Yini iNafarelin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokuningi

INafarelin iyisifutho sekhala esinconywayo esisiza ukuphatha izimo ezihlobene namahomoni njenge-endometriosis kanye nokuthomba kwasekuqaleni ezinganeni. Leli homoni elenziwe ngendlela yokwenziwa lisebenza ngokunciphisa okwesikhashana ukukhiqizwa kwamahomoni athile okuzala emzimbeni wakho, linikeze uhlelo lwakho ithuba lokuphola noma lokuqalisa kabusha.

Cabanga nge-nafarelin njengenkinobho yokumisa ukukhiqizwa kwamahomoni emzimbeni wakho. Ngenkathi lokhu kungase kuzwakale kukhathaza, empeleni kuyinqubo elawulwa ngokucophelela odokotela abayisebenzisela ukwelapha izimo ezithile lapho ukunciphisa amahomoni kungahlinzeka khona ngokuqeda okukhulu nokwelapha.

Yini iNafarelin?

INafarelin iyinguqulo eyenziwe ngumuntu yehomoni ebizwa ngokuthi i-gonadotropin-releasing hormone (GnRH) engqondo yakho ekhiqiza ngokwemvelo. Uma usebenzisa i-nafarelin njalo, empeleni itshela umzimba wakho ukuthi uyeke ukwenza amahomoni athile ocansi njenge-estrogen ne-testosterone.

Lo muthi ungoweqembu elibizwa ngokuthi ama-GnRH agonists, okusho ukuthi ulingisa i-hormone yakho yemvelo kodwa ngendlela ehlukile. Esikhundleni sokukhuthaza ukukhiqizwa kwamahomoni njenge-GnRH yakho yemvelo, i-nafarelin ekugcineni iyayicindezela ngemuva kokwanda kokuqala okufushane.

Ifomu lesifutho sekhala lenza kube lula ukulisebenzisa ekhaya, futhi umuthi umuncwa ngokuqondile ngomugqa wekhala lakho ungene ngqo egazini lakho. Le ndlela yokulethwa isiza ukuqinisekisa amazinga amahomoni aqhubekayo kuyo yonke imithi yakho.

Yini iNafarelin Esetshenziselwa Yona?

INafarelin ngokuyinhloko iphatha i-endometriosis kwabesifazane kanye nokuthomba kwasekuqaleni ezinganeni zombili izithandani. Lezi zimo ziyazuza ekunciphiseni okwesikhashana amazinga amahomoni ocansi emzimbeni.

Nge-endometriosis, i-nafarelin isiza ukunciphisa ukukhula kwezicubu okubuhlungu okuthuthuka ngaphandle kwesibeletho. Uma amazinga e-estrogen ehla, lezi zithako ze-endometrial zivame ukuba zincane futhi zingabi buhlungu, zikunikeza ukukhululeka ezimpawini ezinjengobuhlungu besinqe nezikhathi ezinzima.

Ezinganeni ezinokuthomba ngaphambi kwesikhathi, i-nafarelin yehlisa ukuqala kwentuthuko yezocansi ngaphambi kwesikhathi. Lokhu kunika izingane isikhathi esiningi sokukhula nokuthuthuka ngokomzwelo ngaphambi kokuba imizimba yazo idlule ekuthombeni, okungaba yinselele ngokomzwelo uma kwenzeka ngaphambi kwesikhathi.

Ngezinye izikhathi odokotela bangase banikeze i-nafarelin ezinye izimo ezihlobene ne-hormone, nakuba lezi zinto ezisetshenziswayo zingavamile. Umhlinzeki wakho wezempilo uzokuchazela ngqo ukuthi kungani bencoma lo muthi esimweni sakho esithile.

Isebenza Kanjani I-Nafarelin?

I-Nafarelin isebenza ngokugcwalisa ekuqaleni ama-receptors akho e-hormone, bese iwavalela phansi ngokuphelele. Le nqubo ibizwa ngokuthi

Ngaphambi kokusebenzisa isifutho sekhala, vungula ikhala lakho ngobumnene ukuze ususe noma yimuphi umkhuhlane. Bamba ibhodlela liqonde, faka ithiphu emgodini owodwa wekhala, bese ufutha ngenkathi uphefumula ngobumnene. Shintshanisa izimbobo zamakhala ngomthamo ngamunye ukuvimbela ukucasuka.

