Yini i-Methylene Blue (Indlela yokufaka ngemithambo yegazi): Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Methylene blue iyidayi eluhlaza okwesibhakabhaka eyenziwe ngabantu odokotela abayisebenzisa njengomuthi ofakwa ngemithambo yegazi ukwelapha izimo ezithile zezokwelapha. Uma inikezwa nge-IV, leli khambi eliluhlaza okwesibhakabhaka eliqhakazile lisebenza njengomuthi oqinile wokulwa nobuthi kanye nethuluzi lokuxilonga ezibhedlela nasemagumbini eziphuthumayo.

Ungase umangale ukuzwa ukuthi lo muthi, oguqula umchamo wakho ube luhlaza okwesibhakabhaka, usindisa izimpilo isikhathi esingaphezu kwekhulu leminyaka. Abahlinzeki bezempilo bavame ukuwusebenzisa ukwelapha i-methemoglobinemia, isimo esiyingozi lapho igazi lakho lingakwazi ukuthwala umoya-mpilo ngendlela efanele.

Yini i-Methylene Blue?

I-Methylene blue ngumuthi ongaphansi kwezigaba zemithi ebizwa ngokuthi ama-reducing agents. Kuyinhlanganisela eyenziwe ngabantu evela njengempushana eluhlaza okwesibhakabhaka emnyama, eba yisixazululo esiluhlaza okwesibhakabhaka esiqhakazile uma ixutshwe namanzi okujova.

Lo muthi usebenza ezingeni leselula ukusiza ukubuyisela ikhono lomzimba wakho lokusebenzisa umoya-mpilo ngempumelelo. Ekuqaleni yathuthukiswa njengedayi yendwangu ngeminyaka yawo-1800, odokotela bathola izakhiwo zayo zezokwelapha ngengozi lapho beqaphela ukuthi ingelapha amacala athile obuthi.

Ifomu elinikezwa ngemithambo yegazi lenzelwe ngqo ukusetshenziswa esibhedlela, lapho ochwepheshe bezokwelapha bengakuqapha eduze ngesikhathi sokwelashwa. Akuyona into ongayithatha ekhaya, njengoba idinga ukulinganiswa ngokucophelela nokuqashwa kwezokwelapha.

Isetshenziselwani i-Methylene Blue?

I-Methylene blue ilapha i-methemoglobinemia, isimo lapho amaseli akho abomvu egazi engakwazi ukuthwala umoya-mpilo ngendlela efanele ezicutshini zakho. Lokhu kwenzeka lapho insimbi e-hemoglobin yakho iguqulwa, okwenza igazi lakho lingasebenzi kahle ekulethweni komoya-mpilo osindisa impilo emzimbeni wakho wonke.

Ake sibheke izizathu eziyinhloko ezingenza odokotela banikeze lo muthi. Isimo ngasinye sidinga ukuhlolwa nokuqashwa ngokucophelela yithimba lakho lezempilo.

• I-Methemoglobinemia ebangelwa imithi ethile efana nama-antibiotics noma ama-pain relievers
• Ubuthi obuvela kuma-nitrites noma ama-nitrates atholakala kokunye ukudla noma emanzini
• I-Hereditary methemoglobinemia, isimo esingavamile se-genetic
• Ukuvezwa kwamakhemikhali ezintweni ezisetshenziswa embonini noma emikhiqizweni yasekhaya
• I-Drug-induced methemoglobinemia evela kuma-anesthetics endawo afana ne-benzocaine

Kwezinye izimo ezingavamile, odokotela basebenzisa i-methylene blue njengendlela yokuxilonga ngesikhathi sokuhlinzwa okuthile. Ithimba lakho lezokwelapha lizochaza ngqo ukuthi kungani lincoma lokhu kwelashwa esimweni sakho esithile.

Isebenza Kanjani I-Methylene Blue?

I-Methylene blue isebenza ngokuthi isize amaseli akho abomvu egazi aguqule i-hemoglobin eguquliwe ibuyele esimweni sayo esijwayelekile, esithwala umoya-mpilo. Cabanga ngayo njengomsizi oenza amaseli akho egazi abuyele ekwenzeni umsebenzi wawo oyinhloko wokuletha umoya-mpilo emzimbeni wakho wonke.

