Yini i-Oliceridine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Oliceridine iyimithi yobuhlungu ye-opioid entsha enikezwa ngomugqa we-IV (intravenous) ukwelapha ubuhlungu obumaphakathi nendawo obukhulu ezindaweni zasemtholampilo. Le mithi isebenza ngendlela ehlukile kuma-opioids endabuko afana ne-morphine, okungenzeka ukuthi inikeze ukukhululeka kobuhlungu okuphumelelayo ngezinkinga zokuphefumula ezimbalwa nemiphumela emibi.

Uma ubhekene nokuhlinzwa noma ubhekene nobuhlungu obukhulu obudinga ukunakekelwa esibhedlela, ithimba lakho lezokwelapha lingase licabangele i-oliceridine njengengxenye yohlelo lwakho lokuphatha ubuhlungu. Ukuqonda ukuthi le mithi isebenza kanjani kungakusiza ukuthi uzizwe ulungiseleleke futhi uqiniseka ngemithi yakho.

Yini i-Oliceridine?

I-Oliceridine iyi-opioid yokwenziwa eyenzelwe ukuphatha ubuhlungu obukhulu lapho ezinye izindlela zokwelapha zinganele. Ingowesigaba semithi ebizwa ngokuthi ama-opioid agonists, okusho ukuthi ibopha kuma-receptors athile ebuchosheni bakho nasemgogodleni ukuze ivimbele izimpawu zobuhlungu.

Okuhlukile nge-oliceridine yindlela yayo ekhethekile yala ma-receptors. Ngenkathi ama-opioids endabuko ethinta izindlela eziningi, i-oliceridine iqondisa ngokuqondile ezithile. Lesi senzo esiqondiwe singasiza ekunciphiseni eminye imiphumela emibi evamile ye-opioid ngenkathi isahlinzeka ngokukhululeka kobuhlungu obuqinile.

Imithi itholakala kuphela ezibhedlela nasezindaweni zomtholampilo lapho ochwepheshe bezempilo bengakuqapha eduze. Akuyona into ongayithatha ekhaya noma uyithole ekhemisi elivamile.

Yini i-Oliceridine Esetshenziselwa Yona?

I-Oliceridine iphatha ubuhlungu obumaphakathi nendawo obukhulu kubantu abadala abadinga imithi yobuhlungu ye-IV ezindaweni zasemtholampilo. Udokotela wakho angase ayincomise uma imithi yobuhlungu yomlomo ingaqini ngokwanele noma uma ungenakukwazi ukuthatha amaphilisi ngenxa yokuhlinzwa noma ukugula.

Izimo ezivamile lapho i-oliceridine ingase isetshenziswe zihlanganisa ukululama ngemva kokuhlinzwa okukhulu, ubuhlungu obukhulu bokulimala, noma izigameko zobuhlungu obukhulu obudinga ukunakekelwa ngokushesha esibhedlela. Kuyasiza ikakhulukazi uma udinga ukukhululeka ngokushesha, ngempumelelo kobuhlungu obungaqashwa ngokucophelela futhi kulungiswe.

Umuthi ngokuvamile ugcinelwe ukusetshenziswa kwesikhashana ngesikhathi sokuhlala kwakho esibhedlela. Ithimba lakho lezempilo lizohlola ukuthi i-oliceridine iyisinqumo esifanele yini ngokusekelwe ezingeni lakho elithile lobuhlungu, umlando wezokwelapha, kanye neminye imithi oyitholayo.

Isebenza Kanjani I-Oliceridine?

I-Oliceridine isebenza ngokubopha kuma-opioid receptors ebuchosheni bakho nasemgogodleni, ngokuqondile iqondise lokho ososayensi abakubiza ngokuthi indlela ye-G-protein. Lokhu kubopha okukhethekile kusiza ukuvimba izimpawu zobuhlungu ukuthi zingafinyeleli ebuchosheni bakho, zinikeze ukukhululeka ebuhlungwini obumaphakathi nobukhulu.

