Yini i-Margetuximab-cmkb: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokunye

I-Margetuximab-cmkb iyikhambi lomdlavuza eliqondiswe ngqo elisebenza ngokulekelela amasosha akho omzimba ukulwa nezinhlobo ezithile zomdlavuza wamabele. Lo muthi oqokiwe ungowodidi olubizwa ngokuthi ama-monoclonal antibodies, enzelwe ukunamathela kumaseli omdlavuza futhi awamake ukuze abhubhiswe yizivikelo zomzimba wakho zemvelo.

Ungase ufunde ngalo muthi ngoba wena noma othile okhathalelawe utholakale enomdlavuza wamabele we-HER2-positive. Ngenkathi ukufunda ngezindlela zokwelapha umdlavuza kungase kuzizwe kukhulu, ukuqonda izinketho zakho kungakusiza ukuthi uzizwe ulungiseleleke futhi uqiniseka ohambweni lwakho lokunakekelwa.

Yini i-Margetuximab-cmkb?

I-Margetuximab-cmkb iyi-antibody eyenziwe e-laboratory eqondiswe kuphrotheni ethile ebizwa nge-HER2 etholakala kumaseli athile omdlavuza wamabele. Cabanga ngayo njenge-missile eqondisiwe efuna futhi inamathele kumaseli omdlavuza, bese ikhomba amasosha akho omzimba ukuthi awahlole.

Lo muthi wenzelwe ngqo abantu abanomdlavuza wamabele we-HER2-positive metastatic. Ingxenye ethi "cmkb" yegama ibhekisela ekwakhekeni okuthile kwalo muthi, okusiza ukuthi uqhelelaniswe neminye imithi efanayo.

Ngokungafani ne-chemotherapy yendabuko ethinta izinhlobo eziningi zamaseli, i-margetuximab-cmkb ithathwa njengokwelashwa okuqondiswe ngqo ngoba igxila ngqo kumaseli omdlavuza anophrotheni ye-HER2. Le ndlela eqondiswe ngqo ingasiza ekunciphiseni eminye yemiphumela emibi ongase uyithole ngemithi ebanzi yomdlavuza.

Isetshenziselwani i-Margetuximab-cmkb?

I-Margetuximab-cmkb isetshenziselwa ukwelapha abantu abadala abanomdlavuza wamabele we-HER2-positive metastatic. Lokhu kusho ukuthi umdlavuza ususabalale ngaphezu kwamabele nama-lymph nodes uya kwezinye izindawo zomzimba wakho, futhi amaseli akho omdlavuza anamazinga aphezulu e-protein ye-HER2.

Udktela wakho ngokuvamile uzoncoma lo muthi uma usuvele uzamile ezinye izindlela zokwelapha ezihloswe ku-HER2 ezifana ne-trastuzumab (Herceptin) kanye ne-pertuzumab (Perjeta). Ivame ukusetshenziswa ngokuhlanganyela nemithi ye-chemotherapy ukuze kwakhiwe indlela yokwelapha ebanzi.

Lo muthi uvunyelwe ngokuqondile ezimweni lapho umdlavuza usuthuthuke ngaphandle kokwelashwa kwangaphambilini. Ithimba lakho lezempilo lizohlola amaseli akho omdlavuza ukuze liqinisekise ukuthi anayo iphrotheni ye-HER2 ngaphambi kokuqala lokhu kwelashwa, njengoba ngeke kusebenze emidlavuzeni engena-HER2.

Isebenza Kanjani I-Margetuximab-cmkb?

I-Margetuximab-cmkb isebenza ngokubopha kuphrotheni ye-HER2 emaseleni omdlavuza futhi iqashe amasosha akho omzimba ukuba asize ukuwaqeda. Lona umuthi onamandla amaphakathi okwenzelwe ukuthi usebenze ngempumelelo kunezinye izindlela zokwelapha ezihloswe ku-HER2 ezindala.

