Yini i-Nadofaragene Firadenovec: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokuningi

I-Nadofaragene firadenovec iyindlela yokwelapha ngofuzo eyenzelwe ngqo ukwelapha izinhlobo ezithile zomdlavuza wesinye. Lokhu kwelapha okusha kusebenza ngokuletha izinto zofuzo ngqo emangqamuzaneni omdlavuza wesinye ukusiza amasosha akho omzimba ukuthi aqaphele futhi alwe nomdlavuza ngempumelelo.

Uma wena noma othile omkhathalelayo etholakale enomdlavuza wesinye, ukufunda ngale ndlela yokwelapha kungase kuzizwe kumkhulu. Ake sihambe kukho konke okudingeka ukwazi ngale ndlela yokwelapha ngendlela enengqondo futhi ekusiza ukuthi uzizwe unolwazi olwengeziwe mayelana nezinqumo zakho zokunakekelwa kwezempilo.

Yini i-Nadofaragene Firadenovec?

I-Nadofaragene firadenovec iyindlela yokwelapha ngofuzo esebenzisa igciwane elishintshiwe ukuletha izakhi zofuzo ezilwa nomdlavuza ngqo emangqamuzaneni omdlavuza wesinye. Ukwelashwa kunikezwa ngesikhathi se-catheter efakwe esinyeni sakho, okuvumela umuthi ukuthi usebenze ngqo lapho udingeka khona kakhulu.

Le ndlela yokwelapha imelela indlela entsha yokwelapha umdlavuza ebizwa ngokuthi i-immunotherapy. Esikhundleni sokusebenzisa imithi yamakhemikhali yendabuko engathinta wonke umzimba wakho, lokhu kwelapha kusiza ukuqeqesha amasosha akho omzimba ukuthi aqaphele kangcono futhi ahlaselwe amangqamuzana omdlavuza esinyeni sakho.

Lo muthi waziwa nangegama lomkhiqizo elithi Adstiladrin. Yenzelwe ngqo abantu abanezinhlobo ezithile zomdlavuza wesinye ezingazange ziphendule kahle kwezinye izindlela zokwelapha.

Yini i-Nadofaragene Firadenovec Esetshenziselwa Yona?

Le ndlela yokwelapha ngofuzo isetshenziselwa ukwelapha umdlavuza wesinye ongahlaseli imisipha ezingeni eliphezulu equkethe uphawu oluthile lofuzo olubizwa ngokuthi i-BCG-unresponsive carcinoma in situ. Lokhu kungase kuzwakale kuyinkimbinkimbi, kodwa udokotela wakho uzobe ehlolile amangqamuzana omdlavuza wakho ukuze anqume ukuthi le ndlela yokwelapha ilungele yini.

Ukwelashwa kuvame ukucatshangelwa uma ezinye izindlela zokwelapha, ikakhulukazi i-BCG immunotherapy, zingaphumelelanga ekulawuleni umdlavuza wakho. I-BCG ivame ukuba yindlela yokuqala yokwelapha lolu hlobo lomdlavuza wesinye, futhi uma iyeka ukusebenza ngempumelelo, i-nadofaragene firadenovec iba yindlela ebalulekile.

Udokotela wakho womdlavuza angase ancome lokhu kwelashwa uma ungafaneleki ukususwa kwesinye sakho ngokuhlinzwa noma uma ukhetha ukuzama ezinye izindlela ngaphambi kokucabangela ukuhlinzwa. Umgomo uwukusiza ukulawula umdlavuza ngenkathi ugcina isinye sakho futhi ugcine izinga lempilo yakho.

Isebenza Kanjani I-Nadofaragene Firadenovec?

Le gene therapy isebenza ngokusebenzisa i-adenovirus eguquliwe njengohlelo lokuletha ukuthwala ama-gene okuphulukisa ngqo emangqamuzaneni akho omdlavuza wesinye. Igciwane lenziwe ukuthi liphephe futhi alikwazi ukubangela ukugula, kodwa lilunge kakhulu ekungeneni emangqamuzaneni.

Uma ingaphakathi emangqamuzaneni omdlavuza, ukwelashwa kunikeza i-gene ekhiqiza iphrotheni ebizwa ngokuthi i-interferon alfa-2b. Le phrotheni isebenza njengesiginali exwayisa amasosha akho omzimba ngokuba khona kwamaseli omdlavuza futhi isiza ukuxhumanisa impendulo enamandla yamasosha omzimba ngawo.

