Yini i-Pamidronate: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Pamidronate iyimithi kadokotela enikezwa nge-IV (intravenous) infusion ukusiza ukuqinisa amathambo nokuphatha izimo ezithile ezihlobene namathambo. Ingaphansi kweqembu lemithi ebizwa ngokuthi ama-bisphosphonates, asebenza ngokunciphisa amaseli aqeda izicubu zamathambo.

Uma udokotela wakho ekuncomile i-pamidronate, ungase uzibuze ukuthi yini ongayilindela kulokhu kwelashwa. Le mithi ivame ukusetshenziswa lapho okunye ukwelashwa kwamathambo kungasebenzi ngokwanele, noma uma udinga ukuvikelwa kwamathambo okuqinile ngenxa yezimo ezithile zezokwelapha.

Yini i-Pamidronate?

I-Pamidronate iyimithi eqinisa amathambo engatholakala kuphela ngomthambo engalweni yakho. Ngokungafani namaphilisi owathatha ekhaya, le mithi idinga ukuvakashela emtholampilo noma esibhedlela ukuze inikezwe.

Cabanga ngamathambo akho njengokwakha kabusha njalo. Amanye amaseli aqeda ithambo elidala kanti amanye akha ithambo elisha. I-Pamidronate isiza ukuthambisa leli bhalansi ekuqiniseni amathambo aqinile, anempilo ngokunciphisa inqubo yokudiliza.

Umuthi uhlala ohlelweni lwakho amasonto amaningi kuya ezinyangeni ngemuva kwe-infusion ngayinye, yingakho ungayidingi kaningi. Abantu abaningi bathola ukwelashwa njalo emavikini ambalwa noma izinyanga, kuye ngesimo sabo esithile.

Isetshenziselwani i-Pamidronate?

I-Pamidronate isetshenziswa ikakhulukazi ukwelapha amazinga aphezulu e-calcium egazini nezinkinga ezithile zamathambo ezihlobene nomdlavuza. Udokotela wakho angase akubhalele uma une-hypercalcemia, isimo lapho amazinga e-calcium eba phezulu ngendlela eyingozi.

Umuthi uvame ukusetshenziswa futhi kubantu abanomdlavuza osabalale emathanjeni, ikakhulukazi emdlavuzeni webele, umdlavuza wamaphaphu, noma i-multiple myeloma. Kulezi zimo, isiza ukuvimbela ukuqhekeka kwamathambo futhi inciphise ubuhlungu bamathambo.

Ngaphezu kwalokho, i-pamidronate ingelapha isifo sikaPaget, isimo lapho amathambo ekhula ngobukhulu obungajwayelekile futhi abuthakathaka. Abanye odokotela bayayisebenzisa futhi nge-osteoporosis eqinile lapho ezinye izindlela zokwelapha zingasebenzi kahle.

Isebenza Kanjani I-Pamidronate?

I-Pamidronate ithathwa njengomuthi wamathambo oqinile ngokulinganisela osebenza ngokugxila kumaseli athile amathambo akho. Inamathisela ezicutshini zamathambo futhi ivimbele umsebenzi wama-osteoclasts, okuyizicubu ezinomthwalo wemfanelo wokudiliza amathambo.

Lapho lawa maseli aphula amathambo ehamba kancane, amathambo akho anesikhathi esiningi sokwakha kabusha futhi aziqinise. Le nqubo isiza ukunciphisa inani le-calcium elikhishwe egazini lakho futhi yenza amathambo akho amelane kakhulu nokuphuka.

Umuthi awusebenzi ngokushesha. Ungase uqale ukuqaphela ukuthuthuka kobuhlungu bamathambo noma amazinga e-calcium ezinsukwini ezimbalwa kuya emavikini ngemuva kokufakwa kwakho kokuqala. Imiphumela ephelele yokuqinisa amathambo ingathatha izinyanga eziningana ukuthi ithuthuke.

Kufanele Ngiyithathe Kanjani I-Pamidronate?

I-Pamidronate ngaso sonke isikhathi inikezwa njenge-IV infusion ehamba kancane endaweni yezokwelapha, hhayi njengepilisi noma umjovo. Le nqubo ngokuvamile ithatha amahora angu-2 kuya kwangu-4, futhi uzodinga ukuhlala ukhululekile ngalesi sikhathi.

Ngaphambi kokufakwa kwakho, kubalulekile ukuphuza amanzi amaningi ngaphandle uma udokotela wakho ekutshela ngenye indlela. Ukugcinwa kwamanzi kahle kusiza ukuvikela izinso zakho futhi kunciphisa ingozi yemiphumela emibi. Ungadla ngokujwayelekile ngaphambi nangemuva kokwelashwa.