Uma une-methemoglobinemia, insimbi eku-hemoglobin yakho ibambeka esimweni esingajwayelekile. I-Methylene blue isebenza njengebhuloho, inikeza ama-electron asiza ukuguqula le hemoglobin engajwayelekile ibuyele ku-hemoglobin ejwayelekile.

Lo muthi uthathwa njengomuthi onamandla ngokulinganiselwe futhi usebenza ngokushesha. Abantu abaningi baqala ukuzizwa ngcono kungakapheli imizuzu engama-30 kuya ehora elilodwa ngemuva kokuthola umjovo, yize ukululama okuphelele kungathatha amahora amaningana.

Umbala oluhlaza ozowubona emchameni wakho ujwayelekile ngokuphelele futhi ukhombisa ukuthi umuthi usebenza ngendlela yawo emzimbeni wakho. Lo mbala ongajwayelekile wesikhashana futhi uzonciphisa njengoba umzimba wakho usebenza ngomuthi.

Kufanele Ngiyithathe Kanjani I-Methylene Blue?

Ngeke uzithathele wena i-methylene blue - ngaso sonke isikhathi inikezwa ochwepheshe bezempilo esibhedlela noma endaweni yezokwelapha. Umuthi uza ngomjovo oqondiswe ngqo emthanjeni wakho ngomugqa we-IV.

Ithimba lakho lezempilo lizolungisa umuthi ngokuwunciphisa esixazululweni esingenazo izinto ezingcolile. Ngokuvamile bazowunika kancane kancane emizuzwini embalwa ngenkathi beqapha izinga lokushaya kwenhliziyo yakho, umfutho wegazi, kanye namazinga omoya-mpilo ngokuqhubekayo.

Ngaphambi kokuthola umjovo, akudingeki ukuthi uzile noma ugweme noma yiziphi izinhlobo zokudla. Kodwa-ke, kufanele utshele ithimba lakho lezokwelapha ngayo yonke imithi oyithathayo, okuhlanganisa nemithi etholakala ngaphandle kwemvume kadokotela kanye nezithasiselo.

Indawo yokujova ingase izizwe ibanda kancane njengoba umuthi ungena egazini lakho. Lokhu kuvamile, futhi umhlinzeki wakho wezempilo uzohlola ukuqinisekisa ukuthi i-IV isebenza kahle ngaso sonke isikhathi sokwelashwa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Methylene Blue?

I-Methylene blue ngokuvamile inikezwa njengomthamo owodwa noma imithamo embalwa esikhathini esifushane, ngokuvamile kungakapheli amahora angama-24. Ngokungafani nemithi ongase uyithathe nsuku zonke ngezimo ezingamahlalakhona, lokhu kwelashwa kuklanyelwe ukubhekana nesimo sezokwelapha esibucayi.

Udokotela wakho uzoqaphela ukuthi ngabe udinga imithamo eyengeziwe ngokuya ngamazinga akho omoya-mpilo egazini nokuthi usabela kahle kangakanani ekwelashweni. Abantu abaningi badinga umthamo owodwa noma emibili kuphela ukuze babuyisele umthamo ojwayelekile wokuthwala umoya-mpilo.

Ngemuva kokuthola umuthi, ithimba lakho lezempilo lizoqhubeka likuqaphe amahora ambalwa ukuqinisekisa ukuthi ukwelashwa kusebenza ngempumelelo. Bazohlola amazinga akho omoya-mpilo egazini futhi baqaphele noma yiziphi izimpawu zokuthi ukwelashwa okwengeziwe kungase kudingeke.

Imiphumela ye-methylene blue ingahlala amahora ambalwa, futhi umzimba wakho uzoyiqeda kancane kancane imithi ngosuku olulandelayo noma ezimbili. Umchamo wakho ungase uhlale uluhlaza okwesibhakabhaka imizuzu engama-24 ngemuva kokwelashwa.

Yiziphi Imiphumela Eceleni ye-Methylene Blue?

Njengayo yonke imithi, i-methylene blue ingabangela imiphumela emibi, yize abantu abaningi beyibekezelela kahle uma inikezwe ngendlela efanele. Umphumela oqapheleka kakhulu umbala oluhlaza okwesibhakabhaka womchamo wakho, ongenangozi futhi wesikhashana.

