Yini i-Pacritinib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Pacritinib iyikhambi eliqondiswe ngomlomo elenzelwe ukusiza abantu abanezifo ezithile zegazi, ikakhulukazi isimo esingavamile esibizwa ngokuthi i-myelofibrosis. Lo muthi oqokiwe usebenza ngokuvimba amaprotheni athile anegalelo ekuthuthukisweni komdlavuza wegazi, enikeza ithemba ezigulini ezingase zibe nezinketho zokwelapha ezilinganiselwe.

Uma wena noma othile omkhathalelayo eqokiwe i-pacritinib, cishe ufuna imininingwane ecacile, ethembekile mayelana nokuthi yini ongayilindela. Ake sihambe kukho konke okudingeka ukwazi ngalo muthi ngendlela ezizwa ilawuleka futhi inamandla.

Yini i-Pacritinib?

I-Pacritinib iyikhambi elikhethekile lomlomo elingelakho eklasini lemithi ebizwa ngokuthi ama-JAK inhibitors. Iqondisa ngqo amaprotheni abizwa ngokuthi ama-Janus kinases, anendima ekukhuleni nasekusebenzeni kwamaseli egazi emzimbeni wakho.

Lo muthi wenzelwe ngqo abantu abane-myelofibrosis, isifo esingavamile somnkantsha wamathambo lapho izicubu ezinempilo zomnkantsha wamathambo zithathelwa indawo yizicubu ezinamanxeba. Le nqubo iphazamisa ikhono lomzimba wakho lokukhiqiza amaseli egazi anempilo ngokujwayelekile.

Okuhlukanisa i-pacritinib phakathi kwemithi efanayo ukuthi ingasetshenziswa ngokuphepha ngisho nalapho inani lakho lama-platelet liphansi kakhulu. Ezinye izindlela zokwelapha eziningi kulolu hlobo zidinga amazinga aphezulu e-platelet, okwenza i-pacritinib ibe yindlela ebalulekile ezigulini ezingase zingafaneleki kwezinye izindlela zokwelapha.

Isetshenziselwani i-Pacritinib?

I-Pacritinib ikakhulukazi iqokelwa abantu abadala abane-myelofibrosis eyinhloko ephakathi noma enobungozi obukhulu, i-post-polycythemia vera myelofibrosis, noma i-post-essential thrombocythemia myelofibrosis. Lezi zonke izinhlobo ze-myelofibrosis, isimo lapho umnkantsha wakho wamathambo uba namanxeba futhi ungakwazi ukukhiqiza amaseli egazi ngempumelelo.

Umuthi ukhonjiswe ngqo ezigulini ezinenani le-platelet elingaphansi kuka-50,000 ngemayikhrolitha yegazi. Leli nani eliphansi le-platelet livame ukwenza ukwelashwa okuhlukile kungafaneleki noma kungaphephile, yingakho i-pacritinib igcwalisa igebe elibaluleke kangaka ezinkethweni zokwelapha.

Udkt wakho angase ancome i-pacritinib uma uhlangabezana nezimpawu ezinjengokukhathala okukhulu, ukukhula kwespleen, ubuhlungu bamathambo, noma ukujuluka ebusuku okuhlobene ne-myelofibrosis yakho. Umgomo uwukusiza ukunciphisa lezi zimpawu futhi uthuthukise izinga lempilo yakho ngenkathi ulawula isimo esingaphansi.

Isebenza Kanjani I-Pacritinib?

I-Pacritinib isebenza ngokuvimba ama-enzyme athile abizwa ngokuthi i-JAK1 ne-JAK2, asebenza ngokweqile ku-myelofibrosis. Cabanga ngala ma-enzyme njengamashintshi abambeke endaweni ethi "vuliwe", okubangela ukuthi umnkantsha wakho wamathambo uziphathe ngendlela engafanele.

Lapho i-pacritinib ivimba lawa mashintshi, isiza ukunciphisa ukusayina kwamaseli okungajwayelekile okuholela ekulimaleni komnkantsha wamathambo kanye nezimpawu ezingakhululeki ongase uzithole. Lokhu kungasiza ukunciphisa usayizi we-spleen, ukunciphisa ukuvuvukala, futhi kuthuthukise induduzo yakho yonke.