Uma umuthi usunamathele kuphrotheni ye-HER2, uvimba izimpawu ezisiza amaseli omdlavuza ukuthi akhule futhi azale. Ngesikhathi esifanayo, usebenza njengophawu, ubiza amaseli omzimba ukuba eze endaweni ukuzohlasela amaseli omdlavuza amakiwe.

Okwehlukanisa lo muthi nemithi endala ehlose ku-HER2 ukuthi yakhelwe ukusebenza kangcono nohlobo oluthile lwe-receptor yamaseli omzimba. Lokhu kusebenzisana okuthuthukisiwe kungasiza amasosha akho omzimba ukuthi akhe impendulo eqinile ngokuphikisana namaseli omdlavuza.

Kufanele Ngiyithathe Kanjani I-Margetuximab-cmkb?

I-Margetuximab-cmkb inikezwa njenge-intravenous (IV) infusion ngqo egazini lakho esikhungweni sokwelapha umdlavuza noma esibhedlela. Ngeke uthathe lo muthi ekhaya, njengoba idinga ukuqapha ngokucophelela kanye nemishini ekhethekile.

Ukufakwa kwakho kokuqala ngokuvamile kuzothatha imizuzu engaba ngu-120, kuyilapho ukwelashwa okulandelayo kuvame ukuthatha imizuzu engaba ngu-30. Ithimba lakho lezempilo lizokuqapha eduze ngesikhathi sokufakwa ngakunye kanye nesikhathi esithile ngemva kwalokho ukuze libheke noma yiziphi izindlela zokuphendula ngokushesha.

Akudingeki ukuthi ugweme ukudla noma iziphuzo ngaphambi kokwelashwa kwakho, kodwa kuvame ukusiza ukudla ukudla okulula ngaphambi kwesikhathi ukuvimbela isicanucanu. Abanye abantu bakuthola kukhuthaza ukuletha incwadi, ithebhulethi, noma umculo ukusiza ukudlulisa isikhathi ngesikhathi sokufakwa.

Ithimba lakho lokwelapha lizokunika imithi ngaphambi kokufakwa ngakunye ukusiza ukuvimbela ukusabela komzimba. Le mithi yangaphambi kokwelashwa ingahlanganisa ama-antihistamines, ama-steroids, noma izidambisi zomkhuhlane, futhi ziyingxenye ejwayelekile yenqubo yokwelapha.

Ngingayithatha isikhathi esingakanani i-Margetuximab-cmkb?

Ubude bokwelashwa nge-margetuximab-cmkb buhlukahluka kumuntu nomuntu futhi buxhomeke ekutheni umdlavuza wakho usabela kanjani emuthini. Abantu abaningi bathola ukwelashwa njalo emavikini amathathu, futhi uzoqhubeka uma nje umuthi usiza ukulawula umdlavuza wakho futhi uwuthola kahle.

Udokotela wakho uzoqapha njalo inqubekela phambili yakho ngokuskena izithombe, ukuhlolwa kwegazi, nokuhlolwa komzimba. Uma umdlavuza wakho uyeka ukusabela ekwelashweni noma uma uhlangabezana nemiphumela emibi kakhulu, ithimba lakho lezempilo lizoxoxa ezinye izinketho nawe.

Abanye abantu bangase bathole lokhu kwelashwa izinyanga eziningi noma iminyaka, kanti abanye bangase bashintshele kweminye imithi ngokushesha. Okubalulekile ukuthola ukulinganisela okulungile phakathi kokulawula umdlavuza wakho nokugcina izinga lempilo yakho.

Yiziphi Imiphumela Emibi ye-Margetuximab-cmkb?

Njengayo yonke imithi yomdlavuza, i-margetuximab-cmkb ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi eminingi ilawuleka ngokunakekelwa okufanele nokuqapha okuvela eqenjini lakho lezempilo.

