Yini i-Oxycodone ne-Naloxone: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Oxycodone ne-naloxone iyinhlanganisela yemithi esiza ukuphatha ubuhlungu obumaphakathi nendawo obunzima ngenkathi kunciphisa ubungozi bokuyisebenzisa kabi. Lo muthi oqokiwe uhlanganisa umuthi oqinile wokunciphisa ubuhlungu (i-oxycodone) nomuthi ovimba imiphumela ye-opioid (i-naloxone) ukuhlinzeka ngokuphatha ubuhlungu okusebenzayo ngezici zokuphepha ezakhelwe ngaphakathi.

Uma ubhekene nobuhlungu obungapheli obungazange busabele kahle kwezinye izindlela zokwelapha, udokotela wakho angase acabangele le nhlanganisela njengengxenye yohlelo lwakho lokuphatha ubuhlungu. Ukuqonda ukuthi isebenza kanjani nokuthi yini ongayilindela kungakusiza ukuthi uzizwe uqiniseka ngokwengeziwe ngemithi yakho.

Yini i-Oxycodone ne-Naloxone?

Lo muthi uhlanganisa imithi emibili ehlukene esebenza ndawonye ngendlela eyingqayizivele. I-Oxycodone iyisinciphisi sobuhlungu esinamandla se-opioid esisiza ukuvimba izimpawu zobuhlungu ebuchosheni bakho nasemgogodleni wakho. I-Naloxone iyisivimba se-opioid esihlala singasebenzi uma uthatha umuthi njengoba uqokiwe ngomlomo.

Ingxenye ye-naloxone isebenza njengesici sokuphepha. Uma othile ezama ukuchoboza, ukujova, noma ukuhogela umuthi ukuze athole ukuphakama, i-naloxone iyasebenza futhi ivimbe imiphumela ye-opioid. Lo mklamo ohlakaniphile usiza ekuvikeleni ukusetshenziswa kabi ngenkathi usavumela umuthi ukuthi usebenze kahle ekunciphiseni ubuhlungu uma uthathwa ngendlela efanele.

Ungase wazi le nhlanganisela ngamagama emikhiqizo afana ne-Targiniq ER noma ezinye izindlela zokwakheka. Umuthi uza ngamaphilisi akhishwa isikhathi eside akhulula kancane izithako ezisebenzayo emahoreni angu-12.

Yini i-Oxycodone ne-Naloxone Esetshenziselwa Yona?

Odokotela baqoka le nhlanganisela ikakhulukazi ukuphatha ubuhlungu obukhulu, obuqhubekayo obudinga ukwelashwa ubusuku nemini. Lokhu kufaka phakathi izimo ezinjengobuhlungu obuthuthukile bomdlavuza, i-arthritis enzima, noma ubuhlungu obungapheli emhlane obungathuthukanga ngeminye imithi.

Umhlinzeki wakho wezempilo ngokuvamile uzocabangela le nketho uma udinga ukukhululeka okunamandla kobuhlungu kodwa futhi ufuna ukunciphisa ukuqunjelwa, okuyisimo esivamile esivela emithini ye-opioid. Ingxenye ye-naloxone isiza ukulwa nokwehla kokugaya ukudla okungadalwa ama-opioid.

Lena akuyona imithi yobuhlungu obungajwayelekile noma ukungakhululeki kwesikhashana. Yenzelwe ngqo abantu abadinga ukuphathwa kobuhlungu okuqhubekayo, okunamandla isikhathi eside. Udokotela wakho uzohlola ngokucophelela ukuthi le nhlanganisela ilungile yini esimweni sakho esithile.

Isebenza Kanjani I-Oxycodone ne-Naloxone?

Lokhu kuthathwa njengomuthi onamandla osebenza ngendlela eyinkimbinkimbi yokusebenza kabili. Ingxenye ye-oxycodone inamathisela kuma-receptor e-opioid ebuchosheni bakho nasemgogodleni, ivimbela ngempumelelo izimpawu zobuhlungu ukuthi zingafinyeleli ezingqondweni zakho.

