibi ye-Maprotiline?

Njengazo zonke izidakamizwa, i-maprotiline ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi emasontweni ambalwa okuqala.

Ake sibheke imiphumela emibi evame kakhulu ongase uyithole, sikhumbula ukuthi abantu abaningi bayayibekezelela i-maprotiline:

• Ukozela noma ukukhathala (lokhu kuvame ukuthuthuka ngokuhamba kwesikhathi)
• Umlomo owomile (ukuphuza amanzi njalo kungasiza)
• Isiyezi, ikakhulukazi uma usukuma ngokushesha
• Ukuqunjelwa (ukwandisa ukudla okunefayibha namanzi kungasiza)
• Ukubona okungacacile (ngokuvamile okwesikhashana)
• Ukukhuluphala (ngokuvamile okulinganiselwe)
• Ubunzima bokuchama
• Ukujuluka okwengeziwe

Le miphumela emibi evamile ivamise ukulawuleka futhi ivame ukuba ngaphansi kokuphazamisa njengoba umzimba wakho ujwayela umuthi. Umhlinzeki wakho wezempilo angahlinzeka ngamasu okunciphisa ukungakhululeki.

Imiphumela emibi engavamile kodwa ebucayi idinga ukunakekelwa kwezempilo ngokushesha. Nakuba lokhu kungavamile, kubalulekile ukukwazi:

• Ukuhlaselwa yizifo (i-maprotiline inganciphisa umkhawulo wokuhlaselwa yizifo)
• Ukushaya kwenhliziyo okungajwayelekile noma ubuhlungu besifuba
• Isiyezi esibi noma ukuquleka
• Ubunzima bokuphefumula noma ukugwinya
• Ukuphuma kwegazi okungavamile noma ukulimala
• Ukuphendula kwesikhumba okukhulu noma ukuqubuka
• Izimpawu ze-serotonin syndrome (umkhuhlane, ukuqina kwemisipha, ukudideka)

Uma uthola noma iyiphi yale miphumela emibi ebucayi, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezempilo eziphuthumayo. Lezi zimo azivamile kodwa zidinga ukunakekelwa ngokushesha.

Abanye abantu bangase futhi bathole izinguquko emizweni noma emicabangweni, ikakhulukazi emasontweni ambalwa okuqala okwelashwa. Lokhu kuyinto udokotela wakho azoyiqapha eduze, ikakhulukazi uma uneminyaka engaphansi kwengu-25.

Ubani Ongafanele Athole I-Maprotiline?

I-Maprotiline ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo ezithile nezimo zenza lo muthi ungabi nawo umthelela noma ungasebenzi kahle.

Akufanele uthathe i-maprotiline uma wazi ukuthi unokungezwani komzimba nomuthi noma ama-antidepressants afanayo. Udokotela wakho uzophinda aqaphele kakhulu ngokuyinika uma unezimo ezithile zezokwelapha ezingase zibe zimbi kakhulu ngumuthi:

• Ukunqanyulwa kwenhliziyo kwakamuva noma izinkinga ezinkulu zesigqi senhliziyo
• Ukuphazamiseka kokuhlaselwa noma umlando wokuhlaselwa
• Isifo esibi sesibindi noma sezinso
• I-glaucoma ye-narrow-angle
• Izinkinga ezinkulu zokugcinwa komchamo
• Njengamanje uthatha ama-MAOI noma uke wawaqeda phakathi nezinsuku eziyi-14 ezedlule

Udokotela wakho uzodinga ukucabangela ngokucophelela izingozi nezinzuzo uma unezinye izimo ezinjengesifo sikashukela, izinkinga ze-thyroid, noma umlando wokusebenzisa kabi izidakamizwa. Ubudala nabo buyisici - abadala bangase bazwe imiphumela emibi kakhulu futhi badinge imithamo ephansi.

Ukukhulelwa nokuncelisa ngamabele kudinga ukucatshangelwa okukhethekile. Ngenkathi i-maprotiline ingasetshenziswa ngesikhathi sokukhulelwa uma izinzuzo zidlula izingozi, udokotela wakho uzofuna ukuxoxa ngazo zonke izinketho ezitholakalayo nawe ukuze aqinisekise ukukhetha okuphephe kakhulu kuwe nomntwana wakho.

