Yini i-Panobinostat: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Panobinostat iyimithi yomdlavuza eqondiwe esebenza ngokuvimba amaprotheni athile asiza amaseli omdlavuza ukuthi akhule futhi asinde. Ingaphansi kohlobo lwemithi ebizwa ngokuthi ama-histone deacetylase inhibitors, okuyinto esiza ngempela izindlela zomzimba wakho zokulwa umdlavuza ukuthi zisebenze ngempumelelo. Le mithi isetshenziswa ikakhulukazi ukwelapha izinhlobo ezithile zomdlavuza wegazi, ikakhulukazi i-multiple myeloma lapho ezinye izindlela zokwelapha zingasebenzi kahle njengoba bekulindelwe.

Yini i-Panobinostat?

I-Panobinostat iyimithi yomdlavuza yomlomo eqondisa amaseli omdlavuza ezingeni le-molecular. Isebenza ngokungenelela kuma-enzyme abizwa ngokuthi ama-histone deacetylases, okudingwa amaseli omdlavuza ukuze akhule futhi azale.

Cabanga ngayo njengemithi esiza ukubuyisela ikhono lomzimba wakho lemvelo lokulawula ukukhula kwamaseli okungajwayelekile. Ngokungafani ne-chemotherapy ethinta wonke amaseli ahlukanisa ngokushesha, i-panobinostat ikhetha kakhulu endleleni eqondisa ngayo amaseli omdlavuza. Le ndlela eqondiwe ingayenza isebenze ngenkathi kungenzeka ukuthi ibangela imiphumela emincane eceleni kune-chemotherapy yendabuko.

Umuthi uza ngesimo se-capsule futhi uthathwa ngomlomo, okwenza kube lula kunezindlela zokwelapha ezidinga ukuvakashelwa esibhedlela ukuze kuthathwe ama-infusion. Udokotela wakho uzokunika umuthi njengengxenye yohlelo olubanzi lokwelapha umdlavuza olwenzelwe ngqo isimo sakho.

Isetshenziselwani i-Panobinostat?

I-Panobinostat ivunyelwe ngokuqondile ukwelapha i-multiple myeloma, uhlobo lomdlavuza wegazi oluthinta amaseli e-plasma emnkantshweni wakho wamathambo. Ngokuvamile kunqunywa uma usuvele uzamile okungenani ezinye izindlela zokwelapha ezimbili, okuhlanganisa i-immunomodulatory agent kanye ne-proteasome inhibitor.

I-Multiple myeloma ingaba yinselele ukuyelapha ngoba amaseli omdlavuza avame ukuthuthukisa ukumelana nemithi ngokuhamba kwesikhathi. I-Panobinostat inikeza indlela ehlukile yokusebenza, okusho ukuthi ingasiza uma ezinye izindlela zokwelapha ziyekile ukusebenza ngempumelelo.

Uchwepheshe wakho we-oncologist angase ancome i-panobinostat njengengxenye yokwelashwa okuhlanganisiwe, ngokuvamile ihambisana neminye imithi efana ne-bortezomib kanye ne-dexamethasone. Le ndlela yokuhlanganisa isiza ukuhlasela umdlavuza emazingeni amaningi, okungenzeka ithuthukise imiphumela yokwelashwa.

Isebenza Kanjani I-Panobinostat?

I-Panobinostat isebenza ngokuvimba ama-enzyme abizwa ngokuthi ama-histone deacetylases (HDACs) okudingwa amaseli omdlavuza ukulawula ukubonakaliswa kwezakhi zofuzo. Uma lawa ma-enzyme evinjwa, amaseli omdlavuza awakwazi ukulawula kahle izindlela zawo zokukhula nokusinda.

Lo muthi uthathwa njengokwelashwa komdlavuza okuqinile ngokulinganiselwe ngendlela yokusebenza eqondiwe. Yenzelwe ukuthi ibe namandla ngokwanele ukuthinta amaseli omdlavuza ngenkathi ikhetha ngaphezu kwemithi yamakhemikhali yendabuko.

Umuthi ngokuyisisekelo usiza ukubuyisela izinqubo zamaseli ezivamile eziphazanyiswe amaseli omdlavuza. Ngokuphazamisa lezi zindlela ezithile, i-panobinostat ingabangela ukuthi amaseli omdlavuza ayeke ukukhula noma afe, ngenkathi inethonya elincane emangqamuzaneni anempilo emzimbeni wakho wonke.

Kufanele Ngiyithathe Kanjani I-Panobinostat?