Nawa amanye amaphutha ongase uhlangabezane nawo. Lokhu kuvame ukuzixazulula ngokwako njengoba umuthi usuka emzimbeni wakho.

• Ukushintsha komchamo ube luhlaza okwesibhakabhaka-luhlaza (lokhu kulindelekile futhi akulimazi)
• Ukucanuzela kwenhliziyo noma ukuphazamiseka kwesisu okuncane
• Isiyezi noma ukukhathala
• Ikhanda
• Umuzwa wokusha omncane endaweni yokujova
• Ukushintsha kombala kwesikhumba okwesikhashana endaweni yokujova

Imiphumela emibi kakhulu ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Ithimba lakho lezempilo lizokuqapha eduze ngezinketho ezinjalo.

• Ukuphefumula kanzima noma ukuphefumula ngokushesha
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okusheshayo
• Ukunyenyeka okukhulu noma ukuhlanza
• Ukudideka noma izinguquko zengqondo
• Isiyezi esikhulu noma ukuquleka
• Ukungezwani komzimba nezinto ezithile njengokuqubuka noma ukuvuvukala

Ngokuvamile, i-methylene blue ingabangela isimo esibizwa nge-serotonin syndrome kubantu abathatha imithi ethile yokucindezeleka. Ithimba lakho lezokwelapha lizobuyekeza imithi yakho ngokucophelela ngaphambi kokwelashwa ukuze kuncishiswe le ngozi.

Ubani Ongafanele Athathwe I-Methylene Blue?

I-Methylene blue ayiphephile kuwo wonke umuntu, futhi ithimba lakho lezempilo lizobuyekeza umlando wakho wezokwelapha ngokucophelela ngaphambi kokunquma ukuthi ilungele yini. Abantu abanezimo ezithile noma labo abathatha imithi ethile bangase badinge ukwelashwa okuhlukile.

Izimo ezilandelayo zingenza i-methylene blue ingaphephile kuwe. Udokotela wakho uzocabangela lezi zinto lapho ehlela ukwelashwa kwakho.

• Ukuntuleka kwe-G6PD (isimo sezakhi zofuzo esithinta amaseli abomvu egazi)
• Isifo sezinso esibi
• Isifo sesibindi esibi
• Ukungezwani okwaziwayo ne-methylene blue noma izinhlanganisela ezifanayo
• Ukukhulelwa noma ukuncelisa (ngaphandle kokuthi izinzuzo ziqeda izingozi)
• Izimo zenhliziyo ezinzima

Imithi ethile ingase ihlangane ngendlela eyingozi ne-methylene blue, ikakhulukazi lezo ezithinta amazinga e-serotonin. Ithimba lakho lezempilo lidinga ukwazi ngayo yonke imithi yakho.

• Ama-MAO inhibitors (ama-antidepressants athile)
• Ama-SSRIs kanye nama-SNRIs (ama-antidepressants ajwayelekile)
• Eminye imithi yokwelapha ubuhlungu efana ne-tramadol
• Eminye imithi ye-migraine
• Ezinye izibulala-magciwane kanye nemithi elwa nesikhunta

Ithimba lakho lezokwelapha lizohlola izingozi nezinzuzo ngokucophelela, ikakhulukazi uma unezimo ezinjalo noma usebenzisa le mithi. Ngezikhathi ezithile izinzuzo ezisindisa impilo zidlula izingozi ezingaba khona.

Amagama Omkhiqizo we-Methylene Blue

I-Methylene blue itholakala ngaphansi kwamagama amaningi omkhiqizo, nakuba ivame ukubizwa ngokuthi "i-methylene blue injection" emitholampilo. Igama lomkhiqizo elivamile e-United States yi-Provayblue, eyenzelwe ngqo ukwelapha i-methemoglobinemia.

Amanye amagama omkhiqizo ongase uwazwe afaka i-Methylthioninium chloride, esetshenziswa kwamanye amazwe ngaphandle kwe-United States. Ithimba lakho lezempilo lizosebenzisa noma iyiphi ifomula etholakalayo nefanele isimo sakho.

Noma ngabe igama lomkhiqizo linjani, zonke izinjabulo ze-methylene blue ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngendlela efanayo. Okubalulekile ukuthi uthola ifomula efanele yezokwelapha, hhayi imibala yezimboni.

