Yini iNaltrexone neBupropion: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Naltrexone ne-bupropion iyimithi kadokotela ehlanganisa imithi emibili ukusiza ngokuphatha isisindo. Le nhlanganisela isebenza ngokuthinta amakhemikhali obuchopho alawula ukudla nokulangazelela ukudla, okwenza kube lula ukuthi udle okuncane futhi uzizwe wanelisekile ngezingxenye ezincane.

Abantu abaningi bathola ukulahlelelwa isisindo kuyinselele naphezu kwemizamo yabo emihle yokudla nokuzivocavoca. Le mithi inganikeza ukwesekwa okwengeziwe uma izinguquko zendlela yokuphila zodwa zinganele ukufinyelela imigomo yakho yezempilo.

Yini iNaltrexone neBupropion?

Le mithi ihlanganisa i-naltrexone, evimba izamukeli ezithile zobuchopho, ne-bupropion, i-antidepressant ethinta nokudla. Ngokuhlangene, bakha iqembu elinamandla elisiza ukunciphisa indlala nokulangazelela ukudla ngenkathi besekela imizamo yakho yokulahlekelwa isisindo.

Le nhlanganisela yenzelwe ngqo ukuphatha isisindo kubantu abadala abanokukhuluphala noma abanesisindo esiningi esinokuhlobana nezimo zezempilo. Akuyona indlela esheshayo kodwa iyithuluzi elisebenza kanye nokudla okunempilo nokuzivocavoca njalo.

Ungase wazi le mithi ngegama layo lomkhiqizo, okungasiza udokotela wakho noma usokhemisi ukuthi akuhlonze. Izithako ezimbili ezisebenzayo zisebenza kangcono ndawonye kunanoma iyiphi yazo iyodwa.

Yini iNaltrexone neBupropion Esetshenziselwa Yona?

Le mithi isetshenziselwa ikakhulukazi ukusiza abantu abadala ukuthi banciphise isisindo uma benenkomba yobuningi bomzimba (BMI) engama-30 noma ngaphezulu, noma i-BMI engama-27 noma ngaphezulu enezinkinga zezempilo ezihlobene nesisindo. Yenzelwe ukuphathwa kwesisindo eside, hhayi ukulahlekelwa isisindo kwesikhashana.

Udokotela wakho angase ancome le mithi uma unezimo ezihlobene nesisindo ezidinga ukunakwa. Lokhu kuvamile ukuhlanganisa umfutho wegazi ophezulu, uhlobo 2 lukashukela, noma i-cholesterol ephezulu engathuthukanga ngokwanele ngezinguquko zendlela yokuphila kuphela.

Lo muthi ungasiza futhi uma uke waba nenkinga yokudla ngokomzwelo noma ukuthola kunzima ukulawula usayizi wezingxenye. Abantu abaningi baba nokulangazelela okuncane kokudla futhi bazizwe banelisekile ngemva kokudla amanani amancane.

Kwezinye izimo, odokotela bangase babhale lo muthi ngezimo ezinye, nakuba ukuphatha isisindo kuhlala kuyinto esetshenziswa kakhulu. Umhlinzeki wakho wezempilo uzonquma ukuthi kulungile yini ngesimo sakho esithile.

Isebenza Kanjani i-Naltrexone ne-Bupropion?

Lo muthi usebenza ngokugxila ezindaweni ezithile ebuchosheni bakho ezilawula indlala, ukwaneliseka, nemizwa yomvuzo evela ekudleni. Kuthathwa njengomuthi olawula isisindo esinamandla ngokulinganisela odinga ukuqashwa ngokucophelela.

Ingxenye ye-bupropion ithinta amakhemikhali obuchopho afana ne-dopamine ne-norepinephrine, ethonya imizwa yakho nokudla. Lokhu kungasiza ukunciphisa ukulangazelela futhi kukwenze uzizwe ungaqhutshwa kangako ukudla uma ungalambile ngempela.

I-Naltrexone ivimba ama-receptors e-opioid ebuchosheni bakho, okunganciphisa imizwa emnandi oyitholayo ekudleni ukudla okuthile. Lokhu akuqedi ukujabulela ukudla kodwa kungasiza ekuqhekeni imijikelezo yokudla ngokweqile noma ukudla ngokomzwelo.

