Yini i-Olanzapine-and-Samidorphan: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Olanzapine-and-samidorphan iyinhlanganisela yemithi esiza ukwelapha i-schizophrenia kanye ne-bipolar disorder ngenkathi inciphisa ukukhuluphala okujwayelekile okuhambisana ne-olanzapine yodwa. Le nhlanganisela entsha ihlanganisa izinzuzo eziqinisekisiwe zempilo yengqondo ze-olanzapine ne-samidorphan, esiza ukulwa nokuthambekela kwe-olanzapine ekubangeni ukukhuluphala okukhulu.

Ungase wazi lo muthi ngegama lawo lomkhiqizo elithi Lybalvi, elathuthukiswa ngqo ukubhekana nomunye wemiphumela eceleni eyinselele kakhulu yokwelashwa okujwayelekile kwe-antipsychotic. Le nhlanganisela inikeza ithemba kubantu abadinga imithi esebenzayo yezifo zengqondo kodwa abafuna ukunciphisa izinguquko ezingafuneki zesisindo.

Yini i-Olanzapine-and-Samidorphan?

I-Olanzapine-and-samidorphan iyimithi kadokotela ehlanganisa izithako ezimbili ezisebenzayo epilini elilodwa. I-Olanzapine ingeyodwa yeqembu lemithi ebizwa ngokuthi ama-antipsychotics angajwayelekile, kuyilapho i-samidorphan iyi-opioid receptor antagonist esiza ukunciphisa ukukhuluphala.

Le nhlanganisela isebenza ngokuvumela i-olanzapine ukuthi yenze umsebenzi wayo wokuzinzisa amakhemikhali obuchopho ngenkathi i-samidorphan ivimba ama-receptors athile anegalelo ekwandeni kwesifiso sokudla nokukhuluphala. Le nhlanganisela imelela intuthuko enkulu emithini yezifo zengqondo, ibhekana kokubili nezimpawu zempilo yengqondo kanye nezinkinga zekhwalithi yempilo.

Udokotela wakho angase acabangele le nhlanganisela uma ube nemiphumela emihle nge-olanzapine kodwa ube nenkinga yokukhuluphala, noma uma uqala ukwelashwa futhi ufuna ukunciphisa lo mphumela othile eceleni kusukela ekuqaleni.

Isetshenziselwani i-Olanzapine-and-Samidorphan?

Le nhlanganisela yemithi iphatha izimo ezimbili eziyinhloko zempilo yengqondo: i-schizophrenia kanye ne-bipolar I disorder. Nge-schizophrenia, isiza ukuphatha izimpawu ezinjengokucabanga ngamanga, ukukhohlisa, nokucabanga okungahlelekile okungathinta kakhulu impilo yakho yansuku zonke.

Ngesifo se-bipolar I, imithi isiza ukuzinzisa izigameko zemizwa, ikakhulukazi izigameko ze-manic noma ezixubile ezingabandakanya imizwa ephakeme, amandla andisiwe, kanye nokwahlulela okungahambisani kahle. Ingasetshenziswa yodwa noma kanye nezinye izinzisi zemizwa, kuye ngezidingo zakho ezithile.

Umhlinzeki wakho wezempilo uzoqaphela ukuthi le nhlanganisela ilungele wena yini ngokusekelwe ekuxilongweni kwakho, izimpendulo zokwelashwa zangaphambilini, kanye nezici zezempilo zomuntu ngamunye. Umgomo uhlala ukuthola ukwelashwa okuphumelela kakhulu ngemiphumela emibi embalwa.

Isebenza Kanjani I-Olanzapine-and-Samidorphan?

Le nhlanganisela isebenza ngezindlela ezimbili ezihlukene ebuchosheni bakho nasemzimbeni wakho. I-Olanzapine ivimba ama-receptor athile e-neurotransmitter, ikakhulukazi ama-receptor e-dopamine kanye ne-serotonin, okusiza ukuzinzisa ukungalingani kwamakhemikhali okuhambisana nezimo zengqondo.