Amagama Omkhiqizo we-Maprotiline

I-Maprotiline itholakala ngaphansi kwamagama amaningana omkhiqizo, yize ivame ukunqunywa njengomuthi ojwayelekile. Igama lomkhiqizo elaziwa kakhulu yi-Ludiomil, okuyilona brand lokuqala lapho umuthi wethulwa okokuqala.

Ungase futhi ukubone kuthengiswa ngaphansi kwamanye amagama omkhiqizo ngokuya ngendawo yakho nekhemisi. I-maprotiline ejwayelekile itholakala kabanzi futhi iqukethe isithako esifanayo esisebenzayo njengenguqulo yegama lomkhiqizo, okwenza kube yindlela engabizi kakhulu ezigulini eziningi.

Noma ngabe uthola uhlobo lomkhiqizo noma oluvamile, umuthi usebenza ngendlela efanayo. Umkhemisi wakho angakusiza uqonde ukuthi yiluphi uhlobo olulutholayo futhi aphendule noma imiphi imibuzo mayelana nokwehluka kokubukeka noma ukupakishwa.

Ezinye izindlela zokwelapha i-Maprotiline

Uma i-maprotiline ingakulungele, ziningi ezinye izinketho zokwelapha ukucindezeleka ezitholakalayo. Udokotela wakho angase acabange ngemithi emisha efana ne-SSRIs (njenge-sertraline noma i-fluoxetine) noma i-SNRIs (njenge-venlafaxine noma i-duloxetine) njengezinye izindlela.

Ezinye izidambisi zokucindezeleka ze-tetracyclic noma ze-tricyclic nazo zingase zibe izinketho, kuye ngezimpawu zakho ezithile kanye nomlando wakho wezokwelapha. Lokhu kufaka phakathi imithi efana ne-amitriptyline, i-nortriptyline, noma i-mirtazapine, ngalinye linenzuzo yalo eyingqayizivele kanye namaphrofayili emiphumela emibi.

Ukukhethwa kwesidambisi sokucindezeleka kuncike ezintweni eziningi, okuhlanganisa izimpawu zakho, ezinye izimo zezokwelapha, ukusebenzisana okungenzeka kwemithi, nezintandokazi zakho. Udokotela wakho uzosebenza nawe ukuthola umuthi onikeza ibhalansi engcono kakhulu yokusebenza kahle nokubekezeleleka esimweni sakho.

Ukwelashwa okungekona okwemithi njenge-psychotherapy, izinguquko zokuphila, nezinye izindlela zokungenelela nazo zingaba izingxenye ezibalulekile zokwelashwa kokucindezeleka, kungaba zodwa noma ngokuhlangana nemithi.

Ingabe i-Maprotiline ingcono kune-Amitriptyline?

Kokubili i-maprotiline ne-amitriptyline ziyizidambisi zokucindezeleka ezisebenzayo, kodwa zisebenza kancane ngokuhlukile futhi zinamaphrofayili emiphumela emibi ehlukene. Akukho noyedwa othi “ungcono” ngokujwayelekile - ukukhetha okungcono kuncike ezidingweni zakho ngazinye nokuthi usabela kanjani emithini ngayinye.

I-Maprotiline iyisidambisi sokucindezeleka se-tetracyclic esithinta ikakhulukazi i-norepinephrine, kuyilapho i-amitriptyline iyisidambisi sokucindezeleka se-tricyclic esithinta kokubili i-norepinephrine ne-serotonin. Lo mahluko usho ukuthi bangase basebenze kangcono ezinhlotsheni ezihlukene zezimpawu zokucindezeleka.

Ngokuqondene nemiphumela emibi, i-maprotiline ingase ibangele imiphumela emincane ye-anticholinergic (njengomlomo owomile nokuqunjelwa) uma iqhathaniswa ne-amitriptyline, kodwa inengozi enkulu yokubangela ukuquleka kwabanye abantu. I-Amitriptyline ivame ukuba nemiphumela eminingi yokuthulisa, okungaba usizo uma ukhathazeka ngezinkinga zokulala.

