Yini i-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokunye

I-Ombitasvir-paritaprevir-ritonavir-and-dasabuvir iyinhlanganisela yemithi eyenzelwe ngqo ukwelapha ukutheleleka ngegciwane le-hepatitis C (HCV). Le nhlanganisela yemithi emine isebenza ndawonye njengeqembu elinamandla lokuvimbela igciwane ukuthi lingaphindaphani emzimbeni wakho, linike isibindi sakho ithuba lokuphola emonakalweni obangelwe yi-hepatitis C engamahlalakhona.

Uma wena noma othile omkhathalelayo etholiwe ukuthi une-hepatitis C, ungase uzizwe ukhungathekile ngegama eliyinkimbinkimbi lalo muthi. Izindaba ezinhle ukuthi lokhu kwelashwa kuye kwasiza izinkulungwane zabantu ukuthi basuse igciwane emizimbeni yabo futhi babuyisele impilo yabo.

Yini i-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Lo muthi uyinhlanganisela yomthamo olungisiwe wemithi emine ehlukene elwa namagciwane esebenza ndawonye ukulwa ne-hepatitis C. Ingxenye ngayinye inomsebenzi othile ekuvimbeleni igciwane ukuthi lingaphindaphani futhi lingasakazi emzimbeni wakho wonke.

Kucabange njengeqembu elikhethekile lapho ilungu ngalinye linamakhono ahlukile. I-Ombitasvir ivimba iphrotheni eyodwa edingwa igciwane ukuze lisinde, i-paritaprevir imisa enye iphrotheni ebalulekile yegciwane, i-ritonavir isiza eminye imithi ukuthi isebenze kangcono futhi ihlale isikhathi eside ohlelweni lwakho, futhi i-dasabuvir ivimbela igciwane ekuzikopishini.

Le ndlela yokuhlanganisa isebenza kahle kakhulu kunokusebenzisa umuthi owodwa kuphela. Umuthi uza ngesimo samaphilisi futhi ngokuvamile uthathwa njengengxenye yohlelo oluphelele lokwelashwa kwe-hepatitis C.

Isetshenziselwani i-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Lo muthi usetshenziselwa ikakhulukazi ukwelapha ukutheleleka ngegciwane le-hepatitis C elingamahlalakhona kubantu abadala. Isebenza ngokuqondile ezinhlotsheni ezithile ze-hepatitis C, ikakhulukazi i-genotype 1, okuyindlela evame kakhulu etholakala e-United States.

Udktela wakho uzonquma ukuthi lo muthi ukufanele yini ngokusekelwe ezintweni eziningana. Lokhu kuhlanganisa uhlobo oluthile lwe-hepatitis C onalo, ukuthi ngabe uzamile yini eminye imithi ngaphambili, isimo samanje sesibindi sakho, kanye nesimo sakho sempilo esiphelele.

Lo muthi uvame ukusetshenziswa ngokuhlanganyela ne-ribavirin, omunye umuthi olwa namagciwane, ukuze kwakhiwe indlela yokwelapha ebanzi kakhulu. Lokhu kwelashwa ngokuhlanganyela kukhombise imiphumela emihle ezifundweni zomtholampilo, neziguli eziningi zifinyelela lokho odokotela abakubiza ngokuthi "impendulo ye-virologic eqhubekayo" - okusho ukuthi igciwane alitholakali egazini labo.

Isebenza Kanjani I-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Lo muthi ubhekwa njengokuhlanganiswa kwe-antiviral eqondile (DAA), okusho ukuthi iqondisa ngqo igciwane le-hepatitis C kunokuthi limane likhulise amasosha akho omzimba. Kuyindlela yokwelapha eqinile nephumelelayo ehlasela igciwane ezindaweni eziningi emjikelezweni walo wempilo.

Isici ngasinye sisebenza esigabeni esihlukile sokuziphinda kwegciwane. I-Ombitasvir ne-paritaprevir yizinto ezivimbela i-protease ezivimba amaprotheni adingwa igciwane ukuze livuthwe futhi libe nokuqhubeka. I-Dasabuvir iyisithiyo se-polymerase esivimbela igciwane ekukopisheni izinto zalo zofuzo.