Thatha i-panobinostat ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kathathu ngesonto ngezinsuku ezithile. Ishejuli ejwayelekile yiMvulo, uLwesithathu, kanye noLwesihlanu wamasonto 1 kanye no-2 womjikelezo ngamunye wokwelashwa wezinsuku ezingama-21.

Kufanele uthathe amaphilisi ngamanzi, futhi ungawathatha nokudla noma ngaphandle kokudla. Kodwa-ke, ukuwathatha nokudla kungasiza ukunciphisa ukuphatheka kabi kwesisu uma uhlangabezana nesicanucanu. Ungagxobi, uhlafune, noma uvule amaphilisi - wagwinye wonke ukuze uqinisekise ukumuncwa okufanele.

Kubalulekile ukuthatha imithamo yakho cishe ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo omuthi ohlelweni lwakho. Uma uhlanza kungakapheli ihora ngemuva kokuthatha umthamo, ungalithathi elinye ngalolo suku - linda kuze kube umthamo wakho olandelayo ohleliwe.

Ngaphambi kokuqala ukwelashwa, udokotela wakho cishe uzoncoma ukudla ukudla okulula noma ukudla okulula cishe imizuzu engama-30 ngaphambi kokuthatha umuthi. Lokhu kungasiza ekunciphiseni imiphumela emibi emathunjini abanye abantu abayitholayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Panobinostat?

Ubude bokwelashwa nge-panobinostat buhlukahluka kakhulu kumuntu nomuntu futhi kuncike ekutheni umuthi usebenza kahle kangakanani esimweni sakho esithile. Abantu abaningi baqhubeka nokwelashwa uma nje kusiza ukulawula umdlavuza wabo futhi nemiphumela emibi ihlala ilawuleka.

Udokotela wakho uzoqapha impendulo yakho ekwelashweni ngokuhlolwa kwegazi okuvamile, izifundo zokucabanga, nokuhlolwa komzimba. Lokhu kuhlola kusiza ukunquma ukuthi umuthi uyasebenza yini ngempumelelo nokuthi kuphephile yini ukuthi uqhubeke.

Abanye abantu bangase bathathe i-panobinostat izinyanga eziningana, kanti abanye bangase baqhubeke unyaka noma ngaphezulu. Okubalulekile ukuthola ibhalansi efanele phakathi kokulawulwa komdlavuza kanye nekhwalithi yempilo. Ithimba lakho lezempilo lizosebenza nawe ukwenza izinguquko njengoba kudingeka ohambweni lwakho lokwelashwa.

Yini Imiphumela Emibi Ye-Panobinostat?

Njengayo yonke imithi yomdlavuza, i-panobinostat ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ngokuvamile ilawuleka ngosekelo olufanele lwezokwelapha nokuqapha.

Nawa amanye imiphumela emibi ongase uyithole:

• Ukukhathala nobuthakathaka
• Isicanucanu nokuhlanza
• Ukuqunjelwa
• Ukuncipha kwesifiso sokudla
• Ukwehla kwamaseli egazi
• Ukuvuvukala ezandleni, ezinyaweni, noma emilenzeni
• Ubuhlungu bemisipha noma amalunga

Le miphumela emibi ivame ukuba milde kuya esimweni esiphakathi nendawo futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Ithimba lakho lezempilo linganikeza amasu nemithi yokusiza ukuphatha lezi zimpawu ngempumelelo.

Imiphumela emibi engathi sína kodwa engavamile ingabandakanya izifo ezinzima ngenxa yokwehla kwamaseli egazi amhlophe, izinkinga zesigqi senhliziyo, noma isifo sohudo esibi esiholela ekuphelelwe amanzi emzimbeni. Nakuba lokhu kungavamile, kubalulekile ukubika noma yiziphi izimpawu ezikhathazayo kudokotela wakho ngokushesha.

Abanye abantu bangase babe namahlule egazi, ukukhathala okukhulu, noma izinkinga zesibindi. Udokotela wakho uzokuhlola ngokucophelela ngezivivinyo zegazi ezivamile ukuze abambe noma yiziphi izinkinga ezingaba khona kusenesikhathi futhi alungise ukwelashwa kwakho uma kudingeka.

Ubani Ongafanele Athole I-Panobinostat?

I-Panobinostat ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ilungele yini. Abantu abanezimo ezithile zenhliziyo, ikakhulukazi labo abanomlando wokushaya kwenhliziyo okungajwayelekile noma izinkinga zesigqi senhliziyo, kungenzeka bangabi ngabantu abafanelekayo kulo muthi.

