Yini i-Nefazodone: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Nefazodone iyimithi yokucindezela engasiza ekwelapheni ukucindezeleka kanye nezifo zokukhathazeka. Ingaphansi kohlobo lwemithi ebizwa ngokuthi ama-serotonin antagonist kanye nama-reuptake inhibitors (SARIs), asebenza ngendlela ehlukile kunama-antidepressants avamile afana nama-SSRIs.

Le mithi isikhona kusukela ngeminyaka yawo-1990 futhi inikeza indlela eyingqayizivele yokwelapha ukucindezeleka. Nakuba ingabhaliwe kabanzi namuhla ngenxa yokukhathazeka okuthile ngokuphepha, isahlala siyindlela ebalulekile kubantu abangatholanga ukukhululeka ngeminye imithi.

Yini i-Nefazodone?

I-Nefazodone iyimithi yokucindezela ebekwe ngudokotela ethinta amakhemikhali obuchopho abizwa ngokuthi ama-neurotransmitters. Iqondise ngqo i-serotonin, isithunywa samakhemikhali esithonya imizwa, ukulala, kanye namazinga okukhathazeka.

Ngokungafani nama-antidepressants amaningi, i-nefazodone inesenzo esiphindwe kabili. Ivimba ama-serotonin receptors athile ngenkathi futhi ivimbela i-serotonin ukuthi ingangeni kabusha ngokushesha kakhulu ngamaseli obuchopho. Le ndlela eyingqayizivele ingasiza abanye abantu abangazange basabele kahle eminye imithi.

Umuthi uza ngesimo samaphilisi futhi uthathwa ngomlomo. Ngokuvamile kubhalwa lapho ezinye izidakamizwa ezinganikezanga ukukhululeka okwanele noma zibangele imiphumela eceleni ekhathazayo.

Isetshenziselwani i-Nefazodone?

I-Nefazodone isetshenziselwa ikakhulukazi ukwelapha isifo esikhulu sokucindezeleka kubantu abadala. Ingasiza ukuthuthukisa imizwa, ukunciphisa imizwa yokudabuka, nokubuyisela intshisekelo emisebenzini yansuku zonke.

Ngaphandle kokucindezeleka, odokotela ngezinye izikhathi babhala i-nefazodone ngezifo zokukhathazeka, isifo sokucindezeleka ngemva kwengozi (PTSD), kanye nesifo sokwethuka. Abanye abantu bayayithola ilusizo ikakhulukazi ngoba ivame ukubangela imiphumela emincane yocansi uma iqhathaniswa nezinye izidakamizwa zokucindezeleka.

Udktela wakho angase acabangele i-nefazodone uma uzamile ezinye izidambisi zokucindezeleka ngaphandle kwempumelelo. Kwesinye isikhathi futhi kukhethwa uma izinkinga zokulala ziyinkinga enkulu, njengoba kungasiza ukuthuthukisa ikhwalithi yokulala ngaphandle kokubangela ukozela okukhulu emini.

Isebenza Kanjani I-Nefazodone?

I-Nefazodone isebenza ngokwandisa inani le-serotonin elitholakala ebuchosheni bakho. Lokhu ikwenza ngezinyathelo ezimbili eziyinhloko ezenzeka ngasikhathi sinye.

Okokuqala, ivimba i-serotonin ekutheni ingangeni ngokushesha kakhulu ngamaseli ezinzwa, ivumela amakhemikhali amaningi alawula imizwa ukuthi ahlale esebenza. Okwesibili, ivimba izamukeli ezithile ze-serotonin ezingase zithinte ukuthuthuka kwemizwa.

Le ndlela ephindwe kabili yenza i-nefazodone lokho odokotela abakubiza ngokuthi

Ngokuvamile uzoqala ukuqaphela ukuthuthuka kokulala nokudla emasontweni ambalwa okuqala. Nokho, ukuthuthuka okukhulu kwemizwa kuvame ukuthatha amasonto angu-4 kuya kwangu-8 ukuba kubonakale. Ungadangali uma ungezwa ngcono ngokushesha.

