Maralixibat (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Livmarli
Mayelana naleli khambi
I-Maralixibat isetshenziswa ekwelapheni ukukhahlela okubangelwa ukungasebenzi kahle kwebile (ukukhahlela kwesikhumba) kubantu abane-Alagille syndrome (ALGS) ne-progressive familial intrahepatic cholestasis (PFIC). Lolu dokotela lutholakala kuphela ngomyalelo wodokotela. Lo mkhiqizo utholakala ngezindlela zokulinganisela ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma kunqunywe ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokuthatha imithi nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqhelile noma oluhambelana nokwaleka kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unanoma yiluphi olunye uhlobo lwezinto ozaleka kuzo, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ukuhlola ubudlelwano phakathi nobudala nemiphumela yamaralixibat ekwelapheni ukukroba kwesikhumba nge-Alagille syndrome (ALGS) kubantwana abaneminyaka engaphansi kwezinyanga ezi-3 nokwelapha ukukroba kwesikhumba nge-progressive familial intrahepatic cholestasis (PFIC) kubantwana abaneminyaka engaphansi kwezinyanga eziyi-12. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele azikwenzelwanga ukuhlola ubudlelwano phakathi nobudala nemiphumela yamaralixibat kubantu abadala. Ukuphepha nokuphumelela akukaqiniswa. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Tshela ochwepheshe bakho bezempilo uma uthatha noma iyiphi enye imithi yesikripthi noma engekho esikripthi (over-the-counter [OTC]). Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba kungenzeka kube khona ukusebenzisana. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unanoma yiziphi ezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli lemithi njengoba nje udokotela wakho ekuqondisa. Ungathathi okuningi kwalokhu, ungathathi kaningi, futhi ungathathi isikhathi eside kunalokho udokotela wakho akuqondisile. Le mithi ifika ne-Medication Guide nemiyalo yokuqondisa iziguli. Funda futhi ulandele le miyalo ngokucophelela. Buza udokotela wakho uma unemibuzo. Thatha le mithi okungenani imizuzu engama-30 ngaphambi kokudla kokuqala kosuku. Hlola isiliva sibili ebotileni. Kufanele sicaca kuya cishe sicaca futhi singenasithunzi kuya emthunzi olukhanyayo oluphuzi. Ungayisebenzisi imithi uma isiliva sibili silimala, noma inezingcezu kuyo. Ukusebenzisa: Thatha le mithi okungenani amahora angu-4 ngaphambi noma amahora angu-4 ngemuva kokusebenzisa izithambisi ze-bile acid (eg, cholestyramine, colesevelam, colestipol). Inani lemithi leli lizohlukahluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esitikhwini. Ulwazi olulandelayo luhlanganisa kuphela amanani aphakathi ale mithi. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukwenza kanjalo. Inani lemithi oyithatha lixhomeke emandleni emithi. Futhi, inani lemithi oyithatha nsuku zonke, isikhathi esivunyelwe phakathi kwemithi, nobude besikhathi oyithatha imithi kuya ngenkinga yezokwelapha oyisebenzisela imithi. Uma uphuthelwa yidosi yale mithi, yithatha ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi sedosi yakho elandelayo, suka ngedosis ephuthelwe futhi ubuyele esikhathini sakho sokudla okujwayelekile. Ungawandisi ama-doses. Ukuthathwa kwedosi kanye ngosuku: Uma idosi iphuthelwe ngamahora angu-12 noma ngaphansi, yithatha ngokushesha okukhulu, bese ubuyela esikhathini sakho esijwayelekile. Uma idosi iphuthelwe ngamahora angaphezu kwama-12, ungathathi idosi eyengeziwe. Thatha idosi elandelayo ngesikhathi esihleliwe. Gcina ungafinyeleleki ezinganeni. Ungagcini imithi eliphelile noma imithi engasadingeki. Buza ochwepheshe bakho bezempilo ukuthi kufanele ulahle kanjani noma iyiphi imithi ongayisebenzisi. Gcina imithi ekoneni evaliwe emazingeni okushisa kwegumbi, kude nokushisa, ukufuma, nokukhanya okuqondile. Gcina ungaganduki. Gcina le mithi ngekaphi ebotileni. Lahla noma iyiphi imithi engasetshenzisiwe ezinsukwini ezingu-100 ngemuva kokuvula ibhodle.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.