Yini i-Morphine ne-Naltrexone: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Morphine ne-naltrexone iyinhlanganisela yemithi esiza ukuphatha ubuhlungu obukhulu obungapheli ngenkathi kunciphisa ingozi yokusetshenziswa kabi. Le nhlanganisela eyingqayizivele ihlanganisa i-morphine, umuthi onamandla wokudambisa ubuhlungu, ne-naltrexone, into evimbela eminye yemiphumela ye-euphoric ye-morphine. Le nhlanganisela yenzelwe ngqo abantu abadinga ukudambisa ubuhlungu obuqinile, obuhlala isikhathi eside kodwa abafuna ukuvikelwa okwengeziwe ezindabeni ezingase zibe khona zokuncika.

Yini i-Morphine ne-Naltrexone?

I-Morphine ne-naltrexone ihlanganisa imithi emibili ehlukene kakhulu ibe yiphilisi elilodwa ukuze kuphathwe ubuhlungu obukhulu ngokuphephile. I-Morphine iyisidambisi sobuhlungu se-opioid esisebenza ngqo ebuchosheni bakho nasohlelweni lwakho lwezinzwa ukuvimbela izimpawu zobuhlungu. I-Naltrexone isebenza njengesici sokuphepha esakhelwe ngaphakathi esinciphisa amathuba e-morphine okudala “ukuphakama” ngenkathi isavumela ukuthi ilawule ubuhlungu bakho ngempumelelo.

Le nhlanganisela yemithi iza ngama-capsules akhishwe isikhathi eside, okusho ukuthi umuthi ukhishwa kancane ohlelweni lwakho emahoreni amaningi. Ingxenye ye-naltrexone ayiphazamisi izakhiwo ze-morphine zokudambisa ubuhlungu uma uthatha umuthi njengoba unjalo. Kodwa-ke, uma othile ezama ukuchoboza, ukuhlafuna, noma ukuncibilikisa ama-capsules ukuze athole umphumela oqinile, i-naltrexone iba esebenza kakhulu futhi ivimbele imiphumela ye-euphoric.

Isetshenziselwani i-Morphine ne-Naltrexone?

Lo muthi welapha ubuhlungu obukhulu obungapheli obudinga ukuphathwa ngaso sonke isikhathi ngemithi enamandla ye-opioid. Udokotela wakho ngokuvamile uzonquma le nhlanganisela uma eminye imithi yokudambisa ubuhlungu ingazange inikeze ukukhululeka okwanele. Yenzelwe ngqo abantu abadinga ukulawulwa kobuhlungu okuqhubekayo kunokudambisa ubuhlungu ngezikhathi ezithile.

Umuthi usebenza kahle kakhulu ezimeni zobuhlungu obuqhubekayo obuthinta kakhulu impilo yakho yansuku zonke. Izimo ezivamile lapho odokotela benganikeza khona lo muthi zihlanganisa ubuhlungu obukhulu emhlane, ubuhlungu obuhlobene nomdlavuza, noma ezinye izimo ezingamahlalakhona lapho ubuhlungu buqhubeka futhi bukhubaza. Umhlinzeki wakho wezempilo uzohlola ngokucophelela ukuthi lo muthi onamandla ulungele yini isimo sakho esithile.

Lona akuyona imithi yobuhlungu obuncane noma ubuhlungu obuza futhi buhambe ngezikhathi ezithile. Ngenxa yokuthi iqukethe i-opioid enamandla, odokotela bayigcina ezimweni lapho izinzuzo zokukhululeka kobuhlungu obunamandla ziqeda ngokucacile izingozi ezingaba khona nemiphumela emibi.

Isebenza Kanjani I-Morphine ne-Naltrexone?

Lokhu kuthathwa njengomuthi onamandla osebenza ngezindlela ezimbili ezihambisanayo emzimbeni wakho. I-Morphine ibopha kuma-receptors athile ebuchosheni bakho nasemgogodleni obizwa ngokuthi ama-opioid receptors, ngokuvamile athola izimpawu zobuhlungu zemvelo zomzimba wakho. Lapho i-morphine inamathisela kula ma-receptors, empeleni itshela uhlelo lwakho lwezinzwa ukuthi lungazinaki noma linciphise kakhulu imiyalezo yobuhlungu eliyitholayo.