Cabanga ngakho njengokunikeza amasosha akho omzimba imiyalelo engcono yokuthi angawuqaphela futhi awulwe kanjani umdlavuza. Ukwelashwa kusebenza endaweni yesinye sakho, okusho ukuthi kugxila emiphumeleni yawo lapho umdlavuza ukhona kunokuthinta umzimba wakho wonke.

Le ndlela ithathwa njenge-targeted therapy ngoba yenzelwe ukusebenza ngokuqondile emangqamuzaneni omdlavuza ngenkathi ishiya amangqamuzana anempilo engathinteki kakhulu. Amandla alokhu kwelashwa aqhamuka ekunembeni kwawo nasekwazi kwawo ukusebenzisa izivikelo zemvelo zomzimba wakho.

Kufanele Ngiyithathe Kanjani I-Nadofaragene Firadenovec?

I-Nadofaragene firadenovec inikezwa njengokwelashwa ngokuqondile esinyeni sakho ngeshubhu, hhayi njengemithi noma umjovo. Ithimba lakho lezempilo lizosingatha yonke inqubo yokuphatha, ngakho akudingeki ukhathazeke ngokuthatha lo muthi ekhaya.

Ngaphambi kokwelashwa kwakho, uzodinga ukunciphisa ukuthatha uketshezi cishe amahora angu-4 ukuqinisekisa ukuthi isinye sakho asigcwele kakhulu. Udokotela wakho uzofaka ishubhu elincane, eliguquguqukayo elibizwa ngokuthi i-catheter ngomgudu wakho womchamo ungene esinyeni sakho, bese ethumela umuthi ngaleli shubhu.

Ngemuva kokuthi umuthi usenyeni lakho, uzodinga ukuwugcina lapho cishe ihora elingu-1-2 ngaphambi kokuchama. Ngesikhathi esinjalo, ungase ucelwe ukuthi ushintshe izikhundla ngezikhathi ezithile ukuze usize umuthi ukuthi umboze yonke ingaphandle lesinye sakho.

Ukwelashwa kuvame ukunikezwa kanye njalo ezinyangeni ezintathu. Udokotela wakho uzoqapha impendulo yakho ekwelashweni futhi anqume uhlelo olungcono kakhulu lwesimo sakho ngasinye.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Nadofaragene Firadenovec?

Ubude bokwelashwa nge-nadofaragene firadenovec buhlukahluka kumuntu nomuntu futhi buxhomeke ekutheni umdlavuza wakho usabela kahle kangakanani ekwelashweni. Udokotela wakho uzohlola njalo inqubekela phambili yakho nge-cystoscopy nezinye izivivinyo ukuze abone ukuthi ukwelashwa kusebenza kangakanani.

Abantu abaningi baqhubeka nokwelashwa uma nje kusiza ukulawula umdlavuza wabo futhi bekwazi ukukubekezelela kahle. Ezinye iziguli zingase zithole ukwelashwa izinyanga eziningana noma iminyaka, kanti ezinye zingase zidinge inkambo yokwelashwa emfushane.

Udokotela wakho we-oncologist uzosebenza nawe ukudala uhlelo lokwelashwa olulinganisela izinzuzo zokuqhubeka nokwelashwa nekhwalithi yakho yempilo nempilo yonke. Ukuqokwa okulandelayo njalo kuzosiza ukunquma ukuthi ngabe uzoqhubeka, ulungise, noma umise ukwelashwa.

Kubalulekile ukugcina konke ukuqokwa kwakho okuhleliwe nezivivinyo zokulandela, ngisho noma uzizwa kahle. Lezi zivakashi zisiza ithimba lakho lezokwelapha ukuthi lenze izinqumo ezingcono kakhulu mayelana nokunakekelwa kwakho okuqhubekayo.

Ziyini Imiphumela Eceleni ye-Nadofaragene Firadenovec?

Njengazo zonke izindlela zokwelapha umdlavuza, i-nadofaragene firadenovec ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ihlobene nesinye kanye nohlelo lomchamo ngoba yilapho umuthi ulethwa khona.

Ukuqonda ukuthi yini ongayilindela kungakusiza uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungaxhumana nini nethimba lakho lezempilo. Ake sibheke imiphumela emibi ongase uyithole, siqale ngaleyo evame kakhulu:

Imiphumela Evamile Eceleni

Le miphumela emibi yenzeka kubantu abaningi abathola lokhu kwelashwa, kodwa ngokuvamile iyalawuleka futhi ivame ukuthuthuka ngokuhamba kwesikhathi:

• Ukuphatheka kabi kwesinye noma ubuhlungu ngesikhathi sokuchama
• Ukwanda kwemvamisa yokuchama
• Isidingo esiphuthumayo sokuchama
• Igazi emchameni (i-hematuria)
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Umkhuhlane olula noma ama-chills
• Isicanucanu

Lezi zimpawu ngokuvamile zenzeka ezinsukwini ezimbalwa zokuqala ngemva kokwelashwa futhi zivame ukuzixazulula zodwa. Udokotela wakho angatusa izindlela zokulawula le miphumela emibi futhi akwenze uzizwe ukhululekile.

