Yini i-Naloxegol: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Naloxegol iyimithi kadokotela eyenzelwe ukusiza abantu abahlangabezana nokuqunjelwa okubangelwa imithi ebanga ubuhlungu ye-opioid. Uma ubulokhu uthatha ama-opioid ngenxa yobuhlungu obungapheli futhi uzithola ukhathazeka ngokuhamba kwamathumbu okungakhululeki, le mithi ingase inikeze usizo obulufunayo.

Le mithi isebenza ngendlela ehlukile kunamayeza okuqeda ukuqunjelwa avamile ngoba iqondiswe ngqo ekuqunjelweni okuvela ekusetshenzisweni kwama-opioid. Ake sihambe kukho konke okudingeka ukwazi nge-naloxegol ngendlela ezizwakala icacile futhi ilawuleka.

Yini i-Naloxegol?

I-Naloxegol iyimithi ekhethekile eyingxenye yeqembu lemithi ebizwa ngokuthi ama-opioid antagonists. Cabanga ngayo njengomsizi osebenza ngqo ohlelweni lwakho lokugaya ukudla ukuze alwe nemiphumela yokuqunjelwa yemithi ebanga ubuhlungu ye-opioid.

Ngokungafani nama-opioid blockers avamile angaphazamisa ukukhululeka kwakho ubuhlungu, i-naloxegol yenzelwe ukuhlala ikakhulukazi emathunjini akho. Lokhu kusho ukuthi kungasiza ukubuyisela ukusebenza kwamathumbu okuvamile ngaphandle kokunciphisa izinzuzo zokukhulula ubuhlungu zemithi yakho ye-opioid.

Le mithi iza ngesimo samaphilisi futhi ithathwa ngomlomo kanye ngosuku. Udokotela wakho ngokuvamile uzocabangela le nketho lapho ezinye izindlela zokwelapha ukuqunjelwa zingazange zinikeze usizo olwanele.

Yini i-Naloxegol Esetshenziselwa Yona?

I-Naloxegol inikezwa ngokuqondile ukuqunjelwa okubangelwa yi-opioid kubantu abadala abanezinhlungu ezingapheli ezingezona umdlavuza. Lolu hlobo lokuqunjelwa lwenzeka ngoba ama-opioid anciphisa ukunyakaza kwemvelo kwamathumbu akho, okwenza kube nzima ukuba nokuhamba kwamathumbu okuvamile.

Udokotela wakho angase ancome i-naloxegol uma ubulokhu uthatha imithi ebanga ubuhlungu ye-opioid ngezimo ezinjengobuhlungu obungapheli emhlane, i-arthritis, noma ezinye izimo zobuhlungu besikhathi eside. Le mithi iyasiza ikakhulukazi uma udinga ukuqhubeka nokuthatha ama-opioid ukuze ulawule ubuhlungu kodwa ufuna ukukhululeka emiphumeleni engakhululeki yokugaya ukudla.

Kubalulekile ukuqonda ukuthi i-naloxegol ayisetshenziselwa ukuqunjelwa okuvamile noma ukuqunjelwa okubangelwa eminye imithi. Lo muthi wenzelwe ngqo uhlobo oluyingqayizivele lokuqunjelwa okudalwa yi-opioids ohlelweni lwakho lokugaya ukudla.

Isebenza Kanjani I-Naloxegol?

I-Naloxegol isebenza ngokuvimba ama-opioid receptors ngqo emathunjini akho kuyilapho ishiya ama-opioid receptors aqeda ubuhlungu ebuchosheni bakho nasemgogodleni wakho ingathintwanga kakhulu. Lesi senzo esikhethekile sisiza ukubuyisela ukusebenza kwamathumbu okuvamile ngaphandle kokuphazamisa ukuphathwa kobuhlungu bakho.

Uma uthatha ama-opioids, abopha kuma-receptors emzimbeni wakho wonke, okuhlanganisa nalabo abasemathunjini akho alawula ukunyakaza kwamathumbu. I-Naloxegol isebenza njengesihlangu esithambile, sivimbela ama-opioids ukuthi anciphise uhlelo lwakho lokugaya ukudla kuyilapho lisavumela ukuthi linikeze ukukhululeka kobuhlungu lapho ukudinga kakhulu.

Umuthi ngokuvamile uqala ukusebenza kungakapheli amahora kuya ezinsukwini zokuqala ukwelashwa. Ungase uqaphele ukuthuthuka ekuvamekeni kokunyakaza kwamathumbu akho nokunethezeka njengoba uhlelo lwakho lokugaya ukudla luqala ukusebenza ngokujwayelekile futhi.

