Yini iMifepristone: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

IMifepristone iyimithi kadokotela evimba i-hormone i-progesterone emzimbeni wakho. Ungase uyazi kangcono njenge "ipilisi lokukhipha isisu" uma lisetshenziswa neminye imithi ebizwa nge-misoprostol, kodwa futhi lineminye imisebenzi ebalulekile yezokwelapha. Le mithi isebenza ngokungenelela ngama-hormone abalulekile ekugcineni ukukhulelwa, yingakho isebenza ekukhipheni isisu sezokwelapha nakwezinye izimo ezithile.

Yini iMifepristone?

IMifepristone iyisivimbeli se-hormone esenziwe ngumuntu esivimbela i-progesterone ekusebenzeni emzimbeni wakho. I-Progesterone iyi-hormone esiza ukugcina ukukhulelwa ngokugcina umugqa wesibeletho sakho uqina futhi usekela. Uma i-mifepristone ivimba i-progesterone, empeleni itshela umzimba wakho ukuthi uyeke ukusekela ukukhulelwa.

Le mithi yaqala ukugunyazwa yi-FDA ngonyaka ka-2000 futhi isetshenziswe ngokuphepha yizigidi zabantu emhlabeni wonke. Ingesinye sezidakamizwa ezibizwa ngokuthi ama-antiprogestin, okusho ukuthi asebenza ngokumelene nemiphumela evamile ye-progesterone emzimbeni wakho.

Yini iMifepristone Esetshenziselwa Yona?

IMifepristone inezinto ezimbili ezinkulu zokwelapha ezivunywe yi-FDA. Ukusetshenziswa okuyinhloko ukukhipha isisu sezokwelapha ekukhulelweni kwasekuqaleni, ngokuvamile kufika kumaviki ayi-10 kusukela esikhathini sakho sokugcina sokuya esikhathini. Isetshenziselwa futhi ukuphatha ushukela ophezulu egazini kubantu abanesifo i-Cushing's syndrome, isifo esingavamile sama-hormone.

Ukuze kukhishwe isisu sezokwelapha, i-mifepristone cishe ihlala isetshenziswa kanye ne-misoprostol, enye imithi ebangela ukuthi isibeletho sinciphe. Le nhlanganisela isebenza kahle kakhulu futhi ikuvumela ukuthi uqede ukukhulelwa ngaphandle kokuhlinzwa ezimweni eziningi.

Ku-Cushing's syndrome, i-mifepristone isiza ukulawula amazinga kashukela egazini lapho ezinye izindlela zokwelapha zingasebenzanga kahle ngokwanele. Lokhu kusetshenziswa kudinga ukuqapha ngokucophelela ochwepheshe abaqonda lesi simo esiyinkimbinkimbi.

Isebenza Kanjani iMifepristone?

I-Mifepristone isebenza ngokuvimba ama-progesterone receptors emzimbeni wakho. Cabanga nge-progesterone njengokhiye nama-receptors ayo njengama-lock - i-mifepristone empeleni ishintsha ama-lock ukuze ukhiye ungasebenzi. Lokhu kuthathwa njengendlela eqinile nephumelelayo ngoba iphazamisa ngokuqondile ikhono le-hormone lokusebenza.

Lapho i-progesterone ingakwazi ukwenza umsebenzi wayo, izinto eziningana zenzeka emzimbeni wakho. Ukugqama kwesibeletho sakho kuqala ukwehla, futhi intamo yesibeletho sakho ingase iqale ukuthamba futhi ivuleke kancane. Lezi zinguquko zilungiselela umzimba wakho umuthi wesibili, i-misoprostol, obangela ukuncipha ukuze ukhiphe ukukhulelwa.

Umuthi uvame ukuqala ukusebenza phakathi kwamahora angu-24 kuya kwangu-48 ngemva kokuwuthatha. Nokho, ngokuvamile uzodinga umuthi wesibili ukuze uqedele inqubo ngempumelelo.

Kufanele Ngiyithathe Kanjani I-Mifepristone?

I-Mifepristone ithathwa njengomthamo owodwa ngomlomo, ngokuvamile ehhovisi likahulumeni wakho wezempilo noma emtholampilo. Uzogwinya ithebhulethi yonke ngamanzi - ungayichobozi, uyihlafune, noma uyiphule. Umuthi ungafakwa nokudla noma ngaphandle kokudla, njengoba ukudla kungawuthinti ngendlela ephawulekayo ukuthi usebenza kahle kangakanani.