Ngesikhathi esifanayo, i-naloxone isebenza endaweni ethile ohlelweni lwakho lokugaya ukudla ukuze ivimbele ama-receptor e-opioid emathunjini akho. Lokhu kusiza ukuvimbela ukuqunjelwa okukhulu okuvame ukuhambisana nemithi yobuhlungu ye-opioid, kuyilapho kunomthelela omncane ekukhululekeni kobuhlungu ngoba i-naloxone encane kakhulu ingena egazini lakho.

Ifomula yokukhishwa isikhathi eside isho ukuthi yomibili imithi ikhishwa kancane kancane emahoreni angu-12. Lokhu kunikeza ukulawulwa kobuhlungu okuqhubekayo usuku lonke nobusuku, kunokuthi kube nokunyuka nokwehla ongase ukuzwe ngemithi yobuhlungu ekhishwe ngokushesha.

Kufanele Ngiyithathe Kanjani I-Oxycodone ne-Naloxone?

Thatha lo muthi ngendlela udokotela wakho akuyala ngayo, ngokuvamile njalo emahoreni angu-12 ngaphandle noma ngaphandle kokudla. Gwinya amaphilisi wonke ngengilazi yamanzi egcwele - ungaligayi, ulihlafune, noma uliqede, ngoba lokhu kungakhipha inani eliyingozi lomuthi ngasikhathi sinye.

Ungayithatha ngokudla uma ikucasula isisu, kodwa zama ukuhambisana nomkhuba wakho. Abanye abantu bathola ukuthi ukuyithatha ngesnakhi esincane kusiza ukuvimbela isicanucanu, ikakhulukazi lapho beqala umuthi.

Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho ngezindlela ezingezinye esikhundleni sokuzama ukuqhekeza noma ukuchoboza amaphilisi. Ukugcotshwa okukhishwa isikhathi eside kubalulekile ekunikezeni umthamo ophephile nophumelelayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Oxycodone ne-Naloxone?

Isikhathi sincike ngokuphelele esimweni sakho sobuhlungu kanye nendlela ozabela ngayo ekwelashweni. Ezimweni ezingapheli njengobuhlungu bomdlavuza noma i-arthritis ebukhali, ungase udinge lo muthi izinyanga noma iminyaka ngaphansi kokuqashwa kwezokwelapha okucophelelayo.

Udokotela wakho uzobuyekeza njalo amazinga akho obuhlungu, imiphumela emibi, kanye nekhwalithi yakho yempilo iyonke ukuze anqume ukuthi umuthi usawuyindlela engcono kakhulu yini. Bangase balungise umthamo, bashintshele komunye umuthi, noma bawunciphise kancane kancane uma ubuhlungu bakho buba ngcono.

Ungayeki ukuthatha lo muthi ngokuzumayo, ngoba lokhu kungabangela izimpawu zokuhoxisa ezingakhululeki. Uma udinga ukuwuyeka, udokotela wakho uzokwenza isimiso sokunciphisa kancane kancane ukuze usize umzimba wakho ukuthi uzivumelanise ngokuphepha.

Yiziphi Imiphumela Emibi Ye-Oxycodone ne-Naloxone?

Njengayo yonke imithi, le nhlanganisela ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi okulindelekile kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi evame kakhulu ongase uyibone ihlanganisa isicanucanu, isiyezi, ukozela, nekhanda. Lokhu kuvame ukuthuthuka njengoba umzimba wakho uzivumelanisa nomuthi ezinsukwini zokuqala noma emasontweni okuqala okwelashwa.