Ingxenye ye-naltrexone isebenza njengozakwethu ovikelayo kulolu hlelo. Ngaphansi kokusetshenziswa okuvamile, i-naltrexone ihlala ingasebenzi futhi ayiphazamisi imiphumela yokukhulula ubuhlungu ye-morphine. Kodwa-ke, uma othile ezama ukungenelela ngemithi ngokuyichoboza noma ukuyincibilikisa, i-naltrexone iba ngaphezulu ohlelweni lwakho futhi ivimba imiphumela ye-euphoric abantu abangase bayifune lapho beyisebenzisa kabi ama-opioids.

Ifomula yokukhishwa okweluliwe isho ukuthi yomibili imithi ikhishwa kancane kancane emahoreni angu-12, inikeza ukukhululeka kobuhlungu okuqhubekayo usuku lonke. Lokhu kukhishwa okuqhubekayo kusiza ukugcina ukulawulwa kobuhlungu okuzinzile ngenkathi kunciphisa iziqongo nemigodi engenzeka ngemithi yokukhulula ubuhlungu ngokushesha.

Kufanele Ngiyithathe Kanjani I-Morphine ne-Naltrexone?

Thatha lo muthi ngendlela eqondile udokotela wakho akuyala ngayo, ngokuvamile njalo emahoreni ayi-12 ngaphandle noma ngaphandle kokudla. Gwinya amaphilisi wonke ngengilazi yamanzi egcwele, futhi ungalokothi uwachoboze, uwahlafune, uwaphule, noma uwaqede. Ukuphazamisa amaphilisi kungakhipha amanani ayingozi e-morphine ngasikhathi sinye noma kusebenzise i-naltrexone ngezindlela ezinciphisa ukusebenza komuthi.

Ungawuthatha lo muthi ngokudla uma ucasula isisu sakho, nakuba ukudla kungadingeki ukuze umuthi usebenze kahle. Abanye abantu bathola ukuthi ukuwuthatha ngokudla okulula noma ukudla okulula kusiza ukunciphisa isicanucanu, ikakhulu lapho uqala ukuthatha umuthi. Gwema utshwala ngokuphelele ngenkathi uthatha lo muthi, njengoba inhlanganisela ingaba yingozi kakhulu futhi ingase ibe yingozi ekuphileni.

Udkt wakho cishe uzoqala ngomthamo ophansi futhi awunyuse kancane kancane kuze kube yilapho ubuhlungu bakho bulawulwa kahle. Le nqubo, ebizwa ngokuthi i-titration, isiza ukunciphisa imiphumela emibi ngenkathi kutholakala umthamo ofanele wezidingo zakho ezithile. Ungalokothi ulungise umthamo wakho ngokwakho, ngisho noma ubuhlungu bakho bubonakala bubi kakhulu noma bungcono kunokujwayelekile.

Kufanele Ngithathe Isikhathi Esingakanani I-Morphine ne-Naltrexone?

Ubude bokwelashwa buxhomeke ngokuphelele esimweni sakho sobuhlungu ngabanye nokuthi usabela kahle kangakanani emuthini. Abanye abantu abanezimo ezingapheli bangase badinge lo muthi izinyanga noma iminyaka, kanti abanye bangase bawusebenzise isikhathi esifushane ngesikhathi sokuhlaselwa kobuhlungu obunzima. Udokotela wakho uzohlola njalo ukuthi ngabe umuthi uyaqhubeka yini nokudingeka futhi usebenza kahle esimweni sakho.

Ukusetshenziswa kwesikhathi eside kudinga ukuqapha ngokucophelela ngumhlinzeki wakho wezempilo. Bazohlola hhayi nje ukuthi umuthi ulawula kahle kangakanani ubuhlungu bakho kodwa futhi baqaphele noma yiziphi izimpawu zokubekezelelana, ukuncika, noma imiphumela emibi engase ivele ngokuhamba kwesikhathi. Ukuhlolwa okuvamile kusiza ukuqinisekisa ukuthi umuthi uyaqhubeka nokuthuthukisa izinga lempilo yakho ngaphandle kokubangela ingozi.

Ungayeki ukuthatha lo muthi ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Umzimba wakho ungancika emithini ye-opioid ngokomzimba, futhi ukuyeka kungazelelwe kungadala izimpawu zokuhoxisa ezingakhululeki. Uma udinga ukuyeka umuthi, udokotela wakho uzokwenza uhlelo lokunciphisa kancane kancane umthamo wakho ngokuhamba kwesikhathi.