Umhlinzeki wakho wokunakekelwa kwezempilo uzokunikeza imiyalelo ethile mayelana nokuthi uzowuthatha nini umuthi wesibili, i-misoprostol, uma usebenzisa i-mifepristone ukuze ukhulelwe ngokwelashwa. Lesi sikhathi sibalulekile ukuze ukwelashwa kusebenze kahle futhi ngokuphepha.

Akudingeki ukuthi ugweme noma yikuphi ukudla ngaphambi kokuthatha i-mifepristone, kodwa kuyasiza ukudla okuthile okulula uma uzizwa unovalo noma uma isisu sakho singenalutho. Abanye abantu bathola ukuthi ukuba nesnakhi esincane kusiza ekuvikeleni isicanucanu.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Mifepristone?

Ukuze ukhulelwe ngokwelashwa, i-mifepristone ngokuvamile ithathwa njengomthamo owodwa. Ngeke kudingeke ukuthi uyithathe ngokuphindaphindiwe - umthamo owodwa ngokuvamile yilokho okudingekayo ngale njongo. Imiphumela yalo mthamo owodwa ingahlala izinsuku eziningana njengoba umzimba wakho uqhubekisa umuthi.

Uma usebenzisa i-mifepristone ye-Cushing's syndrome, udokotela wakho uzonquma ukuthi udinga ukuyithatha isikhathi esingakanani ngokusekelwe esimweni sakho esithile nokuphendula ekwelashweni. Lokhu kusetshenziswa kudinga ukuqapha okuqhubekayo nokulungiswa.

Umhlinzeki wakho wokunakekelwa kwezempilo uzokunikeza imiyalelo ecacile mayelana nokuqokwa okulandelayo ukuqinisekisa ukuthi umuthi usebenze njengoba bekulindelekile nokuthi uyalulama kahle.

Yiziphi Imiphumela Eceleni ye-Mifepristone?

Njengayo yonke imithi, i-mifepristone ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ihlobene nemiphumela yomuthi ohlelweni lwakho lokuzala kanye nama-hormone.

Nansi imiphumela emibi ongase uyithole, ukhumbula ukuthi eminingi yalezi yizingxenye ezilindelekile zenqubo uma isetshenziselwa ukukhipha isisu sezokwelapha:

• Isicanucanu nokuhlanza
• Ukuqunjelwa noma ukuqaqamba kwesisu
• Ikhanda
• Isiyezi noma ukuzwa ukukhathala
• Ukukhathala noma ubuthakathaka
• Ubuhlungu emhlane
• Ukuphuma kwegazi emithanjeni (kulindelekile ngokukhipha isisu sezokwelapha)

Iningi lale miphumela emibi imild kuya kwemaphakathi futhi ithuthuka ezinsukwini ezimbalwa. Kodwa-ke, abanye abantu bangase babe nemiphumela emibi kakhulu edinga ukunakekelwa kwezempilo ngokushesha.

Imiphumela emibi engavamile kodwa engathi sína ingabandakanya ukuphuma kwegazi okukhulu okumanzisa amaphedi amabili aminyene ngehora ngaphezu kwamahora amabili alandelanayo, izimpawu zokutheleleka njengomkhuhlane nokubanda, noma ubuhlungu obukhulu besisu obungathuthuki ngemithi yokwelapha ubuhlungu.

Ezimweni ezingavamile, abanye abantu bangase babe nokusabela komzimba, amahlule egazi, noma izinkinga zenhliziyo. Lezi zinkinga ezingathi sína azivamile kodwa zidinga ukunakekelwa kwezempilo ngokushesha uma zenzeka.

Ubani Ongafanele Athathwe i-Mifepristone?

IMifepristone ayiphephile kuwo wonke umuntu, futhi kunezimo eziningana ezibalulekile ezenza lo muthi ungafaneleki noma uyingozi. Umhlinzeki wakho wokunakekelwa kwezempilo uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwubhala.

Akufanele uthathe i-mifepristone uma unanoma yiziphi zalezi zimo, njengoba zingakhuphula ingozi yakho yezinkinga ezingathi sína:

• Ukungezwani okwaziwayo ne-mifepristone noma i-misoprostol
• Ukukhulelwa okungaphandle kwesibeletho okusolwayo (ukukhulelwa ngaphandle kwesibeletho)
• Ukwehluleka okungapheli kwe-adrenal
• Izifo zokuphuma kwegazi noma ukusetshenziswa kwamanje kwemithi yokunciphisa igazi
• I-porphyria eyindlalifa (isifo segazi esingavamile)
• Izinkinga zokufinyelela ekunakekelweni kwezimo eziphuthumayo zezokwelapha

Ezinye izimo ezithile zidinga ukuqapha okwengeziwe nokuqapha ngokucophelela. Lokhu kufaka phakathi isifuba esibi kakhulu, isifo senhliziyo, umfutho wegazi ophezulu, izinkinga zesibindi noma izinso, nesifo samathumbu esivuvukalayo.