Ngesikhathi sokufakwa, umuthi uzothontsa kancane emthanjeni wakho ngeshubhu elincane. Umhlengikazi uzokuqapha eduze futhi angahlola umfutho wegazi lakho kanye nezinga lokushisa ngezikhathi ezithile. Ngokuvamile ungafunda, usebenzise ifoni yakho, noma uphumule ngesikhathi sokwelashwa.

Ngemuva kokufakwa, ngokuvamile ungaqhubeka nemisebenzi yakho ejwayelekile ngokushesha. Nokho, abanye abantu bazizwa bekhathele noma behlangabezana nezimpawu ezifana nomkhuhlane ezithambile usuku olulodwa noma ezimbili ngemuva kwalokho, ikakhulukazi ngemuva kokwelashwa kokuqala.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Pamidronate?

Ubude bokwelashwa nge-pamidronate buhlukahluka kakhulu kuye ngesimo sakho nokuthi usabela kanjani emuthini. Abanye abantu badinga ukufakwa okukodwa noma okubili kuphela, kanti abanye bangase baqhubeke nokwelashwa izinyanga noma iminyaka.

Ngezinhlaka eziphezulu ze-calcium, ungase udinge ukufakwa okukodwa kuphela okubuyisela i-calcium yakho ezingeni elijwayelekile. Nokho, uma isimo esibangela lokhu siqhubeka, ungase udinge ukwelashwa okwengeziwe njalo emavikini ambalwa noma izinyanga.

Uma unezinkinga zamathambo ezihlobene nomdlavuza, udokotela wakho cishe uzoncoma ukwelashwa okuqhubekayo uma nje kusiza futhi ukukuthola kahle. Umgomo uwukuvimbela izinkinga zamathambo nokugcina izinga lakho lempilo.

Udokotela wakho uzohlola njalo ukusabela kwakho ngezivivinyo zegazi kanye nokuskena kwamathambo. Bazolungisa isimiso sakho sokwelashwa ngokusekelwe ekutheni amathambo akho asabela kanjani nokuthi ngabe uhlangabezana nanoma yimaphi imiphumela emibi.

Yini Imiphumela Emibi ye-Pamidronate?

Njengayo yonke imithi, i-pamidronate ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ivamise ukuba mncane futhi yesikhashana.

Abantu abaningi bathola izimpawu ezinjenge-flu ngemva kokufakwa kwabo kokuqala, okuyisibonakaliso sokuthi umuthi uyasebenza. Nansi imiphumela emibi evame kakhulu ongase uyibone:

• Umkhuhlane nokubanda, ngokuvamile kuqala kungakapheli amahora angama-24 ngemva kokwelashwa
• Ukulimala kwemisipha nobuhlungu emalungeni obuzwa bufana nokuba nomkhuhlane
• Ukukhathala noma ukuzizwa ukhathele kakhulu kunokujwayelekile usuku olulodwa noma ezimbili
• Isicanucanu noma isisu esincane
• Ikhanda elingase lithathe usuku olulodwa noma ezimbili
• Ubuhlungu noma ukucasuka endaweni ye-IV

Le miphumela emibi ejwayelekile ivamise ukuthuthuka kungakapheli amahora angama-48 futhi ivame ukuba ngaphansi uma kwelashwa okulandelayo. Ukuthatha izidambisi zokulwa nobuhlungu ezingathengiswa ngaphandle kwemvume kadokotela njenge-acetaminophen kungasiza ekuphatheni ukungakhululeki.

Imiphumela emibi engavamile kodwa ebucayi ingenzeka, futhi kufanele uthinte udokotela wakho uma uhlangabezana nanoma yiziphi zalezi:

• Ubuhlungu obukhulu bomhlathi noma ubunzima ekuvuleni umlomo wakho
• Ubuhlungu obusha noma obungavamile bethanga, okhalweni, noma emgqeni
• Ushintsho embonweni wakho noma ubuhlungu emehlweni
• Isicanucanu esiqhubekayo, ukuhlanza, noma ukulahlekelwa isifiso sokudla
• Ukukhathala okukhulu okungathuthuki ngemva kwezinsuku ezimbalwa
• Izimpawu zamazinga e-calcium aphansi njengama-muscle cramps noma ukuluma

Imiphumela emibi engavamile kodwa engathi sína ihlanganisa i-osteonecrosis yomhlathi (ukufa kwamathambo emhlathini) kanye nokuqhekeka kwamathambo ethanga okungavamile. Lezi zinkinga azivamile kodwa kubalulekile ukuzibheka, ikakhulukazi uma zisetshenziswa isikhathi eside.

Ubani Ongafanele Athathe I-Pamidronate?

I-Pamidronate ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinikeza. Akufanele uthole lo muthi uma unesifo esibi sezinso noma unomzimba ongawuthandi ama-bisphosphonates.