Kufanele Ngiyithathe Kanjani I-Naloxegol?

Thatha i-naloxegol ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku esiswini esingenalutho. Lokhu kusho ukuyithatha okungenani ihora elilodwa ngaphambi kokudla kwakho kokuqala kosuku noma amahora amabili ngemva kokudla.

Gwinya ithebhulethi yonke ngamanzi. Ungayichobozi, uyihlukanise, noma uyihlafune ithebhulethi, ngoba lokhu kungathinta indlela umuthi osebenza ngayo emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho ngezinketho zakho.

Zama ukuthatha i-naloxegol ngesikhathi esifanayo nsuku zonke ukuze usize ukusungula umkhuba. Abantu abaningi bakuthola kuwusizo ukuyithatha ekuseni ngaphambi kokudla kwasekuseni, kodwa sebenzisana nodokotela wakho ukuze uthole isikhathi esikusebenzela kangcono neshejuli yakho neminye imithi.

Kufanele Ngiyithathe Isikhathi Eside Kangakanani I-Naloxegol?

Isikhathi sokwelashwa nge-naloxegol ngokuvamile sincike ekutheni uzodinga isikhathi esingakanani ukuqhubeka nokuthatha imithi ebuhlungu ye-opioid. Njengoba lo muthi uqondiswe ngqo ekuqunjelweni okubangelwa yi-opioid, cishe uzodinga ukuwuthatha uma nje usebenzisa ama-opioid ukuphatha ubuhlungu.

Udokotela wakho uzohlola njalo ukuthi i-naloxegol isadingeka futhi iyasebenza yini esimweni sakho. Abanye abantu bangase badinge ukwelashwa kwesikhashana uma belulama emva kokuhlinzwa noma ukulimala, kanti abanye abanezimo zobuhlungu ezingapheli bangase badinge ukusetshenziswa kwesikhathi eside.

Ungayeki ukuthatha i-naloxegol ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Uma udinga ukuyeka umuthi, umhlinzeki wakho wezempilo uzokuqondisa kule nqubo futhi angase acebise ngezindlela ezingezinye zokuphatha ukuqunjelwa.

Yiziphi Imiphumela Eceleni Ye-Naloxegol?

Njengayo yonke imithi, i-naloxegol ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe uqiniseka kakhulu ngemithi yakho futhi wazi ukuthi ungaxhumana nini nodokotela wakho.

Imiphumela emibi evame kakhulu ngokuvamile ithambile futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi:

• Ubuhlungu besisu noma ukungakhululeki esiswini
• Ukuqunjelwa
• Isicanucanu
• Ukuzithutha noma igesi
• Ukuphalaza
• Ikhanda
• Ukujuluka ngokweqile

Le miphumela emibi yokugaya ukudla ivame ukwenzeka ngoba umsebenzi wakho wamathumbu ubuyela kokujwayelekile ngemva kokuhamba kancane ngama-opioid. Abantu abaningi bathola ukuthi lezi zimpawu ziyalawuleka futhi zesikhashana.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Xhumana nodokotela wakho ngokushesha uma uhlangabezana:

• Ubuhlungu obukhulu besisu noma ukucindezela
• Ukuphalaza okuqhubekayo
• Izimpawu ezingase zibonise ukushoda kwamanzi emzimbeni okukhulu
• Izimpawu ezingase zibonise ukugqobhoza kwamathumbu (akuvamile kakhulu kodwa kungathi sína)

Abanye abantu bangase bahlangabezane nezimpawu ezifana nokuhoxiswa uma benamazinga aphezulu e-opioids ohlelweni lwabo lapho beqala i-naloxegol. Lokhu kungabandakanya ukukhathazeka, amaqhwa, ukujuluka, noma ukuzizwa ungazizwa kahle.

Ubani Ongafanele Athole I-Naloxegol?

I-Naloxegol ayifanele wonke umuntu, futhi izimo ezithile noma izimo zenza kungaphephile ukuyisebenzisa. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-naloxegol uma wazi noma usola ukuvaleka emathunjini akho. Lokhu kufaka phakathi izimo ezinjengokuvaleka kwamathumbu, lapho umuthi ungase ube mubi kunokuba ngcono.