Ezinye izindlela ze-Methylene Blue

Ngenkathi i-methylene blue iyindlela yokwelapha ephumelela kakhulu i-methemoglobinemia, kunezindlela ezingezinye udokotela wakho angazicabangela ezimweni ezithile. Lezi zindlela ezihlukile zincike ekuqineni kwesimo sakho kanye nezimo zakho zezokwelapha.

Ezimweni ezithambile ze-methemoglobinemia, ngezinye izikhathi ukunakekelwa okusekelayo kungase kwanele. Lokhu kufaka phakathi ukuhlinzeka nge-oxygen eyengeziwe nokuqapha isimo sakho ngokucophelela ngenkathi umzimba wakho ululama ngokwemvelo.

Ezimweni lapho i-methylene blue ingasetshenziswa khona, odokotela bangazama i-ascorbic acid (ivithamini C) ngemithamo ephezulu, nakuba lokhu kusebenza kancane kakhulu. Ukushintshaniswa kwegazi, lapho igazi lakho lithathelwa indawo ngegazi lomnikeli, kuyindlela yokugcina ezimweni ezinzima.

Ukwelashwa nge-oxygen ye-hyperbaric, lapho uphefumula khona i-oxygen ehlanzekile ekamelweni elinomfutho ophezulu, kungasiza kwezinye izimo. Kodwa-ke, i-methylene blue ihlala iyindlela yokwelapha yegolide uma ingasetshenziswa ngokuphepha.

Ingabe i-Methylene Blue Ingcono Kunezinye Izindlela Zokwelapha?

I-Methylene blue ithathwa njengendlela yokwelapha esebenza kahle kakhulu futhi esheshayo ye-methemoglobinemia. Isebenza ngokushesha nangokwethembeka kunezinye izindlela zokwelapha ezifana nevithamini C noma ukunakekelwa okusekelayo kuphela.

Uma iqhathaniswa nezinye izindlela zokwelapha, i-methylene blue ngokuvamile iqala ukusebenza kungakapheli imizuzu engama-30 futhi ingathuthukisa kakhulu amazinga akho omoya-mpilo. Ezinye izindlela zokwelapha ezifana ne-vitamin C ngemithamo ephezulu zingathatha amahora noma izinsuku ukukhombisa ukuthuthuka okukhulu.

Izinzuzo eziyinhloko ze-methylene blue yisivinini sayo, ukusebenza kahle, kanye neqiniso lokuthi abantu abaningi bayayibekezelela kahle. Kodwa-ke, akudingeki ukuthi “ingcono” kuzo zonke izimo - udokotela wakho uzokhetha ukwelashwa okuphephe kakhulu futhi okufanele izimo zakho ezithile.

Ezimweni eziphuthumayo lapho impilo yomuntu isengozini ye-methemoglobinemia enzima, i-methylene blue ivame ukuba yindlela ecacile ngenxa yokuthi isebenza ngokushesha kangakanani. Ikhono lokuguqula lesi simo esiyingozi ngokushesha lenza libe yithuluzi elibalulekile emithini ephuthumayo.

Imibuzo Evame Ukubuzwa Mayelana ne-Methylene Blue

Ingabe i-Methylene Blue Iphephile Ezigulini Zezifo Zenhliziyo?

I-Methylene blue ingasetshenziswa kubantu abanezifo zenhliziyo, kodwa idinga ukuqapha okwengeziwe nokuqapha. Udokotela wakho wenhliziyo kanye nodokotela oqeqeshayo bazosebenzisana ukuze banqume ukuthi iphephile yini ngesimo sakho senhliziyo esithile.

Abantu abanenhliziyo ehlulekayo noma izinkinga ezithile zesigqi senhliziyo bangase badinge ukuqashwa okukhethekile ngesikhathi sokwelashwa. Umuthi ngezinye izikhathi ungase uthinte izinga lenhliziyo nomfutho wegazi, ngakho ithimba lakho lezempilo lizobheka lokhu ngokucophelela.

Ezimweni eziphuthumayo lapho i-methemoglobinemia isongela impilo, izinzuzo ze-methylene blue zivame ukwedlula izingozi zenhliziyo. Ithimba lakho lezokwelapha lizokwenza lesi sinqumo ngokusekelwe esimweni sakho somuntu ngamunye.