Nansi imiphumela emibi ihlelwe ngokuthi ivela kaningi kangakanani:

Imiphumela Emibi Evamile (ethinta abantu abangaphezu koyedwa kwabayi-10)

• Isicanucanu nokuhlanza
• Isiyezi noma ukukhathala
• Ukozela noma ukukhathala
• Ikhanda
• Umlomo owomile
• Ukujuluka
• Ukulahlekelwa isifiso sokudla

Lezi zinto ezilandelayo zivame ukuba mnene futhi zivame ukwehla njengoba umzimba wakho ujwayela imithi. Ukuhlala unamanzi nokuthatha imithi ngesikhathi sokudla kungasiza ekunciphiseni ezinye zalezi zimpawu.

Imiphumela engavamile kodwa ebalulekile

• Ukuqunjelwa (nakuba kungavamile njengoba kunjalo ngamanye ama-opioids)
• Izinkinga zokulala noma amaphupho acacile
• Ukukhathazeka noma izinguquko zemizwa
• Ukuhluleka ukuchama
• Ukuqubuka kwesikhumba noma ukuluma
• Ubuthakathaka bemisipha
• Ukubona kabukhali

Uma uhlangabezana nanoma yimiphi yale miphumela ngokuqhubekayo noma iba yimbi ngokuhamba kwesikhathi, kubalulekile ukuxoxa ngayo nomhlinzeki wakho wezempilo. Bavame ukukwazi ukulungisa umthamo wakho noma baphakamise izindlela zokulawula lezi zimpawu.

Imiphumela emibi engathi sína (idinga ukunakekelwa kwezempilo ngokushesha)

• Ukuphefumula kancane noma okunzima
• Isiyezi esikhulu noma ukuquleka
• Ukudideka noma ukucabanga
• Ukushaya kwenhliziyo okungajwayelekile
• Ubuhlungu obukhulu besisu
• Izimpawu zokungezwani komzimba (ukuqubuka, ukuvuvukala, ubunzima bokuphefumula)
• Ukushaywa yisithuthwane

Nakuba le miphumela emibi engathi sína ingavamile, idinga ukunakekelwa kwezempilo ngokushesha. Unganqikazi ukufuna ukunakekelwa okuphuthumayo uma uhlangabezana nanoma yiziphi zalezi zimpawu.

Ubani okungafanele athathe i-Oxycodone ne-Naloxone?

Lo muthi awulungele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwubhala. Izimo eziningana nezimo zenza le nhlanganisela ingaphephile noma ingasebenzi kahle.

Akufanele uthathe lo muthi uma unezinkinga ezinkulu zokuphefumula, okuhlanganisa isifuba esikhulu noma ezinye izimo zokuphefumula ezingase zibe zimbi ngama-opioids. Umuthi unganciphisa ukuphefumula kwakho, okungaba yingozi uma usuvele unezinkinga zokuphefumula.

Abantu abanezimo ezithile zokugaya ukudla kufanele bakugweme lokhu kuhlanganiswa. Uma unokuvaleka esiswini sakho noma emathunjini, isifo esibi sokuvuvukala kwamathumbu, noma ezinye izinkinga ezinkulu zokugaya ukudla, ingxenye ye-naloxone ingase ingakulungele.

Izimo Zezokwelapha Ezingase Zivimbele Ukusetshenziswa

• Isifuba esikhulu noma izinkinga zokuphefumula
• Ukuvaleka kwamathumbu noma izinkinga ezinkulu zokugaya ukudla
• Isifo esibi sesibindi noma sezinso
• Ukulimala ekhanda noma umdlavuza wobuchopho
• Umlando wokulutheka kwezidakamizwa noma utshwala (kudinga ukucatshangelwa okukhethekile)
• Ezinye izinkinga zesigqi senhliziyo
• Umfutho wegazi ophansi kakhulu

Udokotela wakho uzoqaphela izinzuzo ngokumelene nezingozi zesimo ngasinye salezi, njengoba abanye abantu bengase bakwazi ukusebenzisa imithi ngokuqapha eduze.

