Pacritinib (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Vonjo
Mayelana naleli khambi
IPacritinib isetshenziswa ekwelapheni i-myelofibrosis ephakathi noma engokungozini okuphezulu, okuhlanganisa i-myelofibrosis eyinhloko, i-myelofibrosis ngemuva kwe-polycythemia vera, ne-myelofibrosis ngemuva kwe-essential thrombocythemia. I-Myelofibrosis yinkinga yomgogodla wamathambo eyingozi ebomini ebonakala ngale mihlola elandelayo: ukhulukazi lwespleen (splenomegaly), ukukhahlela okukhulu, ukuvuvukala, ukubila ubusuku, ukulahlekelwa isisindo, ubuhlungu lwamathambo, noma ukukhathala okungavamile noma ubuthakathaka. IPacritinib iyilokhu okuvimba i-kinase esebenza ohlelweni lokuvikela umzimba. Lena imithi itholakala kuphela ngomyalelo wochwepheshe wezokwelapha. Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekwahluleni kokusebenzisa imithi, izingozi zokuthatha imithi kufanele ziqhathaniswe nezinzuzo ezizoletha. Lo ngumqululo owenzayo wena nodokotela wakho. Kule mithi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nanoma iyiphi impendulo engavamile noma ebangelwa uketshezi kule mithi noma kunoma iyiphi eminye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zoketshezi, njengokudla, izibenge, izigcini, noma izilwane. Ngomkhiqizo ongenamibhalo, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubuhlobo bobudala nemiphumela ye-pacritinib kubantu abancane. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalinda ukusetshenziswa kwe-pacritinib kubantu abadala. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izimithi kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izindlela zokuphepha zingadingeka. Uma uthatha le mithi, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlaliswe ngezansi. Ukuhlangana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi noma ashintshe ezinye izimithi ozithathayo. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akunconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyisebenzisa kangakanani enye noma zombili izimithi. Ezinye izimithi akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba ukuhlangana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba nezinye izimithi kungabangela ukuhlangana. Ukuhlangana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ngokuvamile akunconywa, kodwa kungaphepheki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyisebenzisa kangakanani le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli leyeza kuphela njengoba kunqunyiwe udokotela wakho. Umthamo wakho uyahlukahluka ngokubalwa kwamapulethi akho futhi kudingeka ushintshwe izikhathi eziningi ukuze uthole ukuthi yini esebenza kangcono kuwe. Ungasebenzisi leyeza eliningi, ungalisebenzisi kaningi, futhi ungalisebenzisi isikhathi eside kunalokho udokotela wakho akuqondile. Leli leyeza liza ne-insert yolwazi lwabaguli. Funda futhi ulandele imiyalo ngokucophelela. Buza udokotela wakho uma unemibuzo. Qhubeka usebenzisa leli leyeza isikhathi eside njengoba udokotela wakho ekutshelile. Ungashintshi umthamo wakho noma uyeke ukuthatha leli leyeza ngaphandle kokukhuluma kuqala nodokotela wakho. Thatha leli leyeza ngokudla noma ngaphandle kokudla. Gwinya ikhaphsuli yonke. Ungayivuli, ungayaphula, noma ungayikhili. Thatha leli leyeza cishe ngesikhathi esifanayo nsuku zonke. Uma usebenzisa abanye abavimbi be-kinase, udokotela wakho angalungisa umthamo wakho noma ayeke ukuthatha amanye amayeza avimbi be-kinase ngaphambi kokuba uqale ukwelashwa nge-pacritinib. Umthamo waleli leyeza uzobahlukile kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemthethweni. Ulwazi olulandelayo luhlanganisa kuphela imithamo yaleli leyeza. Uma umthamo wakho uhlukile, ungawushintshi ngaphandle kokuthi udokotela wakho akuqondile ukuba wenze njalo. Inani leyeza olithathayo liyahlukahluka ngamandla leyeza. Futhi, inani lemithamo olithathayo nsuku zonke, isikhathi esivunyelwe phakathi kwemithamo, nobude besikhathi olithatha leli leyeza kuyahlukahluka ngokuxhomekeke enkingeni yezokwelapha oyisebenzisela leli leyeza. Uma uphuthelwe umthamo waleli leyeza, susa lowo mthamo ophuthelwe bese ubuyela esimisweni sakho sokuthola umthamo ojwayelekile. Ungawandisi imithamo. Gcina leli leyeza esitsheni esivaliwe ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungalwi. Gcina kungafinyeleleki izingane. Ungagcini leyeza eliphelile noma leyeza elingasadingeki. Buza ochwepheshe bakho bezempilo ukuthi kufanele ulahle kanjani noma yiliphi leyeza ongelisebenzisi.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.