Palovarotene (indlela yokwelapha ngomlomo)
Imikhiqizo etholakalayo
Izinhlungu
Mayelana naleli khambi
IPalovarotene isetshenziselwa ukunciphisa inani le-heterotopic ossification entsha (amathambo akha ezicutshini ezithambile) kubantu abane-fibrodysplasia ossificans progressiva (FOP). Lolu lwelapha luyatholakala kuphela ngomyalelo wochwepheshe wezokwelapha. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma ukhetha ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokusebenzisa imithi nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma iyiphi impendulo engaqondakali noma ebangelwa ukungezwani nale mithi noma eminye imithi. Tshela futhi ochwepheshe bezempilo uma unezinye izinhlobo zokungezwani, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantwana ezizobeka umkhawulo ekusebenziseni i-palovarotene kubantwana besifazane abaneminyaka engu-8 nangaphezulu nakubantwana besilisa abaneminyaka engu-10 nangaphezulu. Ukuphepha nokusebenza kahle kuye kwaqiniswa. Noma kunjalo, le mithi ayinconyelwe ukusetshenziswa kubantwana besifazane abaneminyaka engaphansi kwengu-8 nakubantwana besilisa abaneminyaka engaphansi kwengu-10. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezizobeka umkhawulo ekusebenziseni i-palovarotene kubantu abadala. Noma kunjalo, iziguli ezikhulile zinezinkinga ezihlobene nobudala zobhedu, izinso, noma inhliziyo, okungase kudinge ukuba kuqaphele futhi kulungiswe umthamo kwabaguli abamukela le mithi. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izimithi kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingase zidingeke. Uma uthatha le mithi, kubalulekile kakhulu ukuthi ochwepheshe bezempilo bakwazi uma uthatha noma iyiphi imithi ehlaliswe ngezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akuyona into enconywayo, kodwa kungase kudingeke kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imithi. Ezinye izimithi akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla njengoba kungenzeka kube khona ukusebenzisana. Ukusebenzisa utshwala noma utshaba nezinye izimithi kungase futhi kubangele ukusebenzisana. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ngokuvamile akuyona into enconywayo, kodwa kungase kungakhuphuki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani le mithi, noma akupe imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli leyeza ngokuqondile njengoba uqondiswe ngudokotela wakho. Ungalithathi ngokweqile, ungalithathi kaningi, futhi ungalithathi isikhathi eside kunalokho oqondiswe ngudokotela wakho. Ukwenza kanjalo kungandisa amathuba ezingozi ezihambisana naleli leyeza. Leli leyeza liza neNcwadi Yokwelapha. Funda futhi ulandele imiyalo ngokucophelela. Buza udokotela wakho uma unemibuzo. Thatha leli leyeza ngokudla cishe ngesikhathi esifanayo nsuku zonke. Gwinya ikhaphsuli yonke. Uma ungakwazi ukugwinya ikhaphsuli yonke, ungayivula bese uyixuba nethisipuni eli-1 (amamilliliter angu-5) yokudla okuthambile (isib. usosa we-apple, iyogathi ephansi kokuthamba, noma i-oatmeal efudumele) bese uyithatha kungakapheli ihora eli-1 ngemuva kokuvula. Ungadli i-grapefruit noma i-pomelo, noma uphuze ijusi le-grapefruit noma i-pomelo ngenkathi usebenzisa leli leyeza. Inani leli leyeza lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemthethweni. Ulwazi olulandelayo luhlanganisa kuphela amanani ajwayelekile aleli leyeza. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukuba wenze njalo. Inani leyeza olithathayo lixhomeke emandleni leyeza. Futhi, inani lezinye olithathayo nsuku zonke, isikhathi esivunyelwe phakathi kwezinye, nobude besikhathi olithatha leli leyeza kuya ngesimo sezokwelapha olisebenzisela lona leli leyeza. Uma uphuthelwa yinyama yaleli leyeza, yithathe ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi sokuthatha inyama yakho elandelayo, suka inyama ephuthelwe bese ubuyela esimweni sakho esivamile sokuthatha leli leyeza. Ungawandisi amanani. Uma uphuthelwa yinyama futhi sekudlule amahora angu-6, suka inyama ephuthelwe bese ubuyela esimweni sakho esivamile. Gcina leli leyeza esitsheni esivalekile ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okuqondile. Gcina ungalwi. Gcina kungafinyeleleki izingane. Ungagcini leyeza eliphelile noma leyeza elingasasetshenziswa. Buza ochwepheshe bakho bezempilo ukuthi kufanele ulahle kanjani noma yiliphi leyeza olungalisebenzisi.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.