Ngokungafani nama-opioid endabuko asebenzisa izindlela eziningi zamaselula, i-oliceridine igxila ngokuqondile ezindleleni zokuvimba ubuhlungu ngenkathi inethonya elincane ezindleleni ezibangela izinkinga zokuphefumula. Lesi senzo esikhethekile yingakho sithathwa njenge-“biased” opioid agonist.

Umuthi uthathwa njengonamandla ngokulinganisela emndenini we-opioid. Unamandla kakhulu kunemithi efana ne-codeine kodwa ingase ibe nephrofayili ehlukile yemiphumela engemihle uma iqhathaniswa ne-morphine noma i-fentanyl. Umzimba wakho ngokuvamile uphendula ku-oliceridine ngemizuzu ngemva kokuyithola nge-IV yakho.

Kufanele Ngiyithathe Kanjani I-Oliceridine?

I-Oliceridine inikezwa kuphela ochwepheshe bezempilo ngomugqa we-IV ezindaweni zesibhedlela. Ngeke kudingeke ukhathazeke ngokuyithatha wena uqobo noma ukukhumbula imithamo, njengoba ithimba lakho lezokwelapha lizosingatha konke ukuphatha nokuqapha.

Umuthi unikezwa njengesijovo esinensayo ngqo emthanjeni wakho. Umhlengikazi wakho noma udokotela uzobala ngokucophelela umthamo ofanele ngokuya ngesisindo sakho, izinga lobuhlungu, nokuthi usabela kanjani emuthini. Bazokuqapha eduze ngesikhathi nangemva komthamo ngamunye.

Njengoba i-oliceridine inikezwa ngomjovo emthanjeni, akudingeki ucabangele ukuxhumana kokudla noma isikhathi sokudla. Kodwa-ke, ithimba lakho lezempilo lingashintsha ukuthi uthola nini imithamo ngokusekelwe ohlelweni lwakho lokwelashwa olujwayelekile, eminye imithi, noma izinqubo ezihleliwe.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Oliceridine?

I-Oliceridine yenzelwe ukusetshenziswa kwesikhashana, ngokuvamile ihlala amahora ambalwa kuya ezinsukwini ezimbalwa kuye ngezidingo zakho zokuphatha ubuhlungu. Abantu abaningi bayithola kuphela ngesikhathi sokuhlala kwabo esibhedlela ngezikhathi zobuhlungu obukhulu noma ngemva kokululama kokuhlinzwa.

Ithimba lakho lezempilo lizohlola njalo amazinga akho obuhlungu futhi lilungise noma liyeke i-oliceridine njengoba isimo sakho sithuthuka. Bangase bakushintshele emithini yobuhlungu yomlomo noma ezinye izindlela zokwelapha njengoba ululama futhi ulungiselela ukukhishwa.

Isikhathi esiqondile sincike ezintweni ezifana nohlobo lokuhlinzwa kwakho, ukuqhubeka kokuphola, nokuthi usabela kahle kangakanani emuthini. Odokotela bakho bazosebenza nawe ukudala uhlelo lokuphatha ubuhlungu oluhlanganisa ukwehla emithini ye-IV uma kufanelekile.

Yiziphi Imiphumela Eceleni Ye-Oliceridine?

Njengayo yonke imithi ye-opioid, i-oliceridine ingabangela imiphumela emibi, nakuba abantu abaningi behlangabezana nezinkinga zokuphefumula ezimbalwa uma kuqhathaniswa nama-opioid endabuko. Ukuqonda okulindelekile kungakusiza ukuthi uxhumane ngempumelelo nethimba lakho lezempilo mayelana nendlela ozizwa ngayo.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa isicanucanu, ukuhlanza, isiyezi, nekhanda. Le miphumela ngokuvamile iyaphathwa futhi ithimba lakho lezokwelapha linganikeza ukwelashwa ukusiza ukunciphisa ukungakhululeki. Iziguli eziningi zithola ukuthi le miphumela emibi iyancipha njengoba umzimba wazo ujwayela umuthi.