Imiphumela Eceleni Engavamile Kodwa Ebucayi

Ngenkathi ingavamile, eminye imiphumela emibi idinga ukunakekelwa kwezokwelapha ngokushesha. Xhumana nethimba lakho lezempilo ngokushesha uma uhlangabezana:

• Ubuhlungu obukhulu besinye noma ama-spasms
• Ukuphuma kwegazi eliningi emchameni
• Ukungakwazi ukuchama
• Umkhuhlane ophezulu (ngaphezu kuka-101°F)
• Izimpawu ezinjengomkhuhlane ezinzima
• Izimpawu zokutheleleka

Ithimba lakho lezokwelapha lizokunikeza imiyalelo ethile mayelana nokuthi ungawabiza nini nokuthi yiziphi izimpawu okufanele uzibheke. Ukuba nolu lwazi kusiza ukuqinisekisa ukuthi uthola ukunakekelwa okusheshayo uma kudingeka.

Imiphumela Eceleni Engavamile

Abanye abantu bangase babe nemiphumela emibi engavamile ethinta ezinye izingxenye zomzimba. Lokhu kungabandakanya:

• Ukusabela okukhulu komzimba emithini
• Ukusabela komzimba okuzenzakalelayo okuthinta ezinye izitho
• Ukusabela okukhulu kokuvuvukala
• Izinkinga ezihlobene nokufakwa kwe-catheter

Ngenkathi le miphumela emibi engavamile ikhathaza, ithimba lakho lezempilo liqeqeshwe ukuyibona nokuphatha ngokushesha. Izinzuzo zokwelashwa zivame ukwedlula lezi zingozi, ikakhulukazi kubantu abanezinketho zokwelashwa ezilinganiselwe.

Ubani Ongafanele Athathe i-Nadofaragene Firadenovec?

I-Nadofaragene firadenovec ayifanele wonke umuntu onomdlavuza wesinye. Udokotela wakho uzohlola ngokucophelela ukuthi ngabe lokhu kwelashwa kuphephile futhi kufanelekile yini esimweni sakho esithile.

Lokhu kwelashwa akufanele kusetshenziswe uma unesifo esithathelwanayo somgudu womchamo noma uma usebenzisa imithi ecindezela amasosha omzimba engaphazamisa indlela yokwelashwa esebenza ngayo. Amasosha akho omzimba adinga ukusebenza kahle ukuze le gene therapy isebenze.

Abantu abanezimo ezithile ze-autoimmune noma labo abake baba nokusabela okukhulu ekwelashweni okufanayo esikhathini esidlule kungenzeka bangabi ngabazali abahle balokhu kwelashwa. Udokotela wakho uzobuyekeza umlando wakho wezokwelapha ophelele ukwenza lesi sinqumo.

Abesifazane abakhulelwe noma abancelisa ngamabele akufanele bathole lokhu kwelashwa, njengoba imiphumela ezinganeni ezisakhulayo ingaziwa. Uma useminyakeni yokuzala, udokotela wakho uzoxoxa ngezindlela ezifanele zokuvimbela inzalo ngesikhathi sokwelashwa.

Igama Lomkhiqizo le-Nadofaragene Firadenovec

Igama lomkhiqizo le-nadofaragene firadenovec yi-Adstiladrin. Leli igama ozolibona eshedyulini yakho yokwelashwa kanye nemibhalo yezokwelapha.

I-Adstiladrin ikhiqizwa yi-Ferring Pharmaceuticals futhi yavunywa yi-FDA ngokuqondile ukwelapha umdlavuza wesinye ongawuphenduli umuthi i-BCG. Lapho nixoxa ngokwelashwa kwakho nezinkampani zomshuwalense noma ezinye izinhlangano zezempilo, kungadingeka ukuthi usebenzise kokubili igama elivamile negama lomkhiqizo.

Iqembu lakho lezokwelapha ngokuvamile lizobhekisela kulo nganoma yiliphi igama elijwayelekile kubona, kodwa womabili la magama abhekisela emuthini ofanayo nokwelashwa.