Abantu abanezinkinga ezinzima zezinso noma isibindi bangase badinge ukulungiswa komthamo noma bangase bangakwazi ukuthatha i-naloxegol ngokuphepha. Udokotela wakho cishe uzoqhuba ukuhlolwa kwegazi ukuze ahlole ukusebenza kwezitho zakho ngaphambi kokuqala ukwelashwa.

Uma uthatha imithi ethile esebenzisana ne-naloxegol, udokotela wakho angase adinge ukulungisa imithamo noma akhethe indlela yokwelapha ehlukile. Lokhu kubaluleke kakhulu ngama-antibiotics athile, imithi elwa nesikhunta, neminye imithi ethinta indlela umzimba wakho oqhubula ngayo imithi.

Abesifazane abakhulelwe noma abancelisa ngamabele kufanele baxoxe ngobungozi nezinzuzo ngokucophelela nomhlinzeki wabo wezempilo, njengoba ukuphepha kwe-naloxegol ngesikhathi sokukhulelwa nokunakekela akusungulwanga ngokugcwele.

Amagama Omkhiqizo we-Naloxegol

I-Naloxegol itholakala ikakhulukazi ngaphansi kwegama lomkhiqizo elithi Movantik e-United States. Lolu uhlobo oluvame kakhulu oluyalelwe lomuthi ongase uhlangane nawo ekhemisi lakho.

Ezinye izifunda zingase zibe namagama omkhiqizo ahlukene e-naloxegol, kodwa isithako esisebenzayo nendlela esisebenza ngayo ihlala injalo. Njalo qiniseka ukuthi uthola umuthi ofanele ngokuhlola nomelaphi wakho uma unemibuzo mayelana nalokho okutholayo.

Izinhlobo ezijwayelekile ze-Naloxegol

Izinhlobo ezijwayelekile ze-naloxegol zingase zitholakale ngokuhamba kwesikhathi, ezinganikeza izinzuzo ezifanayo ngezindleko ezingase zibe ngaphansi. Udokotela wakho noma usokhemisi angakusiza ukuthi uqonde izinketho zakho nokuthi yini engasebenza kahle esimweni sakho kanye nesabelomali.

Ezinye izindlela zokwelapha ze-Naloxegol

Uma i-naloxegol ingakulungele, ziningi ezinye izinketho zokuphatha ukuqunjelwa okubangelwa yi-opioid. Udokotela wakho angakusiza ukuthi uhlole lezi ezinye izindlela ngokusekelwe ezidingweni zakho ezithile kanye nomlando wakho wezokwelapha.

I-Methylnaltrexone (Relistor) ingenye i-opioid antagonist esebenza ngendlela efana ne-naloxegol kodwa inikezwa njengomjovo. Abanye abantu bakhetha le nketho, ikakhulukazi uma benenkinga ngemithi yomlomo noma bedinga ukukhululeka okusheshayo.

I-Lubiprostone (Amitiza) isebenza ngendlela ehlukile ngokwandisa uketshezi emathunjini akho ukusiza ukuthambisa izihlalo futhi kukhuthaze ukuhamba kwamathumbu. Le mithi ingasebenza kubantu abangaphenduli kahle kuma-opioid antagonists.

Izindlela zendabuko ezinjengokwandisa ukudla kwe-fiber, izithambisi zezihlalo, noma ama-laxatives akhuthazayo angase afaneleke kwabanye abantu, nakuba ngokuvamile engasebenzi kahle ekuqunjelweni okubangelwa yi-opioid ngokukhethekile.

Umhlinzeki wakho wokunakekelwa kwezempilo angase futhi acabangele ukulungisa indlela yakho yokuphatha ubuhlungu, njengokushintsha imithi ye-opioid noma ukuhlanganisa amasu okuphatha ubuhlungu angezona i-opioid ukunciphisa inkinga yokuqunjelwa emthonjeni wayo.

Ingabe i-Naloxegol ingcono kune-Methylnaltrexone?

Kokubili i-naloxegol ne-methylnaltrexone ziyimithi esebenzayo yokuqunjelwa okubangelwa yi-opioid, kodwa zinezinzuzo ezihlukene ezingenza enye ifaneleke kakhulu esimweni sakho esithile.

I-Naloxegol inikeza lula lokuthathwa ngomlomo kanye ngosuku, okutholakala abantu abaningi kulula ukukuhlanganisa emsebenzini wabo wansuku zonke. Ifomu lomlomo futhi livumela ukukhululeka okuncane, okuzinzile usuku lonke.

