Yini i-Pafolacianine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Pafolacianine iyisithombe esikhanyayo esisiza odokotela abahlinzayo ukuthi babone amaseli omdlavuza ngokucacile ngesikhathi sokuhlinzwa. Lo muthi okhethekile usebenza njenge-highlighter yezicubu zomdlavuza, okwenza zikhanye ngaphansi kokukhanya okukhethekile kwe-infrared ukuze odokotela bakwazi ukuhlonza kangcono nokususa izimila ngenkathi begcina izicubu ezinempilo.

Lo muthi umele intuthuko enkulu ekunembeni kokuhlinzwa, ikakhulukazi ezinqubweni zomdlavuza wama-ovari. Unikezwa nge-IV ngaphambi kokuhlinzwa futhi uqongelela kumaseli omdlavuza, usiza odokotela abahlinzayo ukuthi bahambe ngemisebenzi eyinkimbinkimbi ngethemba elikhulu nokunemba.

Yini i-Pafolacianine Esetshenziselwa Yona?

I-Pafolacianine isetshenziswa ikakhulukazi ukusiza odokotela abahlinzayo ukuthi bahlonze izicubu zomdlavuza wama-ovari ngesikhathi sokuhlinzwa. Lo muthi usebenza njengesiqondiso esibonakalayo, ugqamisa amaseli omdlavuza okungenzeka ukuthi kube nzima ukuwahlukanisa nezicubu ezinempilo ngamehlo anqunu.

Lesi sithombe sivunyelwe ngokuqondile abesifazane abadala abahlinzwa ngenxa yokusolwa noma ukuqinisekiswa komdlavuza wama-ovari. Sisiza odokotela abahlinzayo ukuthi benze izinqumo ezinolwazi olwengeziwe mayelana nokuthi yiziphi izicubu okufanele zisuswe nokuthi yiziphi okufanele zigcinwe, okungenzeka ukuthi kuthuthukise imiphumela yokuhlinzwa.

Lo muthi futhi ufundwa ezinye izinhlobo zokuhlinzwa komdlavuza, nakuba umdlavuza wama-ovari usahlala ukusetshenziswa kwawo okuyinhloko okuvunyelwe. Ithimba lakho lokuhlinzwa lizinqumela ukuthi ngabe lesi sithombe sifanele yini isimo sakho esithile.

Isebenza Kanjani i-Pafolacianine?

I-Pafolacianine isebenza ngokugxila kuma-folate receptors, okuyizinhlobo zamaprotheni atholakala emazingeni aphezulu kumaseli amaningi omdlavuza. Cabanga ngalezi zitholi njengeziteshi zokumisa ezisetshenziswa amaseli omdlavuza ukuqoqa izakhamzimba azidingayo ukuze akhule futhi asinde.

Uma iselwe emithanjeni yakho yegazi, umuthi uhamba emzimbeni wakho wonke bese unamathisela kulawo ma-folate receptors. Amaseli omdlavuza ngokuvamile anama-receptors amaningi kunawo amaseli anempilo, ngakho-ke umuthi uqongelela kakhulu ezicutshini ezinomdlavuza.

Ngesikhathi sokuhlinzwa, udokotela ohlinzayo usebenzisa uhlelo olukhethekile lwekhamera ye-infrared ukubona lapho umuthi oqongelele khona. Izicubu ezinomdlavuza zibonakala zikhanya noma zikhanye ngaphansi kwalokhu kukhanya okukhethekile, okwenza umehluko ocacile phakathi kwezindawo ezinempilo nezinezifo zomdlavuza.

Lokhu kuthathwa njenge-ejenti yokuthwebula izithombe enamandla aphakathi nendawo enikeza imininingwane ebalulekile ngaphandle kokushintsha kakhulu imisebenzi ejwayelekile yomzimba wakho. Umuthi awuphathi umdlavuza ngokwawo kodwa usebenza njethuluzi lokuhlinzwa.

Ngingawuthatha kanjani i-Pafolacianine?

I-Pafolacianine inikezwa kuphela ochwepheshe bezempilo ngomugqa we-intravenous (IV) esibhedlela noma esikhungweni sokuhlinzwa. Ngeke uthathe lo muthi ekhaya noma ngomlomo.

Umithi ngokuvamile unikezwa amahora angu-1 kuya kwangu-9 ngaphambi kokuthi ukuhlinzwa kwakho kuqale. Ithimba lakho lezokwelapha lizinquma isikhathi esiqondile ngokusekelwe ezinqubweni zakho ezithile nezidingo zezokwelapha.