Abesifazane abakhulelwe noma abancelisa ngamabele akufanele basebenzise i-pamidronate, njengoba ingalimaza ingane esakhula. Umuthi ungahlala emathanjeni akho iminyaka, ngakho-ke abesifazane abangase bakhulelwe kufanele baxoxe ngalokhu ngokucophelela nodokotela wabo.

Abantu abanezinkinga ezithile zamazinyo noma labo abahlela izinqubo zamazinyo bangase badinge ukulibazisa ukwelashwa. Udokotela wakho angase ancome ukubona udokotela wamazinyo ngaphambi kokuqala i-pamidronate, ikakhulukazi uma udinga ukukhishwa kwamazinyo noma ukuhlinzwa ngomlomo.

Uma unamazinga e-calcium aphansi, izinkinga zesigqi senhliziyo, noma uthatha imithi ethile, udokotela wakho uzodinga ukukuqapha eduze noma alungise uhlelo lwakho lokwelashwa.

Amagama Omkhiqizo we-Pamidronate

I-Pamidronate iyatholakala ngaphansi kwegama lomkhiqizo elithi Aredia e-United States. Ungase futhi uyibone ibizwa ngegama layo elivamile, i-pamidronate disodium.

Umuthi ukhiqizwa yizinkampani eziningana zemithi, kodwa isithako esisebenzayo nemiphumela kuhlala kufana kungakhathaliseki umkhiqizo. Ikhemisi lakho lesibhedlela noma lomtholampilo lizinquma ukuthi iyiphi inguqulo oyitholayo.

Ezinye izinhlelo zomshuwalense zingase zibe nezintandokazi zabakhiqizi abathile, kodwa lokhu akufanele kulithinte izinga lokwelashwa kwakho. Into ebalulekile ukuthi uthola umthamo ofanele we-pamidronate ngesimo sakho.

Ezinye izindlela ze-Pamidronate

Eminye imithi eminingi ingelapha izimo zamathambo ezifanayo, kodwa udokotela wakho uzokhetha inketho engcono kakhulu ngokusekelwe esimweni sakho esithile. Ezinye izinto ze-bisphosphonates ezifana ne-zoledronic acid (Zometa) zingase zisetshenziswe esikhundleni se-pamidronate.

Nge-osteoporosis, ama-bisphosphonates omlomo njenge-alendronate (Fosamax) noma i-risedronate (Actonel) ingaba izinketho uma ukwazi ukubekezelela amaphilisi. Lezi zithathwa ngomlomo kunokuba nge-IV.

Imithi emisha efana ne-denosumab (Prolia) isebenza ngendlela ehlukile kune-bisphosphonates futhi ingase ifanele abanye abantu abangakwazi ukuthatha i-pamidronate. Ukwelashwa ngamahomoni noma eminye imithi eyakha amathambo nayo ingase icatshangelwe.

Udokotela wakho uzocabangela izinto ezifana nokusebenza kwezinso zakho, eminye imithi, nezintandokazi zomuntu siqu lapho ekhetha ukwelashwa okungcono kakhulu empilweni yamathambo akho.

Ingabe i-Pamidronate ingcono kune-Zoledronic Acid?

Kokubili i-pamidronate ne-zoledronic acid bangama-bisphosphonates asebenzayo, kodwa banezinto ezithile ezingase zikwenze ukuthi enye ifaneleke kakhulu kuwe kunenye. I-Zoledronic acid ngokuvamile ithathwa njengeqinile futhi inikezwa kaningi.

Ukufakwa kwe-Pamidronate kuthatha amahora angu-2 kuya kwangu-4, kuyilapho i-zoledronic acid inganikezwa ngemizuzu engu-15 kuya kwengu-30. Lokhu kungase kwenze i-zoledronic acid ilungele abanye abantu, nakuba kokubili kuyizindlela zokwelapha ezisebenzayo.

Ukukhetha phakathi kwale mithi kuvame ukuncika esimweni sakho esithile, ukusebenza kwezinso, nokuthi ukubekezelela kahle kangakanani ukwelashwa ngakunye. Abanye abantu benza ngcono ngomuthi owodwa kunomunye mayelana nemiphumela emibi.

Udokotela wakho uzocabangela izimo zakho ngazinye, okuhlanganisa ezinye izimo zempilo nemithi, lapho enquma ukuthi iyiphi i-bisphosphonate engcono kakhulu kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Pamidronate

Ingabe i-Pamidronate iphephile kubantu abanezifo zezinso?

I-Pamidronate idinga ukucatshangelwa ngokucophelela kubantu abanezinkinga zezinso. Umuthi usebenza ngezinso zakho, ngakho ukuncipha kokusebenza kwezinso kungakhuphula ingozi yemiphumela emibi.

