Yini iMecasermin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

IMecasermin iyinguqulo yokwenziwa ye-insulin-like growth factor-1 (IGF-1) esiza izingane ukuthi zikhule lapho imizimba yazo ingakwenzi ngokwanele lokhu okubalulekile kwe-hormone ngokwemvelo. Lo muthi wenzelwe ngqo izingane ezinokushoda okukhulu kwe-IGF-1 okuyinhloko, isimo esingavamile lapho umzimba ungenzi i-hormone yokukhula eyanele noma ungasabela kahle kuyo.

Uma ingane yakho itholwe inokushoda kwe-hormone yokukhula futhi ayizange isabele kahle ekwelashweni kwe-hormone yokukhula kwendabuko, i-mecasermin ingase ibe yisinyathelo esilandelayo udokotela wakho azosicabangela. Inikezwa njengesijovo sansuku zonke ngaphansi kwesikhumba, njenge-insulin yesifo sikashukela.

Yini iMecasermin?

IMecasermin iyikhophi eyenziwe ngumuntu ye-insulin-like growth factor-1, iphrotheni umzimba wakho oyenza ngokwemvelo ukusiza amaseli ukuthi akhule futhi athuthuke. Lapho izingane zinesifo esikhulu se-IGF-1 esiyinhloko, imizimba yazo ayenzi i-IGF-1 eyanele noma ayikwazi ukuyisebenzisa ngempumelelo, okuholela ekukhuleni okuhlehlayo kakhulu.

Lo muthi empeleni ushintsha lokho okufanele umzimba wengane yakho ukwenze ngokwawo. Cabanga ngayo njengokuhlinzeka ngengxenye elahlekile evumela ukukhula okuvamile nokuthuthuka ukuthi kwenzeke. I-FDA ivume i-mecasermin ngqo ngalesi simo esingavamile, okuyenza ibe yindlela yokwelapha ekhethekile.

Ngokungafani ne-hormone yokukhula ejwayelekile, i-mecasermin isebenza ngokuqondile njenge-IGF-1 kunokuthi ikhuthaze umzimba ukuthi ukhiqize okwengeziwe kwayo. Lokhu kuyenza ibe usizo ikakhulukazi ezinganeni ezingakwazi ukusabela ekwelashweni kwe-hormone yokukhula.

Yini iMecasermin Esetshenziselwa Yona?

IMecasermin iphatha ukushoda okukhulu kwe-IGF-1 okuyinhloko ezinganeni ezingasabelanga ekwelashweni kwe-hormone yokukhula. Lesi simo sithinta cishe ingane eyodwa kwabangu-100,000, okwenza kube yinto engavamile kodwa ebucayi uma kwenzeka.

Udktela wakho ngokuvamile uzocabangela i-mecasermin uma ingane yakho ihlangabezana nemibandela ethile. Lokhu kufaka phakathi amazinga aphansi kakhulu e-IGF-1 ekuhlolweni kwegazi, ekhombisa ukukhula okuncane naphezu kokudla okunomsoco okwanele, futhi engaphenduli eminyakeni okungenani eyodwa yokwelashwa nge-hormone yokukhula.

Umuthi usetshenziselwa nezingane ezinokususwa kofuzo lwe-hormone yokukhula noma ukungazweli okukhulu kwe-hormone yokukhula. Ezimweni ezinjalo, ukwelashwa okujwayelekile nge-hormone yokukhula ngeke kusebenze ngoba umzimba awukwazi ukucubungula noma ukuphendula kahle ku-hormone yokukhula.

Isebenza Kanjani I-Mecasermin?

I-Mecasermin isebenza ngokunikeza ngqo umzimba wengane yakho nge-IGF-1 ewudingayo ukuze ikhule futhi ithuthuke ngendlela ejwayelekile. Lokhu kuthathwa njengomuthi onamandla aphakathi nendawo odinga ukuqashwa ngokucophelela kanye nokulinganisa okunembile.

Uma isijovwe ngaphansi kwesikhumba, i-mecasermin ingena egazini futhi ihambe iye ezicutshini ezihlukahlukene emzimbeni wonke. Bese ibopha kuma-receptors e-IGF-1 emangqamuzaneni, iqale izinqubo zokukhula okufanele zenzeke ngokwemvelo ngesikhathi sobuntwana.