Akudingeki ukuthi uthathe lo muthi ngokudla noma ubisi njengoba unikezwa ngokuqondile emithanjeni yakho yegazi. Kodwa-ke, ithimba lakho lokuhlinzwa lingakunika imiyalelo ethile mayelana nokudla noma ukuphuza ngaphambi kwenqubo yakho, okufanele uyilandele ngokucophelela.

Inqubo yokulungiselela iqondile. Umhlengikazi wakho uzoqala umugqa we-IV bese ejova kancane umuthi ngemizuzu embalwa. Ngemuva kwalokho uzolinda isikhathi esifanele ngaphambi kokuthi ukuhlinzwa kwakho kuqale.

Kufanele ngiyithathe isikhathi esingakanani i-Pafolacianine?

I-Pafolacianine inikezwa njengomthamo owodwa ngaphambi kokuhlinzwa, hhayi njengokwelashwa okuqhubekayo. Uzothola umuthi kanye, futhi uzosebenza kuyo yonke inqubo yakho yokuhlinzwa.

Umuthi uhlala usebenza emzimbeni wakho amahora amaningi, okuyisikhathi esanele izinqubo eziningi zokuhlinzwa. Umzimba wakho ngokwemvelo uzowukhipha umuthi ezinsukwini ezilandelayo ngaphandle kokwelashwa okwengeziwe okudingekayo.

Ngokungafani nemithi eminingi edinga imithamo yansuku zonke noma izifundo zokwelashwa ezinwetshiwe, i-pafolacianine yakhelwe ukusetshenziswa kanye kuphela. Akunasidingo sokukhathazeka ngokukhumbula ukuthatha imithamo noma ukuphatha isimiso semithi esiyinkimbinkimbi.

Yiziphi Imiphumela Eceleni Ye-Pafolacianine?

Abantu abaningi bayayibekezelela i-pafolacianine kahle, nemiphumela emibi ngokuvamile iba mnene futhi yesikhashana. Izimpendulo ezivame kakhulu zenzeka ngokushesha ngemva kokuthola umjovo futhi ngokuvamile zixazululeka ngokushesha.

Nansi imiphumela emibi ongase uyithole, ukhumbula ukuthi abantu abaningi abanayo imiphumela ebonakalayo nhlobo:

Imiphumela emibi ejwayelekile ihlanganisa:

• Isicanucanu noma isisu esincane esicasukile
• Ukushintsha kombala kwesikhashana komchamo (kungase kubonakale kuphuzi noma kuluhlaza)
• Ukuphendula kwesikhumba okuncane endaweni yokujova
• Isiyezi esifushane noma ukuzwa ukukhanya ekhanda
• Ushintsho lwesikhashana endleleni izinto ezizwakala ngayo

Imiphumela emibi engavamile kodwa engathi sína ingase ihlanganise:

• Ukuphendula komzimba okungavamile ngezimpawu ezinjengokuqubuka, ukuluma, noma ubunzima bokuphefumula
• Ushintsho olukhulu emfutheni wegazi
• Isicanucanu esibi noma ukuhlanza
• Ubuhlungu besifuba noma izinguquko zesigqi senhliziyo
• Ukuphendula okukhulu endaweni yokujova

Ithimba lakho lezokwelapha lizokuqapha ngokusondele ngemva kokuthola umuthi kanye nasekwenzeni ukuhlinzwa kwakho. Uma uhlangabezana nanoma yiziphi izimpawu ezikhathazayo, balungiselelwe kahle ukuzixazulula ngokushesha.

Ubani Ongafanele Athole I-Pafolacianine?

I-Pafolacianine ayifaneleki kuwo wonke umuntu, futhi ithimba lakho lezokwelapha lizobuyekeza ngokucophelela umlando wakho wezempilo ngaphambi kokunquma ukuthi ilungile yini kuwe. Umuthi unezinkomba ezithile eziwenza ungafaneleki kubantu abathile.

Akufanele uthole i-pafolacianine uma unokungezwani okwaziwayo nomuthi noma yiziphi izingxenye zawo. Udokotela wakho uzoxoxa nganoma yiziphi izindlela zokungezwani komzimba owaye nazo emithini noma ezithombeni zokuthwebula.