Ngokuhlangene, le miphumela ingakusiza ukuthi uzizwe wanelisekile ngezingxenye ezincane futhi ube nokulangazelela okuncane kokudla okunamandla usuku lonke. Umuthi awusebenzi ngokushesha futhi ngokuvamile kuthatha amasonto amaningana ukukhombisa imiphumela yawo ephelele.

Kufanele Ngiyithathe Kanjani i-Naltrexone ne-Bupropion?

Thatha lo muthi ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kabili ngosuku ngokudla ukusiza ukuvimbela isisu esibuhlungu. Ukuqala ngokudla esiswini sakho kunganciphisa kakhulu isicanucanu, okuvame ukwenzeka lapho uqala lo muthi.

Udokotela wakho cishe uzoqala ngomthamo ophansi bese ewukhulisa kancane kancane emasontweni amaningana. Le ndlela yokunyuka isiza umzimba wakho ukuthi ulungiswe futhi inciphisa ithuba lemiphumela emibi efana nesicanucanu noma isiyezi.

Thatha umthamo wakho wasekuseni ngesidlo sasekuseni nomthamo wakho wakusihlwa ngesidlo sakusihlwa, ubanze ngamahora angaba ngu-8 kuya kwangu-12. Isikhathi esiqhubekayo sisiza ukugcina amazinga aqhubekayo omuthi emzimbeni wakho.

Gwinya amaphilisi wonke ngaphandle kokuwachoboza, ukuwahlafuna, noma ukuwaqhekeza. Ifomula yokukhishwa okwandisiwe yenzelwe ukusebenza kancane usuku lonke, futhi ukuguqula amaphilisi kungabangela ukuthi umuthi omningi ukhishwe ngesikhathi esisodwa.

Uma ukhohlwa umthamo, wuthatha ngokushesha lapho ukhumbula, kodwa ungathathi imithamo emibili ngesikhathi esisodwa. Kungcono ukweqa umthamo owuphuthelwe uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe.

Kufanele Ngithathe Isikhathi Esingakanani I-Naltrexone ne-Bupropion?

Lo muthi uvame ukusetshenziselwa ukuphatha isisindo eside, ngokuvamile izinyanga eziningana kuya eminyakeni kuye ngempendulo yakho nezidingo zempilo. Udokotela wakho uzohlola inqubekela phambili yakho njalo ezinyangeni ezimbalwa ukuze anqume ukuthi kufanele uqhubeke yini.

Abantu abaningi babona imiphumela yokuqala phakathi kwamasonto angu-8 kuya kwangu-12, kodwa izinzuzo eziphelele zingathatha amasonto angafika kwangu-16 ukuthi zivele. Uma ungazange ulahlekelwe okungenani u-5% wesisindo sakho sokuqala ngemuva kwamasonto angu-12, udokotela wakho angase ancome ukuyeka umuthi.

Ubude bokwelashwa buxhomeke ekutheni umuthi usebenza kahle kangakanani kuwe nokuthi ngabe uhlangabezana nemiphumela emibi enezinkinga. Abanye abantu bayawuthatha izinyanga eziningi noma iminyaka njengengxenye yamasu abo okuqhubeka nokuphatha isisindo.

Umhlinzeki wakho wezempilo uzohlola njalo inqubekela phambili yakho, umfutho wegazi, nempilo yonke ngenkathi uthatha lo muthi. Bazokusiza ukuthi unqume ukuthi kufanelekile nini ukuqhubeka, ukulungisa umthamo, noma ukucabangela ukuyeka.

Yiziphi Imiphumela Eceleni ye-Naltrexone ne-Bupropion?

Njengayo yonke imithi, i-naltrexone ne-bupropion ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi imnene kuya esimweni esiphakathi nendawo futhi ivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini.

Imiphumela eseceleni evame kakhulu ongase uhlangabezane nayo ihlanganisa isicanucanu, ukuqunjelwa, ikhanda elibuhlungu, nesiyezi. Lokhu kuvamile ukuthi kwenzeke emasontweni ambalwa okuqala okwelashwa futhi ngokuvamile kuba ngaphansi kokukhathaza ngokuhamba kwesikhathi.

