Yini i-Nintedanib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Nintedanib iyimithi kadokotela esiza ukunciphisa ukulimala kwamaphaphu kubantu abanezifo ezithile zamaphaphu ezingathi sína. Yenzelwe ngqo ukuhlasela amaprotheni abangela ukwakheka kwezicubu ezinamanxeba ngokweqile emaphashini akho, inike umzimba wakho ithuba lokuphefumula kalula ngokuhamba kwesikhathi.

Le mithi imelela ukuqanjwa okubalulekile ekwelapheni izimo ezake zathathwa njengezingelapheki. Nakuba ingakwazi ukwelapha ukulimala kwamaphaphu, inganciphisa kakhulu ukuqhubeka kwayo futhi isize ukugcina izinga lakho lempilo.

Yini i-Nintedanib?

I-Nintedanib iyimithi yokwelapha eqondiwe eyingxenye yeqembu lemithi ebizwa ngokuthi ama-tyrosine kinase inhibitors. Cabanga ngayo njengethuluzi eliqondile elivimba amaprotheni athile abangela ukwakheka kwezicubu ezinamanxeba ngokweqile emaphashini akho.

Imithi iza ngesimo samaphilisi athambile futhi ithathwa ngomlomo kabili ngosuku. Yenzelwe ngqo abantu amaphaphu abo alinyazwa yizinqubo ezingavamile zokulimala ezenza ukuphefumula kube nzima ngokwengeziwe.

Ngokungafani nokwelashwa okudala okuphatha kuphela izimpawu, i-nintedanib empeleni ihlasela inqubo yesifo esiyisisekelo. Lokhu kuyenza ibe ukwelashwa okuguqula isifo kunokuba nje umkhululi wezimpawu.

Isetshenziselwani i-Nintedanib?

I-Nintedanib isetshenziswa ikakhulukazi ukwelapha i-idiopathic pulmonary fibrosis (IPF), isimo samaphaphu esibi lapho izicubu zamaphaphu ezinempilo zithathelwa indawo yizicubu ezinamanxeba. Iphinde ivunywe ezinye izinhlobo ezithile zezifo eziqhubekayo zokulimala kwamaphaphu.

I-IPF ithinta cishe abantu abayi-100,000 e-United States futhi ngokuvamile ithuthuka kubantu abaneminyaka engaphezu kwengama-50. Igama elithi

Udktela wakho angase futhi akunikeze i-nintedanib ye-systemic sclerosis-associated interstitial lung disease (SSc-ILD). Lokhu kwenzeka lapho isimo se-autoimmune esibizwa nge-scleroderma sithinta amaphaphu akho, okubangela izinkinga ezifanayo zokulimala.

Kwezinye izimo, odokotela bangase basebenzise i-nintedanib kwezinye izinhlobo ze-progressive pulmonary fibrosis lapho ukulimala kuqhubeka nokuba kubi ngaphandle kokwelashwa okunye. Kodwa-ke, lokhu kusetshenziswa kudinga ukuhlolwa ngokucophelela nguchwepheshe wamaphaphu.

Isebenza Kanjani I-Nintedanib?

I-Nintedanib isebenza ngokuvimba ama-receptors amathathu athile okukhula okushukumisa inqubo yokulimala emaphaphu akho. Lawa ma-receptors ngokuvamile asiza ekupholiseni, kodwa ku-pulmonary fibrosis, aba-overactive futhi adale inyama eningi yokulimala.

Umuthi uthathwa njengokwelashwa okuqinile okulinganiselwe okudinga ukuqapha ngokucophelela. Akuyona imithi emnene, kodwa ngokuvamile iyabekezeleleka kahle uma isetshenziswa ngaphansi kokuqondiswa okufanele kwezokwelapha.

Ngokuvimba lezi zimpawu ezingaphezu kwamandla, i-nintedanib isiza ukunciphisa izinga lapho inyama yamaphaphu enempilo ithathelwa indawo yinyama yokulimala. Lokhu kungasiza ukugcina ukusebenza kwamaphaphu akho kanye nekhono lokuphefumula isikhathi eside.

Umuthi futhi unayo eminye imiphumela elwa nokuvuvukala, engasiza ukunciphisa umonakalo oqhubekayo enyameni yamaphaphu akho. Kodwa-ke, amandla ayo ayinhloko asezindaweni zokumisa inqubo yokulimala kunokuguqula umonakalo okhona.

Kufanele Ngiyithathe Kanjani I-Nintedanib?