Udokotela wakho uzohlola ukusebenza kwezinso zakho ngezivivinyo zegazi ngaphambi kokwelashwa ngakunye futhi angase alungise umthamo wakho noma isivinini sokufakwa uma kudingeka. Abantu abanezifo ezinzima zezinso ngokuvamile abakwazi ukuthola i-pamidronate ngokuphepha.

Uma unezinkinga zezinso eziphakathi nendawo, udokotela wakho angase akunikeze umthamo ophansi noma andise isikhathi sokufakwa ukuze kunciphise ukucindezeleka ezinso zakho. Ukuhlala unamanzi kahle ngaphambi nangemva kokwelashwa kubaluleke kakhulu.

Ngingenzani uma ngithola i-Pamidronate eningi ngengozi?

Njengoba i-pamidronate inikezwa endaweni yezokwelapha elawulwayo, ukweqisa akavamile kakhulu. Kodwa-ke, uma ukhathazekile ngokuthola umuthi omningi, tshela ithimba lakho lezempilo ngokushesha.

Izimpawu zokuthola i-pamidronate eningi zingabandakanya izimpawu ezinjenge-flu ezinzima, ukwehla okukhulu kwamazinga e-calcium, noma izinkinga zezinso. Abasebenzi bezokwelapha bazokuqapha ngokucophelela futhi bangakunikeza ukunakekelwa okusekelayo uma kudingeka.

Izindaba ezinhle ukuthi ukweqisa kwe-pamidronate akuvamile kakhulu ngoba umuthi ubhalwa ngokucophelela futhi unikezwa ochwepheshe abaqeqeshiwe. Ithimba lakho lezokwelapha lizoqinisekisa kabili umthamo ngaphambi kokuqala ukufakwa kwakho.

Ngingenzani uma ngiphuthelwa umthamo we-Pamidronate?

Uma uphuthelwa ukufakwa kwe-pamidronate okuhleliwe, xhumana nehhovisi likadokotela wakho ngokushesha ngangokunokwenzeka ukuze ulungise kabusha. Ungazami ukwenza umthamo ophuthelwe ngokuthola umuthi owengeziwe kamuva.

Ukuphuthelwa ukwelashwa okukodwa ngokuvamile ngeke kubangele izinkinga ngokushesha, kodwa kubalulekile ukugcina isimiso sakho sokwelashwa ukuze uthole imiphumela engcono kakhulu. Udokotela wakho angase alungise isikhathi somthamo wakho olandelayo ngokusekelwe ukuthi sekudlule isikhathi esingakanani kusukela ekufakweni kwakho kokugcina.

Uma uphuthelwe ukwelashwa okuningi, udokotela wakho angase afune ukuhlola amazinga e-calcium yegazi lakho noma izimpawu zamathambo ngaphambi kokuqhubeka nokwelashwa. Bazokusiza ukuthi ubuyele emkhondweni ngohlelo lwakho lokwelashwa.

Ngingayeka nini ukuthatha i-Pamidronate?

Isinqumo sokuyeka i-pamidronate sincike esimweni sakho esiyisisekelo nokuthi usabela kahle kangakanani ekwelashweni. Ungalokothi uyeke ukwelashwa ngaphandle kokuxoxa ngakho nodokotela wakho kuqala.

Ngezinga eliphezulu le-calcium, ungangayeka uma i-calcium yakho ibuyela kokujwayelekile futhi ihlala izinzile. Kodwa-ke, uma imbangela eyisisekelo iqhubeka, ungase udinge ukwelashwa okuqhubekayo ukuvimbela amazinga e-calcium ukuthi anyuke futhi.

Abantu abanezinkinga zamathambo ezihlobene nomdlavuza bavame ukuqhubeka nokwelashwa uma nje kusiza futhi bekubekezelela kahle. Udokotela wakho uzohlola njalo ukuthi izinzuzo ziyaqhubeka yini ukwedlula noma yiziphi izingozi noma imiphumela emibi.

Ngingathatha eminye imithi ngenkathi ngithola i-Pamidronate?

Imithi eminingi ingathathwa ngokuphepha nge-pamidronate, kodwa kubalulekile ukutshela udokotela wakho ngayo yonke imithi, izithasiselo, namavithamini owathathayo. Eminye imithi ingase ihlangane ne-pamidronate noma ithinte ukwelashwa kwakho.

Izithasiselo ze-calcium kanye nama-antacids kufanele zithathwe ngezikhathi ezihlukene kunokufakwa kwakho kwe-pamidronate ukuze kugwenywe ukuphazamiseka. Udokotela wakho angase ancome isikhathi esithile salezi zithasiselo.

Ama-thinners egazi, ama-antibiotics athile, kanye neminye imithi yomdlavuza ingase idinge ukuqapha okukhethekile uma isetshenziswa ne-pamidronate. Ithimba lakho lezempilo lizoxhumanisa imithi yakho ukuze liqinisekise ukuthi isebenza ngokuphepha ndawonye.