Ngesikhathi esifanayo, i-samidorphan ivimba ama-receptor e-opioid ukuthi i-olanzapine ingawaqala, okuvame ukuholela ekwandeni kwesifiso sokudla nokuzuza isisindo. Cabanga nge-samidorphan njengesihlangu esivikelayo esivimbela eminye yemiphumela engathandeki ye-olanzapine ngenkathi ivumela izinzuzo zayo zokwelapha ukuthi ziqhubeke.

Le mithi ithathwa njengeqinile ngokulinganisela esigabeni se-antipsychotic. Isebenza ngempumelelo ekuphatheni izimpawu ezingathi sína zempilo yengqondo ngenkathi inikeza ukuphathwa okungcono kwesisindo kune-olanzapine yodwa, nakuba isadinga ukuqapha ngokucophelela kanye nokulandela njalo nomhlinzeki wakho wezempilo.

Kufanele Ngiyithathe Kanjani I-Olanzapine-and-Samidorphan?

Thatha le mithi njengoba kunqunywe ngudokotela wakho, ngokuvamile kanye ngosuku ngaphandle kokudla noma ngaphandle kokudla. Ungayithatha ngamanzi, ubisi, noma ijusi - noma yini ozizwa ukhululekile ngayo.

Akukho sidingo esithile sokudla ngaphambi noma ngemuva kokuthatha imithi, nakuba ukuyithatha nokudla kungasiza ukunciphisa noma yikuphi ukuphathwa kwesisu. Abanye abantu bakuthola kuwusizo ukuyithatha ngesikhathi esifanayo nsuku zonke ukuze bagcine amazinga aqhubekayo ohlelweni lwabo.

Uma ushintsha usuka ku-olanzapine ejwayelekile uya kulolu hlobo lokwelapha, udokotela wakho uzokuqondisa ngokucophelela ngesikhathi sokushintsha. Ungayeki ukuthatha lo muthi kungazelelwe, ngoba lokhu kungaholela ezimpawini zokuhoxisa noma ukubuyela emuva kwezimpawu zakho zengqondo.

Gwinya ithebhulethi yonke ngaphandle kokuyichoboza, ukuyihlafuna, noma ukuyiqhekeza. Umuthi wenziwe ukuthi ukhululwe kahle uma uthathwa ungashintshiwe, ngakho ukuguqula ithebhulethi kungathinta ukuthi isebenza kahle kangakanani.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Olanzapine-and-Samidorphan?

Ubude bokwelashwa buhlukahluka kakhulu kumuntu nomuntu futhi buxhomeke esimweni sakho esithile kanye nokuphendula kwakho emuthini. Abantu abaningi abane-schizophrenia noma i-bipolar disorder badinga ukwelashwa kwesikhathi eside ukuze bagcine ukuzinza futhi bavimbele ukuphindeka kwezimpawu.

Udokotela wakho uzohlola njalo ukuthi umuthi usebenza kahle kangakanani kuwe nokuthi ngabe uhlangabezana nemiphumela emibi ekhathazayo. Lokhu kuhlolwa kusiza ukunquma ukuthi kufanele uqhubeke yini, ulungise umthamo, noma ucabange ezinye izindlela zokwelapha.

Kwabanye abantu, ukwelashwa kungaqhubeka izinyanga noma iminyaka, kanti abanye bangase badinge ukulungiswa ngokushesha. Okubalulekile ukugcina ukuxhumana okuvulekile nomhlinzeki wakho wezempilo mayelana nokuthi uzizwa kanjani ngokwengqondo nangokomzimba.

Ungalokothi unqume ukuyeka lo muthi ngokwakho, ngisho noma uzizwa ungcono. Ukuyeka kungazelelwe kungaholela ezimpawini ezimbi zokuhoxisa kanye nokubuyela emuva kwezimpawu zengqondo ezingase zibe nzima ukuzelapha.

Yiziphi Imiphumela Emibi Ye-Olanzapine-and-Samidorphan?

Njengayo yonke imithi, i-olanzapine-and-samidorphan ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda okulindelekile kungakusiza ukuthi uzizwe ulungiselelwe kangcono futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela evame kakhulu ongase uhlangabezane nayo ihlanganisa ukozela, isiyezi, nomlomo owomile. Lokhu kuvame ukuthuthuka njengoba umzimba wakho ujwayela umuthi, ngokuvamile emasontweni ambalwa okuqala okwelashwa.