Abantu abanezifo ezinzima zezinso kungenzeka bangabi ngabantu abafanelekayo kulo muthi, njengoba umzimba uthembele ekusebenzeni kwezinso ukuqeda umuthi. Udokotela wakho uzobukeza izivivinyo zakho zokusebenza kwezinso ngaphambi kokwenza lesi sinqumo.

Uma ukhulelwe noma uncelisa, ukuphepha kwe-pafolacianine akukamiswanga ngokugcwele. Ithimba lakho lezokwelapha lizohlola izinzuzo nezingozi ngokucophelela kulezi zimo.

Ezinye izimo zenhliziyo noma izinkinga zomfutho wegazi nazo zingenza lo muthi ungafaneleki. Udokotela wakho ohlinzayo kanye nodokotela we-anesthesiologist bazobukeza umlando wakho wezokwelapha ophelele ukuqinisekisa ukuphepha kwakho.

Amagama Omkhiqizo we-Pafolacianine

I-Pafolacianine ithengiswa ngaphansi kwegama lomkhiqizo elithi Cytalux e-United States. Leli yigama eliyinhloko lezentengiso okungenzeka ukuthi uzohlangana nalo lapho uxoxa ngalo muthi nethimba lakho lezempilo.

Umuthi ungase ubizwe ngegama lawo elivamile (pafolacianine) noma igama lomkhiqizo (Cytalux) ngokushintshana ezindaweni zezokwelapha. Womabili la magama abhekisela emuthini ofanayo onezindawo nemiphumela efanayo.

Lapho uhlela ukuhlinzwa kwakho noma ubukeza uhlelo lwakho lokwelashwa, ungase ubone noma yiliphi igama elisetshenziswa emarekhodini akho ezokwelapha noma emiyalweni yokukhishwa. Ungakhathazeki uma ubona womabili amagama - bangumuthi ofanayo.

Ezinye izindlela ze-Pafolacianine

Njengamanje, zikhona ezinye izindlela eziqondile ze-pafolacianine zokuhlinzwa okuqondiswa yi-fluorescence emdlalweni wama-ovari. Izindlela zokuhlinzwa zendabuko zithembela ekuhloleni kombono nodokotela ohlinzayo ngaphandle kokuqondiswa yi-fluorescent.

Ezinye izindlela zokuthwebula izithombe ezisetshenziswa ngesikhathi sokuhlinzwa zihlanganisa i-ultrasound yangaphakathi, esebenzisa amaza omsindo ukudala izithombe zangempela zezakhiwo zangaphakathi. Kodwa-ke, lokhu kunikeza ulwazi oluhlukile kunokuthwebula izithombe nge-fluorescent.

Ezinye izikhungo zezokwelapha zisebenzisa ezinye izinto ze-fluorescent zezinhlobo ezahlukene zokuhlinzwa komdlavuza, kodwa lezi ngokuvamile azishintshani ne-pafolacianine ezinqubweni zomdlavuza wama-ovari.

Udkt wakho ohlinzayo uzoxoxa ngendlela engcono kakhulu yesimo sakho esithile, okungase kuhlanganise ukusebenzisa i-pafolacianine, izindlela zokuhlinzwa zendabuko, noma inhlanganisela yezindlela zokufeza umphumela ongcono kakhulu.

Ingabe i-Pafolacianine Ingcono Kunezinye Izindlela Zokuthwebula Izithombe?

I-Pafolacianine inikeza izinzuzo eziyingqayizivele ngaphezu kwezindlela zokuthwebula izithombe zokuhlinzwa zendabuko, ikakhulukazi ekwazi kwayo ukugqamisa izicubu zomdlavuza ngesikhathi sangempela ngesikhathi sokuhlinzwa. Lokhu kungaba usizo ikakhulukazi ezimweni eziyinkimbinkimbi lapho izicubu zomdlavuza zingase zibe nzima ukuzihlukanisa nezicubu ezinempilo.

Izindlela zokuhlinzwa zendabuko zincike ikakhulukazi ekuhlolweni okubonakalayo kukadkt ohlinzayo, ukuhlolwa kokuthinta, kanye nolwazi. Ngenkathi lezi zindlela zisebenza kahle, azinikezi ulwazi olwengeziwe olubonakalayo olunikwa ukuthwebula izithombe nge-fluorescent.