Nansi imiphumela emibi ongase uhlangabezane nayo ngesikhathi sokwelashwa:

• Isicanucanu nokuhlanza
• Isiyezi noma ukukhathala
• Ikhanda
• Ukuqunjelwa
• Ukozela noma ukukhathala
• Umlomo owomile
• Ukuluma noma ukusabela kwesikhumba

Lezi zimo ezivamile ezithinta umzimba ngokuvamile zinesikhashana futhi zingalawulwa ngokunakekelwa okusekelayo ngenkathi usesibhedlela.

Imiphumela emibi kakhulu ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Ithimba lakho lezempilo likuqapha ngokucophelela ngalezi zimo, ezingabandakanya izinkinga ezinkulu zokuphefumula, ukwehla okuyingozi komfutho wegazi, noma izimpawu zokungezwani komzimba nezinto ezithile.

Imiphumela emibi engavamile kodwa ebucayi edinga ukungenelela kwezokwelapha ngokushesha ihlanganisa:

• Ubunzima obukhulu bokuphefumula noma ukuphefumula okuhamba kancane kakhulu
• Ukwehla okukhulu komfutho wegazi noma izinga lokushaya kwenhliziyo
• Ukungezwani komzimba okukhulu okunezinduna, ukuvuvukala, noma ubunzima bokuphefumula
• Ukudideka okukhulu noma ubunzima bokuhlala uphapheme
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile
• Izimpawu ze-serotonin syndrome uma zihlanganiswe neminye imithi ethile

Ngenxa yokuthi uthola i-oliceridine endaweni yesibhedlela, ithimba lakho lezokwelapha lingakwazi ukubhekana ngokushesha nanoma yiziphi izimpawu ezikhathazayo ezingase zivele.

Ubani Ongafanele Athole I-Oliceridine?

I-Oliceridine ayiphephile kuwo wonke umuntu, futhi ithimba lakho lezempilo lizobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokucabangela lo muthi. Izimo ezithile noma izimo zenza i-oliceridine ingafaneleki noma ingaba yingozi kwabanye abantu.

Akufanele uthole i-oliceridine uma unezinkinga ezinkulu zokuphefumula, izimo ezithile zenhliziyo, noma ukungezwani komzimba okwaziwayo nemithi ye-opioid. Udokotela wakho uzogwema lo muthi uma unesifo esibi sesibindi noma sezinso esingathinta indlela umzimba wakho osebenza ngayo ngemithi.

Abantu okufanele bagweme i-oliceridine ngokuvamile bahlanganisa labo abane:

• Ukucindezeleka okukhulu kokuphefumula noma izifo zokuphefumula
• Ukungezwani komzimba okwaziwayo ne-oliceridine noma imithi efanayo ye-opioid
• Isifo esibi sesibindi noma sezinso
• Izinkinga ezithile zokushaya kwenhliziyo
• Isifuba somoya esibukhali noma esibi
• Ukuvinjelwa kwamathumbu

Iqembu lakho lezokwelapha lizohlola lezi zinto ngokumelene nesidingo sakho sokukhululeka ebuhlungwini ukuze lenze isinqumo esiphephe kakhulu sokunakekelwa kwakho.

Ukuqapha okukhethekile kuyadingeka kubantu abadala, abesifazane abakhulelwe, kanye nabantu abanomlando wokusebenzisa izidakamizwa. Ithimba lakho lezempilo lizobheka ngokucophelela lezi zimo futhi lingakhetha amasu okwelapha ubuhlungu ahlukile uma i-oliceridine iletha izingozi eziningi kakhulu.