Udokotela wakho uzoqapha njalo inqubekela phambili yakho futhi angase alungise uhlelo lwakho lokwelapha ngokufanele. Abanye abantu badinga ukwelashwa isikhathi eside, ikakhulu uma beke baba neziqephu eziningi zokucindezeleka. Ungayeki ukuthatha i-nefazodone ngokuzumayo, ngoba lokhu kungabangela izimpawu zokuhoxisa.

Ziyini Imiphumela Eceleni ye-Nefazodone?

Njengayo yonke imithi, i-nefazodone ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Ukuqonda okukulindele kungakusiza ukuthi uzizwe ulungiseleleke kangcono futhi wazi ukuthi ungaxhumana nini nodokotela wakho.

Imiphumela emibi evamile ethinta abantu abaningi ihlanganisa ukozela, isiyezi, isicanucanu, nomlomo owomile. Lezi zimpawu zivame ukuba mnene futhi zivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi emasontweni ambalwa okuqala.

Nawa amanye imiphumela emibi ebikwa kaningi:

• Ukozela noma ukukhathala
• Isiyezi noma ukuzwa sengathi uyakhanya
• Isicanucanu noma isisu esibuhlungu
• Umlomo owomile
• Ukubona okungacacile
• Ukuqunjelwa
• Ikhanda

Le miphumela evamile ngokuvamile ilawuleka futhi ithambekele ekunciphiseni ngokuhamba kwesikhathi njengoba umzimba wakho ujwayela umuthi.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Okukhathaza kakhulu nge-nefazodone yithuba elingavamile lezinkinga zesibindi, yingakho lo muthi udinga ukuqashwa ngokucophelela.

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu zokuxwayisa:

• Ukuphuzi kwesikhumba noma amehlo (i-jaundice)
• Umchamo omnyama noma izihlalo eziphuthukayo
• Ukukhathala okukhulu noma ubuthakathaka
• Ukulahlekelwa isifiso sokudla esihlala izinsuku eziningana
• Isicanucanu nokuhlanza okuqhubekayo
• Ubuhlungu besisu noma ukuzwela

Lezi zimpawu zingase zikhombe izinkinga zesibindi, ezenzeka kubantu abangaphansi koyedwa kwabayi-1,000 abathatha i-nefazodone kodwa zidinga ukuhlolwa ngokushesha.

Obani okungafanele bathathe i-Nefazodone?

Abantu abathile kufanele bagweme i-nefazodone ngenxa yengozi eyengeziwe yezinkinga ezinzima. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-nefazodone uma unesifo sesibindi esisebenzayo noma umlando wezinkinga zesibindi ezivela ekusetshenzisweni kwe-nefazodone kwangaphambilini. Umuthi ungase ulimaze isibindi ngezikhathi ezithile, ngakho-ke abantu abanezimo zesibindi esivele sikhona basengozini enkulu.

Abantu abathatha ama-MAO inhibitors (uhlobo lwe-antidepressant) kufanele bagweme i-nefazodone ngokuphelele. Kudingeka kube nebanga okungenani lezinsuku eziyi-14 phakathi kokuyeka i-MAO inhibitor nokuqala i-nefazodone, noma okuphambene nalokho, ukuvimbela ukusebenzisana okuyingozi.

Izimo ezengeziwe lapho i-nefazodone ingase ingafaneleki zihlanganisa:

• Ukunqamuka kwenhliziyo kwamuva noma isifo senhliziyo esingazinzile
• Isifo sezinso esibi kakhulu
• Umlando wokuhlaselwa noma isithuthwane
• I-Bipolar disorder (ngaphandle kwama-mood stabilizers)
• Ukukhulelwa noma ukuncelisa

Udokotela wakho uzohlola izinzuzo ezingaba khona ngokumelene nezingozi uma unezinye zalezi zimo, futhi ukwelashwa okuhlukile kungase kufaneleke kakhulu esimweni sakho.