Uma unedivayisi ye-intrauterine (IUD), kufanele ikhishwe ngaphambi kokuthatha i-mifepristone. Umhlinzeki wakho wokunakekelwa kwezempilo uzoxoxa ngalokhu nawe ngesikhathi sokuqokwa kwakho.

Amagama Omkhiqizo we-Mifepristone

E-United States, i-mifepristone itholakala ngaphansi kwegama lomkhiqizo elithi Mifeprex uma lisetshenziselwa ukukhipha isisu sezokwelapha. Ukuze welashwe i-Cushing's syndrome, ithengiswa ngaphansi kwegama lomkhiqizo elithi Korlym, nakuba lokhu kuyindlela ehlukile kanye nomthamo.

Yomibili imithi iqukethe isithako esifanayo esisebenzayo - i-mifepristone - kodwa zenziwe ngezindlela ezihlukene futhi zisetshenziselwa izinjongo ezihlukene. Ikhemisi lakho lizokhipha inguqulo ethile udokotela wakho ayibhalele isimo sakho esithile.

Izinhlobo ezivamile ze-mifepristone nazo ziyatholakala kwezinye izimo, kodwa umhlinzeki wakho wokunakekelwa kwezempilo uzonquma ukuthi iyiphi ifomula ethile efaneleka kakhulu izidingo zakho.

Ezinye Izindlela ze-Mifepristone

Kukhona ezinye izindlela ezingasetshenziswa kuye ngokuthi yisiphi isimo ozama ukusiphatha. Ukuqeda ukukhulelwa kwasekuqaleni, ukukhipha isisu ngokuhlinzwa kuyindlela enkulu esetshenziswa esikhundleni sokukhipha isisu ngemithi nge-mifepristone. Lokhu kuhilela inqubo emfushane engenziwa ngaphandle esikhundleni sokuthatha imithi.

Ezinye izindlela zokukhipha isisu ngemithi ziyatholakala kodwa azivamile ukusetshenziswa e-United States. Ezinye zihilela imithi ehlukene noma isikhathi esihlukile, kodwa i-mifepristone ehlanganiswe ne-misoprostol isahlala iyindlela efundwe kakhulu futhi esetshenziswa kabanzi.

Ngesifo i-Cushing, ezinye izindlela zokwelapha zihlanganisa ukuhlinzwa ukususa izimila, ukwelashwa ngemisebe, noma eminye imithi esebenza ngendlela ehlukile kune-mifepristone ukulawula amazinga e-cortisol.

Umhlinzeki wakho wezempilo angaxoxa ngalezi zindlela nawe futhi akusize ukuthi unqume ukuthi iyiphi indlela engase ibe ngcono esimweni sakho esithile nezintandokazi zakho.

Ingabe i-Mifepristone Ingcono Kune-Misoprostol Yodwa?

Yebo, inhlanganisela ye-mifepristone elandelwa yi-misoprostol isebenza kahle kakhulu kunokusebenzisa i-misoprostol yodwa ekukhipheni isisu ngemithi. Ucwaningo lubonisa ukuthi le nhlanganisela iphumelela cishe ngama-95-98% wamacala, kuyilapho i-misoprostol yodwa iphumelela cishe ngama-85-90% wamacala.

Le nhlanganisela futhi ivame ukusebenza ngokushesha futhi ingase ibangele ukugcwala nokopha okungapheli uma kuqhathaniswa ne-misoprostol yodwa. Yingakho abahlinzeki bezempilo abaningi bekhetha indlela yemithi emibili uma zombili zitholakala.

Noma kunjalo, kwezinye izingxenye zomhlaba lapho i-mifepristone ingatholakali, i-misoprostol yodwa isasetshenziswa njengenketho ephephile nephumelelayo. Umhlinzeki wakho wezempilo uzoncoma indlela engcono kakhulu ngokusekelwe kulokho okutholakalayo nokufaneleka kakhulu esimweni sakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Mifepristone

Ingabe i-Mifepristone Iphephile Kubantu Abanesifo Sikashukela?

I-Mifepristone ngokuvamile ingasetshenziswa ngokuphepha ngabantu abanesifo sikashukela, kodwa idinga ukuqashwa ngokucophelela. Umuthi ungathinta amazinga kashukela egazini, ikakhulukazi uma uwusebenzisela i-Cushing's syndrome. Umhlinzeki wakho wezempilo uzofuna ukuqapha ushukela wakho wegazi eduze ngesikhathi sokwelashwa.

