Ofatumumab (indlela ye-intravenous, indlela ye-subcutaneous)
Imikhiqizo etholakalayo
Arzerra, Kesimpta
Mayelana naleli khambi
Isikhubekiso se-Ofatumumab sisetshenziswa ndawonye ne-chlorambucil ukuze kuphathwe uhlobo lwe-kansa yamaseli egazi amhlophe ebizwa ngokuthi yi-chronic lymphocytic leukemia (CLL) kubantu abangakaze baphathwe. Kusetshenziswa futhi ndawonye ne-fludarabine ne-cyclophosphamide ukuze kuphathwe abantu abane-CLL ebuyile. Lolukhuni luphinde lusetshenziswe kubantu abane-CLL abake baphathwa ngeminye imithi (isib. i-alemtuzumab, i-fludarabine) engasebenzi kahle. Isikhubekiso se-Ofatumumab sisetshenziswa futhi ukuze kuphathwe izimo ezivuselela ze-multiple sclerosis (MS), kufaka phakathi i-clinically isolated syndrome, isifo esiphindaphindayo, nesifo esiphambili esisebenzayo. Lolukhuni ngeke luphilise i-MS, kodwa lungathintele ezinye zeziphumo ezingasebenzi kahle futhi lunciphise inani lokuphindaphinda kwesifo. I-Ofatumumab iphazamisa ukukhula kwamaseli ekansa, aqedwa ekugcineni umzimba. Njengoba ukukhula kwamaseli omzimba ajwayelekile kungase kuthonyeke yi-ofatumumab, ezinye iziphumo ezingafuneki nazo ziyoba khona. Ezinye zalezi zingaba nzima futhi kufanele zibikwe kudokotela wakho. Ezinye iziphumo ezingafuneki, njengokuqhuma kwesikhumba, zingase zingabi nzima kodwa zingase zikhathaze. Ezinye zeziphumo ezingafuneki aziveli kuze kube ngeminyaka noma ngeminyaka eminingi ngemuva kokusetshenziswa kwemithi. Ngaphambi kokuba uqale ukwelashwa nge-ofatumumab, wena nodokotela wakho kufanele nixoxe ngezinzuzo le mithi izokwenza kanye nezingozi zokuyisebenzisa. I-Arzerra® kufanele inikezwe kuphela yi-dokota wakho noma ngaphansi kokunakekelwa kwakhe okuqondile. I-Kesimpta® itholakala kuphela ngesikripthi sodokotela wakho. Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekwahluleni kokusebenzisa imithi, kufanele kuqhathaniswe ingozi yokusebenzisa imithi nezinzuzo ezizoletha. Lo ngumqulu ozowenza wena nodokotela wakho. Kulo muthi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqakathekile noma oluhambisana nokwaleka kulo muthi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokwaleka, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubuhlobo bobudala nemiphumela yokubeka i-ofatumumab kubantwana. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingakhawulela ukusetshenziswa kwe-ofatumumab injection kubantu abadala. Noma kunjalo, abantu abadala banesilinganiso esikhulu sokuba nemiphumela emibi engathandeki (isib. neutropenia, pneumonia) engadinga ukuqapha. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokusebenzisa le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthatha le mithi, kubalulekile ngokukhethekile ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlwini elingezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi noma ashintshe ezinye izidakamizwa ozithathayo. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile ayinconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili izidakamizwa. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Umshwalela noma omunye ochwepheshe bezempilo oqeqeshwe uzohlinzeka ngale miyekezo esikhungweni sezempilo. Inikezwa nge-IV catheter ebekwe kwenye yezinzwa zakho noma njengokuqhuma phansi kwesikhumba sakho, ngokuvamile phambi kwamaphaphu akho, isisu, noma izingalo eziphezulu. I-Arzerra® kufanele inikezwe kancane, ngakho-ke i-IV izohlala ibekwe okungenani ihora elilodwa. Ungase futhi uthole imithi ezosiza ukuvimbela ukusabela okungafani. Lolu lwemiyekezo luza ne-Medication Guide nemiyalo yokuqondisa. Funda bese ulandela imiyalo ngokucophelela. Buza udokotela wakho uma unemibuzo. I-Kesimpta®ngezinye izikhathi inganikezwa ekhaya kubantu abangadingi ukuba esibhedlela noma ekliniki. Uma usebenzisa le miyekezo ekhaya, udokotela wakho noma umsana uzoqeqesha indlela yokulungiselela nokugcoba umuthi. Qiniseka ukuthi uyayiqonda indlela yokusebenzisa umuthi. Uma usebenzisa le miyekezo ekhaya, uzoqondiswa izindawo zomzimba lapho leli qhuma linganikezwa khona. Sebenzisa indawo ehlukile yomzimba njalo lapho uzinikeza noma ingane yakho i-shot. Gcina uqapha ukuthi unikeza kuphi i-shot ngayinye ukuqinisekisa ukuthi uqala izindawo zomzimba. Lokhu kuzosiza ukuvimbela izinkinga zesikhumba. Ukusebenzisa i-syringe noma ipeni eliqediwe: Inani lale miyekezo lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalelo elebhelini. Ulwazi olulandelayo luhlanganisa kuphela amanani aphakathi ale miyekezo. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukwenza kanjalo. Inani lomuthi owuthatha lixhomeke emandleni womuthi. Futhi, inani lezingxenye ozithatha nsuku zonke, isikhathi esivunyelwe phakathi kwezingxenye, nobude besikhathi othatha umuthi kuya ngenkinga yezokwelapha oyisebenzisela umuthi. Lolu lwemiyekezo kufanele lunikezwe ngesikhathi esibekiwe. Uma uphuthelwa yingxenye, shayela udokotela wakho, umhlinzeki wezempilo ekhaya, noma ikliniki yokwelashwa ukuze uthole imiyalo. Gcina ungafinyeleleki ezinganeni. Ungagcini umuthi osele uphelile noma umuthi ongafuni. Buza ochwepheshe bezempilo bakho ukuthi kufanele uphule kanjani noma yimiphi imithi ongayisebenzisi. Gcina esihlalweni. Ungayiganduki. Gcina umuthi ebhokisini lawo lokuqala ukuze umvikele ekukhanyeni. Ungagcina le miyekezo ekamelweni okushisa okulinganiselwe kuze kube izinsuku eziyi-7. Uma igcinwe ekamelweni okushisa okulinganiselwe, ungabuyisela umuthi ongagcinwanga esihlalweni bese uwusebenzisa phakathi kwezinsuku eziyi-7. Lahla umuthi uma ungasetshenziswanga phakathi nalezo zinsuku eziyi-7. Lahla amapeni nama-syringe asebenziwe ebhodweni eliqinile, evaliwe lapho izimpumputhe zingakwazi ukugqobhoza khona. Gcina leli bhodwe kude nezingane nezilwane ezifuywayo.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.