Njengokwelashwa okuqondiwe, i-pacritinib ithathwa njengomuthi onamandla ngokulinganiselwe. Yenzelwe ngqo ukusebenza ezingeni le-molecular kunokuthinta uhlelo lwakho lonke ngokubanzi. Le ndlela eqondiwe ivame ukusho imiphumela emincane engemihle uma iqhathaniswa ne-chemotherapy yendabuko, nakuba iseyilapho elibucayi elidinga ukuqashwa ngokucophelela.

Kufanele Ngiyithathe Kanjani I-Pacritinib?

I-Pacritinib iza ngama-capsule owathatha ngomlomo kabili ngosuku, cishe ngamahora ayi-12 ahlukene. Umthamo ovamile wokuqala ungu-200 mg kabili ngosuku, kodwa udkt wakho uzonquma umthamo oqondile olungile esimweni sakho esithile.

Ungayithatha i-pacritinib ngaphandle kokudla noma ngaphandle kokudla, kodwa zama ukuhambisana nomkhuba wakho. Uma ukhetha ukuyithatha ngokudla, namathela kulowo mkhuba, futhi uma ukhetha ukuyithatha esiswini esingenalutho, yenza lokho njalo. Lokhu kusiza ukugcina amazinga aqhubekayo omuthi ohlelweni lwakho.

Gwinya amaphilisi wonke ngengilazi enkulu yamanzi. Ungawavuli, uwachoboze, noma uwahlafune, ngoba lokhu kungathinta indlela umuthi omuncwa ngayo futhi kungase kwandise imiphumela emibi. Uma unenkinga yokugwinya amaphilisi, khuluma nethimba lakho lezempilo mayelana namaqhinga angase asize.

Kuyasiza ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke ukuze kumiswe umkhuba. Abantu abaningi bakuthola kulula ukukhumbula uma behlanganisa izikhathi zabo zemithi nemisebenzi yansuku zonke efana nokudla noma imikhuba yokulala.

Ngingayithatha isikhathi esingakanani i-Pacritinib?

Ubude bokwelashwa kwe-pacritinib buhlukahluka kakhulu kumuntu nomuntu futhi kuncike ekutheni usabela kahle kangakanani emuthini nokuthi uwuthatha kahle kangakanani. Abanye abantu bangayithatha izinyanga, kanti abanye bangase baqhubeke iminyaka.

Udokotela wakho uzoqapha impendulo yakho ngokuhlolwa kwegazi njalo nokuhlolwa komzimba. Bazohlola ukuthi ngabe izimpawu zakho ziyathuthuka yini, uma usayizi wakho we-spleen wehla, nokuthi izibalo zakho zegazi zisabela kanjani ekwelashweni.

Isinqumo sokuthi uzoqhubeka isikhathi esingakanani ukwelashwa sizosekelwa ekulinganiseni phakathi kwezinzuzo ozitholayo kanye nanoma yimiphumela emibi ongase ube nayo. Ithimba lakho lezempilo lizosebenza nawe ukuthola indlela efanele yesimo sakho ngasinye.

Ungayeki ukuthatha i-pacritinib ngokuzumayo ngaphandle kokuxoxa ngayo nodokotela wakho kuqala. Bangase badinge ukulungisa umthamo wakho kancane kancane noma bakuqaphe eduze ngesikhathi sokushintsha kokwelashwa.

Yiziphi Imiphumela Emiqoka ye-Pacritinib?

Njengazo zonke izidakamizwa, i-pacritinib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini okufanele uyibheke kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungaxhumana nini nethimba lakho lezempilo.

Imiphumela emibi evame kakhulu ivame ukulawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Nansi imiphumela emibi ongase uhlangabezane nayo:

• Ukuqunjelwa, okungahluka kusuka kokuncane kuya kokulingene
• Ukucanuzela kwenhliziyo nokuhlanza ngezikhathi ezithile
• Ukuvuvukala emilenzeni yakho, emaqakaleni, noma ezinyaweni
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Ukulimala kalula kunokujwayelekile
• Isiyezi noma ukuzizwa unesiyezi
• Ubuhlungu bemisipha noma amalunga

Le miphumela emibi ejwayelekile ivame ukuba yesikhashana futhi ingalawulwa ngokunakekelwa okusekelayo noma ukulungiswa komthamo. Ithimba lakho lezempilo linganikeza amasu athile okukusiza ukuthi uzizwe ukhululekile.