Imiphumela Evamile

Nansi imiphumela emibi eyenzeka kaningi, ethinta abantu abaningi abathatha lo muthi:

• Ukozela noma ukuzola, ikakhulukazi uma uqala ukuwuthatha
• Isiyezi noma ukuzwa ukukhanya ekhanda, ikakhulukazi uma usukuma
• Umlomo owomile ongase uthuthuke ngokuhamba kwesikhathi
• Ukuqunjelwa okungalawulwa ngezinguquko ekudleni
• Ukukhuphuka kwesifiso sokudla, nakuba ngokuvamile kungabi ngaphezu kwalokho okutholakala nge-olanzapine yodwa
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Ikhanda elivame ukunyama njengoba umzimba wakho ujwayela

Le miphumela emibi ngokuvamile iyalawuleka futhi ivame ukuba ngaphansi kokuphazamisa njengoba umzimba wakho ujwayela umuthi. Umhlinzeki wakho wezempilo angahlinzeka ngamasu okusiza ukunciphisa umthelela wawo empilweni yakho yansuku zonke.

Imiphumela Emibi Engavamile Kodwa Ebucayi

Nakuba ingavamile, eminye imiphumela emibi idinga ukunakekelwa kwezokwelapha ngokushesha ngoba ingaba yingozi kakhulu:

• Ukukhuluphala okukhulu naphezu kwemiphumela evikelayo ye-samidorphan
• Amazinga kashukela egazi aphezulu noma izimpawu zesifo sikashukela
• Ukuhamba kwemisipha okungajwayelekile noma ukuqina
• Ukungezwani komzimba okukhulu okunezinduna, ukuvuvukala, noma ubunzima bokuphefumula
• Ushintsho lwesigqi senhliziyo noma ubuhlungu besifuba
• Isiyezi esikhulu noma ukuquleka
• Izimpawu zokutheleleka njengomkhuhlane noma umphimbo obuhlungu oqhubekayo

Uma uhlangabezana nanoma yiziphi zalezi zimpawu, xhumana nomhlinzeki wakho wezempilo ngokushesha. Ukubona ngokushesha nokwelashwa kwemiphumela emibi engathi sína kungavimbela izinkinga futhi kuqinisekise ukuphepha kwakho.

Imiphumela Emibi Engavamile Kodwa Ebucayi

Le miphumela emibi ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha uma kwenzeka:

• I-Neuroleptic malignant syndrome (umkhuhlane ophezulu, ukuqina kwemisipha, ukudideka)
• I-Tardive dyskinesia (ukuhamba kwemisipha okungahleliwe, ikakhulukazi ebusweni)
• Ukwehla okukhulu kwenani lamangqamuzana amhlophe egazi
• Ukushaywa yisithuthwane, ikakhulukazi kubantu abangenayo umlando wokuphazamiseka kokushaywa yisithuthwane
• Izinkinga ezinkulu zesibindi ezinokuphuzi kwesikhumba noma amehlo
• Amaqhubu egazi noma izinkinga zokujikeleza kwegazi

Ngenkathi le miphumela emibi ingavamile, ukuyazi kukusiza ukuthi uhlale uqaphile futhi ufune usizo ngokushesha uma kudingeka. Udokotela wakho uzokuhlola njalo ukuze abambe noma yiziphi izinkinga ezingaba khona ekuqaleni.

Ubani Ongafanele Athatha I-Olanzapine-and-Samidorphan?

Lo muthi awulungelwe wonke umuntu, futhi izimo ezithile zezempilo noma izimo zenza kube yingozi. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela le nhlanganisela.

Abantu abanezifo zesibindi ezinzima akufanele bathathe lo muthi ngoba zombili izingxenye zicutshungulwa yisibindi. Ngokufanayo, uma wazi ukuthi unokungezwani komzimba ne-olanzapine, i-samidorphan, noma yiziphi izithako ezingasebenziwe kuthebhulethi, kufanele ugweme lo muthi.