Udokotela wakho uzocabangela izimpawu zakho ezithile, umlando wezokwelapha, nezinye izinto lapho ekhetha phakathi kwale mithi. Okusebenza kahle kumuntu oyedwa kungase kungabi yindlela ekahle komunye, ngakho isinqumo kufanele senziwe ngabanye ngabanye.

Imibuzo Evame Ukubuzwa Mayelana ne-Maprotiline

Ingabe i-Maprotiline iphephile ezigulini zenhliziyo?

I-Maprotiline idinga ukucatshangelwa ngokucophelela uma unezinkinga zenhliziyo. Ngenkathi ingasetshenziswa kwezinye iziguli zenhliziyo, ingase ithinte ukushaya kwenhliziyo nomfutho wegazi, ngakho udokotela wakho uzodinga ukukuqapha ngokucophelela.

Uma unomlando wokuhlaselwa yinhliziyo, ukushaya kwenhliziyo okungajwayelekile, noma ezinye izimo zenhliziyo ezinzima, udokotela wakho angase akhethe i-antidepressant ehlukile ephephe kakhulu ohlelweni lwakho lwe-cardiovascular. Hlala utshela udokotela wakho nganoma yiziphi izinkinga zenhliziyo ngaphambi kokuqala i-maprotiline.

Ngingenzani uma ngiphuzile i-Maprotiline eningi ngengozi?

Uma ngengozi uphuza i-maprotiline eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukweqisa kungaba kubi futhi kungase kubangele izimpawu ezinjengokulala ngokweqile, ukudideka, ukushaya kwenhliziyo okungajwayelekile, noma ukuquleka.

Ungalindi ukuthi izimpawu zivele - funa ukwelashwa ngokushesha. Uma kungenzeka, yiba nebhodlela lomuthi nawe ukuze abahlinzeki bezempilo bazi kahle ukuthi yini nokuthi ungakanani owathathayo.

Ngingenzani uma ngiphuthelwa umthamo we-Maprotiline?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle kwalapho sekuseduze isikhathi somthamo wakho olandelayo. Kulokho, weqa umthamo ophuthelwe futhi uqhubeke neshejuli yakho ejwayelekile - ungaphuza imithamo emibili ngesikhathi esisodwa.

Ukushoda umthamo owodwa ngezikhathi ezithile ngeke kubangele izinkinga ezinkulu, kodwa zama ukugcina isikhathi esiqhubekayo ukuze ugcine amazinga aqhubekayo omuthi emzimbeni wakho. Ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi kungakusiza ukuthi uhlale emgwaqeni.

Ngingayeka nini ukuthatha i-Maprotiline?

Ungalokothi uyeke ukuthatha i-maprotiline ngokuzumayo noma ngaphandle kwesiqondiso sikadokotela wakho. Noma ngabe uzizwa ungcono kakhulu, ukuyeka ngokuphazima kweso kungadala izimpawu zokuhoxisa futhi kwandise ingozi yokuthi ukucindezeleka kubuye.

Udokotela wakho uzokusiza ukuthi unciphise kancane umthamo lapho sekuyisikhathi sokuyeka umuthi. Le nqubo, ebizwa ngokuthi ukunciphisa, ivame ukuthatha amasonto amaningana futhi isiza umzimba wakho ukuthi ujwayele ngokuphepha ukungabi khona komuthi.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Maprotiline?

Kungcono ukugwema utshwala ngenkathi uthatha i-maprotiline. Utshwala bungandisa ukozela neminye imiphumela emibi, futhi kungaphazamisa nokusebenza komuthi ekwelapheni ukucindezeleka kwakho.

Uma ukhetha ukuphuza ngezikhathi ezithile, yenza kanjalo ngokulinganisela okukhulu futhi unake indlela ozizwa ngayo. Njalo xoxa ngokusebenzisa kwakho utshwala nodokotela wakho ukuze bakwazi ukukunikeza isiqondiso esiqondene nawe ngokusekelwe esimweni sakho.