Uma unezinkinga zesibindi ezinzima noma izifo ezisebenzayo, ezingalawuleki, udokotela wakho cishe uzoncoma ukulinda kuze kube yilapho lezi zimo zilawulwa kangcono ngaphambi kokuqala i-panobinostat. Umuthi ungase uthinte amasosha akho omzimba, okwenza izifo zibe zimbi kakhulu.

Abesifazane abakhulelwe noma abancelisa ibele akufanele bathathe i-panobinostat, njengoba ingalimaza izingane ezisakhula. Uma useminyakeni yokuzala, uzodinga ukusebenzisa izindlela zokulawula inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nasezinyangeni eziningana ngemva kokuyeka umuthi.

Abantu abanezinkinga ezinzima zezinso noma labo abathatha imithi ethile ethinta isigqi senhliziyo bangase badinge ezinye izindlela zokwelashwa. Udokotela wakho uzobuyekeza yonke imithi yakho yamanje kanye nezimo zempilo ukuze aqinisekise ukuthi i-panobinostat iphephile kuwe.

Amagama Omkhiqizo we-Panobinostat

I-Panobinostat itholakala ngaphansi kwegama lomkhiqizo elithi Farydak emazweni amaningi, okuhlanganisa ne-United States. Leli yigama eliyinhloko lomkhiqizo ozolibona ebhodleleni lakho likanokusho kanye nokupakishwa komuthi.

Njengamanje, i-Farydak yilona hlobo oluyinhloko olutholakalayo, njengoba i-panobinostat iyimithi esanda kuthuthukiswa esavikelwe ngamalungelo obunikazi. Izinhlobo ezivamile azikatholakali kabanzi, nakuba lokhu kungashintsha esikhathini esizayo njengoba amalungelo obunikazi ephelelwa yisikhathi.

Uma nixoxa ngomuthi wakho nabahlinzeki bezempilo noma osokhemisi, ungangenawo umuthi nganoma yiliphi igama - i-panobinostat noma i-Farydak - futhi bazokwazi kahle ukuthi nikhuluma ngani.

Ezinye izindlela ze-Panobinostat

Uma i-panobinostat ingakulungele noma iyeka ukusebenza kahle, kunezindlela eziningi zokwelapha ezingenye ezitholakalayo ze-multiple myeloma. Udokotela wakho angase acabange ezinye izithiyo ze-histone deacetylase noma imithi enezindlela ezihlukene zokusebenza.

Ezinye izindlela zokwelapha zihlanganisa ezinye izindlela zokwelapha ezihloswe ngqo njenge-carfilzomib, i-pomalidomide, noma i-daratumumab. Le mithi isebenza ngezindlela ezihlukene zokuhlasela amaseli omdlavuza, inikeza izinketho uma i-panobinostat ingafaneleki esimweni sakho.

Izindlela ezintsha zokwelapha ngomzimba, okuhlanganisa i-CAR-T cell therapy, nazo zingaba izinketho kuye ngezimo zakho ezithile. Izivivinyo zemitholampilo eziphenya ngemithi yokwelapha yokuhlola zingahlinzeka ngezinketho ezengeziwe kubantu abaye bazama izindlela eziningi zokwelapha ezijwayelekile.

Enye indlela engcono kakhulu incike ekwelashweni kwakho kwangaphambilini, impilo yonke, nezici ezithile zomdlavuza wakho. Udokotela wakho we-oncologist uzosebenza nawe ukuze anqume izinyathelo ezifanele kakhulu uma i-panobinostat ingasebenzi noma ibangela imiphumela engemukeleki.

Ingabe i-Panobinostat ingcono kune-Bortezomib?

I-Panobinostat ne-bortezomib zisebenza ngezindlela ezihlukene, ngakho ukuqhathanisa akulula. I-Bortezomib iyisithiyo se-proteasome esivame ukusetshenziswa ekuqaleni kokwelashwa kwe-multiple myeloma, kuyilapho i-panobinostat ngokuvamile igcinelwa imigqa yokwelapha kamuva.

Ezifundweni zomtholampilo, i-panobinostat ivame ukusetshenziswa ngokuhlangana ne-bortezomib kunokuthi ithathe indawo yayo. Le ndlela yokuhlanganisa ikhombise imiphumela engcono kunezinye zemithi yodwa kubantu abane-multiple myeloma ebuyayo.