Amagama Omkhiqizo we-Nefazodone

I-Nefazodone ekuqaleni yathengiswa ngaphansi kwegama lomkhiqizo elithi Serzone, kodwa lo mkhiqizo wayekhishwe e-United States ngo-2004. Namuhla, umuthi utholakala kuphela njengomuthi ojwayelekile.

Ungase usazwe abahlinzeki bezempilo bekhuluma ngayo njenge-Serzone, ikakhulukazi odokotela abadala abayiyalela lapho umkhiqizo wawutholakala. Kodwa-ke, yonke i-nefazodone etholakala e-US njengamanje ijwayelekile.

Izinhlobo ezijwayelekile zisebenza kahle njengomuthi wokuqala wegama lomkhiqizo. Ziqukethe isithako esifanayo esisebenzayo futhi zihlangabezana namazinga ekhwalithi afanayo asethwe yi-FDA.

Ezinye izindlela ze-Nefazodone

Ezinye izidambisi zokucindezeleka zingasebenza njengezinye izindlela ze-nefazodone, ngasinye sinenzuzo yaso kanye nohlu lwemiphumela emibi. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho uma i-nefazodone ingakulungele.

Ezinye izindlela ezivamile zihlanganisa ama-SSRI afana ne-sertraline (Zoloft) noma i-escitalopram (Lexapro), okuthi ngokuvamile zizanywe kuqala ngenxa yamaphrofayili abo okuphepha aqinisekisiwe. Le mithi isebenza ngendlela efanayo ngokuthinta i-serotonin kodwa inezindlela ezihlukene zemiphumela emibi.

Ezinye izinketho udokotela wakho angazicabangela zihlanganisa:

• Trazodone (indlela efanayo, ivame ukubekezeleleka kangcono)
• Mirtazapine (ilungele ukulala nezinkinga zokudla)
• Bupropion (akungenzeki ukuthi kubangele imiphumela emibi yezocansi)
• Venlafaxine (ithinta kokubili i-serotonin ne-norepinephrine)
• Duloxetine (isiza nezimo zobuhlungu)

Enye indlela engcono kakhulu incike ezimpawini zakho ezithile, umlando wezokwelapha, kanye nezimpendulo zangaphambilini emithini. Udokotela wakho uzosebenza nawe ukuthola inketho efaneleka kakhulu.

Ingabe i-Nefazodone Ingcono Kune-Trazodone?

Kokubili i-nefazodone ne-trazodone bangabeqembu elifanayo lezidambisi zokucindezeleka, kodwa banezinto ezibalulekile ezihlukile. Akukho noyedwa othi ngokuqinisekile “ungcono” kunomunye - ukukhetha okungcono kuncike ezidingweni zakho ngazinye nokuthi usabela kanjani emithini ngayinye.

I-Nefazodone ingase ithandwe uma ukhathazekile ngemiphumela emibi yezocansi, njengoba ivame ukubangela izinkinga ezimbalwa kule ndawo uma iqhathaniswa ne-trazodone. Ivame futhi ukubangela ukulala emini okuncane, okungasiza uma udinga ukuhlala uqaphile emini.

Nokho, i-trazodone ivame ukukhethwa ngaphezu kwe-nefazodone ngoba ayithwali ingozi efanayo yezinkinga zesibindi. I-Trazodone nayo ivame ukunqunywa ngezinkinga zokulala kanye nokucindezeleka, njengoba isebenza kahle ekuthuthukiseni ikhwalithi yokulala.

Udkt. wakho uzocabangela izinto ezinjengamaphethini akho okulala, amazinga amandla, izinkathazo zomsebenzi wobulili, kanye nomlando wakho wezokwelapha lapho ekhetha phakathi kwalawo makhambi. Kokubili kungasebenza ekwelapheni ukucindezeleka kanye nezifo zokukhathazeka.