Uma kuqhathaniswa nezinye izindlela zokuthwebula izithombe njenge-CT scans noma i-MRI, i-pafolacianine inikeza ulwazi ngesikhathi sokuhlinzwa kwangempela kunokuba ngaphambi kwalo. Lokhu kuqondisa kwesikhathi sangempela kungasiza odkt abahlinzayo ukuthi benze izinqumo ezinolwazi olwengeziwe mayelana nokususwa kwezicubu.

Ukukhetha phakathi kwe-pafolacianine nezinye izindlela kuncike esimweni sakho esithile, ukuyinkimbinkimbi kokuhlinzwa kwakho, kanye nobuchwepheshe bukadkt wakho ohlinzayo. Odkt abaningi abahlinzayo basebenzisa izindlela eziningi ndawonye ukuze bathole imiphumela engcono kakhulu.

Imibuzo Evame Ukubuzwa Mayelana ne-Pafolacianine

Ingabe i-Pafolacianine Iphephile Kubantu Abanezifo Zezinso?

I-Pafolacianine kungenzeka ingafaneleki kubantu abanezifo ezinzima zezinso ngoba izinso zidlala indima ebalulekile ekususeni imithi emzimbeni wakho. Udokotela wakho uzobukeza izivivinyo zomsebenzi wezinso zakho ngaphambi kokunquma ukuthi lo muthi ukufanele yini.

Uma unezinkinga ezingatheni noma eziphakathi nendawo zezinso, ithimba lakho lezokwelapha lingase lisacabangela ukusebenzisa i-pafolacianine kodwa lizokuqapha eduze. Bangase futhi balungise ezinye izici zokunakekelwa kwakho ukuze kubalwe ukususwa kwemithi okuhamba kancane.

Kufanele Ngenzeni Uma Ngithola Ukusabela Okungalungile Ku-Pafolacianine?

Njengoba i-pafolacianine inikezwa endaweni yesibhedlela lapho kukhona ochwepheshe bezokwelapha, noma yikuphi ukusabela okungalungile kuzobonwa ngokushesha futhi kwelashwe yithimba lakho lezempilo. Akudingeki ukuthi uthathe noma yisiphi isinyathelo esithile wena.

Izimpawu zokusabela okungalungile zihlanganisa ukuqubuka, ukuluma, ubunzima bokuphefumula, noma ukuvuvukala. Ithimba lakho lezokwelapha liqeqeshwe ukubhekana nalezi zimo futhi linemithi esheshayo etholakalayo uma idingeka.

Kufanele Ngenzeni Uma Nginokukhathazeka Ngomuthi?

Ngokungafani nemithi oyithatha ekhaya, i-pafolacianine iphathwa ochwepheshe bezempilo abazokuqapha kuyo yonke inqubo. Uma unokukhathazeka ngaphambi kokuthola umuthi, xoxa ngakho nethimba lakho lokuhlinzwa.

Abahlinzeki bakho bezempilo balapho ukuze baphendule noma yimiphi imibuzo noma ukukhathazeka ongase ube nakho ngomuthi noma ukuhlinzwa kwakho. Unganqikazi ukuphakamisa uma kukhona okungazwakali kahle.

Uzofuluka Nini Umuthi Emzimbeni Wami?

I-Pafolacianine ngokuvamile isuswa emzimbeni wakho ezinsukwini ezimbalwa ngemuva kokuhlinzwa kwakho. Izinso zakho ngokwemvelo zizohlunga umuthi, futhi uzoqeda ngomchamo wakho.

Ungase uqaphele ukushintsha kombala komchamo wakho okwesikhashana ngosuku olulodwa noma ezimbili ngemuva kokuthola umuthi. Lokhu kujwayelekile futhi kubonisa ukuthi umzimba wakho uyawucubungula futhi uqeda umuthi njengoba kulindelekile.

Ngingashayela Ngemva Kokuthola I-Pafolacianine?

Njengoba i-pafolacianine inikezwa ngaphambi kokuhlinzwa, ngeke ushayele ngokushesha ngemva kokuyithola. Umuthi ngokwawo ngokuvamile awukuthinti ukukwazi kwakho ukushayela, kodwa uzobe uhlinzwa futhi kungenzeka ukuthi uthola i-anesthesia.

Ithimba lakho lokuhlinza lizohlinzeka ngemiyalelo ethile mayelana nokuthi ungaqala nini ukushayela ngokuya ngenqubo yakho nokululama. Lesi sinqumo sizoxhomeka kakhulu ekuhlinzweni kwakho nase-anesthesia kune-pafolacianine ngokwayo.