Ukukhetha phakathi kwale mithi kuncike emlandweni wakho wokwelashwa, ukuthi umdlavuza wakho uphendule kanjani ekwelashweni kwangaphambilini, kanye nesimo sakho sempilo esiphelele. Udokotela wakho uzocabangela izinto ezinjengezifo ezingezinhle zangaphambilini, izimpawu zamanje, kanye nezici ezithile zomdlavuza wakho lapho enza izincomo zokwelashwa.

Imibuzo Evame Ukubuzwa Mayelana ne-Panobinostat

Ingabe i-Panobinostat Iphephile Kubantu Abanezinkinga Zezinhliziyo?

I-Panobinostat idinga ukuqapha ngokucophelela kubantu abanezifo zenhliziyo ngoba ingathinta ukushaya kwenhliziyo. Udokotela wakho uzoqhuba i-electrocardiogram (ECG) ngaphambi kokuqala ukwelashwa futhi njalo ngesikhathi sokwelashwa ukuqapha umsebenzi kagesi wenhliziyo yakho.

Uma unomlando wezinkinga zokushaya kwenhliziyo, ukuhluleka kwenhliziyo, noma ezinye izimo zenhliziyo ezibalulekile, udokotela wakho angase ancome ezinye izindlela zokwelashwa noma athathe izinyathelo ezengeziwe uma i-panobinostat iyindlela yakho engcono kakhulu. Bazosebenza eduze nodokotela wenhliziyo ukuqinisekisa ukuthi impilo yakho yenhliziyo ivikelekile ngesikhathi sokwelashwa.

Ngingenzani Uma Ngiphuzile I-Panobinostat Engaphezu Kwemithi Ngengozi?

Uma ngengozi uphuza i-panobinostat eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini - kungcono ukufuna iseluleko sezokwelapha ngokushesha.

Ukuphuza i-panobinostat eningi kungandisa ingozi yezifo ezingezinhle ezingathi sína, ikakhulukazi izinkinga zokushaya kwenhliziyo nokwehla okukhulu kwenani lamaseli egazi. Ithimba lakho lezempilo lingase lifune ukukuqapha ngokucophelela futhi mhlawumbe lilungise imithamo yakho ezayo ukuqinisekisa ukuphepha kwakho.

Ngingenzani Uma Ngiphuthelwa Umthamo We-Panobinostat?

Uma uphuthelwa umthamo we-panobinostat, ungaluthathi uma sekudlule amahora angaphezu kwayi-12 kusukela ngesikhathi sakho esihleliwe. Kunalokho, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile esihleliwe.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yemiphumela emibi engathi sína. Uma uvame ukuphuthelwa imithamo, khuluma neqembu lakho lezempilo mayelana namaqhinga okukusiza ukuthi ukhumbule, njengokusetha ama-alamu ocingo noma ukusebenzisa umhleli wamaphilisi.

Ngingayeka nini Ukuthatha i-Panobinostat?

Kufanele uyeke kuphela ukuthatha i-panobinostat ngaphansi kwesiqondiso sikadokotela wakho. Isinqumo sokuyeka ukwelashwa sincike ekutheni umuthi usebenza kahle kangakanani, yimiphi imiphumela emibi oyitholayo, kanye nesimo sakho sempilo esiphelele.

Abanye abantu bangase badinge ukuyeka okwesikhashana uma bethola imiphumela emibi engathi sína, kanti abanye bangase bayeke unomphela uma umdlavuza uqhubeka noma imiphumela emibi iba nzima ukuyilawula. Udokotela wakho uzokusiza ukuthi ulinganise izinzuzo nezingozi ukuze wenze isinqumo esingcono kakhulu sesimo sakho esithile.

Ngingathatha Eminye Imithi Ngenkathi ngise-Panobinostat?

Imithi eminingi ingasebenzisana ne-panobinostat, ngakho-ke kubalulekile ukutshela udokotela wakho ngayo yonke imithi kadokotela, imithi etholakala ngaphandle kwe-oda, kanye nezithasiselo ozithathayo. Eminye imithi ingakhuphula amazinga e-panobinostat egazini lakho, okungenzeka ukuthi ibangela imiphumela emibi eyengeziwe.

Udokotela wakho uzobuyekeza yonke imithi yakho futhi angase adinge ukulungisa imithamo noma ancome ezinye izindlela zemithi ethile. Ungaqali noma iyiphi imithi emisha noma izithasiselo ngaphandle kokuxoxa ngazo neqembu lakho lezempilo kuqala, ngoba ngisho nemikhiqizo ebonakala ingenangozi ngezinye izikhathi ingasebenzisana nokwelashwa komdlavuza.