Ezinye izindlela zokwelapha ze-Nadofaragene Firadenovec

Uma i-nadofaragene firadenovec ingakulungele noma ingasebenzi kahle, ezinye izindlela zokwelapha ziyatholakala zomdlavuza wesinye. Enye indlela engcono kakhulu incike ohlotsheni lwakho oluthile lomdlavuza nempilo yakho yonke.

Ezinye izindlela zokwelapha ezingena ngqo esinyeni (ngqo esinyeni) zihlanganisa izinhlobo ezahlukene zemithi ye-immunotherapy efana ne-BCG, uma ungakayizami okwamanje, noma ama-ejenti e-chemotherapy afana ne-mitomycin C noma i-gemcitabine. Lezi zindlela zokwelapha zisebenza ngezindlela ezahlukene kodwa futhi zilethwa ngqo esinyeni sakho.

Kwabanye abantu, izinketho zokuhlinzwa zingase zicatshangelwe, okuhlanganisa ukususwa kwesinye (i-cystectomy) noma ezinye izinqubo zokususa isicubu somdlavuza. Udokotela wakho wezifo zokuzala angachaza lezi zinketho futhi akusize uqonde izinzuzo nezingozi zendlela ngayinye.

Izivivinyo zemitholampilo eziphenya ngezindlela ezintsha zokwelapha umdlavuza wesinye nazo zivame ukutholakala. Lezi zivivinyo zikunikeza ukufinyelela ekwelashweni okusezingeni eliphezulu okungakatholakali kabanzi kodwa okubonisa ithemba ekwelapheni uhlobo lwakho lomdlavuza.

Ingabe i-Nadofaragene Firadenovec ingcono kune-BCG?

I-Nadofaragene firadenovec ne-BCG zisebenza ngezindlela ezahlukene, ngakho ukuqhathanisa ngokuqondile akulula. I-BCG ngokuvamile iyindlela yokuqala yokwelapha ezanywayo yomdlavuza wesinye ongahlaseli imisipha, kuyilapho i-nadofaragene firadenovec ivame ukucatshangelwa lapho i-BCG iyeka ukusebenza.

I-BCG isetshenziswe amashumi eminyaka futhi inerekhodi elihle lokusebenza kwabantu abaningi abanomdlavuza wesinye. Kodwa-ke, lapho i-BCG yehluleka ukulawula umdlavuza noma idala imiphumela engabekezeleleki, i-nadofaragene firadenovec inikeza enye indlela ebalulekile.

Ukwakheka kwemiphumela emibi yalokhu kwelashwa kuhluke. I-BCG ingabangela izimpawu ezingaphezu kohlelo ezifana nomkhuhlane, kuyilapho i-nadofaragene firadenovec ivame ukubangela imiphumela emibi ehlobene nomchamo.

Udkt wakho uzokusiza ukuthi uqonde ukuthi yikuphi ukwelashwa okufanele kakhulu isimo sakho ngokusekelwe ezintweni eziphawula umdlavuza wakho, umlando wakho wokwelashwa wangaphambilini, nezintandokazi zakho kanye nesimo sempilo yakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Nadofaragene Firadenovec

Ingabe i-Nadofaragene Firadenovec iphephile kubantu abanezifo zenhliziyo?

I-Nadofaragene firadenovec ngokuvamile ithathwa njengephephile kubantu abanezifo zenhliziyo ngoba isebenza endaweni yomchamo kunokuthi ithinte umzimba wakho wonke. Kodwa-ke, udkt wakho wenhliziyo kanye nodkt womdlavuza kufanele basebenzisane ukuze baqaphe impilo yakho yonke ngesikhathi sokwelashwa.

Ukwelashwa ngokuvamile akubangeli imiphumela emibi ehlobene nenhliziyo, kodwa noma yikuphi ukwelashwa komdlavuza kungaba nengcindezi emzimbeni wakho. Ithimba lakho lezokwelapha lizohlola isimo senhliziyo yakho kanye nempilo yonke ukuze liqinisekise ukuthi lokhu kwelashwa kufaneleka kuwe.

Uma unesifo senhliziyo, qiniseka ukutshela udkt wakho womdlavuza ngayo yonke imithi yakho yenhliziyo, njengoba eminye imithi ingathinta amasosha akho omzimba noma isebenzisane nokwelashwa komdlavuza.

Ngingenzani uma ngingaliphuthelwa ngengozi umthamo we-Nadofaragene Firadenovec?