Ungathatha i-nafarelin ngaphandle kokudla, njengoba ukudla kungawuthinti umsebenzi womuthi. Kodwa-ke, zama ukuyisebenzisa ngezikhathi ezifanayo nsuku zonke ukuze ugcine ukucindezelwa kwamahomoni okuqhubekayo.

Gwema ukuvungula ikhala lakho okungenani imizuzu engama-30 ngemuva kokusebenzisa isifutho ukuqinisekisa ukumuncwa okufanele. Uma unomkhuhlane noma ukuminyana kwamakhala, yazisa udokotela wakho, njengoba lokhu kungase kuthinte ukuthi umuthi umuncwa kahle kangakanani.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Nafarelin?

Abantu abaningi bathatha i-nafarelin izinyanga eziyi-6 lapho belapha i-endometriosis, nakuba abanye bengase badinge izikhathi zokwelashwa ezimfushane noma ezinde. Udokotela wakho uzonquma ubude obufanele ngokuya ngezimpawu zakho nokuthi usabela kahle kangakanani ekwelashweni.

Ezinganeni ezinokuvuthwa ngaphambi kwesikhathi, ubude bokwelashwa buhlukahluka kakhulu futhi busekelwe eminyakeni yengane, isigaba sokukhula, nokuphendula ekwelashweni. Ezinye izingane zingase zidinge ukwelashwa iminyaka eminingi kuze kube yilapho zifinyelela eminyakeni efanele yokuvuthwa kwemvelo.

Ukuthatha i-nafarelin isikhathi eside kunokunconywe kungakhuphula ingozi yakho yokulahlekelwa ukuminyana kwamathambo neminye imiphumela emibi. Udokotela wakho uzokuhlola njalo futhi angase ancome ama-calcium kanye nezithasiselo zikavithamini D ukuvikela amathambo akho ngesikhathi sokwelashwa.

Ungayeki ukuthatha i-nafarelin ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Nakuba ngokuvamile kuphephile ukuyeka, umhlinzeki wakho wezempilo angase afune ukukuhlola ngezimpawu ezibuyayo noma ahlele ezinye izindlela zokwelapha.

Yiziphi Imiphumela Emibi ye-Nafarelin?

Imiphumela emibi evame kakhulu ye-nafarelin ihlobene namazinga aphansi e-hormone futhi ihlanganisa ukushisa okushisayo, izinguquko zemizwa, nokoma kwesitho sangasese sowesifazane. Lezi zimpawu zifana nokuya esikhathini futhi zithinta abantu abaningi abasebenzisa lo muthi.

Ukuqonda lokho ongakulindela kungakusiza ukuthi uzizwe ulungiseleleke kakhulu lezi zinguquko:

• Ukushisa okukhulu ebusuku nokujuluka ebusuku kwenzeka cishe kuma-90% abasebenzisi
• Ukwehla kwesifiso socansi kuthinta abantu abaningi ngesikhathi sokwelashwa
• Ukuguquguquka kwemizwa, ukucasuka, noma ukucindezeleka okuncane kuvamile
• Ukomiswa kwesitho sangasese sowesifazane nokuncipha kokuthambisa kwabesifazane
• Ukucindezeleka kwekhanda nobuhlungu bemisipha
• Ucasuko lwamakhala oluvela esifutheni uqobo
• Ukuphazamiseka kokulala nokukhathala

Le miphumela emibi ngokuvamile iyalawuleka futhi iyashintsheka ngokuphelele uma uyeka ukwelashwa. Udokotela wakho angase ancome izindlela zokunciphisa ukungakhululeki ngesikhathi sokwelashwa kwakho.

Imiphumela emibi engathi sína kodwa engavamile idinga ukunakekelwa kwezokwelapha ngokushesha. Nakuba kungavamile, lokhu kungabandakanya izinguquko ezinzima zemizwa, imicabango yokuzilimaza, noma izimpawu zokulahlekelwa kwamathambo okukhulu njengokuphuka okungavamile.

Abanye abantu baba nokusabela komzimba ku-nafarelin, nakuba lokhu kungavamile. Qaphela izimpawu ezinjengokuqubuka okukhulu, ubunzima bokuphefumula, noma ukuvuvukala kobuso bakho noma umphimbo, futhi funa ukunakekelwa okuphuthumayo uma lokhu kwenzeka.

Ubani Ongafanele Athathwe i-Nafarelin?