Uma unesifo sikashukela futhi udinga i-mifepristone ngenxa yokukhipha isisu, ukusetshenziswa kwesikhashana ngokuvamile akubangeli izinkinga ezinkulu ekulawuleni ushukela wegazi. Kodwa-ke, kufanele usazise umhlinzeki wakho wezempilo ngesifo sakho sikashukela ukuze bakwazi ukuhlinzeka ngokuqapha nokunakekela okufanele.

Kufanele Ngenzeni Uma Ngithatha I-Mifepristone Eningi Ngengozi?

Uma ngengozi uthatha i-mifepristone eningi kunaleyo ebekiwe, xhumana nomhlinzeki wakho wezempilo noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi nezinkinga.

Ungazami ukuzenza uhlanze ngaphandle uma uqondiswe ngqo yisazi sezempilo. Gcina ukupakishwa komuthi nawe ukuze ukwazi ukuhlinzeka ngolwazi oluqondile mayelana nokuthi uthatheni ini nokuthi kungakanani.

Izimpawu zokweqisa zingabandakanya isicanucanu esibi, ukuhlanza, isifo sohudo, noma izimpawu zokungasebenzi kahle kwe-adrenal njengobuthakathaka obukhulu kanye nomfutho wegazi ophansi. Funani ukunakekelwa kwezempilo ngokushesha uma uhlangabezana nanoma yiziphi izimpawu ezikhathazayo.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Mifepristone?

Ngokukhipha isisu, i-mifepristone ngokuvamile inikezwa njengomthamo owodwa, ngakho ukuphuthelwa umthamo akuyona inkinga. Kodwa-ke, uma kufanele uthathe omunye umuthi njenge-misoprostol futhi uphuthelwa leso sikhathi, xhumana nomhlinzeki wakho wezempilo ngokushesha ukuze uthole isiqondiso.

Uma uthatha i-mifepristone ngenxa ye-Cushing's syndrome futhi uphuthelwa umthamo, yithathe ngokushesha lapho ukhumbula ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe.

Umhlinzeki wakho wokunakekelwa kwezempilo uzokunikeza imiyalelo ethile mayelana nesikhathi esibalulekile empilweni yakho nokusebenza kahle komuthi.

Ngingayeka nini ukuthatha i-Mifepristone?

Ukuqeda isisu ngemithi, ngokuvamile uthatha i-mifepristone kanye kuphela, ngakho-ke akukho ukwelashwa okuqhubekayo okumele kumiswe. Kodwa-ke, uzodinga ukuqokwa okulandelayo ukuqinisekisa ukuthi ukwelashwa kuphumelele nokuthi uyalulama kahle.

Uma uthatha i-mifepristone ye-Cushing's syndrome, ungalokothi uyeke ukuyithatha kungazelelwe ngaphandle kokukhuluma nomhlinzeki wakho wokunakekelwa kwezempilo kuqala. Ukuyeka kungazelelwe kungadala izinkinga ezinkulu ezihlobene namagciwane akho e-adrenal kanye namazinga e-cortisol.

Udokotela wakho uzoqapha ukusabela kwakho ekwelashweni futhi anqume ukuthi kuphephile nini ukunciphisa umthamo noma ukuyeka ngokuphelele umuthi. Lesi sinqumo sincike esimweni sakho ngasinye nokuthi usabela kahle kangakanani ekwelashweni.

Ngingakhulelwa futhi ngemva kokuthatha i-Mifepristone?

Yebo, i-mifepristone ayithinti ukuzala kwakho kwesikhathi esizayo noma ikhono lokukhulelwa. Umjikelezo wakho wokuya esikhathini ngokuvamile uzobuyela kokujwayelekile phakathi kwamasonto angu-4-8 ngemva kokusebenzisa i-mifepristone ukuqeda isisu ngemithi.

Eqinisweni, ungakhulelwa futhi ngokushesha ngemva kokuthatha i-mifepristone, ngisho nangaphambi kokuba ukuya esikhathini kwakho kokuqala kubuye. Uma ungafuni ukukhulelwa futhi ngokushesha, kubalulekile ukuqala ukusebenzisa izindlela zokuvimbela inzalo ngokushesha nje lapho usulungele ukuqala kabusha ukuziphatha ngokocansi.

Umhlinzeki wakho wokunakekelwa kwezempilo angaxoxa nawe ngezinketho zokuvimbela inzalo futhi akusize ukhethe indlela ekufanele nesimo sakho.