Imiphumela Eceleni Evamile

Le miphumela eseceleni yenzeka njalo kodwa ivamise ukulawuleka futhi ithambekele ekuthuthukiseni ngokuhamba kwesikhathi:

• Isicanucanu nokungakhululeki kwesisu
• Ukuqunjelwa
• Ikhanda elibuhlungu
• Isiyezi
• Ubunzima bokulala
• Umlomo owomile
• Ukuphuma isifo sohudo
• Ukukhathazeka noma ukungazinzi

Abantu abaningi bathola ukuthi le miphumela iba ngaphansi kokuqashelwa ngemuva kwenyanga yokuqala yokwelashwa. Ukuthatha imithi nokudla kungasiza ukunciphisa isicanucanu nezinkinga zesisu.

Imiphumela Eceleni Engathi Sína

Ngenkathi ingavamile, eminye imiphumela eseceleni idinga ukunakekelwa kwezokwelapha ngokushesha futhi akufanele inganakwe:

• Ushintsho olukhulu lwemizwa noma ukucindezeleka
• Imicabango yokuzilimaza
• Ukushaywa yisithuthwane
• Ukuphendula okukhulu komzimba
• Ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• Umfutho wegazi ophezulu kakhulu
• Izinkinga zesibindi (ukuphuzi kwesikhumba noma amehlo)
• Izinkinga ezinzima zezinso

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nanoma iyiphi yale miphumela eseceleni engathi sína. Bangasiza ukuthola ukuthi kufanele uqhubeke yini nomuthi noma ushintshe kokunye ukwelashwa.

Imiphumela Eceleni Engavamile

Le miphumela eseceleni yenzeka ngezikhathi ezithile kodwa kubalulekile ukuyazi:

• Umonakalo omkhulu wesibindi
• I-angle-closure glaucoma
• Ukuphendula okukhulu komzimba nokuvuvukala
• I-Serotonin syndrome (uma ihlanganiswe neminye imithi ethile)
• Izinkinga ezinzima zezinso
• Izinkinga zesigqi senhliziyo

Ngenkathi le miphumela eseceleni engavamile ingavamile, udokotela wakho uzokuhlola njalo ukuze abambe noma yiziphi izinkinga ezingaba khona ekuqaleni.

Ubani Ongafanele Athathwe I-Naltrexone ne-Bupropion?

Lo muthi awuphephile kuwo wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwunikeza. Ezinye izimo zezempilo nemithi kungenza le nhlanganisela ibe yingozi noma ingasebenzi kahle.

Abantu abanomlando wokuba nezithuthwane, izifo zokudla, noma abasebenzisa imithi ye-opioid njengamanje akufanele bathathe lo muthi. Le nhlanganisela ingandisa ingozi yokuba nezithuthwane futhi ingase ingasebenzi kahle uma usebenzisa ama-opioid.

Kufanele futhi ugweme lo muthi uma unomfutho wegazi ophezulu ongagadiwe, ezinye izimo zenhliziyo, noma isifo esibi sesibindi noma sezinso. Udokotela wakho uzohlola lezi zimo ngaphambi kokuqala ukwelashwa.

Uma ukhulelwe, uhlela ukukhulelwa, noma uncelisa, lo muthi akukhuthazwa. Ukuphepha ngesikhathi sokukhulelwa akukamiswanga, futhi kungadlulela obisini lwebele.

Abantu abathatha ama-MAO inhibitors noma labo abawayekile ezinsukwini eziyi-14 ezedlule akufanele basebenzise lo muthi ngenxa yokusebenzisana kwemithi okuyingozi.

Amagama Omkhiqizo we-Naltrexone kanye ne-Bupropion

Igama elivamile lomkhiqizo wale nhlanganisela yomuthi yi-Contrave, etholakala kabanzi emakhemisi kulo lonke elase-United States. Leli yigama lomkhiqizo okungenzeka ukuthi uzohlangana nalo lapho udokotela wakho ekunikeza lo muthi.

Ezinye izinhlelo zomshuwalense zingase zihlanganise igama lomkhiqizo kanti ezinye zikhetha izinguqulo ezivamile uma zitholakala. Umuthi wakho we-pharmacist angakusiza ukuthi uqonde izinketho zakho zokukhokhelwa futhi uthole inguqulo eshibhile.