Imithi Engase Isebenzisane

• Eminye imithi ebuhlungu ye-opioid
• Ama-Benzodiazepines (imithi yokukhathazeka)
• Imithi yokulala
• Ezinye izidambisi zokucindezeleka
• Izidambisi zemisipha
• Imithi yokuquleka
• Ezinye izibulala-magciwane kanye nemithi elwa nesikhunta

Njalo tshela udokotela wakho ngayo yonke imithi, izithasiselo, nemikhiqizo yezitshalo oyithathayo. Ezinye izinhlanganisela zingaba yingozi, kanti ezinye zingase zidinge ukulungiswa kwemithamo noma ukuqapha okwengeziwe.

Amagama Omkhiqizo we-Oxycodone kanye ne-Naloxone

Lokhu kuhlanganiswa kuyatholakala ngaphansi kwamagama amaningi omkhiqizo, i-Targiniq ER ingenye yezindlela ezivamile e-United States. Ezinye izindawo zingase zibe namagama omkhiqizo ahlukene ngengxube efanayo yezithako ezisebenzayo.

Ezinye izindlela zingase zibe nezindlela ezihlukile zokukhululwa noma amandla, kodwa zonke ziqukethe inhlanganisela efanayo eyisisekelo ye-oxycodone kanye ne-naloxone. Umuthi wakho wezidakamizwa angakusiza ukuthi uqonde noma yikuphi ukungafani phakathi kwamagama omkhiqizo uma incwadi yakho kadokotela ishintsha.

Izinhlobo ezivamile zingase zitholakale, eziqulathe izithako ezifanayo ezisebenzayo njengezinhlobo ezinamagama omkhiqizo kodwa zingase zibukeke zihlukile. Ukusebenza kahle kufanele kufane kungakhathaliseki ukuthi uthola uhlobo olinegama lomkhiqizo noma oluvamile.

Ezinye izindlela ze-Oxycodone ne-Naloxone

Uma le nhlanganisela ingasebenzi kahle kuwe noma idala imiphumela engathandeki, ezinye izindlela ezingase zifaneleke. Udokotela wakho angakusiza ukuthi uhlole ezinye izinketho ngokusekelwe esimweni sakho esithile sobuhlungu nomlando wakho wezokwelapha.

Eminye imithi ye-opioid ekhishwe isikhathi eside ihlanganisa i-morphine, iziqeshana ze-fentanyl, noma amafomula e-tramadol. Ngayinye inamandla ahlukene, amaphrofayili emiphumela, nezimiso zokulinganisa ezingase zifaneleke kakhulu esimweni sakho.

Ezinye izindlela ezingezona ze-opioid zingase zihlanganise izinhlobo ezikhishwe isikhathi eside zemithi efana ne-gabapentin yobuhlungu bemizwa, noma izindlela zokuhlanganisa zisebenzisa imithi elwa nokuvuvukala, ama-muscle relaxants, noma ezinye izindlela zokuphatha ubuhlungu.

Ingabe i-Oxycodone ne-Naloxone ingcono kunezinye izidakamizwa ze-Opioids?

Le nhlanganisela inikeza izinzuzo eziyingqayizivele ngaphezu kwe-opioids yendabuko, ikakhulukazi ekunciphiseni ukuqunjelwa kanye nokusetshenziswa kabi okungenzeka. Ingxenye ye-naloxone isiza ukulwa nemiphumela yokugaya ukudla eyenza ezinye izidakamizwa ze-opioids zibe nzima ukuzibekezelela isikhathi eside.

Uma kuqhathaniswa ne-oxycodone yodwa, le nhlanganisela ngokuvamile idala ukuqunjelwa okuncane okungathi sína, okuyinto evame ukuba yimiphumela engathandeki kakhulu yemithi yobuhlungu be-opioid. Lokhu kungathuthukisa kakhulu izinga lakho lempilo futhi kunciphise isidingo seminye imithi yokuphatha ukuqunjelwa.