Umuthi ukhuthaza ukukhula kwamathambo, ukuthuthukiswa kwemisipha, nokuvuthwa okungokomzimba okuphelele. Futhi kusiza nge-protein synthesis futhi kungathuthukisa imetabolism. Ngenxa yokuthi isebenza ezingeni leselula, ungase ungaboni izinguquko ngokushesha, kodwa ukukhula kufanele kuthuthuke kancane kancane ezinyangeni eziningana zokwelashwa.

Kufanele Ngiyithathe Kanjani I-Mecasermin?

I-Mecasermin kufanele inikezwe njengesijovo esingaphansi kwesikhumba kabili ngosuku, cishe imizuzu engama-20 ngaphambi noma ngemuva kokudla. Umhlinzeki wakho wezempilo uzokufundisa ukuthi ungazilungiselela kanjani futhi unikeze lezi zijovo ngokuphepha ekhaya.

Njalo nika i-mecasermin ngokudla noma isidlo ukuvimbela ushukela ophansi wegazi, okungaba umphumela ongemuhle ongathi sína. Umuthi ungabangela amazinga kashukela egazini ukuthi ehlise kakhulu, ikakhulukazi ezinganeni ezingadli njalo noma ezinenkinga yesisu.

Shintshanisa izindawo zokujova phakathi kwezingalo, imilenze, nesisu ukuvimbela izinkinga zesikhumba. Hlanza indawo yokujova ngotshwala futhi usebenzise inaliti entsha ngaso sonke isikhathi. Gcina amavial angavuliwe esiqandisini, kodwa wavumele afinyelele ezingeni lokushisa legumbi ngaphambi kokujova.

Ungalokothi unyakazise umuthi, ngoba lokhu kungalimaza amaprotheni. Uma uqaphela noma yiziphi izinhlayiya noma amafu emuthini, ungawusebenzisi futhi uthintane nekhemisi lakho ukuze uthole omunye.

Kufanele Ngithathe Isikhathi Esingakanani I-Mecasermin?

Ingane yakho ngokuvamile izodinga ukwelashwa nge-mecasermin iminyaka eminingana, ngokuvamile kuze kube yilapho ifinyelela ubude bayo obukhulu noma amapuleti abo okukhula evaleka. Lokhu kuvame ukwenzeka phakathi neminyaka yobusha, kodwa isikhathi siyahlukahluka enganeni ngayinye.

Udokotela wakho uzoqapha ukukhula kwengane yakho njalo emavikini amathathu kuya kwayisithupha ukuze anqume ukuthi umuthi usebenza ngempumelelo yini. Bazokala ubude, isisindo, futhi bangenza ama-X-ray ukuze bahlole iminyaka yamathambo nokuthuthukiswa kwamapuleti okukhula.

Ezinye izingane zingase zidinge ukwelashwa iminyaka engu-5-10 noma ngaphezulu, kuye ngokuthi baqala nini ukwelashwa nokuthi umzimba wabo usabela kanjani. Umgomo uwukusiza ingane yakho ukuthi ifinyelele amandla ayo e-genetic okukhula nentuthuko.

Ukwelashwa ngokuvamile kuqhubeka uma nje ingane yakho isakhula futhi umuthi uyasiza. Udokotela wakho ekugcineni uzoncoma ukuyeka lapho ukukhula kwehla kakhulu noma kuqedwa.

Yiziphi Imiphumela Eceleni Ye-Mecasermin?

Njengayo yonke imithi, i-mecasermin ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Umphumela oceleni okhathazayo kakhulu ukushukela okuphansi egazini (i-hypoglycemia), okungaba yingozi uma kungelashwa ngokushesha.