Kufanele Ngenzeni Uma Ngithola I-Methylene Blue Engaphezu Kwemithamo Ngengozi?

Uma usesibhedlela, ithimba lakho lezempilo lizosingatha noma yikuphi ukukhathazeka ngomthamo - akudingeki uzikhathaze ngalokhu wena. Ochwepheshe bezokwelapha babala ngokucophelela futhi baqaphe imithamo ye-methylene blue ukuvimbela ukweqisa.

Izimpawu ze-methylene blue eningi kakhulu zihlanganisa isicanucanu esibi, ubuhlungu besifuba, ubunzima bokuphefumula, noma isiyezi esikhulu. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, ithimba lakho lezokwelapha lizohlinzeka ngokunakekelwa nokubheka okusekelayo.

Ukwelashwa kwe-methylene blue overdose ngokuvamile kuhilela ukunakekelwa okusekelayo, okuhlanganisa uketshezi lwe-IV, i-oxygen, nokuqapha eduze izimpawu zakho ezibalulekile. Umuthi uzophuma kancane kancane emzimbeni wakho ngokuhamba kwesikhathi.

Kufanele Ngenzeni Uma Ngeqa Umthamo We-Methylene Blue?

Njengoba i-methylene blue inikezwa esibhedlela ngabasebenzi bezempilo, akudingeki ukhathazeke ngokweqa imithamo. Ithimba lakho lezokwelapha lizinquma isikhathi kanye nenani lemithamo oyidingayo.

Uma kudingeka imithamo eyengeziwe, ithimba lakho lezempilo lizoyihlela ngokusekelwe emazingeni akho e-oxygen yegazi nokuthi usabela kanjani ekwelashweni. Bazokuqapha ngokuqhubekayo ukuze banqume ukuthi ngabe umuthi owengeziwe uyadingeka yini.

Isikhathi semithamo ye-methylene blue sisekelwe esimweni sakho sezokwelapha, hhayi esheduli ejwayelekile njengemithi yansuku zonke. Ithimba lakho lezempilo lizokwenza zonke izinqumo mayelana nokuthi nini nokuthi umuthi ongakanani owudingayo.

Ngingayeka Nini Ukuthatha I-Methylene Blue?

Awukwazi ukunquma ukuthi uzoyeka nini i-methylene blue - lesi sinqumo senziwa ithimba lakho lezempilo ngokusekelwe emazingeni akho omoya-mpilo egazini kanye nokululama kwakho konke. Abantu abaningi badinga imithamo emibili kuphela.

Udokotela wakho uzoyeka umuthi uma amazinga akho omoya-mpilo egazini ebuyela kokujwayelekile futhi ahlale ezinzile. Lokhu kuvamile ukwenzeka kungakapheli amahora ambalwa kuya osukwini olulodwa ngemuva kokuqala kokwelashwa.

Ngemuva kokuphela kokwelashwa, ithimba lakho lezempilo lizoqhubeka likuqapha ukuze liqinisekise ukuthi i-methemoglobinemia ayibuyi. Bazophinda babhekane nanoma iyiphi imbangela ekhona, njengokuyeka imithi engase iqale lesi simo.

Ingabe i-Methylene Blue izophazamisa ezinye izivivinyo zezokwelapha?

Yebo, i-methylene blue ingaphazamisa izivivinyo ezithile zezokwelapha, ikakhulukazi lezo ezilinganisa amazinga omoya-mpilo egazini lakho. Ithimba lakho lezempilo lizocabangela lokhu lapho lichaza imiphumela yokuhlolwa.

Umuthi ungathinta ukufundwa kwe-pulse oximetry, okulinganisa amazinga omoya-mpilo ngomunwe wakho. Ithimba lakho lezokwelapha lizosebenzisa ezinye izindlela zokuqapha amazinga akho omoya-mpilo ngenkathi umuthi usemhlabeni wakho.

Izivivinyo zegazi nazo zingabonisa ukushintsha kombala okuluhlaza okwesikhashana ngemuva kokwelashwa. Lokhu akuthinti imiphumela eminingi yokuhlolwa, kodwa ithimba lakho lezempilo lizobona ukuthi uthole i-methylene blue lapho lichaza noma yikuphi okutholakele okungajwayelekile.