Ziyini Izimo Ezingezinhle ze-Morphine kanye ne-Naltrexone?

Njengayo yonke imithi ye-opioid, le nhlanganisela ingadala imiphumela eminingi engemihle, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi ulawule noma yimiphi imiphumela eyenzekayo futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi ejwayelekile ivame ukulawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi:

• Ukuqunjelwa (kuthinta abantu abaningi abathatha ama-opioid)
• Isicanucanu nokuhlanza, ikakhulukazi uma uqala
• Ukozela noma isiyezi
• Umlomo owomile
• Ikhanda
• Ukujuluka
• Ubunzima bokulala noma ukuphazamiseka kokulala

Le miphumela ivame ukubonakala kakhulu emasontweni ambalwa okuqala kokwelashwa futhi ivame ukuba ngaphansi kokukhathaza njengoba umzimba wakho ujwayela umuthi.

Imiphumela emibi kakhulu idinga ukunakekelwa kwezokwelapha ngokushesha futhi ihlanganisa izinkinga zokuphefumula, ukozela okukhulu, ukudideka, noma izimpawu zokungezwani komzimba. Abanye abantu bangase babe nokuguquka kwemizwa, ukucabanga ngento engekho, noma ubuhlungu obukhulu besisu. Le miphumela ayivamile kodwa idinga ukuhlolwa okusheshayo ngumhlinzeki wakho wezempilo.

Izinkinga ezingavamile kodwa ezinzima zingabandakanya ukuqunjelwa okukhulu okuholela ekuvinjelweni kwamathumbu, ukuphefumula okuhamba kancane ngendlela eyingozi, noma ukungezwani komzimba okukhulu. Abanye abantu bangase bakhe ukubekezelelana ngokuhamba kwesikhathi, okusho ukuthi badinga imithamo ephezulu ukuze bathole ukukhululeka kobuhlungu obufanayo. Nakuba kungavamile, abanye abantu bangase babe nezimpawu zokuhoxisa uma bephuthelwa imithamo noma beyeka umuthi ngokuzumayo.

Ubani Ongafanele Athatha i-Morphine kanye ne-Naltrexone?

Lo muthi awuphephile kuwo wonke umuntu, futhi izimo ezithile zezokwelapha noma izimo zenza kungafaneleki noma kube yingozi. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuchazela le nhlanganisela ukuze aqinisekise ukuthi iphephile kuwe.

Abantu abanezinkinga ezinkulu zokuphefumula, okuhlanganisa isifuba esikhulu noma ubunzima bokuphefumula, akufanele bathathe lo muthi. Ingxenye ye-morphine inganciphisa ukujula kokuphefumula, okungase kubeke ukuphila engozini. Ngokufanayo, uma unokuvaleka kwamathumbu noma izinkinga ezinzima zokuqunjelwa, lo muthi ungenza lezi zimo zibe zimbi kakhulu.

Ezinye izimo eziningana zenza lo muthi ungafaneleki, futhi udokotela wakho uzodinga ukwazi nganoma yiziphi zalezi zimo:

• Ukusetshenziswa kwamuva kweminye imithi ye-opioid noma ukuhoxiswa kwe-opioid
• Isifo esibi sesibindi noma sezinso
• Ukulimala ekhanda noma izimo zobuchopho ezikhuphula ingcindezi ekhakhazini lakho
• Umlando wokulutheka kwezidakamizwa noma utshwala (idinga ukucatshangelwa okukhethekile)
• Ezinye izimo zempilo yengqondo noma imithi
• Ukukhulelwa noma ukuncelisa
• Iminyaka engaphansi kwengu-18

Udokotela wakho uzocabangela neminye imithi oyithathayo, njengoba ezinye izinhlanganisela zingaba yingozi. Lokhu kuhlanganisa ama-antidepressants athile, imithi yokukhathazeka, noma ezinye izidambisi zokucasuka ezingase zihlangane ne-morphine.

Amagama Omkhiqizo we-Morphine ne-Naltrexone

Le nhlanganisela yomuthi iyatholakala ngaphansi kwegama lomkhiqizo elithi Embeda e-United States. Amaphilisi e-Embeda aqukethe i-morphine sulfate ne-naltrexone hydrochloride ngamanani athile aklanyelwe ukuhlinzeka ngokuqeda ubuhlungu obusebenzayo ngenkathi kuhlanganiswa izakhiwo zokuvimbela ukuhlukunyezwa.