Ngokuvamile, abanye abantu bathola imiphumela emibi engathi sína edinga ukunakekelwa kwezempilo ngokushesha. Nakuba lokhu kungavamile, kubalulekile ukukwazi:

• Ukuphuma kwegazi okukhulu noma ukulimala okungajwayelekile
• Izimpawu zokutheleleka njengomkhuhlane oqhubekayo noma amaqhwa
• Ukuqunjelwa okukhulu okuholela ekuphelelwe amanzi emzimbeni
• Ukuvuvukala okukhulu noma ubunzima bokuphefumula
• Ushintsho lwesigqi senhliziyo noma ukushaya kwenhliziyo okusheshayo

Uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína, xhumana nomhlinzeki wakho wezempilo ngokushesha. Bangasiza ukunquma ukuthi ngabe lokhu kuhlobene yini nomuthi wakho nokuthi yiziphi izinyathelo okufanele zithathwe ngokulandelayo.

Ubani Ongafanele Athole I-Pacritinib?

I-Pacritinib ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ingabe iyona yini ekufanele isimo sakho esithile. Izimo ezithile zezokwelapha noma izimo zingenza lo muthi ungafaneleki noma zidinge izinyathelo zokuphepha ezikhethekile.

Abantu abanezinkinga ezinkulu zesibindi akufanele bathathe i-pacritinib, njengoba umuthi uqhutshwa esibindini futhi ungase uqhubekisele phambili ukusebenza kwesibindi. Udokotela wakho uzohlola ukusebenza kwesibindi sakho ngaphambi kokuqala ukwelashwa futhi akubheke njalo ngenkathi uthatha umuthi.

Uma unomlando wezinkinga ezinkulu zokushaya kwenhliziyo, udokotela wakho uzodinga ukukala izinzuzo nezingozi ngokucophelela. I-Pacritinib ingathinta ukushaya kwenhliziyo kwabanye abantu, ngakho lokhu kudinga ukuqapha okuseduze nokucatshangelwa kwezinye izindlela zokwelapha.

Izifo eziqhubekayo, ezinzima kungenye into ebalulekile okufanele icatshangelwe. Njengoba i-pacritinib ingathinta ikhono lomzimba lakho lokulwa nezifo, ukuqala ukwelashwa ngesikhathi sokutheleleka okusebenzayo kungaba yingozi. Udokotela wakho uzofuna ukwelapha noma yiziphi izifo kuqala ngaphambi kokuqala i-pacritinib.

Ukukhulelwa nokuncelisa ngamabele kudinga ukucatshangelwa okukhethekile. I-Pacritinib ingase ilimaze ingane esakhula, ngakho-ke abesifazane abaneminyaka yokuzala badinga ukusebenzisa izindlela zokuvimbela inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nesikhathi esithile ngemuva kokuyeka umuthi.

Amagama Omkhiqizo we-Pacritinib

I-Pacritinib itholakala ngaphansi kwegama lomkhiqizo elithi Vonjo e-United States. Leli igama lezentengiso ozolibona ebhodleleni lakho likanokusho kanye nokupakishwa komuthi.

I-Vonjo yavunywa yi-FDA ngokuqondile ukwelapha i-myelofibrosis ezigulini ezinamazinga aphansi e-platelet. Uma ubona leli gama emuthini wakho, ngumuthi ofanayo ebesiwuxoxa kuyo yonke le ndatshana.

Njengamanje, i-pacritinib itholakala kuphela njengomuthi wegama lomkhiqizo. Izinhlobo ezivamile azikatholakali okwamanje, okusho ukuthi izindleko zingase zibe phezulu kunezindlela zokwelapha ezinokunye okuhlukile okujwayelekile.

Ezinye izindlela ze-Pacritinib

Eminye imithi eminingana iyatholakala yokwelapha i-myelofibrosis, nakuba ngamunye enezidingo ezihlukene nokucatshangelwa. Udokotela wakho uzosiza ekunqumeni ukuthi iyiphi inketho engase ibe ngcono esimweni sakho esithile.

