Olaparib (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Lynparza
Mayelana naleli khambi
I-Olaparib isetshenziswa njengonyango oluqhubekayo kubantu abane-kansa ye-ovari ephambili, i-kansa yomgudu we-fallopian, noma i-kansa ye-peritoneal ephambili enenye into ehlukile ye-BRCA gene ezuzwe (germline) noma etholakele (somatic). Udokotela wakho uzohlola ukuba kukhona yini le gene. Isetshenziswa kubantu abaphelelwe yinyango ephelele noma engaphelele ngemithi ye-kansa esekelwe kwi-platinum. I-Olaparib isetshenziswa kanye ne-bevacizumab njengonyango oluqhubekayo kubantu abane-kansa ye-ovari ephambili, i-kansa yomgudu we-fallopian, noma i-kansa ye-peritoneal ephambili enenye into ehlukile ye-BRCA gene noma ukuhlolwa kwe-tumor okuhle kakhulu kokungazinzi kwe-genomic okuthiwa yi-HRD. Udokotela wakho uzohlola ukuba kukhona yini le gene. Isetshenziswa kubantu abaphelelwe yinyango ephelele noma engaphelele ngemithi ye-kansa esekelwe kwi-platinum. I-Olaparib isetshenziswa futhi ukwelapha i-kansa ye-ovari, i-kansa yomgudu we-fallopian, noma i-kansa ye-peritoneal ephambili enenye into ehlukile ye-BRCA gene ezuzwe (germline) noma etholakele (somatic) ebuyile. Udokotela wakho uzohlola ukuba kukhona yini le gene. Isetshenziswa kubantu abaphelelwe yinyango ephelele noma engaphelele ngemithi ye-kansa esekelwe kwi-platinum. I-Olaparib isetshenziswa futhi ukwelapha i-kansa yebhubesi ekuqaleni ye-HER2-negative kubantu abaphelelwe yimithi ye-kansa. Isetshenziswa uma amaseli e-kansa enezinguquko ze-germline BRCA. Udokotela wakho uzosebenzisa ukuhlolwa okukhethekile ukubheka lezi zinguquko. Inikezwa kubantu ngemuva kokuthi kuqediwe ukuhlinzwa ukususa i-tumor. I-Olaparib isetshenziswa futhi ukwelapha i-kansa yebhubesi ye-metastatic (i-kansa esakazeke) ye-HER2-negative kubantu abaphelelwe yimithi ye-kansa. Isetshenziswa uma amaseli e-kansa enezinguquko ze-germline BRCA. Udokotela wakho uzosebenzisa ukuhlolwa okukhethekile ukubheka lezi zinguquko. I-Olaparib isetshenziswa futhi njengonyango oluqhubekayo kubantu abane-kansa ye-pancreas ye-metastatic (i-kansa esakazeke) enenye into ehlukile ye-BRCA gene ezuzwe (germline), lapho isifo sasingakaqhubeki futhi abaphelelwe yimithi ye-kansa esekelwe kwi-platinum okungenani amasonto angu-16. I-Olaparib isetshenziswa futhi ukwelapha i-kansa ye-prostate ye-metastatic castration-resistant (i-kansa ye-prostate esakazeke futhi imelelana nezinye izindlela zokwelapha noma ukuhlinzwa okunciphisa i-testosterone) kubantu abaphelelwe yimithi ye-kansa (isib. i-abiraterone, i-enzalutamide). Isetshenziswa uma amaseli e-kansa enenye into ehlukile ye-HRR gene ezuzwe (germline) noma etholakele (somatic). Udokotela wakho uzohlola ukuba kukhona yini le gene. I-Olaparib isetshenziswa kanye ne-abiraterone ne-prednisone noma i-prednisolone ukwelapha i-kansa ye-prostate ye-metastatic castration-resistant (i-kansa ye-prostate esakazeke futhi imelelana nezinye izindlela zokwelapha noma ukuhlinzwa okunciphisa i-testosterone) enenye into ehlukile ye-BRCA gene ezuzwe noma etholakele. Udokotela wakho uzohlola ukuba kukhona yini le gene. Lolu lwemi iyatholakala kuphela ngomyalo wodokotela. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma kunquma ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokusebenzisa imithi nezinzuzo ezizoletha. Lo ngumqulu ozowenza wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqakathekile noma oluhambisana nokwaleka kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unanoma yiluphi olunye uhlobo lwezifo ezingaleki, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenamibhalo, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubudlelwano bobudala nemiphumela ye-olaparib kubantu abancane. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalinda ukusetshenziswa kwe-olaparib kubantu abadala. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokusebenzisa le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha kungase kudingeke. Uma uthatha le mithi, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlwini elingezansi. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akunconywa, kodwa kungase kudingeke kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma ngesikhathi sokudla izinhlobo ezithile zokudla ngoba kungenzeka kube khona ukusebenzisana. Ukusebenzisa utshwala noma utshaba ngezinye izidakamizwa kungabangela ukusebenzisana. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ngokuvamile akunconywa, kodwa kungase kungakhuphuki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unanoma yiziphi ezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Imithi ebizwa ngokuthi i-cancer inamandla kakhulu futhi ingaba nemiphumela eminingi emibi. Ngaphambi kokusebenzisa le mithi, qiniseka ukuthi uyayiqonda yonke imingcipheko nezinzuzo. Kubalulekile ukuthi usebenzisane eduze nodokotela wakho phakathi nokuphathwa kwakho. Thatha le mithi ngokuqondile njengoba uqondiswe udokotela wakho. Ungayithathi ngaphezulu, ungayithathi kaningi, futhi ungayithathi isikhathi eside kunalokho oqondiswe udokotela wakho. Ukwenza kanjalo kungandisa amathuba emiphumela emibi. Le mithi ifika ne-Medication Guide. Funda futhi ulandele lezi zinkomba ngokucophelela. Buza udokotela wakho uma unemibuzo. Ungayihlanganisi izindlela ezimbili zokulinganisela kule mithi. Ama-Lynparza®ama-capsules namaphilisi awafani futhi anezinga ezahlukene. Gwinya ama-capsules namaphilisi wonke. Ungawachobozi, ungawaphula, ungawuhlwayeli, ungawavuli, noma ungawachithi. Ungawuthathi ama-capsules uma ebonakala ewonakele noma enokuqhekeka. Ungayithatha le mithi ngokudla noma ngaphandle kokudla. Uma une-hormone receptor positive early breast cancer, kufanele uqhubeke nokuthatha imithi ye-hormone phakathi nokuphathwa nge-Lynparza®amaphilisi. Udokotela wakho angakunika neminye imithi (eg, imithi ye-gonadotropin-releasing hormone) phakathi nokuphathwa kwe-cancer ye-prostate nge-Lynparza®amaphilisi noma kufanele ube ususiwe ama-testes ngaphambi kokusebenzisa le mithi. Ungadli i-grapefruit noma ama-Seville oranges, noma uphuze ijusi le-grapefruit noma ijusi le-Seville orange ngenkathi usebenzisa le mithi. Inani lemithi lizoba lehlukile kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemthethweni. Ulwazi olulandelayo luhlanganisa kuphela izilinganiso ezimayelana nale mithi. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukuba wenze njalo. Inani lemithi oyithatha lixhomeke emandleni emithi. Futhi, inani lezingxenye oyithatha nsuku zonke, isikhathi esivunyelwe phakathi kwezingxenye, nobude besikhathi oyithatha imithi kuya ngenkinga yezokwelapha oyisebenzisela imithi. Uma uphuthelwa yingxenye yale mithi, susa ingxenye ephuthelwe futhi ubuyele esimweni sakho sokuthatha imithi. Ungawandisi ama-doses. Gcina kubantwana. Ungagcini imithi eliphelile noma imithi engasadingeki. Buza ochwepheshe bakho bezempilo ukuthi kufanele ulahle kanjani noma iyiphi imithi ongayisebenzisi. Gcina imithi esitsheni esivalekile ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungayifrizi. Gcina amaphilisi esitsheni sawo sokuqala.