I-Nintedanib kufanele ithathwe ngendlela eqondile njengoba kunqunywe udokotela wakho, ngokuvamile i-150 mg kabili ngosuku, cishe amahora angu-12 ngaphandle. Ukuyithatha nokudla kubalulekile ngoba lokhu kunciphisa kakhulu ukuphazamiseka kwesisu futhi kusiza umzimba wakho ukuba umunce umuthi ngendlela efanele.

Gwinya amaphilisi wonke ngenkomishi yamanzi egcwele. Ungavuli, uchoboze, noma uhlafune amaphilisi, ngoba lokhu kungabangela ukucasuka emlonyeni nasemphinjeni wakho futhi kungase kuthinte indlela umuthi osebenza ngayo.

Ukuthatha i-nintedanib ngesidlo noma ukudla okukhulu kubalulekile ukuze uzizwe ukhululekile. Ukudla akudingeki kube kukhulu, kodwa ukuba nokuthile esiswini sakho kusiza ekuvikeleni isicanucanu nokucasuka kwamathumbu okuvame ukwenzeka ngalo muthi.

Zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo ohlelweni lwakho. Abantu abaningi bakuthola kuwusizo ukuthatha umthamo owodwa ngesidlo sasekuseni nomunye ngesidlo sakusihlwa.

Uma uhlangabezana nokucasuka okukhulu kwesisu, udokotela wakho angase anciphise umthamo wakho okwesikhashana noma ancome ukudla okuthile okusebenza kahle ngemithi. Ungalokothi ulungise umthamo wakho ngaphandle kwesiqondiso sezokwelapha.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Nintedanib?

I-Nintedanib ngokuvamile iyindlela yokwelapha yesikhathi eside okungenzeka ukuthi uzodinga ukuqhubeka nayo unomphela, inqobo nje uma isiza ekunciphiseni ukulimala kwamaphaphu akho futhi uyayibekezelela kahle. Abantu abaningi bayithatha iminyaka kungezinyanga.

Udokotela wakho uzoqapha inqubekela phambili yakho ngokusebenzisa izivivinyo ezijwayelekile zomsebenzi wamaphaphu, ukuskena kwesifuba, nomsebenzi wegazi. Lokhu kusiza ukunquma ukuthi ngabe imithi iyasebenza ngempumelelo nokuthi ngabe kuphephile ukuthi uqhubeke.

Umgomo uwukunciphisa ukuqhubeka kokulimala kwamaphaphu isikhathi eside ngangokunokwenzeka. Ukuyeka imithi ngokuvamile kuvumela inqubo yokulimala ukuthi iqale kabusha ngejubane layo langaphambilini, yingakho ukwelashwa okuqhubekayo kuvame ukunconywa.

Abanye abantu bangase badinge ukuphumula emithini uma beba nemiphumela emibi edinga isikhathi sokuthi ilulame. Udokotela wakho uzosebenza nawe ukuthola ibhalansi efanele phakathi kokusebenza kahle nokubekezeleleka.

Yiziphi Imiphumela Emibi Ye-Nintedanib?

Njengayo yonke imithi, i-nintedanib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu iyalawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi.

Ake siqale ngemiphumela emibi okungenzeka ukuthi uzohlangabezana nayo, ethinta abantu abaningi abathatha le mithi:

• Ukuqunjelwa (kuthinta cishe u-60% wabantu) - ngokuvamile kulula kuya kokulingene futhi kulawuleka ngokulungiswa kokudla
• Ukucanuzela kwenhliziyo nokuphatheka kabi kwesisu - ukuthatha imithi nokudla kusiza kakhulu
• Ukuncipha kwesifiso sokudla nokuncipha kwesisindo - udokotela wakho uzokugada lokhu ngokucophelela
• Ubuhlungu besisu noma ukuqaqamba - ngokuvamile kuthuthuka ngokuhamba kwesikhathi nangokudla okufanele
• Ukuphalaza - akuvamile njengokucanuzela kwenhliziyo kodwa kungenzeka, ikakhulukazi emasontweni ambalwa okuqala

Le miphumela esecansini yokugaya ukudla iyizikhalazo ezivame kakhulu, kodwa ngokuvamile iba lula ukulawuleka njengoba umzimba wakho ujwayela imithi.

Abanye abantu bahlangabezana nemiphumela engavamile kodwa esabalulekile engadinga ukuqashwa:

• Ama-enzyme esibindi andisiwe - atholwa ngezivivinyo zegazi, ngokuvamile ngaphandle kwezimpawu
• Ukukhathala noma ukudinwa - kungahlobana nemithi noma isimo sakho esingaphansi kwamaphaphu
• Ukucindezeleka kwekhanda - ngokuvamile kulula futhi kuphendula izidambisi zokucindezeleka ezingaphezu kwe-counter
• Isiyezi - sivame kakhulu lapho uqala imithi noma ukhuphula umthamo
• Ukuqubuka kwesikhumba noma ukuluma - ngokuvamile kulula kodwa kufanele kubikwe kudokotela wakho

Udokotela wakho uzohlola ukusebenza kwesibindi sakho njalo ngoba i-nintedanib ingathinta ama-enzyme esibindi kwabanye abantu.