I-Ritonavir isebenza njenge "booster" enciphisa ukuthi isibindi sakho sizicubungula ngokushesha kangakanani ezinye izidakamizwa. Lokhu kusho ukuthi imithi esebenzayo ihlala esistemini yakho isikhathi eside, okwenza isebenze kahle ekulweni igciwane.

Indlela yokuhlanganisa yenza kube nzima kakhulu ukuthi igciwane likwazi ukumelana. Noma ngabe igciwane lizama ukuguqula ukuze liphumelele emthini owodwa, ezinye ezintathu zisaqhubeka nokulilawula.

Kufanele Ngiyithathe Kanjani I-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Kufanele uthathe lo muthi ngendlela udokotela wakho akuyala ngayo, ngokuvamile kanye ngosuku ngokudla. Ukuyithatha ngokudla kusiza umzimba wakho ukuba umunce kahle umuthi futhi kunganciphisa ithuba lokucasuka kwesisu.

Umuthi uvame ukuza njengephakethe elihlanganisiwe elinamaphilisi anemibala ehlukene. Uzothatha amaphilisi amabili ekuseni ngesikhathi sokudla - elilodwa eliqukethe i-ombitasvir, i-paritaprevir, ne-ritonavir, nelinye eliqukethe i-dasabuvir.

Kubalulekile ukuthatha imithamo yakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo omuthi egazini lakho. Khetha isikhathi esisebenzela kahle ngomsebenzi wakho wansuku zonke, njengokudla kwasekuseni, ukuze ungakhohlwa kalula.

Ungawachobozi, ungawaqhekezi, noma uwahlafune amaphilisi. Gwinya wonke ngamanzi noma esinye isiphuzo. Ukugcotshwa kwamaphilisi kusiza ekuqinisekiseni ukuthi umuthi ukhululwa ngendlela efanele ohlelweni lwakho lokugaya ukudla.

Kufanele Ngithathe Isikhathi Esingakanani I-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Abantu abaningi bathatha lo muthi amasonto angu-12, nakuba ubude bokwelashwa kwakho buxhomeke ezintweni eziningi ezithile esimweni sakho. Udokotela wakho uzoqoka ubude obuqondile ngokuya ngohlobo lwakho lwe-hepatitis C, isimo sesibindi sakho, nomlando wokwelashwa.

Ezinye iziguli zingase zidinge ukwelashwa amasonto angu-24, ikakhulukazi uma zinezici ezithile eziyingozi noma zizame ezinye izindlela zokwelapha i-hepatitis C ngaphambili. Udokotela wakho uzoqapha inqubekela phambili yakho ngesikhathi sokwelashwa ngezivivinyo zegazi ezivamile.

Kubalulekile ukuqeda inkambo ephelele yokwelashwa ngisho noma uqala ukuzizwa ungcono. Igciwane lingase lisatholakala emzimbeni wakho ngisho noma uzizwa kahle, futhi ukuyeka ukwelashwa ngaphambi kwesikhathi kungavumela ukuthi libuye futhi lingase lithuthukise ukumelana nomuthi.

Ngesikhathi sokwelashwa, uzoba nokuhlolwa okuvamile ukuze uqaphele ukuthi umuthi usebenza kahle kangakanani nokubheka noma yiziphi izifo ezingezinhle. Udokotela wakho uzophinda ahlole ukusebenza kwesibindi sakho namazinga e-viral load.

Ziyini Izifo Ezingezinhle Ze-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Njengayo yonke imithi, le nhlanganisela ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ngokuvamile ithambile futhi ingalawuleka ngokunakekelwa okufanele nokuqapha.