I-Nafarelin ayiphephile kubantu besifazane abakhulelwe noma labo abazama ukukhulelwa, njengoba ingalimaza izingane ezisakhula. Abesifazane abaneminyaka yokuzala kumele basebenzise izindlela zokulawula inzalo ezingahlobene namahomoni ngesikhathi sokwelashwa.

Abantu abanezimo ezithile zezokwelapha kufanele bagweme i-nafarelin noma bayisebenzise ngokucophelela okwengeziwe. Udokotela wakho uzobuyekeza umlando wakho wezokwelapha ngokucophelela ngaphambi kokukuyala lo muthi.

Nazi izimo ezingase zikuvimbele ukuthi usebenzise i-nafarelin ngokuphepha:

• Ukukhulelwa noma ukuncelisa ibele
• Ukuphuma kwegazi okungachazeki esithweni sangasese
• I-osteoporosis enzima noma umlando wokuphuka kwamathambo
• Ukucindezeleka okukhulu noma izimo zempilo yengqondo
• Ukungezwani komzimba ne-nafarelin noma imithi efanayo
• Izinhlobo ezithile zomdlavuza ozwela kumahomoni

Uma unomlando wezinkinga zamathambo, udokotela wakho angase akwazi ukukwenza i-nafarelin kodwa uzoqapha ukuminyana kwamathambo akho ngokucophelela. Bangase futhi bancomise ukwelashwa okwengeziwe ukuvikela amathambo akho ngesikhathi sokwelashwa.

Amagama Omkhiqizo we-Nafarelin

I-Nafarelin ivame ukuthengiswa ngaphansi kwegama lomkhiqizo elithi Synarel e-United States nakwamanye amazwe amaningi. Leli yigama lomkhiqizo lokuqala elizobonwa odokotela abaningi kanye nabokhemisi.

Amanye amazwe angase abe namagama omkhiqizo ahlukene e-nafarelin, kodwa isithako esisebenzayo sihlala sifana. Hlala utshela abahlinzeki bakho bezempilo igama elivamile elithi "nafarelin" kanye nanoma yiliphi igama lomkhiqizo ukuze ugweme ukudideka.

Izinhlobo ezivamile ze-nafarelin zingase zitholakale kwezinye izindawo, nakuba zingavamile njengenguqulo yegama lomkhiqizo. Umkhemisi wakho angakusiza ukuthi uqonde ukuthi yini etholakalayo endaweni okuyo nokuthi ngabe ukushintshwa kufanelekile yini.

Ezinye izindlela ze-Nafarelin

Eminye imithi eminingi ingelapha izimo ezifanayo ne-nafarelin, okuhlanganisa ezinye izinhlobo ze-GnRH agonists njenge-leuprolide (Lupron) kanye ne-goserelin (Zoladex). Lezi zindlela ezingezinye zisebenza ngendlela efanayo kodwa zingase zinikezwe ngemijovo esikhundleni se-nasal sprays.

Nge-endometriosis, ezinye izinketho zokwelapha zihlanganisa ukulawulwa kokuzalwa ngamahomoni, ukwelashwa nge-progestin, noma imithi elwa nokuvuvukala. Abanye abantu bathola ukukhululeka ngokwelashwa okuncane ngaphambi kokuzama ama-GnRH agonists afana ne-nafarelin.

Ekwelapheni ukuvuthwa ngaphambi kwesikhathi, ezinye izindlela zingase zihlanganise ezinye izinhlobo ze-GnRH agonists noma, kwezinye izimo, ukuqapha ngokucophelela ngaphandle kwemithi uma isimo sithambile. Udokotela wakho uzosiza ekunqumeni ukuthi iyiphi indlela engcono kakhulu esimweni sakho esithile.

Ukukhetha phakathi kwe-nafarelin nezinye izindlela kuvame ukuncika ezintweni ezifana nokulula, ukubekezelelana nemiphumela emibi, kanye nezindleko. Abanye abantu bakhetha ifomethi ye-nasal spray, kanti abanye bangase bathole imijovo ilula.

Ingabe i-Nafarelin ingcono kune-Lupron?

I-Nafarelin ne-Lupron (leuprolide) yomibili iyi-GnRH agonists esebenza ngendlela efanayo futhi inokusebenza okufanayo ekwelapheni i-endometriosis kanye ne-precocious puberty. Umehluko omkhulu ukuthi zinikezwa kanjani nokuthi kufanele uzisebenzise kaningi kangakanani.