Nansi imiphumela emibi evame kakhulu ongase uyithole ngesikhathi sokwelashwa:

• Ukukhathala nokuzizwa ukhathele kunokujwayelekile
• Isicanucanu futhi ngezinye izikhathi ukuhlanza
• Ukuqunjelwa noma izinguquko ekuhambeni kwamathumbu
• Ukuncipha kwesifiso sokudla
• Ukucindezeleka
• Ukuba buhlungu kwemisipha noma amalunga
• Ukuphendula kokufakwa njengomkhuhlane, amakhaza, noma ukuqubuka ngesikhathi sokwelashwa
• Ukwehla kwamaseli amhlophe egazi, okungandisa ingozi yokutheleleka

Le miphumela emibi ejwayelekile ivame ukuba milde kuya phakathi nendawo futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi. Ithimba lakho lokunakekela linamasu amaningi okusiza ukuphatha lezi zimpawu futhi likugcine ukhululekile.

Ngenkathi kungavamile, kunezinye izimpembelelo ezimbi ezingathi sína ezidinga ukunakekelwa kwezempilo ngokushesha:

• Izinkinga zenhliziyo, okuhlanganisa ukuba buthakathaka kwemisipha yenhliziyo noma ukushaya kwenhliziyo okungajwayelekile
• Ukuphendula okukhulu komzimba okubangela ubunzima bokuphefumula noma ukuvuvukala
• Ukutheleleka okungathi sína ngenxa yokwehla kwamasosha omzimba
• Izinkinga zamaphaphu noma ubunzima bokuphefumula
• Ukuqunjelwa okukhulu okungaphenduli ekwelashweni
• Izimpawu ze-tumor lysis syndrome, lapho amaseli omdlavuza ewohloka ngokushesha kakhulu

Ithimba lakho lezempilo lizokuqapha ngokucophelela le miphumela engathi sína ngokusebenzisa izivivinyo ezijwayelekile zomsebenzi wenhliziyo, umsebenzi wegazi, kanye nokuhlolwa komzimba. Abantu abaningi bangaqhubeka nokwelashwa ngokuphepha ngokuqapha okufanele nokunakekelwa okusekelayo.

Ubani Ongafanele Athole i-Margetuximab-cmkb?

I-Margetuximab-cmkb ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ilungile yini kuwe. Le mithi yenzelwe ngqo imidlavyuza ye-HER2-positive, ngakho ngeke isebenze uma umdlavuza wakho ungenayo le phrotheni.

Akufanele uthole le mithi uma uke waba nokuphendula okukhulu komzimba ku-margetuximab-cmkb noma yiziphi izithako zayo esikhathini esidlule. Udokotela wakho uzophinda acabangele ngokucophelela impilo yakho yonke nanoma yiziphi ezinye izimo zezokwelapha ongase ube nazo.

Abantu abanezimo ezithile zenhliziyo bangase badinge ukuqashwa okwengeziwe noma bangase bangabi ngabazongenela ukwelashwa lokhu. Ithimba lakho lokunakekelwa kwezempilo lizohlola ukusebenza kwenhliziyo yakho ngaphambi kokuqala ukwelashwa futhi likuqaphe njalo ngesikhathi sonke sokunakekelwa kwakho.

Uma ukhulelwe noma uncelisa, lo muthi awunconyelwe ngoba ungalimaza ingane yakho. Udokotela wakho uzoxoxa ngezindlela zokulawula inzalo ezisebenzayo uma uneminyaka yokuzala, njengoba uzodinga ukugwema ukukhulelwa ngesikhathi sokwelashwa kanye nangezinyanga eziningana ngemuva.

Igama Lomkhiqizo le-Margetuximab-cmkb

I-Margetuximab-cmkb ithengiswa ngaphansi kwegama lomkhiqizo elithi Margenza. Leli gama lomkhiqizo yilokho okungenzeka ukuthi uzokubona eshedyulini yakho yokwelashwa kanye nemibhalo yomshuwalense.

Lo muthi ukhiqizwa yi-MacroGenics futhi wagunyazwa yi-FDA ngonyaka ka-2020. Uma ukhuluma ngokwelashwa kwakho nethimba lakho lokunakekelwa kwezempilo, bangase bakubize ngegama elivamile elithi margetuximab-cmkb noma ngegama lomkhiqizo elithi Margenza.