Nawa imiphumela emibi evame kakhulu ongase uyibone, futhi kubalulekile ukuqonda ukuthi eminingi yalezi ingalawulwa ngokunakekelwa okufanele:

• Izimpawu zikashukela ophansi njengokuthuthumela, ukujuluka, ukudideka, noma ukucasuka
• Ukucindezeleka kwekhanda, ikakhulukazi emasontweni ambalwa okuqala okwelashwa
• Ukuphendula endaweni yokujova njengobubomvu, ukuvuvukala, noma ubuhlungu obuncane
• Ubuhlungu bemisipha noma amalunga njengoba umzimba ujwayela ukukhula
• Ukucanuzela kwenhliziyo noma ukuhlanza, ikakhulukazi uma kungathathwa nokudla
• Isiyezi noma ukuzwa sengathi uyakhathala

Le miphumela emibi evamile ivame ukuthuthuka njengoba umzimba wengane yakho ujwayela imithi. Kodwa-ke, kufanele ngaso sonke isikhathi uthinte udokotela wakho uma iba nzima noma ikhathaza.

Imiphumela emibi engathi sína kodwa engavamile idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu okungenzeka okungavamile kufaka phakathi ukusabela okukhulu komzimba, ushukela ophansi ogxilile ongawuphenduli ukwelashwa, noma izimpawu zokwanda kwengcindezi ebuchosheni njengokucindezeleka kwekhanda okukhulu nezinguquko embonweni.

Ezinye izingane zingase futhi zibe namathoni amakhulu noma i-sleep apnea, ikakhulukazi labo asebenobunzima bokuphefumula. Udokotela wakho uzoqapha lezi zinkinga ngesikhathi sokuhlolwa okuvamile.

Ubani Ongafanele Athole I-Mecasermin?

I-Mecasermin ayifanele wonke umuntu, futhi udokotela wakho uzoqapha ngokucophelela ukuthi iphephile yini ingane yakho. Izingane ezinomdlavuza osebenzayo noma osolwayo akufanele zithole lo muthi, njengoba i-IGF-1 ingakhuthaza ukukhula komdlavuza.

Ingane yakho akufanele ithathe i-mecasermin uma inezifo ezinzima zezinso noma zesibindi, njengoba lezi zimo zingathinta indlela umzimba osebenza ngayo imithi. Izingane ezinama-growth plates avaliwe nazo ngeke zizuze ekwelashweni ngoba amathambo azo angeke asakhula.

Nawa amanye amakhondishini abalulekile angase avimbele ingane yakho ukuthi ingasebenzisi i-mecasermin ngokuphepha:

• Ukuxilongwa komdlavuza wamanje noma wangaphambilini
• Izinkinga ezinzima zezinso noma zesibindi
• I-Diabetic retinopathy noma ezinye izinkinga zamehlo ezingathi sína
• Izimo zenhliziyo ezinzima
• Ukungezwani okwaziwayo ne-mecasermin noma yiziphi izithako zayo

Ngaphezu kwalokho, izingane ezinemibandela ethile yofuzo noma lezo ezithatha imithi ethile zingase zidinge ezinye izindlela zokwelapha. Udokotela wakho uzobukeza umlando wezokwelapha wengane yakho ngaphambi kokunquma ukuthi ingathatha i-mecasermin.

Amagama Omkhiqizo we-Mecasermin

I-Mecasermin iyatholakala ngaphansi kwegama lomkhiqizo elithi Increlex e-United States nakwamanye amazwe amaningi. Lona njengamanje ngumkhiqizo owodwa kuphela ovunyelwe yi-FDA we-mecasermin otholakalayo wokwelapha ukuntuleka okukhulu kwe-IGF-1.

I-Increlex yenziwa yi-Ipsen Biopharmaceuticals futhi iza njengesixazululo esicacile emabhodleleni amancane okujova. Ibhodlela ngalinye liqukethe ama-40 mg e-mecasermin kuma-4 mL esixazululo.

Ngeke uthole izinguqulo ezivamile ze-mecasermin ngoba iyimithi eyinkimbinkimbi yamaprotheni okunzima ukuyikopisha ngqo. Lokhu futhi kusho ukuthi imithi ingaba yibiza kakhulu, kodwa izinhlelo eziningi zomshuwalense nezinhlelo zokusiza iziguli zingasiza ngezindleko.

Ezinye izindlela ze-Mecasermin

Ezinganeni eziningi ezinokuntuleka kwe-hormone yokukhula, ukwelashwa okuvamile kwe-hormone yokukhula (somatropin) yikwelashwa kokuqala. I-Mecasermin ngokuvamile igcinelwe amacala lapho i-hormone yokukhula ingasebenzi noma ingasetshenziswa.