Umuthi uza ngamandla ahlukahlukene, ngezilinganiso ezahlukene ze-morphine ezihambisana namanani amancane e-naltrexone. Udokotela wakho uzoqoka amandla athile afanele izidingo zakho zokuphatha ubuhlungu. Izinhlobo ezivamile zingase zitholakale, yize kufanele zihlangabezane nezindinganiso ezifanayo zokuphepha nokusebenza njengomuthi wegama.

Ezinye izindlela ze-Morphine ne-Naltrexone

Eminye imithi eminingi ingelapha ubuhlungu obungapheli obukhulu, yize ngamunye enezinzuzo nezingozi ezihlukene. Udokotela wakho angase acabangele eminye imithi ye-opioid ekhishwe isikhathi eside njenge-oxycodone, iziqeshana ze-fentanyl, noma i-methadone, kuye ngezidingo zakho ezithile nomlando wakho wezokwelapha.

Ezinye izindlela ezingezona ze-opioid zifaka imithi ethile yokucindezeleka, imithi yokulwa nokuhlaselwa, noma ukwelashwa okungaphezulu okungasiza ngezinhlobo ezithile zobuhlungu obungapheli. Abanye abantu bayazuza ekuhlanganiseni izinhlobo ezahlukene zemithi noma ukufaka izindlela ezingezona zemithi njengokwelashwa ngokomzimba, amabhuloki emizwa, noma ezinye izinqubo zokungenelela.

Ukukhetha okunye kuncike ezintweni ezinjengohlobo nobukhulu bobuhlungu bakho, umlando wakho wezokwelapha, eminye imithi oyithathayo, nezintandokazi zakho. Udokotela wakho uzosebenza nawe ukuthola indlela yokwelapha efanele kakhulu isimo sakho somuntu ngamunye.

Ingabe i-Morphine ne-Naltrexone ingcono kunezinye izidakamizwa ze-Opioids?

Le nhlanganisela inikeza izinzuzo eziyingqayizivele ngaphezu kwemithi ye-opioid yendabuko, ikakhulukazi ngezakhiwo zayo zokuvimbela ukuhlukunyezwa. Ingxenye ye-naltrexone inikeza ungqimba olwengeziwe lokuphepha olungatholakali ku-morphine ejwayelekile noma eminye imithi ye-opioid, okwenza kube ngaphephile kubantu abasengozini yokusetshenziswa kabi kwemithi.

Uma kuqhathaniswa nama-opioid akhishwa ngokushesha, ifomula yokukhishwa isikhathi eside inikeza ukulawulwa kobuhlungu okuqhubekayo usuku lonke ngokulinganiselwa okuncane. Lokhu kungasho ukuphathwa kobuhlungu okungcono kanye nekhwalithi yempilo ethuthukisiwe kubantu abaningi. Ishejuli yokulinganisa yamahora angu-12 ivame ukuba lula kakhulu kunokuthatha imithamo eminingi yemithi esebenza ngokushesha usuku lonke.

Kodwa-ke, noma ngabe le nhlanganisela “ingcono” kuncike ezimweni zakho. Abanye abantu bangase basabele kangcono kuma-opioid ahlukene, kanti abanye bangase badinge izinzuzo ezithile ezinikezwa yile nhlanganisela. Udokotela wakho uzocabangela izinto ezinjengohlobo lobuhlungu bakho, umlando wezokwelapha, kanye nezici eziyingozi lapho enquma ukuthi imuphi umuthi ofaneleka kakhulu kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Morphine ne-Naltrexone

Ingabe i-Morphine ne-Naltrexone iphephile kubantu abanezifo zenhliziyo?

Abantu abanezimo zenhliziyo bangavame ukuthatha lo muthi ngokuphepha, kodwa kudinga ukuqapha ngokucophelela ngudokotela wakho. Umuthi ungase uthinte umfutho wegazi nesilinganiso senhliziyo, ngakho-ke umhlinzeki wakho wezempilo uzodinga ukuhlola isimo sakho senhliziyo esithile kanye nesimo sempilo esiphelele. Bangase baqale ngemithamo ephansi futhi bakuqaphe eduze uma unezinkinga zenhliziyo nemithambo yegazi.