I-Ruxolitinib (Jakafi) ngomunye umvimbeli we-JAK ovame ukusetshenziselwa i-myelofibrosis. Nokho, ngokuvamile idinga ukubalwa kwamapuleti aphezulu kune-pacritinib, okwenza ingafaneleki ezigulini ezinamapuleti aphansi kakhulu. Lona omunye womehluko omkhulu phakathi kwalawo makhambi amabili.

I-Fedratinib (Inrebic) enye inketho esebenza ngendlela efana ne-pacritinib kodwa inezinhlobo ezihlukene zemiphumela emibi kanye nezidingo. Abanye abantu bangase bakwazi ukubekezelela elinye lamakhambi kangcono kunelinye, ngakho ukuba nezinketho eziningi kuyazuzisa.

Kweziguli ezithile, ezinye izindlela ezinjengokumpontshelwa igazi, imithi yokulawula izimpawu ezithile, noma ukubamba iqhaza ezivivinyweni zemitholampilo kungase kucatshangelwe. Ukukhetha okungcono kuncike empilweni yakho yonke, ukubalwa kwegazi, ubunzima bezimpawu, nezintandokazi zakho.

Ingabe i-Pacritinib Ingcono Kune-Ruxolitinib?

I-Pacritinib ne-ruxolitinib bobabili bavimbela i-JAK abasebenzayo, kodwa basebenzela iziguli ezihlukene futhi banezinzuzo ezihlukile. Ukukhetha okungcono kuncike ngokuphelele esimweni sakho sezokwelapha kanye nezidingo zakho.

Inzuzo enkulu ye-pacritinib ukuthi ingasetshenziswa ngokuphepha ezigulini ezinokubalwa kwamapuleti aphansi kakhulu (ngaphansi kuka-50,000). I-Ruxolitinib ngokuvamile idinga amazinga aphezulu wamapuleti, ngakho i-pacritinib igcwalisa igebe elibalulekile ezigulini ezingakwazi ukusebenzisa ezinye izindlela zokwelapha.

I-Ruxolitinib itholakale isikhathi eside futhi inemininingwane eminingi yesikhathi eside, abanye odokotela neziguli abakuthola kuqinisekisa. Futhi ifundwe ezinhlobonhlobo zezimo ezingaphezu kwe-myelofibrosis.

Amaphrofayili emiphumela emibi ahlukile phakathi kwalawo makhambi amabili. Abanye abantu bangase bakwazi ukubekezelela elinye kangcono kunelinye, futhi udokotela wakho angasiza ukuqagela ukuthi yikuphi okungase kusebenze kangcono ngokusekelwe emlandweni wakho wezokwelapha kanye nesimo sempilo yakho yamanje.

Isinqumo phakathi kwalawo makhambi kufanele senziwe ngaso sonke isikhathi ngokubambisana nethimba lakho lezempilo, kucatshangelwa ukubalwa kwegazi lakho elithile, izimpawu, ezinye izimo zezokwelapha, kanye nemigomo yokwelapha.

Imibuzo Evame Ukubuzwa Mayelana ne-Pacritinib

Ingabe i-Pacritinib iphephile kubantu abanezinkinga zenhliziyo?

I-Pacritinib idinga ukucatshangelwa ngokucophelela uma unezinkinga zenhliziyo, ikakhulukazi iziyaluyalu zokushaya kwenhliziyo. Umuthi ungase ukwazi ukuthinta ukushaya kwenhliziyo, ngakho udokotela wakho uzodinga ukuhlola impilo yakho yenhliziyo ngaphambi kokuqala ukwelashwa.

Uma unomlando wezinkinga zokushaya kwenhliziyo, udokotela wakho cishe uzofuna ukwenza i-electrocardiogram (EKG) ngaphambi kokuqala i-pacritinib futhi akuqaphele eduze ngesikhathi sokwelashwa. Bangase futhi bahlole amazinga akho e-electrolyte njalo, njengoba ukungalingani kungakhuphula izingozi zokushaya kwenhliziyo.