Uma ingane yakho ingakwazi ukuthatha i-mecasermin, ezinye izindlela zokulungiselela i-hormone yokukhula zingase zicatshangelwe, okuhlanganisa imikhiqizo ehlukene noma amafomula e-somatropin. Ezinye izingane zingazuza ekwelashweni okuhlanganisiwe noma amashejuli okulinganisa ahlukene.

Ezimweni ezingavamile lapho i-hormone yokukhula noma i-mecasermin ingafaneleki, odokotela bangase batusa ukusekelwa kokudla okunomsoco, ukwelashwa ngokomzimba, noma ezinye izindlela zokwelapha ezisekelayo ukuze kuthuthukiswe ukukhula nentuthuko ngaphakathi kwemingcele yengane yakho.

Nokho, kubalulekile ukuqonda ukuthi akukho okunye okungathatha indawo ye-mecasermin ezinganeni ezinokuntuleka okukhulu kwe-IGF-1. Le mithi igcwalisa indima eyingqayizivele engatholakali kwezinye izindlela zokwelapha.

Ingabe i-Mecasermin Ingcono Kune-Hormone Yokukhula?

I-Mecasermin akudingeki ukuthi "ingcono" kune-hormone yokukhula, kodwa isebenza ngendlela ehlukile futhi inenjongo ethile. Ukwelashwa nge-hormone yokukhula kuyindlela yokuqala yokwelapha ezinganeni eziningi ezinokushoda kwe-hormone yokukhula ngoba ngokuvamile kulula ukuyisebenzisa futhi inesikhathi eside sokusebenza.

Kodwa-ke, i-mecasermin iba yindlela engcono lapho ukwelashwa nge-hormone yokukhula kuhluleka noma kungenzeki. Ezinganeni ezinokushoda okukhulu kwe-IGF-1, i-mecasermin ingase ibe yindlela yokwelapha esebenzayo kuphela etholakalayo.

I-hormone yokukhula ikhuthaza umzimba ukuthi ukhiqize i-IGF-1, kuyilapho i-mecasermin inikeza ngokuqondile i-IGF-1. Lokhu kusho ukuthi i-mecasermin ingasiza izingane ezingakwazi ukusabela ku-hormone yokukhula noma ukukhiqiza i-IGF-1 ngokwemvelo.

Ukukhetha phakathi kwale mithi kuncike ngokuphelele esimweni esithile sengane yakho nokuthi umzimba wayo usabela kanjani ekwelashweni. Udokotela wakho uzoqoka ukuthi iyiphi indlela efanele kakhulu ngokusekelwe ekuhlolweni kwegazi, amaphethini okukhula, kanye nomlando wokwelashwa.

Imibuzo Evame Ukubuzwa Mayelana ne-Mecasermin

Ingabe i-Mecasermin iphephile ezinganeni ezinomdlavuza?

I-Mecasermin idinga ukuqapha okwengeziwe ezinganeni ezinomdlavuza ngoba inganciphisa kakhulu amazinga kashukela egazini. Uma ingane yakho inomdlavuza, udokotela wayo uzodinga ukuqapha ngokucophelela i-glucose yegazi futhi mhlawumbe alungise imithi yomdlavuza.

Inhlanganisela ye-mecasermin nemithi yomdlavuza ingandisa ingozi kashukela ophansi wegazi. Ithimba lakho lezempilo lizosebenza nawe ukuthuthukisa uhlelo lokuqapha olucophelelayo futhi likufundise ukuthi ungayibona kanjani futhi uyelaphe kanjani i-hypoglycemia ngokushesha.

Ukuvivinywa okuvamile kashukela wegazi kubaluleke nakakhulu lapho ingane yakho ithatha i-mecasermin. Uzodinga ukuhlola amazinga kaningi futhi uhlale unamathuba kashukela asebenza ngokushesha atholakala kalula.

Ngingenzani uma ngiphuthelwa nginikeza i-Mecasermin eningi kakhulu?

Uma ngengozi unikeza ingane yakho i-mecasermin eningi kakhulu, qaphela ngokucophelela izimpawu zikashukela ophansi wegazi bese uthintana nodokotela wakho ngokushesha. Izimpawu zihlanganisa ukuthuthumela, ukujuluka, ukudideka, ukucasuka, noma ukuziphatha okungajwayelekile.