Nansi imiphumela emibi ongase uyithole, ukhumbula ukuthi akubona bonke abantu abazoba nalezi zimo:

Imiphumela emibi ejwayelekile ihlanganisa:

• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Isicanucanu noma ukuqaqamba kwesisu okuncane
• Ikhanda
• Ubunzima bokulala noma izinguquko emaphethini okulala
• Ukuqina kwesikhumba noma ukuqubuka okuncane
• Ubuthakathaka noma ukuzizwa ungaphilile ngokujwayelekile

Imiphumela emibi engavamile kodwa ebucayi ingahlanganisa:

• Ukusabela kwesikhumba okukhulu noma ukuqubuka okusabalale kakhulu
• Izinkinga zesibindi ezinkulu noma ukwanda komsebenzi wesibindi
• Ukukhathala okukhulu okuphazamisa imisebenzi yansuku zonke
• Isicanucanu esiqhubekayo noma ukuhlanza
• Ukuphuzi kwesikhumba noma amehlo (i-jaundice)
• Umchamo omnyama noma izitulo eziphuthukile

Imiphumela emibi eminingi ingeyesikhashana futhi iyathuthuka njengoba umzimba wakho ujwayela umuthi. Kodwa-ke, kubalulekile ukuhlala uxhumana eduze nethimba lakho lokunakekelwa kwezempilo ngaso sonke isikhathi sokwelashwa ukuze bakwazi ukusiza ukuphatha noma yikuphi ukukhathazeka okuzayo.

Ubani Ongafanele Athathe I-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Lo muthi awufanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ngabe yikho yini okulungile esimweni sakho esithile. Ezinye izimo zempilo nemithi kungenza lokhu kwelashwa kungaphephile noma kungasebenzi kahle.

Akufanele uthathe lo muthi uma unezinkinga zesibindi eziphakathi nendawo kuya kwezinkulu ezingaphezu kwalezo ezibangelwa yi-hepatitis C. Umuthi ungafaka ingcindezi eyengeziwe esibindini sakho, okungaba yingozi uma umsebenzi wesibindi sakho usuvele ulimele kakhulu.

Abantu abathatha imithi ethile kufanele futhi bagweme le nhlanganisela. Ingalumelana nemithi eminingi ejwayelekile, okuhlanganisa eminye imithi yenhliziyo, imithi yokuvimbela ukuquleka, kanye nezinto ezicindezela amasosha omzimba ezisetshenziswa ngemva kokufakelwa izitho zomzimba.

Abesifazane abakhulelwe noma abahlela ukukhulelwa kufanele baxoxe ngezindlela zokwelapha ezingezinye nodokotela wabo. Ukuphepha kwalo muthi ngesikhathi sokukhulelwa akukamiswanga, futhi ezinye izakhi zingase zibe yingozi ezinganeni ezisakhula.

Uma une-HIV kanye ne-hepatitis C, uzodinga ukucatshangelwa okukhethekile. Ngenkathi ukwelashwa kungenzeka, udokotela wakho uzodinga ukuxhumanisa ngokucophelela imithi yakho ye-HIV nalokhu kwelashwa kwe-hepatitis C ukuze kugwenywe ukuxhumana okuyingozi.

Igama Lomkhiqizo le-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir

Le nhlanganisela yomuthi ithengiswa ngaphansi kwegama lomkhiqizo elithi Viekira Pak e-United States. Igama lomkhiqizo lenza kube lula ukuhlonza nokuxoxa nethimba lakho lezempilo, usokhemisi, kanye nenkampani yomshuwalense.

I-Viekira Pak iza njengephakethe lezithako zansuku zonke eliqukethe amaphilisi aqondile owadingayo ngosuku ngalunye lokwelashwa. Lolu hlelo lokupakisha lusiza ukuqinisekisa ukuthi uthatha inhlanganisela efanele yemithi ngesikhathi esifanele.

Ezinye izinhlelo zomshuwalense zingase zibe nezidingo ezithile zokumboza imithi yegama lomkhiqizo. Ihhovisi likadokotela wakho lingakusiza ukuthi uzulazule ezinqubweni zokugunyazwa komshuwalense futhi lingase likwazi ukuhlinzeka ngolwazi mayelana nezinhlelo zokusiza iziguli uma izindleko ziyinkinga.

Ezinye izindlela ze-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir

Ezinye izindlela zokwelapha i-hepatitis C ziyatholakala uma lo muthi ungalungile kuwe. Udokotela wakho angase ancome ezinye izindlela ezisuselwe ku-genotype yakho ethile, isimo sesibindi, nezinye izinto zezempilo.