Ezinye Izindlela Zokwelapha ze-Margetuximab-cmkb

Uma i-margetuximab-cmkb ingakulungele noma iyeka ukusebenza ngempumelelo, zikhona ezinye izindlela zokwelapha ezitholakala ngomdlavuza webele we-HER2-positive. Udokotela wakho we-oncologist uzosebenza nawe ukuthola enye indlela engcono kakhulu esekelwe esimweni sakho esithile.

Eminye imithi eqondiswe ku-HER2 ihlanganisa i-trastuzumab (Herceptin), i-pertuzumab (Perjeta), kanye ne-trastuzumab emtansine (Kadcyla). Ngamunye walaba usebenza ngendlela ehlukile futhi angase afaneleke kakhulu kuye ngokwelashwa kwakho kwangaphambilini kanye nesimo sakho sempilo samanje.

Izinketho ezintsha zihlanganisa i-tucatinib (Tukysa) kanye ne-neratinib (Nerlynx), okuyimithi yomlomo engathathwa ekhaya. Udokotela wakho angase futhi acabange ngezinhlanganisela zale mithi noma azihlanganise nemithi ehlukene ye-chemotherapy.

Ukukhethwa kokwelashwa okuhlukile kuncike ezintweni eziningi, okuhlanganisa ukuthi yimiphi imithi osuzame ngayo ngaphambili, ukuthi umdlavuza wakho uphendule kanjani, kanye nempilo yakho yonke. Ithimba lakho lokunakekelwa kwezempilo lizokuqondisa ngalezi zinketho uma kudingeka.

Ingabe iMargetuximab-cmkb Ingcono KuneTrastuzumab?

IMargetuximab-cmkb yakhelwe ukuthi isebenze ngempumelelo kune-trastuzumab (Herceptin) kubantu abathile abanomdlavuza webele we-HER2-positive. Ucwaningo lwezempilo lubonise ukuthi lunganikeza imiphumela engcono ezigulini ezithile, ikakhulukazi lezo ezinezici ezithile zofuzo.

Inzuzo enkulu ye-margetuximab-cmkb ukuthi yakhelwe ukuthi isebenze kangcono namandla omzimba wakho okulwa nomdlavuza. Lokhu kuthuthukiswa kokuphendula komzimba kungasiza ukuthi kusebenze ngempumelelo kune-trastuzumab kwezinye izimo.

Kodwa-ke, "ngcono" kuncike esimweni sakho ngasinye. I-Trastuzumab isetshenziswe ngempumelelo iminyaka eminingi futhi inesithombe sokuphepha esaziwayo. Udokotela wakho uzocabangela izici ezithile zomdlavuza wakho, ukwelashwa kwangaphambilini, nempilo yonke lapho enquma ukuthi yimuphi umuthi ongcono kuwe.

Yomibili imithi inezici ezifanayo zemiphumela emibi, nakuba izimpendulo zomuntu ngamunye zingahluka. Ukukhetha phakathi kwazo kuvame ukwehla ngesikhathi ohambweni lwakho lokwelashwa nokuthi umdlavuza wakho uphendule kanjani ekwelashweni kwangaphambilini.

Imibuzo Evame Ukubuzwa Mayelana neMargetuximab-cmkb

Umbuzo 1. Ingabe iMargetuximab-cmkb Iphephile Kubantu Abanezifo Zenhliziyo?

IMargetuximab-cmkb ingathinta ukusebenza kwenhliziyo, ngakho-ke abantu abanezifo zenhliziyo ezikhona badinga ukuqapha okwengeziwe. Udokotela wakho uzohlola impilo yenhliziyo yakho ngaphambi kokuqala ukwelashwa futhi angase ayale i-echocardiogram noma ezinye izivivinyo zokusebenza kwenhliziyo.

Uma unezinkinga zenhliziyo ezilula, ungase ukwazi ukuthola lo muthi ngokuqapha eduze. Kodwa-ke, abantu abanenhliziyo ehlulekayo enkulu noma ukulimala okukhulu kwenhliziyo bangase badinge ukucabangela ezinye izindlela zokwelapha. Udokotela wakho wenhliziyo kanye nodokotela we-oncologist bazosebenzisana ukuze banqume indlela ephephe kakhulu yesimo sakho esithile.