Uma njengamanje uthatha imithi ye-opioid yokulawula ubuhlungu, le nhlanganisela kungenzeka ingafaneleki ngoba i-samidorphan ingavimba imiphumela ye-opioids. Udokotela wakho uzodinga ukucabangela ngokucophelela ezinye izindlela zokwelapha kulesi simo.

Abesifazane abakhulelwe noma abancelisa ibele badinga ukucatshangelwa okukhethekile, njengoba ukuphepha kwale nhlanganisela ngesikhathi sokukhulelwa nokuncelisa akusungulwanga ngokugcwele. Umhlinzeki wakho wezempilo uzokala izinzuzo ngokumelene nezingozi ezingaba khona uma uhlela ukukhulelwa noma usuvele ukhulelwe.

Igama Lomkhiqizo Le-Olanzapine-and-Samidorphan

Igama lomkhiqizo lalo muthi ohlanganisiwe yi-Lybalvi, ekhiqizwa yi-Alkermes. Okwamanje lena yiyo yodwa inhlanganisela ye-olanzapine ne-samidorphan etholakala ngokuthengisa e-United States.

I-Lybalvi iza ngamandla amaningi amaphilisi ukuvumela ukulinganiswa komuntu ngamunye ngokusekelwe ezidingweni zakho ezithile nokuphendula ekwelashweni. Udokotela wakho uzoqoka amandla afanele futhi angawashintsha ngokuhamba kwesikhathi.

Lapho ukhuluma ngalo muthi nomhlinzeki wakho wezempilo noma usokhemisi, ungaqoka kuwo ngegama lawo elivamile (olanzapine-and-samidorphan) noma igama lawo lomkhiqizo (Lybalvi). Zombili lezi zisho zibhekisela emuthini ofanayo.

Ezinye Izindlela Zokwelapha I-Olanzapine-and-Samidorphan

Imithi eminingi ehlukile ingelapha i-schizophrenia kanye nesifo se-bipolar uma le nhlanganisela ingakulungele. Ezinye izidakamizwa ezingavamile ze-antipsychotics zihlanganisa i-risperidone, i-quetiapine, i-aripiprazole, ne-ziprasidone, ngalinye linohlu lwalo lwezinzuzo nemiphumela emibi.

Kubantu abakhathazeke kakhulu ngokuzuza isisindo, i-aripiprazole noma i-ziprasidone kungaba ezinye izindlela ezinhle, njengoba ngokuvamile zibangela ukuzuza isisindo esincane kunezidakamizwa ezisekelwe ku-olanzapine. I-Lurasidone enye inketho ethambekele ekungathathi isisindo.

Udokotela wakho angase futhi acabangele izinzisi zemizwa ezinjenge-lithium noma i-valproate yesifo se-bipolar, noma izindlela zokuhlanganisa ezisebenzisa imithi eminingi ukuze kufezwa ukulawulwa okungcono kakhulu kwezimpawu ezinemiphumela emibi encane.

Ukukhetha okunye ukwelashwa kuncike ezimpawini zakho ezithile, umlando wezokwelapha, eminye imithi oyithathayo, kanye nezintandokazi zakho mayelana nemiphumela emibi nezimiso zokulinganisa.

Ingabe i-Olanzapine-and-Samidorphan Ingcono Kune-Olanzapine Yodwa?

Kubantu abaningi, i-olanzapine-and-samidorphan inikeza izinzuzo ngaphezu kwe-olanzapine yodwa, ikakhulukazi mayelana nokuphathwa kwesisindo. Izifundo zemitholampilo zibonisa ukuthi le nhlanganisela ngokuvamile ibangela ukuzuza isisindo esincane kune-olanzapine ngokwayo.

Izinzuzo zokwelashwa ngengqondo zihlala zifana phakathi kwezinketho ezimbili, njengoba i-olanzapine iyona esebenzayo ekwelapheni izimpawu zakho zempilo yengqondo. Ukwengezwa kwe-samidorphan kuqondiswe ngqo enkingeni yokukhuluphala ngaphandle kokuyekethisa ukusebenza kahle kwe-schizophrenia noma i-bipolar disorder.