I-Methylnaltrexone, enikezelwa ngomjovo, ingase isebenze ngokushesha kwabanye abantu futhi ingaba usizo uma unesicanucanu esibi noma ukuhlanza okwenza kube nzima ukugcina imithi yomlomo phansi. Kodwa-ke, abantu abaningi bakhetha ukugwema imijovo uma kungenzeka.

Ukukhetha phakathi kwale mithi kuvame ukwehla ezintweni ozithandayo, ukuthi uyayibekezelela kanjani inketho ngayinye, kanye nezinto ezibonakalayo njengokulula nezindleko. Udokotela wakho angakusiza ukuthi ulinganise lezi zici futhi angase aze acebise ukuzama eyodwa bese ushintshela kwenye uma kudingeka.

Imibuzo Evame Ukubuzwa Mayelana ne-Naloxegol

Ingabe i-Naloxegol iphephile kubantu abanezifo zenhliziyo?

I-Naloxegol ngokuvamile ithathwa njengephephile kubantu abanezimo zenhliziyo, kodwa udokotela wakho uzofuna ukubukeza impilo yakho yenhliziyo nemithambo yegazi ngaphambi kokuyinikeza. Umuthi ngokuvamile awuthinti ngqo izinga lokushaya kwenhliziyo noma umfutho wegazi.

Kodwa-ke, uma unezinkinga zenhliziyo ezinzima noma uthatha imithi eminingi yenhliziyo, udokotela wakho angase afune ukukuqapha eduze lapho uqala i-naloxegol. Lokhu ikakhulukazi kuyisinyathelo sokuzivikela ukuqinisekisa ukuthi yonke imithi yakho isebenza kahle ndawonye.

Ngingenzani uma ngiphuzile i-Naloxegol eningi ngengozi?

Uma ngengozi uphuza i-naloxegol eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuphuza okuningi kungase kubangele izinhlungu ezinkulu zesisu, isifo sohudo, noma izimpawu ezifanayo nokuhoxiswa kwe-opioid.

Ungazami ukuzihlanza ngaphandle uma uqondiswe ngqo uchwepheshe wezempilo. Kunalokho, phuza amanzi amaningi futhi ufune iseluleko sezokwelapha ngokushesha. Gcina ibhodlela lomuthi nawe ukuze abahlinzeki bezempilo bakwazi ukubona kahle ukuthi yini nokuthi ungakanani okuthathile.

Ngingenzani uma ngiphuthelwa umthamo we-Naloxegol?

Uma uphuthelwa umthamo we-naloxegol, yithathe ngokushesha nje lapho ukhumbula, uma nje isesiswini esingenalutho. Uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho olujwayelekile lokuthatha imithi.

Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabanga ngokumisa i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukhumbule.

Ngingayeka nini ukuthatha i-Naloxegol?

Ngokuvamile ungaqeda ukuthatha i-naloxegol lapho ungasadingi imithi ebuhlungu ye-opioid noma lapho udokotela wakho enquma ukuthi akusadingeki. Njengoba imithi ikhuluma ngokuqondile ngokuqina kwamathumbu okubangelwa yi-opioid, ngokuvamile ayidingeki uma usuyekile ukuthatha ama-opioids.

Njalo xoxa ngokuyeka i-naloxegol nodokotela wakho kunokuzinqumela wena. Bangakusiza ukuthi uhlele isikhathi futhi bangase baphakamise izindlela ezingezinye zokuphatha noma yiziphi izinkinga zokugaya ezisele.

Ngingayithatha i-Naloxegol nezinye izithambisi zamathumbu?

Ngesinye isikhathi udokotela wakho angase ancome ukuhlanganisa i-naloxegol nezinye izithambisi zamathumbu ezimnene noma izithambisi zendle, kodwa lokhu kufanele kwenziwe ngaphansi kokuqondisa kwezokwelapha. Ukuthatha imithi eminingi yokuqina kwamathumbu ngaphandle kokuqondiswa kungaholela emiphumeleni emibi engalindelekile noma ukunyakaza kwamathumbu okunamandla ngokweqile.

Uma usuvele uthatha ezinye izindlela zokwelapha ukuqina kwamathumbu, qiniseka ukuthi utshela udokotela wakho ngazo zonke lezo zindlela lapho nixoxa nge-naloxegol. Bangakusiza ukuthi udale uhlelo oluphephile noluphumelelayo olubhekana nezidingo zakho ezithile ngaphandle kokubangela izinkinga.