Abantu abaningi abanezimo zenhliziyo ezithambile bangayithatha ngokuphepha i-pacritinib ngokuqapha okufanele. Okubalulekile ukuxhumana okuvulekile nethimba lakho lezempilo mayelana nomlando wakho wenhliziyo nanoma yiziphi izimpawu ozibonayo ngesikhathi sokwelashwa.

Ngingenzani uma ngiphuthelwa ngengozi ukuthatha i-Pacritinib eningi kakhulu?

Uma ngengozi uthatha i-pacritinib eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi uzizwa ulungile yini, njengoba eminye imiphumela yokweqisa ingase ingabonakali ngokushesha.

Ukuthatha i-pacritinib eningi kakhulu kungakhuphula ingozi yakho yemiphumela emibi engathi sína, ikakhulukazi ukopha, izinkinga zokushaya kwenhliziyo, noma isifo sohudo esibi. Ukunakekelwa kwezokwelapha okusheshayo kungasiza ekuvikeleni noma ekuphatheni lezi zinkinga.

Uma ushayela ucingo ukuze uthole usizo, lungisa ibhodlela lakho lemithi ukuze ukwazi ukunikeza imininingwane ethile mayelana nokuthi uthathe malini nokuthi nini. Lolu lwazi lusiza abahlinzeki bezempilo ukuthi bakunikeze isiqondiso esifanele kakhulu.

Ngingenzani uma ngiphuthelwa umthamo we-Pacritinib?

Uma uphuthelwa umthamo we-pacritinib, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe futhi uqhubeke neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ongekho. Lokhu kungakhuphula ingozi yakho yemiphumela engemihle ngaphandle kokuhlinzeka ngenzuzo eyengeziwe. Kungcono ukugcina isimiso sakho esivamile siqhubeka.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha ama-alamu ocingo, usebenzise umhleli wamaphilisi, noma ucele amalungu omndeni ukuthi akusize ukukukhumbuza. Ukuthatha imithamo njalo kusiza ukugcina amazinga emithi aqhubekayo ohlelweni lwakho.

Ngingayeka nini ukuthatha i-Pacritinib?

Isinqumo sokuyeka i-pacritinib kufanele senziwe ngaso sonke isikhathi ngokubonisana nodokotela wakho. Bazocabangela izinto ezinjengokuthi imithi isebenza kahle kangakanani, yimiphi imiphumela engemihle oyitholayo, kanye nesimo sakho sempilo esiphelele.

Abanye abantu bangase badinge ukuyeka uma behlangabezana nemiphumela engemihle engabekezeleleki noma uma isimo sabo siqhubeka ngaphandle kokwelashwa. Abanye bangase bayeke uma befinyelela ekulawuleni okuhle kwesifo futhi udokotela wabo ezwa ukuthi ikhefu lokwelashwa lilungile.

Udkt wakho cishe uzofuna ukukugada eduze ngemva kokuyeka i-pacritinib ukuze abheke noma yiziphi izinguquko esimweni sakho. Bangase bancomise ukushintshela ekwelashweni okuhlukile noma ukusebenzisa amasu okuqapha engeziwe.

Ngingathatha eminye imithi ngenkathi ngisebenzisa i-Pacritinib?

Imithi eminingi ingathathwa ngokuphepha ne-pacritinib, kodwa ezinye izindlela zokusebenzisana kungenzeka. Njalo yazisa udokotela wakho ngayo yonke imithi, izithasiselo, kanye nemithi etholakala ngaphandle kwemvume kadokotela oyithathayo ngaphambi kokuqala i-pacritinib.

Eminye imithi ingase ithinte indlela i-pacritinib esebenza ngayo noma ikhuphule ingozi yemiphumela engemihle. Udokotela wakho angase adinge ukulungisa imithamo, akuqaphe eduze, noma ancome eminye imithi uma kutholakala ukusebenzisana okukhulu.

Gcina uhlu olusha lwazo zonke izidakamizwa zakho futhi ululethwe kuyo yonke imihlangano yezokwelapha. Lokhu kusiza ithimba lakho lezempilo ukuthi lenze izinqumo ezinolwazi mayelana nohlelo lwakho lokwelashwa futhi libambe noma yiziphi izinkinga ezingaba khona ekuqaleni.