Igama Lomkhiqizo le-Oliceridine

I-Oliceridine itholakala ngaphansi kwegama lomkhiqizo elithi Olinvyk e-United States. Le nguqulo enegama yiyona kuphela uhlobo lwe-oliceridine olutholakala njengamanje, njengoba izinguqulo ezivamile zingakakhiwa okwamanje.

Lapho ithimba lakho lezempilo lixoxa ngemithi ye-oliceridine, lingase libhekisele kuyo nganoma yiliphi igama. Zombili lezi zisho zibhekisela emuthini ofanayo onemiphumela efanayo kanye nezinto okufanele ziqashelwe ngokuqina.

I-Olinvyk ikhiqizwa yi-Trevena, Inc., futhi yavunywa yi-FDA ngokuqondile ukusetshenziswa nge-IV ezindaweni zase-hospital. Umuthi uza ngamavial womthamo owodwa okuzolungiswa futhi anikezwe ithimba lakho lezempilo.

Ezinye izindlela ze-Oliceridine

Eminye imithi eminingi ye-IV opioid ingelapha ubuhlungu obumaphakathi nendawo obukhulu ezindaweni zase-hospital. Ithimba lakho lezempilo lingase licabange lezi ezinye izindlela ngokusekelwe ezidingweni zakho ezithile, umlando wezokwelapha, nokuthi ukwamukela kanjani imithi ehlukene.

Ama-opioid e-IV endabuko afana ne-morphine, fentanyl, kanye ne-hydromorphone ahlala ezingxenyeni zokuqala zokwelashwa kobuhlungu obukhulu. Le mithi inemlando omude futhi nocwaningo oluningi olusekela ukusetshenziswa kwayo, nakuba ingase ilethe imiphumela ehlukene.

Ezinye izindlela ezivamile udokotela wakho angazicabangela zihlanganisa:

\n
• I-Morphine - isetshenziswa kakhulu futhi ifundwe kahle ngezinhlungu ezingamahlalakhona
\n
• I-Fentanyl - isebenza ngokushesha futhi inamandla ezinhlungwini ezinzima
\n
• I-Hydromorphone - isebenza kahle ezinhlungwini eziphakathi nendawo kuya kwezinzima
\n
• I-Oxycodone IV - uma itholakala, ngezimo ezithile zokuzwa ubuhlungu
\n
• Amaphampu e-analgesia alawulwa yiziguli (PCA) anama-opioid ahlukahlukene
\n
• Imithi ye-IV engeyona i-opioid efana ne-ketorolac yezinhlobo ezithile zobuhlungu
\n

Ithimba lakho lokunakekelwa kwezempilo lizokhetha inketho efanele kakhulu ngokusekelwe esimweni sakho ngasinye kanye nemigomo yakho yokuphatha ubuhlungu.

Ingabe i-Oliceridine ingcono kune-Morphine?

I-Oliceridine ne-morphine zombili ziphatha ngempumelelo ubuhlungu obuphakathi nendawo kuya kobunzima, kodwa zisebenza ngendlela ehlukile emzimbeni wakho. Noma ngabe eyodwa

I-Oliceridine idinga ukucatshangelwa ngokucophelela kubantu abanezifo zezinso, njengoba ukuncipha komsebenzi wezinso kungathinta indlela umzimba wakho oqhubula ngayo futhi uqede ngayo imithi. Ithimba lakho lezempilo cishe lizosebenzisa imithamo ephansi noma likuqaphe eduze uma unezinkinga zezinso.

Abantu abanezifo zezinso ezingathí sina bangase bakwazi ukuthola i-oliceridine ngokuphepha ngokulungiswa komthamo okufanele. Kodwa-ke, labo abanezifo zezinso ezinzima kungenzeka badinge ezinye izindlela zokuphatha ubuhlungu. Udokotela wakho uzobukeza izivivinyo zakho zomsebenzi wezinso kanye nomlando wakho wezokwelapha ukuze anqume indlela ephephe kakhulu yesimo sakho.