Imibuzo Evame Ukubuzwa Mayelana ne-Nefazodone

Ingabe i-Nefazodone iphephile ezifweni zenhliziyo?

I-Nefazodone ingasetshenziswa kubantu abanezifo zenhliziyo, kodwa idinga ukuqashwa ngokucophelela. Umuthi ungabangela izinguquko emfutheleni wegazi kanye nesigqi senhliziyo, ikakhulukazi uma uqala ukuwuthatha noma uma umthamo wenyusiwe.

Uma unezifo zenhliziyo, udkt. wakho cishe uzoqala ngomthamo ophansi futhi akuqaphele eduze. Bangase futhi bayale i-electrocardiogram (EKG) ukuhlola isigqi senhliziyo yakho ngaphambi nangemva kokwelashwa. Abantu abaningi abanezifo zenhliziyo ezinzile bangathatha i-nefazodone ngokuphepha ngaphansi kokuqashwa okufanele kwezokwelapha.

Ngingenzani uma ngithatha i-Nefazodone eningi ngengozi?

Uma ngengozi uthatha i-nefazodone eningi, xhumana nokulawulwa kwezinto ezinobuthi noma funa ukunakekelwa kwezimo eziphuthumayo ngokushesha. Ukuthatha okuningi kungabangela izimpawu ezinzima ezihlanganisa ukozela okukhulu, isicanucanu, ukuhlanza, nezinkinga zesigqi senhliziyo.

Ungazami ukuzenza uhlanze noma ulinde ukubona ukuthi izimpawu ziyavela yini. Noma ngabe uzizwa kahle ekuqaleni, ukweqisa kungabangela imiphumela elibazisekile engaba yingozi. Gcina ibhodlela lomuthi nawe ukuze ochwepheshe bezokwelapha bakwazi ukubona kahle ukuthi uthathe ini nokuthi uthathe kangakanani.

Ngingenzani uma ngiphuthelwa umthamo we-Nefazodone?

Uma uphuthelwa umthamo we-nefazodone, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo. Esimweni esinjalo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho yokulinganisa ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgwaqeni ngeshejuli yakho yemithi.

Ngingayeka nini ukuthatha i-Nefazodone?

Kufanele uyeke ukuthatha i-nefazodone ngaphansi kwesiqondiso sikadokotela wakho kuphela. Ukuyeka kungazelelwe kungabangela izimpawu zokuhoxisa njengokugajuka, isicanucanu, ikhanda, kanye nezinguquko zemizwa ezingaba nzima kakhulu.

Udkt wakho ngokuvamile uzonciphisa umthamo wakho kancane kancane emasontweni amaningana lapho sekuyisikhathi sokuyeka umuthi. Le nqubo yokunciphisa isiza ukunciphisa izimpawu zokuhoxisa futhi inciphisa ingozi yokuthi ukucindezeleka kubuye. Noma ngabe uzizwa ungcono ngokuphelele, ungayeki wedwa - sebenzisana nomhlinzeki wakho wezempilo ukuze udale uhlelo lokuyeka oliphephile.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Nefazodone?

Kungcono ukugwema utshwala ngenkathi uthatha i-nefazodone, njengoba le nhlanganisela ingakhuphula ukozela futhi iphazamise ukuxhumana kwakho nokwahlulela kwakho. Utshwala bungaphazamisa nokusebenza komuthi futhi bungase lenze izimpawu zokucindezeleka zibe zimbi.

Uma ukhetha ukuphuza ngezikhathi ezithile, zilinganisele ezingxenyeni ezincane futhi ungaphuza noma nini lapho uzizwa imiphumela yomuthi. Njalo xoxa ngokusebenzisa utshwala nodokotela wakho, njengoba bengakunikeza iseluleko esiqondene nawe ngokusekelwe esimweni sakho esithile kanye nesimo sempilo.