Ezinye izinhlanganisela zama-antiviral aqondile zihlanganisa izindlela zokwelapha ezisekelwe ku-sofosbuvir, ezisebenza ngendlela ehlukile kodwa futhi ziphumelela kakhulu. Lezi ezinye izindlela zingase zifaneleke kangcono kubantu abanezinhlobo ezithile ze-hepatitis C noma labo abangakwazi ukuthatha inhlanganisela ye-ombitasvir.

I-Glecaprevir-pibrentasvir ingenye inketho esebenza ngokumelene nezinhlobo eziningi ze-hepatitis C futhi inesikhathi esifushane sokwelashwa kwabanye iziguli. Udokotela wakho uzocabangela izinto ezinjengomlando wakho wokwelashwa nokusebenza kwezinso lapho ekhetha phakathi kwezinketho.

Ukukhethwa kokwelashwa kuncike ezintweni eziningi zomuntu ngamunye. Okusebenza kahle kakhulu kumuntu oyedwa kungase kungabi kuhle komunye, ngakho kubalulekile ukusebenzisana eduze nomhlinzeki wezempilo onolwazi ekwelapheni i-hepatitis C.

Ingabe i-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir ingcono kune-Sofosbuvir?

Zombili lezi zithako zemithi ziphumelela kakhulu ekwelapheni i-hepatitis C, kodwa zisebenza ngendlela ehlukile futhi zingase zifaneleke kangcono ezigulini ezihlukene. Ukukhetha phakathi kwazo kuncike esimweni sakho esithile kunokuthi esinye singcono ngokujwayelekile kunomunye.

I-Ombitasvir-paritaprevir-ritonavir-and-dasabuvir isebenza kahle kakhulu ku-hepatitis C genotype 1, kuyilapho ukwelashwa okusekelwe ku-sofosbuvir kungasebenza ngokumelene nezinhlobo eziningi. Uma une-genotype 1 hepatitis C enomsebenzi wezinso ojwayelekile, zombili izinketho zingaba izinqumo ezinhle kakhulu.

Izindlela zokwelapha ezisekelwe ku-Sofosbuvir zingase zithandwe uma unezinkinga zezinso, njengoba ngokuvamile zithambile ezinso. Zivame futhi ukuba nokuxhumana okuncane kwemithi, okungase kubaluleke uma uthatha imithi eminingi.

Inhlanganisela ye-ombitasvir ingase ikhethwe uma unezinto ezithile zokukhava yomshuwalense noma uma udokotela wakho enolwazi oluningi ngale ndlela ethile yokwelapha. Zombili izindlela zokwelapha zinezilinganiso zokuphulukisa ezifanayo uma zisetshenziswa ngendlela efanele.

Imibuzo Evame Ukubuzwa Mayelana ne-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir

Ingabe i-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir iphephile kubantu abanesifo sikashukela?

Yebo, lo muthi ngokuvamile uphephile kubantu abanesifo sikashukela, kodwa udinga ukuqashwa ngokucophelela. Le nhlanganisela ngezinye izikhathi ingathinta amazinga kashukela egazini, ngakho udokotela wakho uzofuna ukugcina iso elibukhali ekuphathweni kwesifo sakho sikashukela ngesikhathi sokwelashwa.

Kungenzeka udinga ukuhlola ushukela wakho wegazi kaningi ngenkathi uthatha lo muthi. Abanye abantu bahlangabezana nezinguquko kumaphethini abo kashukela wegazi, nakuba lezi zinto zivame ukulawuleka ngokuqashwa okufanele kanye nokulungiswa okungenzeka emithini yesifo sikashukela.

Kubalulekile ukutshela udokotela wakho ngayo yonke imithi yakho yesifo sikashukela ngaphambi kokuqala ukwelashwa. Eminye imithi yesifo sikashukela ingasebenzisana nalokhu kwelashwa kwe-hepatitis C, idinga ukulungiswa komthamo noma eminye imithi.

Ngingenzani Uma Ngiphuzile Kakhulu I-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Uma ngengozi uthatha okungaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma usokhemisi ngokushesha ukuze uthole isiqondiso. Nakuba imiphumela emibi yokweqisa ingavamile, kubalulekile ukuthola iseluleko sochwepheshe mayelana nokuthi yini okufanele yenziwe ngokulandelayo.