I-Nafarelin inikeza lula lokusebenzisa ekhaya nsuku zonke njenge-nasal spray, kanti i-Lupron ngokuvamile idinga imijovo yanyanga zonke noma njalo eminyakeni embalwa ehhovisi likadokotela wakho. Abanye abantu bakhetha ukulawula ukulinganisa kwansuku zonke, kanti abanye bathanda ukulula kwemijovo engavamile.

Imiphumela emibi ngokuvamile iyafana phakathi kwemithi emibili, nakuba abanye abantu bengase bayibekezelele ngcono kunenye. Ukucasuka kwamakhala kuqhelelene ne-nafarelin, kuyilapho ukusabela kwendawo yokujova kuqondene ne-Lupron.

Umehluko wezindleko ungase ube khona ngokuya ngomshwalense wakho kanye nendawo. Udokotela wakho angakusiza ukuthi ulinganise izinzuzo nobubi benketho ngayinye ngokusekelwe endleleni yakho yokuphila, okuthandayo, nezidingo zezokwelapha.

Imibuzo Evame Ukubuzwa Mayelana ne-Nafarelin

Ingabe i-nafarelin iphephile kubantu abanesifo sikashukela?

I-Nafarelin ingasetshenziswa ngokuphepha kubantu abanesifo sikashukela, nakuba ingase ithinte amazinga kashukela egazini kwabanye abantu. Ushintsho lwamahomoni olubangelwa yi-nafarelin ngezinye izikhathi lungenza ukulawula ushukela wegazi kube yinselele enkulu.

Uma unesifo sikashukela, udokotela wakho uzofuna ukuqapha amazinga kashukela wakho wegazi eduze ngesikhathi sokwelashwa nge-nafarelin. Ungase udinge ukulungiswa emithini yakho yesifo sikashukela noma ukuhlolwa kwe-glucose okuvamile.

Ngingenzani uma ngiphuthelwa ngengozi ukusebenzisa i-nafarelin eningi kakhulu?

Uma ngengozi usebenzisa umthamo owengeziwe we-nafarelin, ungesabi. Nakuba kungakuhle, ukweqisa ngezikhathi ezithile akunakwenzeka ukuthi kubangele ukulimala okukhulu ngoba umuthi wenzelwe ukucindezela amahomoni kancane kancane.

Xhumana nodokotela wakho noma usokhemisi ukuze uthole isiqondiso, ikakhulukazi uma usebenzise okuningi kakhulu kunokuba kubhaliwe. Bangase bancomise ukuqapha imiphumela emibi eyengeziwe noma ukulungisa isikhathi somthamo wakho olandelayo.

Kumele ngenzeni uma ngiphuthelwa umthamo we-nafarelin?

Uma uphuthelwa umthamo we-nafarelin, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Esimeni esinjalo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa imiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa uhlelo lokusebenza lokulandelela imithi.

Ngingayeka nini ukuthatha i-nafarelin?

Ungayeka ukuthatha i-nafarelin lapho udokotela wakho enquma ukuthi imigomo yakho yokwelashwa ifinyelelwe noma uma uhlangabezana nemiphumela emibi edlula izinzuzo. Nge-endometriosis, lokhu kuvamile ngemuva kwezinyanga eziyi-6 zokwelashwa.

Abantu abaningi bangayeka i-nafarelin ngokuphepha ngaphandle kokunciphisa kancane umthamo, nakuba udokotela wakho angafuna ukukuqapha ngezimpawu ezibuyayo. Ukukhiqizwa kwakho kwama-hormone emvelo kufanele kuqale kabusha ezinyangeni ezimbalwa ngemuva kokuyeka.

Ngingakhulelwa yini ngenkathi ngithatha i-nafarelin?

Ukukhulelwa akunakwenzeka kakhulu ngenkathi uthatha i-nafarelin ngoba imithi icindezela ukuvuthwa kwamaqanda kwabesifazane. Kodwa-ke, kufanele usasebenzisa izindlela zokulawula inzalo ezingezona ezama-hormone njengesinyathelo esengeziwe sokuphepha.

Uma ucabanga ukuthi ungase ukhulelwe ngenkathi usebenzisa i-nafarelin, yeka imithi ngokushesha bese uthintana nodokotela wakho. I-Nafarelin ingalimaza ingane esakhulayo, ngakho-ke ukuhlolwa kwezokwelapha okusheshayo kubalulekile.