Uma unezinkinga zenhliziyo ezinzima noma uthatha imithi eminingi yenhliziyo, udokotela wakho uzokala izinzuzo zokukhululeka kobuhlungu ngokumelene nezingozi ezingaba khona zenhliziyo nemithambo yegazi. Bangase bancomise ukuqapha okwengeziwe noma bakhethe izindlela zokulawula ubuhlungu ezingezinye ngokuya ngesimo sakho.

Ngingenzani uma ngithatha i-Morphine ne-Naltrexone eningi ngengozi?

Ukuthatha umuthi omningi kakhulu kuyisimo esiphuthumayo sezokwelapha esidinga ukunakwa ngokushesha. Shayela ku-911 noma uye egumbini eliphuthumayo eliseduze ngokushesha uma wena noma omunye umuntu ethatha okungaphezu kwenani elinqunyiwe. Izimpawu zokweqisa zingabandakanya ukozela okukhulu, ukudideka, ubunzima bokuphefumula, noma ukulahlekelwa ukwazi.

Ungazami ukwelapha ukweqisa ekhaya noma ulinde ukubona ukuthi izimpawu ziyathuthuka yini. Noma ngabe umuntu ubonakala elungile ekuqaleni, ukweqisa kwe-opioid kungahlehliswa futhi kube yingozi empilweni. Ochwepheshe bezokwelapha eziphuthumayo banemithi ethile, okuhlanganisa i-naloxone, engaphikisa nemiphumela yokweqisa i-opioid.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Morphine kanye ne-Naltrexone?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho yokuthatha imithi ejwayelekile. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungaholela emiphumeleni eyingozi yokweqisa.

Ukuphuthelwa imithamo ngezikhathi ezithile ngeke kubangele ingozi enkulu, kodwa zama ukugcina isikhathi esiqhubekayo ukuze uthole ukulawulwa kobuhlungu okungcono kakhulu. Uma uvame ukukhohlwa imithamo, cabangela ukusetha ama-alamu ocingweni noma ukusebenzisa umhleli wamaphilisi ukukusiza ukhumbule. Xhumana nodokotela wakho uma unenkinga yokunamathela eshedyulini yakho yokuthatha imithi.

Ngingayeka nini ukuthatha i-Morphine kanye ne-Naltrexone?

Kufanele uyeke kuphela ukuthatha lo muthi ngaphansi kokuqondisa nokuqashwa kukadokotela wakho. Umhlinzeki wakho wezempilo uzokusiza ukuthi unqume ukuthi kufanelekile nini ukuyeka umuthi ngokuya ngamazinga akho obuhlungu, impilo yonke, kanye nemigomo yokwelashwa. Bangase baphakamise ukuyeka uma ubuhlungu bakho buthuthuke kakhulu noma uma imiphumela emibi idlula izinzuzo.

Inqubo yokuyeka ngokuvamile ihlanganisa ukunciphisa kancane kancane umthamo wakho emasontweni amaningana noma izinyanga ukuvimbela izimpawu zokuhoxiswa. Udokotela wakho uzokwenza ishejuli yokunciphisa eyenziwe ngendlela oyifisayo enciphisa ukungakhululeki ngenkathi ikuyeka ngokuphepha emuthini. Ungalokothi uyeke ngokuzumayo ngokwakho, ngoba lokhu kungabangela izimpawu ezinzima zokuhoxiswa.

Ngingashayela yini ngenkathi ngithatha i-Morphine kanye ne-Naltrexone?

Lo muthi unganciphisa ikhono lakho lokushayela ngokuphepha, ikakhulukazi uma uqala ukuwuthatha noma uma umthamo wakho ukhuphuka. Ukozela nesiyezi okuvame ukwenzeka kunganciphisa isivinini sokuphendula kwakho futhi kuthinte ukwahlulela kwakho ngemuva kwesondo. Akufanele ushayele uze wazi ukuthi umuthi ukuthinta kanjani wena uqobo.

Abanye abantu bathola ukuthi bangashayela ngokuphepha ngemuva kokuthatha umuthi amasonto amaningana futhi bajwayele imiphumela yawo, kanti abanye bangase badinge ukugwema ukushayela ngokuphelele ngenkathi besalokhu belashwa ngalo. Xoxa ngesimo sakho esithile nodokotela wakho, futhi ucabangele ezinye izindlela zokuthutha uma ukushayela kungakuphephile.