Umbuzo 2. Kufanele Ngenzeni Uma Ngiphuthelwa Ngengozi Umthamo weMargetuximab-cmkb?

Njengoba i-margetuximab-cmkb inikezwa njengokumnika esikhungweni sezokwelapha, ngeke ngephutha uphuthelwe umthamo ekhaya. Kodwa-ke, uma udinga ukuhlela kabusha i-aphoyintimenti, xhumana nethimba lakho lezempilo ngokushesha ngangokunokwenzeka ukuze uhlele isikhathi esisha sokwelashwa.

Kubalulekile ukuzama ukuhlala ohlelweni lokwelashwa kwakho, njengoba ukunikezwa imithi okuqhubekayo kusiza ukugcina ukusebenza kahle komuthi. Ithimba lakho lingasebenza nawe ukuthola izikhathi zokuqokwa ezihambisana nohlelo lwakho futhi zikusize ukuthi ugcine izikhawu zokwelashwa ezivamile.

Q3. Kufanele Ngenzeni Uma Nginokuphendula Ngesikhathi Sokumnika Kwami?

Uma uhlangabezana nanoma yiziphi izimpawu ezingavamile ngesikhathi sokumnika kwakho, njengobunzima bokuphefumula, ukuqina kwesifuba, ukuqubuka, noma amaqhwa amakhulu, yazisa ithimba lakho lezempilo ngokushesha. Baqeqeshwe ukubhekana nokuphendula kokumnika futhi banemithi etholakalayo yokuyelapha ngokushesha.

Iningi lokuphendula kokumnika lithambile futhi lingalawulwa ngokunciphisa izinga lokumnika noma ngokunikeza imithi eyengeziwe ngaphambi kokwelashwa. Ithimba lakho lizokuqapha ngokucophelela kuyo yonke imithi futhi lingashintsha isivinini sokumnika noma lime ukwelashwa uma kudingeka.

Q4. Ngingayeka Nini Ukuthatha i-Margetuximab-cmkb?

Uzoqhubeka nokuthatha i-margetuximab-cmkb uma nje isiza ukulawula umdlavuza wakho futhi uyayibekezelela kahle. Udokotela wakho uzohlola njalo ukuthi usabela kanjani ekwelashweni ngokusebenzisa izithombe kanye nokuhlolwa kwegazi, futhi uzoxoxa nganoma yiziphi izinguquko ohlelweni lwakho lokwelashwa nawe.

Ungalokothi uyeke lo muthi ngokwakho, ngisho noma uzizwa ungcono noma uhlangabezana nemiphumela emibi. Ithimba lakho lezempilo lingasiza ekuphatheni imiphumela emibi futhi lizokwenza noma yiziphi izinguquko ezidingekayo ohlelweni lwakho lokwelashwa ngokusekelwe ekuphenduleni kwakho komuntu ngamunye nezidingo zakho.

Q5. Ngingathatha Eminye Imithi Ngesikhathi Ngithola i-Margetuximab-cmkb?

Ngokuvamile ungaqhubeka nokuthatha imithi yakho ejwayelekile ngenkathi uthola i-margetuximab-cmkb, kodwa kubalulekile ukuxoxa ngayo yonke imithi yakho nethimba lakho lezempilo. Lokhu kufaka phakathi imithi kadokotela, imithi etholakala ngaphandle kwemvume kadokotela, amavithamini, kanye nezithasiselo zemvelo.

Eminye imithi ingase ihlangane nokwelashwa kwakho umdlavuza noma ithinte indlela umzimba wakho osebenza ngayo ngemithi. Udokotela wakho noma usokhemisi angabukeza uhlu lwakho olugcwele lwemithi futhi enze noma yiziphi izinguquko ezidingekayo ukuze aqinisekise ukuthi konke kusebenza ngokuphepha.