Inhlanganisela ejwayelekile ingase itholakale ngaphansi kwamanye amagama noma njengemithi ehlukene ethathwa ndawonye. Udokotela wakho uzocacisa ukuthi iyiphi ifomula engcono kakhulu esimweni sakho.

Ezinye izindlela ze-Naltrexone kanye ne-Bupropion

Uma lo muthi ungasebenzi kahle kuwe noma ubangela imiphumela emibi, ezinye izindlela ziyatholakala zokuphatha isisindo. Udokotela wakho angakusiza ukuthi uhlole ezinye izinketho ezingase zikufanele kangcono.

Eminye imithi yokunciphisa umzimba edinga ukubhala incwadi kadokotela ihlanganisa i-orlistat, evimbela ukumuncwa kwamafutha, kanye nemithi emisha efana ne-semaglutide noma i-liraglutide, esebenza ngezindlela ezahlukene zokulawula ukudla. Ngayinye inezinzuzo zayo nemiphumela engase ibe khona.

Izindlela ezingasebenzisi imithi zihlala ziyizindlela ezibalulekile, okuhlanganisa izinhlelo zokudla ezihlelekile, ukwelulekwa ngokuziphatha, futhi kwezinye izimo, ukuhlinzwa kokunciphisa umzimba. Abantu abaningi baphumelela ngezindlela ezihlanganisiwe ezihlanganisa izinguquko zokuphila kanye nokusekelwa kwezokwelapha.

Umhlinzeki wakho wezempilo angakusiza ukuthi uqonde ukuthi yiziphi ezinye izindlela ezingase zisebenze kangcono ngokusekelwe emlandweni wakho wezempilo, eminye imithi oyithathayo, kanye nemigomo yakho yokunciphisa umzimba.

Ingabe i-Naltrexone ne-Bupropion ingcono kune-Phentermine?

Yomibili le mithi ingasebenza ekunciphiseni umzimba, kodwa isebenza ngendlela ehlukile futhi ingase ilungele abantu abahlukene. I-Phentermine ivame ukusetshenziswa isikhathi esifushane, kanti i-naltrexone ne-bupropion yakhelwe ukusetshenziswa isikhathi eside.

I-Phentermine ikakhulukazi icindezela ukudla futhi ingabangela imiphumela engathi iyashukumisa njengokwanda kwesilinganiso senhliziyo nomfutho wegazi. I-Naltrexone ne-bupropion isebenza ezindleleni ezihlukene zobuchopho futhi ingase ibe ngcono kubantu abahlupheka ngokudla ngokomzwelo noma ukulangazelela ukudla.

Ukukhetha phakathi kwale mithi kuncike ezimweni zakho zempilo ezithile, eminye imithi oyithathayo, kanye nemigomo yakho yokunciphisa umzimba. Abantu abanezimo zenhliziyo bangase benze kangcono nge-naltrexone ne-bupropion, kanti labo abadinga ukucindezelwa kokudla kwesikhashana bangase bakhethe i-phentermine.

Udokotela wakho uzocabangela isithombe sakho esiphelele sezokwelapha ukuze anqume ukuthi iyiphi imithi efanelekayo esimweni sakho. Abanye abantu bangase bazame umuthi owodwa kuqala bese beshintshela komunye uma kudingeka.

Imibuzo Evame Ukubuzwa Mayelana ne-Naltrexone ne-Bupropion

Ingabe i-Naltrexone ne-Bupropion iphephile ku-Diabetes?

Lo muthi ungasetshenziswa ngokuphepha ngabantu abaningi abanesifo sikashukela sohlobo 2 futhi ungase ngisho usize ukuthuthukisa ukulawulwa kukashukela wegazi ngokuncipha kwesisindo. Nokho, udokotela wakho uzodinga ukuqapha amazinga kashukela wegazi lakho eduze lapho uqala lo muthi.

Ukuncipha kwesisindo okuvela kulomuthi ngezinye izikhathi kungathuthukisa ukuphathwa kwesifo sikashukela futhi kungavumela ukulungiswa kwemithi yakho yesifo sikashukela. Ungalokothi ushintshe imithamo yakho yemithi yesifo sikashukela ngaphandle kokubonisana nomhlinzeki wakho wezempilo kuqala.