Njengoba i-nadofaragene firadenovec inikezwa yithimba lakho lezempilo endaweni yezokwelapha, ukungaphuthelwa umthamo ngokuvamile kusho ukungaphuthelwa ukuqokwa okuhleliwe. Uma lokhu kwenzeka, xhumana nehhovisi likadkt wakho womdlavuza ngokushesha ngangokunokwenzeka ukuze uhlele kabusha.

Uhlelo lwakho lokwelashwa lwenzelwe ukunika amasosha akho omzimba isikhathi sokuphendula ngenkathi kugcinwa ingcindezi eqhubekayo emangqamuzaneni omdlavuza. Ukulibazisa ukwelashwa isikhashana ngokuvamile akulimazi, kodwa kubalulekile ukubuyela emkhondweni ngokushesha.

Udktela wakho angase adinge ukulungisa isimiso sakho sokwelashwa noma akuqaphele eduze uma kuye kwaba nokubambezeleka okukhulu. Bazosebenza nawe ukuthola indlela engcono kakhulu yokuqhubeka nokwelashwa kwakho.

Kufanele ngenzeni uma ngizwa imiphumela emibi kakhulu?

Uma uzwa imiphumela emibi kakhulu efana nobuhlungu obukhulu besinye, ukuphuma kwegazi okuningi, umkhuhlane ophezulu, noma ukungakwazi ukuchama, xhumana nethimba lakho lezempilo ngokushesha noma uye egumbini eliphuthumayo. Lezi zimpawu zidinga ukunakekelwa kwezokwelapha ngokushesha.

Ngezimpawu ezingabi zimbi kakhulu kodwa ezikhathazayo, shayela ihhovisi likadokotela wakho we-oncologist ngesikhathi somsebenzi. Bangakunikeza isiqondiso sokulawula imiphumela emibi futhi banqume ukuthi ngabe udinga ukubonwa ngokushesha kunokuqokwa kwakho okulandelayo.

Gcina uhlu lwezimpawu zakho nokuthi zenzeka nini. Lolu lwazi lusiza ithimba lakho lezokwelapha ukuthi liqonde ukuthi usabela kanjani ekwelashweni futhi lenze noma yiziphi izilungiso ezidingekayo ohlelweni lwakho lokunakekelwa.

Ngingayeka nini ukuthatha i-Nadofaragene Firadenovec?

Isinqumo sokuyeka ukwelashwa nge-nadofaragene firadenovec kufanele senziwe ngaso sonke isikhathi ngokubonisana nodokotela wakho we-oncologist. Ungase uyeke ukwelashwa uma umdlavuza wakho uphendula ngokuphelele futhi uhlala ulawulwa, uma uzwa imiphumela emibi engabekezeleleki, noma uma ukwelashwa kuyeka ukusebenza.

Udktela wakho uzosebenzisa izivivinyo ze-cystoscopy ezivamile, izivivinyo zomchamo, kanye nezifundo zokuthwebula izithombe ukuqapha ukusabela kwakho ekwelashweni. Ngokusekelwe kulezi ziphumo, bazoncoma ukuthi uqhubeke, ulungise, noma uyeke ukwelashwa kwakho.

Noma ngabe uyeka ukwelashwa, uzodinga ukuqapha okuqhubekayo ukuze ubheke ukuvela kabusha komdlavuza. Uhlelo lwakho lokunakekelwa olulandelayo luzolungiswa esimweni sakho ngasinye kanye nokusabela ekwelashweni.

Ngingahamba yini ngesikhathi sokwelashwa nge-Nadofaragene Firadenovec?

Ukwenza uhambo ngokuvamile kungenzeka ngesikhathi sokwelashwa nge-nadofaragene firadenovec, kodwa isikhathi sibalulekile. Kungcono ukugwema ukuhamba izinsuku ezimbalwa ngemuva kweseshini ngayinye yokwelashwa, njengoba yilapho imiphumela emibi ingenzeka khona.

Uma uhlela ukuhamba, xoxa ngezinhlelo zakho nodokotela wakho womdlavuza kusenesikhathi. Bangakusiza ukuthi uhlele ukwelashwa ngokuya ngezinsuku zakho zokuhamba futhi banikeze isiqondiso sokulawula noma yimiphi imiphumela engase yenzeke ngenkathi ungekho.

Qiniseka ukuthi uletha imininingwane yokuxhumana yeqembu lakho lezokwelapha futhi ube nohlelo lokuthola ukunakekelwa kwezempilo uma kudingeka ngenkathi uhamba. Cabangela umshwalense wokuhamba ohlanganisa izimo eziphuthumayo zezokwelapha, ikakhulukazi uma uhamba phesheya.