Manje, ake sixoxe ngemiphumela engavamile kodwa ebucayi kakhulu edinga ukunakekelwa kwezempilo ngokushesha:

• Izinkinga ezinkulu zesibindi - izimpawu zihlanganisa ukuphuzi kwesikhumba noma amehlo, umchamo omnyama, noma ubuhlungu obukhulu besisu
• Izinkinga zenhliziyo - ubuhlungu besifuba, ukushaya kwenhliziyo okungajwayelekile, noma ukuphefumula okungavamile
• Izinkinga zokujiya kwegazi - ukuphuma kwegazi okungavamile noma ukulimala, ikakhulukazi uma kubi kakhulu
• Izinkinga ezinzima zamaphaphu - ukukhwehlela okusha noma okubi kakhulu, umkhuhlane, noma ubunzima bokuphefumula
• Ukuphendula kwesikhumba okukhulu - ukuqubuka okusabalale, ukuqhekeka, noma ukukhipha isikhumba

Le miphumela emibi ayivamile, kodwa kubalulekile ukuyiqaphela futhi ufune ukunakekelwa kwezempilo ngokushesha uma kwenzeka.

Obani okungafanele bathathe i-Nintedanib?

I-Nintedanib ayilungele wonke umuntu, futhi udokotela wakho uzoqapha ngokucophelela ukuthi iphephile yini kuwe ngokusekelwe emlandweni wakho wezokwelapha kanye nesimo sempilo yakho yamanje.

Akufanele uthathe i-nintedanib uma unenkinga yokungezwani nayo, i-soy, noma amantongomane, ngoba amaphilisi aqukethe i-soy lecithin. Abantu abanokuzwela okwaziwayo kunoma iyiphi ingxenye yomuthi kufanele bawugweme ngokuphelele.

Izimo eziningana zezokwelapha zenza i-nintedanib ibe yingozi noma idinga izinyathelo zokuphepha ezikhethekile:

• Isifo sesibindi esibi noma izinkinga zesibindi ezisebenzayo - umuthi ungenza ukusebenza kwesibindi kube kubi
• Ukuqina kwenhliziyo kwakamuva noma isifo senhliziyo esingazinzile - i-nintedanib ingathinta isigqi senhliziyo
• Izifo zokuphuma igazi ezisebenzayo - umuthi ungandisa ingozi yokuphuma igazi
• Isifo sezinso esibi - izinso zakho zisiza ukucubungula umuthi
• Ukuhlinzwa okukhulu kwakamuva - ingozi eyengeziwe yokuphuma igazi ngesikhathi sokuphola

Ukukhulelwa nokuncelisa yizinto ezingavumelekile ngokuphelele, njengoba i-nintedanib ingalimaza izingane ezisakhula futhi ingadlulela obisini lwebele.

Abanye abantu badinga ukuqapha okwengeziwe kodwa bangase bakwazi ukuthatha i-nintedanib ngokulungiswa:

• Izinkinga zesibindi ezilula kuya kweziphakathi - idinga ukulungiswa komthamo nokuqapha njalo
• Umlando wezinkinga zenhliziyo - idinga ukuhlolwa kwenhliziyo nokuqapha okuqhubekayo
• Ukuthatha ama-blood thinners - idinga ukuxhumana ngokucophelela nodokotela wakho
• Abantu abadala - bangase badinge imithamo ephansi ngenxa yokwanda kokuzwela
• Abantu abanezilonda zesisu - ingozi enkulu yezinkinga zokugaya ukudla

Udokotela wakho uzoqaphela izinzuzo ngokumelene nezingozi zesimo sakho esithile futhi angase ancome ezinye izindlela zokwelapha uma i-nintedanib ingakulungele.

Amagama e-Brand ye-Nintedanib

I-Nintedanib itholakala ngaphansi kwegama lomkhiqizo elithi Ofev emazweni amaningi, okuhlanganisa ne-United States. Leli yigama lomkhiqizo elaziwa kakhulu lomuthi.

Kwezinye izifunda, ungahlangana ne-nintedanib ngaphansi kwamagama ahlukene omkhiqizo, kodwa i-Ofev isahlala ingumkhiqizo oyinhloko osetshenziswa abahlinzeki bezempilo abaningi kanye namakhemisi.