Ungazami ukuthi "ukwenza" umthamo owengeziwe ngokuqaqa umthamo wakho olandelayo ohleliwe. Lokhu kungaphazamisa amazinga aqhubekayo emithi ohlelweni lwakho adingekayo ukulwa igciwane ngempumelelo.

Uma uhlangabezana nanoma yiziphi izimpawu ezingavamile ngemva kokuthatha imithi eminingi kakhulu, njengokucasuka okukhulu, isiyezi, noma izinguquko emazingeni okushaya kwenhliziyo, funa ukwelashwa ngokushesha. Gcina ukupakishwa komuthi nawe ukuze abahlinzeki bezempilo bazi kahle ukuthi yini nokuthi ungakanani owathathayo.

Ngingenzani Uma Ngeqa Umthamo We-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Uma weqa umthamo futhi sekudlule amahora angaphansi kwangu-12 kusukela ngesikhathi sakho esijwayelekile sokulinganisa, thatha umthamo owuphuthelwe ngokushesha lapho ukhumbula. Qiniseka ukuthi uyawuthatha nokudla, njengoba ungathatha umthamo wakho ovamile.

Uma amahora angaphezu kwangu-12 edlule kusukela ngesikhathi sakho esijwayelekile sokuthatha umuthi, weqa umthamo owuphuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile. Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuphuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi.

Zama ukusetha izikhumbuzi zokukusiza ukuthi ukhumbule umthamo wakho wansuku zonke. Ungasebenzisa i-alamu yefoni, umhleli wamaphilisi, noma uhlelo lokusebenza lwemithi ukusiza ukugcina isimiso sakho sokuthatha imithi ngesikhathi sonke sokwelashwa.

Ngingayeka nini Ukuthatha i-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Kufanele uyeke kuphela ukuthatha lo muthi uma udokotela wakho ekutshela ukuthi wenze njalo, ngokuvamile ngemva kokuqeda inkambo ephelele yokwelashwa ebekiwe. Abantu abaningi bayawuthatha amasonto angu-12, kodwa abanye bangase badinge amasonto angu-24 kuye ngesimo sabo esithile.

Udokotela wakho uzoqapha ukuqhubeka kwakho ngezivivinyo zegazi ezivamile ukuze ahlolisise amazinga akho e-viral load. Noma ngabe igciwane lingatholakali ekuqaleni kokwelashwa, kubalulekile ukuqeda inkambo ephelele ukuvimbela igciwane ukuthi libuye.

Ngemva kokuqeda ukwelashwa, udokotela wakho uzoqhubeka nokukuqapha izinyanga eziningana ukuze aqinisekise ukuthi igciwane alitholakali. Lesi sikhathi sokulandela siza ukuqinisekisa ukuthi ukwelashwa kuphumelele futhi igciwane lisusiwe unomphela ohlelweni lwakho.

Ngingakwazi yini Ukuphuza Utshwala Ngenkathi Ngithatha i-Ombitasvir-Paritaprevir-Ritonavir-and-Dasabuvir?

Kungcono ukugwema utshwala ngokuphelele ngenkathi uthatha lo muthi. Utshwala bungabeka ingcindezi eyengeziwe esibindini sakho, esivele sisebenza kanzima ukucubungula umuthi nokuphulukisa ekulimaleni kwe-hepatitis C.

Isibindi sakho sidinga wonke amandla aso agxile ekululameni ngesikhathi sokwelashwa. Ukwengeza utshwala emxube kunganciphisa ukuphulukiswa futhi kungenzeka ukuthi kwandise ingozi yemiphumela emibi ehlobene nesibindi evela emuthini.

Uma ukhathazekile ngokusebenzisa utshwala noma udinga ukusekelwa ekugwemeni utshwala ngesikhathi sokwelashwa, xoxa lokhu obala nethimba lakho lezempilo. Bangakunikeza izinsiza nokusekelwa ukukusiza ukuthi ugcine imikhuba yokungathathi utshwala ngalesi sikhathi esibalulekile sokwelashwa.