Noma kunjalo, ukuthi

Umbuzo 1. Ingabe i-Oxycodone ne-Naloxone Iphephile Ezigulini Zezinhliziyo?

Abantu abanezifo zenhliziyo bangasebenzisa le mithi ngokuphepha, kodwa idinga ukuqashwa ngokucophelela ngumhlinzeki wakho wezempilo. Umuthi ungathinta umfutho wegazi nesivinini senhliziyo, ngakho udokotela wakho uzodinga ukucabangela isimo sakho senhliziyo esithile.

Uma unezinkinga ezinkulu zenhliziyo, ukushaya kwenhliziyo okungajwayelekile, noma usebenzisa imithi yezifo zenhliziyo, udokotela wakho angase aqale ngomthamo ophansi noma akuqaphele eduze. Ingxenye ye-naloxone ngokuvamile ayengezi izingozi ezinkulu zenhliziyo ngaphandle kwalezo ze-oxycodone yodwa.

Umbuzo 2. Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi I-Oxycodone ne-Naloxone Eningi Kakhulu?

Uma ngengozi uthatha okuningi kakhulu, funa ukunakekelwa kwezempilo ngokushesha, ngisho noma uzizwa ulungile ekuqaleni. Ukweqisa kwe-Opioid kungaba yingozi empilweni, futhi izimpawu zingase zingaveli ngokushesha ngamafomula akhishwe isikhathi eside.

Izimpawu zokweqisa zihlanganisa ukozela okukhulu, ukuphefumula okuhamba kancane noma okunzima, izindebe eziluhlaza noma izinzipho, isikhumba esibandayo noma esimanzi, nokulahlekelwa ukwazi. Shayela izinsiza eziphuthumayo ngokushesha uma uqaphela noma yiziphi zalezi zimpawu kuwe noma komunye umuntu.

Umbuzo 3. Kufanele Ngenzeni Uma Ngedlula Umthamo We-Oxycodone ne-Naloxone?

Uma udlula umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle uma sekuyisikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo odluliwe bese uqhubeka neshejuli yakho ejwayelekile - ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo odluliwe.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha ama-alamu ocingo noma ukusebenzisa umhleli wamaphilisi ukusiza ukugcina ishejuli yakho. Ukulinganisa okungaguquki kubalulekile ekugcineni ukulawulwa kobuhlungu obuqhubekayo nokugwema izimpawu zokuhoxiswa.

Umbuzo 4. Ngingayeka nini ukuthatha i-Oxycodone ne-Naloxone?

Misa ukuthatha lo muthi kuphela ngaphansi kwesiqondiso sikadokotela wakho. Noma ngabe ubuhlungu bakho buyathuthuka, ukuyeka kungazelelwe kungadala izimpawu zokuhoxisa ezingakhululeki njengokucasuka, ukuqaqamba kwemisipha, ukukhathazeka, nezinkinga zokulala.

Udokotela wakho uzokwenza isimiso sokunciphisa kancane kancane, anciphise kancane umthamo wakho ezinsukwini noma emasontweni ukunciphisa imiphumela yokuhoxisa. Le nqubo ivumela umzimba wakho ukuthi uzivumelanise ngokwemvelo namazinga aphansi omuthi.

Q5. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Oxycodone ne-Naloxone?

Kufanele ugweme utshwala ngokuphelele ngenkathi uthatha lo muthi. Utshwala landisa ingozi yemiphumela emibi eyingozi, okuhlanganisa ukozela okukhulu, izinkinga zokuphefumula, nezinkinga ezingase zibe yingozi empilweni.

Ngisho namanani amancane otshwala angaba yingozi uma ehlanganiswe nemithi ye-opioid. Lokhu kufaka phakathi ubhiya, iwayini, imimoya, kanye nemithi equkethe utshwala. Hlala uhlola nomuthi wakho mayelana nokuqukethwe kotshwala kweminye imithi ongase uyithathe.