Umuthi ukhiqizwa yi-Boehringer Ingelheim, inkampani yezemithi ekhethekile emithini yokuphefumula. Izinhlobo ze-nintedanib ezivamile azitholakali kakhulu ezimakethe eziningi.

Uma ukhuluma ngemithi yakho nabahlinzeki bezempilo noma osokhemisi, ungabhekisa kuyo ngegama layo elivamile (nintedanib) noma igama lomkhiqizo (Ofev). Womabili la magama abhekisela emuthini ofanayo.

Ezinye izindlela ze-Nintedanib

Uma i-nintedanib ingakulungele noma ingasebenzi kahle, kukhona ezinye izindlela zokwelapha i-pulmonary fibrosis. Udokotela wakho uzosiza ekunqumeni inketho engcono kakhulu ngokusekelwe esimweni sakho esithile kanye nomlando wezokwelapha.

I-Pirfenidone (igama lomkhiqizo i-Esbriet) ngomunye umuthi ovunyelwe yi-FDA we-idiopathic pulmonary fibrosis. Isebenza ngendlela ehlukile kune-nintedanib ngokunciphisa ukuvuvukala nokunciphisa ukwakheka kwezicubu ezinamanxeba ngezindlela ezihlukene.

Kwabanye abantu, ukwelashwa kwendabuko kungase kusafanele:

• Ama-Corticosteroids - asiza ukunciphisa ukuvuvukala kodwa anokusebenza okulinganiselwe kwe-IPF
• Imithi yokucindezela amasosha omzimba - ingasetshenziswa ezinhlotsheni ezithile ze-pulmonary fibrosis
• I-Oxygen therapy - isiza ngezimpawu zokuphefumula kodwa ayisheshisi ukuqhubeka kwesifo
• Ukuvuselelwa kwamaphaphu - izinhlelo zokuzivocavoca nokuphefumula ukugcina umsebenzi

Ezimweni ezithuthukile, ukufakelwa kwamaphaphu kungase kucatshangelwe ezigulini ezifanele ezingasabeli emithini.

Abanye abantu bayazuza ezindleleni zokuhlanganisa, njengokusebenzisa imithi kanye ne-oxygen therapy kanye nokuvuselelwa kwamaphaphu. Uchwepheshe wakho wamaphaphu uzokwenza uhlelo lokwelapha olubanzi olwenzelwe izidingo zakho.

Ingabe i-Nintedanib ingcono kune-Pirfenidone?

Kokubili i-nintedanib ne-pirfenidone ziyizindlela zokwelapha eziphumelelayo ze-idiopathic pulmonary fibrosis, kodwa zisebenza ngezindlela ezihlukene futhi zinezinhlobo ezihlukene zemiphumela emibi. Akukho noyedwa othi ngokuqinisekile "ungcono" kunomunye kuzo zonke iziguli.

Ucwaningo lubonisa ukuthi womabili amakhambi anganciphisa ukwehla komsebenzi wamaphaphu ngamanani afanayo. Ukukhetha phakathi kwawo kuvame ukuncika emiphumeleni emibi ongase ukwazi ukuyibekezelela kanye nezimo zakho zezokwelapha.

I-Nintedanib ivame ukubangela imiphumela emibi eminingi yokugaya ukudla njengokuhuda nesicanucanu, kanti i-pirfenidone ivame ukubangela ukuzwela kwesikhumba elangeni nokungahambi kahle kwesisu. Abanye abantu bayibekezelela kangcono enye kunomunye.

Udokotela wakho uzocabangela izici eziningana lapho ekhetha phakathi kwala makhambi, okuhlanganisa ezinye izimo zakho zempilo, imithi yamanje, nezici zokuphila. Ukukhetha "okungcono" yilokho okusebenza kahle esimweni sakho esithile.

Kwezinye izimo, odokotela bangase bazame ikhambi elilodwa kuqala bese beshintshela kolunye uma ukukhetha kokuqala kungabekezeleleki kahle noma kungabonakali kusebenza ngempumelelo.

Imibuzo Evame Ukubuzwa Mayelana ne-Nintedanib

Q1. Ingabe i-Nintedanib iphephile kubantu abanezifo zenhliziyo?

I-Nintedanib ingasetshenziswa kubantu abanezifo zenhliziyo ezinzile, kodwa idinga ukuqapha ngokucophelela ngudokotela wakho. Umuthi ungase ukwazi ukuthinta ukushaya kwenhliziyo futhi wandise ingozi yemiphumela emibi ehlobene nenhliziyo.