Abantu abanesifo sikashukela sohlobo 1 noma izinkinga ezinzima zesifo sikashukela bangase badinge ukucatshangelwa okukhethekile ngaphambi kokuqala lo muthi. Udokotela wakho uzohlola ukuphathwa kwakho konke kwesifo sikashukela ngaphambi kokukuyala.

Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi I-Naltrexone ne-Bupropion Engaphezu Kakhulu?

Uma ngengozi uthatha umuthi omningi kakhulu, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ikakhulukazi uma uzizwa ungazizwa kahle. Ukuthatha okuningi kakhulu kungakhuphula ingozi yokuhlaselwa yizifo nezinye izinto ezingezinhle ezingathi sína.

Izimpawu zokuthatha okuningi zingabandakanya isicanucanu esibi, ukuhlanza, ukudideka, ukushaya kwenhliziyo okusheshayo, noma ukuzizwa ukhathazeke kakhulu. Ungalindi ukubona ukuthi izimpawu ziyavela yini - funa usizo lwezokwelapha ngokushesha.

Gcina ibhodlela lomuthi unawo lapho ufuna ukunakekelwa kwezokwelapha ukuze abahlinzeki bezempilo bazi kahle ukuthi yini nokuthi ungakanani owathathayo. Banganikeza ukwelashwa okufanele ngokuya ngomuthi othile kanye nenani elihilelekile.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Naltrexone ne-Bupropion?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, kodwa kuphela uma kungasondeli isikhathi somthamo wakho olandelayo ohleliwe. Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe.

Uma uphuthelwa imithamo eminingi, xhumana nodokotela wakho ngaphambi kokuqhubeka nomuthi. Bangase bakufune ukukuqala kabusha ngomthamo ophansi ukuze kuvinjelwe imiphumela emibi, ikakhulukazi uma uphuthelwe izinsuku eziningana.

Zama ukuthatha imithi yakho ngezikhathi ezifanayo nsuku zonke ukuze usize ukukhumbula imithamo. Ukusetha ama-alamu ocingweni noma ukusebenzisa umhleli wamaphilisi kungakusiza ukuthi uhlale emgqeni ngeshejuli yakho yemithi.

Ngingayeka nini ukuthatha i-Naltrexone ne-Bupropion?

Ungayeka ukuthatha lo muthi uma wena nodokotela wakho nivumelana ngokuthi kufanelekile, kodwa ungayeki kungazelelwe ngaphandle kwesiqondiso sezokwelapha. Udokotela wakho uzokusiza ukuthi unqume isikhathi esifanele esekelwe ekuqhubekeleni phambili kwakho ekulahle-kelweni isisindo kanye nempilo yakho yonke.

Uma ungalahlekelwanga okungenani u-5% wesisindo sakho sokuqala ngemuva kwamasonto angu-12, udokotela wakho angase ancome ukuyeka umuthi. Ngokuphambene, uma isebenza kahle futhi uyayibekezelela, ungaqhubeka izinyanga eziningi noma isikhathi eside.

Lapho uyeka, udokotela wakho angase ancome ukunciphisa kancane kancane umthamo kunokuyeka kungazelelwe. Lokhu kungasiza ekuvikeleni noma yiziphi izimpawu zokuhoxiswa futhi kukuvumele ukuthi uguqukele ekugcineni ukulahlekelwa kwakho isisindo ngezindlela ezinye.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Naltrexone ne-Bupropion?

Kungcono ukukhawulela ukusetshenziswa kotshwala ngenkathi uthatha lo muthi, njengoba zombili izingxenye zingathinta ubuchopho bakho futhi inhlanganisela ingase ikhulise imiphumela ethile emibi. Utshwala bungenza imiphumela emibi efana nesiyezi nokucasuka kube kubi kakhulu.

I-Bupropion inganciphisa ukubekezelelana kwakho notshwala, okusho ukuthi ungase uzwe imiphumela yotshwala ngokuqinile kunokujwayelekile. Lokhu kungaba yingozi futhi kwandise ingozi yakho yezingozi noma ukwahlulela okubi.

Uma ukhetha ukuphuza ngezikhathi ezithile, yenza kanjalo ngokulinganisela okukhulu futhi unake indlela ozizwa ngayo. Khuluma nodokotela wakho mayelana nemikhawulo ephephile yokusetshenziswa kotshwala ngenkathi uthatha lo muthi.