Kodwa-ke, "ngcono" kuncike ezimweni zakho. Uma ube uzinzile ku-olanzapine kuphela ngaphandle kokukhuluphala okukhulu, ukushintsha kungenzeka kungadingeki. Udokotela wakho uzokusiza ukuthi ulinganise izinzuzo nezingozi zenketho ngayinye.

Inhlanganisela ibiza ngaphezu kwe-olanzapine ejwayelekile yodwa, okungase kube yinto okufanele icatshangelwe ngokuya ngomshuwalense wakho kanye nesimo sakho sezezimali.

Imibuzo Evame Ukubuzwa Mayelana ne-Olanzapine-and-Samidorphan

Ingabe i-olanzapine-and-samidorphan iphephile ngesifo sikashukela?

Lo muthi udinga ukuqashwa ngokucophelela uma unesifo sikashukela, njengoba i-olanzapine ingathinta amazinga kashukela egazini. Ngenkathi i-samidorphan ingasiza ekunciphiseni imiphumela ethile ye-metabolic, abantu abanesifo sikashukela basadinga ukuqapha njalo ushukela wegazi ngenkathi bethatha le nhlanganisela.

Udokotela wakho cishe uzohlola ushukela wakho wegazi kaningi lapho uqala lo muthi futhi kungadingeka ukuthi alungise imithi yakho yesifo sikashukela. Inhlanganisela ayiphephile ngokuzenzakalela kubantu abanesifo sikashukela, kodwa idinga ukugadwa okuseduze kwezokwelapha.

Ngingenzani uma ngiphuzile i-olanzapine-and-samidorphan eningi ngengozi?

Uma ngengozi uphuza ngaphezu komthamo wakho obekiwe, xhumana nomhlinzeki wakho wezempilo noma ukulawulwa ngokushesha. Izimpawu zokweqisa zingabandakanya ukozela okukhulu, ukudideka, inkulumo engacacile, noma ubunzima bokuphefumula.

Ungazami ukuzenza uhlanze noma uthathe eminye imithi ukuze ulwe nokweqisa. Funani usizo lwezokwelapha ngokushesha, futhi nilethe ibhodlela lomuthi nawe uma uya egumbini eliphuthumayo.

Ngingenzani uma ngiphuthelwa umthamo we-olanzapine-and-samidorphan?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Esimeni esinjalo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile - ungasithathi imithamo emibili ngesikhathi esisodwa.

Ukuphuthelwa imithamo ngezikhathi ezithile ngeke kubangele izinkinga ngokushesha, kodwa zama ukugcina ukuqina ukuze uthole umphumela omuhle wokwelapha. Cabangela ukusetha isikhumbuzi sansuku zonke ocingweni lwakho noma usebenzise umhleli wamaphilisi ukukusiza ukhumbule.

Ngingayeka nini ukuthatha i-olanzapine-and-samidorphan?

Ungayeki ukuthatha lo muthi kungazelelwe ngaphandle kokubonisana nodokotela wakho kuqala. Ukuyeka kungazelelwe kungaholela ezimpawini zokuhoxisa kanye nokubuyela ezimpawini zengqondo ezingase zibe zimbi kakhulu kunangaphambi kokwelashwa.

Udokotela wakho uzokusiza ukuthi uthuthukise ishejuli yokunciphisa kancane kancane uma ukuyeka kufanelekile. Le nqubo ngokuvamile ithatha amasonto amaningana noma izinyanga, kuye ngokuthi usuthatha isikhathi esingakanani umuthi kanye nokuphendula kwakho ngakunye.

Ngingawuphuza utshwala ngenkathi ngithatha i-olanzapine-and-samidorphan?

Kungcono ukugwema utshwala ngenkathi uthatha lo muthi, njengoba zombili izinto zingabangela ukozela nesiyezi. Ukuzihlanganisa kwandisa ingozi yakho yokuwa, izingozi, kanye nokukhubazeka kokwahlulela.

Uma ukhetha ukuphuza ngezikhathi ezithile, yenza kanjalo ngokulinganisela okukhulu futhi uqaphele imiphumela emibi eyengeziwe. Njalo xoxa ngokusetshenziswa kotshwala nodokotela wakho, njengoba bengase bancomise ukugwema ngokuphelele ngokuya ngesimo sakho sempilo.