Nikeza ingane yakho okuthile okuneshukela okufanele ikudle noma ikuphuze ngokushesha, njengokuthi ijusi lezithelo, amaphilisi e-glucose, noma uswidi. Hlala nabo futhi uqhubeke nokubheka izimpawu ngenkathi ulinde isiqondiso sezokwelapha.

Ungalindi ukubona ukuthi izimpawu ziyavela yini. Ushukela ophansi wegazi ovela ku-mecasermin eningi kakhulu ungaba yingozi futhi ungadinga ukwelashwa okuphuthumayo. Shayela umugqa ophuthumayo kadokotela wakho noma uye egumbini eliphuthumayo eliseduze uma ungafinyeleli kumhlinzeki wakho wezempilo.

Kufanele Ngenzeni Uma Ngeqa Umthamo We-Mecasermin?

Uma weqa umthamo we-mecasermin, mnike ngokushesha lapho ukhumbula, kodwa kuphela uma kungaphakathi kwamahora ambalwa esikhathi esihleliwe. Qiniseka ukuthi ingane yakho idla okuthile ngaphambi noma ngemuva kokujova ukuvimbela ushukela ophansi wegazi.

Uma sekuseduze isikhathi somthamo olandelayo, weqa umthamo oweqiwe bese ubuyela esimisweni sakho esivamile. Ungalokothi unikeze imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo oweqiwe, ngoba lokhu kungadala ukwehla okuyingozi kushukela wegazi.

Gcina umkhondo wemithamo eyeqiwe futhi wazise udokotela wakho uma unenkinga yokugcina isimiso. Bangase bakwazi ukusikisela amasu okukusiza ukuthi ukhumbule noma ulungise isikhathi ukuze silingane kangcono nomkhuba womndeni wakho.

Ngingayeka Nini Ukuthatha I-Mecasermin?

Akufanele neze uyeke i-mecasermin ngaphandle kokubonisana nodokotela wengane yakho kuqala. Isikhathi sincike ekuqhubekeleni phambili kokukhula kwengane yakho, iminyaka yamathambo, kanye nentuthuko iyonke, okuthi ithimba lakho lezempilo liyibheke njalo.

Izingane eziningi zingayeka i-mecasermin lapho amathambo azo evaleka, ngokuvamile phakathi neminyaka yobusha. Udokotela wakho uzosebenzisa ama-X-ray nezilinganiso zokukhula ukunquma ukuthi lokhu kwenzeka nini nokuthi ngabe ukuqhubeka nokwelashwa kungaba yinzuzo yini.

Ezinye izingane zingase zidingeke ukuthi ziqhubeke nokwelashwa isikhathi eside uma zisaqhubeka nokukhula futhi zizuza emuthini. Ezinye zingase ziyeke ngaphambi kwesikhathi uma imiphumela emibi iba yinkinga noma uma ukukhula sekufinyelele ezingeni elamukelekayo.

Ingabe i-Mecasermin ingabangela izinkinga zempilo zesikhathi eside?

Izifundo zesikhathi eside nge-mecasermin zisaqhubeka njengoba kungumuthi omusha. Kodwa-ke, ucwaningo lwamanje luphakamisa ukuthi uma lusetshenziswa ngendlela efanele ngaphansi kokuqashwa kwezokwelapha, izinzuzo ngokuvamile zidlula izingozi ezinganeni ezinokuntuleka okukhulu kwe-IGF-1.

Udokotela wakho uzoqapha ingane yakho njalo ukuze abone imiphumela yesikhathi eside, okuhlanganisa izinguquko ekusebenzeni komzimba, ukukhula kwamathambo, nempilo yonke. Lokhu kuhlolwa kusiza ukubamba noma yiziphi izinkinga zisasekuqaleni futhi kulungise ukwelashwa njengoba kudingeka.

Into ebaluleke kakhulu ukugcina ama-aphoyintimenti okulandelwa njalo nokubika noma yiziphi izimpawu ezikhathazayo ngokushesha. Lokhu kuvumela ithimba lakho lezempilo ukuthi liqinisekise ukuthi ingane yakho ithola inzuzo enkulu ekwelashweni ngenkathi kunciphisa izingozi ezingaba khona.