Kufanele ngenzeni uma ngithola i-Oliceridine eningi ngengozi?

Njengoba i-oliceridine inikezwa kuphela ochwepheshe bezempilo ezindaweni zase-hospital, ukweqisa ngengozi akuvamile kodwa kudinga ukunakekelwa kwezokwelapha ngokushesha. Uma usola ukuthi uthole imithi eningi, yazisa umhlengikazi wakho noma udokotela ngokushesha.

Izimpawu ze-oliceridine eningi zihlanganisa ukozela okukhulu, ukuphefumula okuhamba kancane noma okunzima, ukudideka, noma ukulahlekelwa ukwazi. Ithimba lakho lezokwelapha linemithi efana ne-naloxone (Narcan) etholakalayo kalula ukuze iguqule imiphumela ye-opioid uma kunesidingo. Bazogada ukuphefumula kwakho, izinga lokushaya kwenhliziyo, kanye nezinga lokuqwashisa ngokucophelela futhi banikeze ukunakekelwa okusekelayo njengoba kudingeka.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Oliceridine?

Akudingeki ukhathazeke ngokulahlekelwa imithamo ye-oliceridine ngoba inikezwa ithimba lakho lezempilo ngesisekelo esihleliwe esibhedlela. Abahlengikazi nodokotela bakho baphethe zonke izinqumo zesikhathi kanye nomthamo ngokusekelwe emazingeni akho obuhlungu kanye nezidingo zakho zezokwelapha.

Uma uzwa ukuthi ubuhlungu bakho abulawulwa ngokwanele noma uma sekudlule isikhathi eside kunokulindelekile kusukela emthamo wakho wokugcina, vele wazise ithimba lakho lezempilo. Bangahlola izinga lakho lobuhlungu futhi banqume ukuthi imithi eyengeziwe ifanele yini noma ngabe kudingeka ukulungiswa kuhlelo lwakho lokuphatha ubuhlungu.

Ngingayeka nini ukuthatha i-Oliceridine?

Iqembu lakho lezempilo lizinqumela ukuthi lizoyeka nini ukunikeza i-oliceridine ngokusekelwe ezingeni lobuhlungu obuzwayo, inqubekela phambili yokululama, kanye nesimo sakho sempilo esiphelele. Abantu abaningi bayeka ukusebenzisa imithi yokwelapha ubuhlungu nge-IV efana ne-oliceridine njengoba belulama futhi belungiselela ukukhishwa esibhedlela.

Ushintsho ngokuvamile luhlanganisa ukunciphisa kancane kancane imithamo noma ukushintshela emithini yokwelapha ubuhlungu yomlomo ongayithatha ekhaya. Ithimba lakho lezempilo lizosebenza nawe ukuqinisekisa ukuthi ubuhlungu bakho buqhubeka ukulawulwa kahle ngesikhathi soshintsho. Bazophinda banikeze imiyalelo yokulawula ubuhlungu ngemva kokukhishwa esibhedlela nokuthi bangathintwa nini uma unezinkinga.

Ngingashayela ngemva kokuthola i-Oliceridine?

Akufanele ushayele noma usebenzise imishini ngenkathi uthola i-oliceridine noma isikhathi esithile ngemva komthamo wakho wokugcina. Umuthi ungabangela ukozela, isiyezi, nokucabanga okungahambisani kahle okwenza ukushayela kube yingozi.

Njengoba i-oliceridine inikezwa ezindaweni zase-hospital, cishe uzoba nezinhlelo zokuthuthwa lapho ukhishwa. Ithimba lakho lezempilo lizokweluleka ngokuthi kuphephile nini ukuqala ukushayela ngokusekelwe ekululameni kwakho, eminye imithi oyithathayo, nokuthi sekudlule isikhathi esingakanani ngomthamo wakho wokugcina we-oliceridine.