Uma unomlando wezinkinga zenhliziyo, udokotela wakho cishe uzofuna ukwenza izivivinyo zomsebenzi wenhliziyo ngaphambi kokuqala i-nintedanib futhi akuqaphele eduze ngesikhathi sokwelashwa. Abantu abanezifo zenhliziyo zakamuva noma izimo zenhliziyo ezingazinzile bangase badinge ukugwema lo muthi.

Udokotela wakho wenhliziyo kanye nochwepheshe wamaphaphu bazosebenzisana ukuze banqume ukuthi i-nintedanib iphephile yini kuwe nokuthi yikuphi ukuqapha okudingekayo ukuze uyisebenzise ngokuphepha.

Q2. Kufanele ngenzeni uma ngiphuzile i-Nintedanib eningi ngengozi?

Uma ngabe uthatha i-nintedanib eningi kunaleyo oyinikiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini, ngoba isenzo esisheshayo sibalulekile ekuphepheni kwakho.

Ukuthatha i-nintedanib eningi kungakhuphula ingozi yakho yemiphumela emibi, ikakhulukazi izinkinga zesibindi kanye nezinkinga zokuphuma kwegazi. Noma ngabe uzizwa kahle, ukuhlolwa kwezokwelapha kuyadingeka ukuqinisekisa ukuthi akukho kulimala okwenzekile.

Letha ibhodlela lomuthi nawe egumbini lezimo eziphuthumayo noma ulibeke ngokushesha uma ucela usizo. Lolu lwazi lusiza ochwepheshe bezokwelapha ukuthi banqume ukuthi yini okufanele yenziwe.

Q3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Nintedanib?

Uma uphuthelwa umthamo we-nintedanib, yithathe ngokushesha lapho ukhumbula, uma nje kungakapheli amahora ambalwa ngesikhathi sakho esihleliwe. Kodwa-ke, uma sekuseduze isikhathi somthamo wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngasikhathi sinye ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Kungcono ukweqa umthamo owodwa kunokuphinda kabili.

Uma uvame ukukhohlwa imithamo, cabangela ukusebenzisa umhleli wamaphilisi noma ukusetha izikhumbuzi zocingo. Ukuthatha imithamo ngokuqhubekayo kusiza ukugcina amazinga aqhubekayo omuthi ohlelweni lwakho ukuze usebenze kahle.

Q4. Ngingayeka nini ukuthatha i-Nintedanib?

Kufanele uyeke kuphela ukuthatha i-nintedanib ngaphansi kwesiqondiso sikadokotela wakho. Lokhu ngokuvamile kuyindlela yokwelapha yesikhathi eside, futhi ukuyeka ngokuvamile kuvumela inqubo yokulimala kwamaphaphu ukuthi iqhubeke ngejubane layo langaphambilini.

Udokotela wakho angase ancome ukuyeka i-nintedanib uma uba nemiphumela emibi engathuthuki ngokulungiswa komthamo, uma ukusebenza kwamaphaphu akho kuqhubeka ukwehla ngaphandle kokwelashwa, noma uma ungasakwazi ukubekezelela umuthi.

Ngesinye isikhathi, ukuphumula okwesikhashana emuthini kuyadingeka ukuze kulawulwe imiphumela emibi, kodwa abantu abaningi baqhubeka nokwelashwa uma izinkinga sezixazululiwe. Hlala uxoxa ngezinkathazo zakho nethimba lakho lezempilo ngaphambi kokwenza izinguquko kunoma yiluphi uhlelo lwakho lokwelashwa.

Q5. Ngingawuthatha i-Nintedanib neminye imithi?

I-Nintedanib ingasebenzisana neminye imithi eminingi, ngakho-ke kubalulekile ukutshela udokotela wakho ngayo yonke imithi kadokotela, imithi etholakala ngaphandle kwemvume kadokotela, kanye nezithasiselo ozithathayo. Ezinye izinhlanganisela zingaba yingozi noma zinciphise ukusebenza kahle kokwelashwa kwakho.

Izinciphisi zegazi ezinjenge-warfarin zidinga ukunakwa okukhethekile ngoba i-nintedanib ingakhuphula ingozi yokopha. Udokotela wakho uzodinga ukuqapha ukujiya kwegazi lakho eduze uma uthatha le mithi yomibili.

Ezinye izibulala-magciwane, imithi elwa nesikhunta, kanye nemithi yokulwa nokuthuthumela ingathinta indlela umzimba wakho oucubungula ngayo i-nintedanib. Udokotela wakho angase adinge ukulungisa imithamo noma akhethe eminye imithi ukuze agweme ukusebenzisana okuyingozi.