Yini i-Pazopanib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Pazopanib iyimithi yomdlavuza eqondiwe esebenza ngokuvimba amaprotheni athile asiza amaseli omdlavuza ukuthi akhule futhi asakale. Iyingxenye yeqembu lemithi ebizwa ngokuthi ama-tyrosine kinase inhibitors, okuyinto esebenza njengezithiyo eziqondile ezingqubuzana nezimpawu zokukhula komdlavuza.

Le mithi imele intuthuko enkulu ekwelashweni komdlavuza ngoba inganciphisa ukukhula kwethumba ngenkathi ivumela ukuthi ugcine izinga elingcono lempilo uma uqhathanisa ne-chemotherapy yendabuko. Udokotela wakho unquma i-pazopanib uma befuna ukuqondisa umdlavuza wakho ngendlela egxile kakhulu.

Yini i-Pazopanib Esetshenziselwa Yona?

I-Pazopanib ngokuyinhloko inikezwa ukwelapha umdlavuza wezinso oqhubekayo, obizwa nangokuthi i-renal cell carcinoma. Isetshenziswa ngokuqondile uma umdlavuza ususabalale ngaphandle kwezinso noma uma ukuhlinzwa kungewona umkhuba.

Udokotela wakho angase futhi ancome i-pazopanib ngezinhlobo ezithile ze-soft tissue sarcomas, okuyizifo eziqala emisipheni, amafutha, imithambo yegazi, noma ezinye izicubu ezisekelayo emzimbeni wakho wonke. Lezi yizifo ezingavamile, kodwa i-pazopanib ikhombise imiphumela ethembisayo ekunciphiseni ukuqhubeka kwazo.

Imithi isebenza kahle kakhulu ezigabeni eziqhubekayo zalezi zifo zomdlavuza lapho umgomo uwukulawula isifo nokukusiza ukuthi ugcine izinga lakho lempilo. Akuyona imithi yokuqala ejwayelekile yezifo zomdlavuza zesigaba sokuqala ezingasuswa ngokuhlinzwa.

Isebenza Kanjani i-Pazopanib?

I-Pazopanib isebenza ngokuvimba amaprotheni amaningi abalulekile amaseli omdlavuza awadingayo ukuze akhule futhi akhe imithambo emisha yegazi. Cabanga ngayo njengokusika imigqa yokuhlinzeka yomdlavuza esikhundleni sokuhlasela ngokuqondile amaseli omdlavuza ngokwawo.

Imithi iqondisa ngokuqondile amaprotheni abizwa ngokuthi i-VEGFR, PDGFR, kanye ne-c-Kit, okufana neziguquli ezitshela amaseli omdlavuza ukuthi aphindaphindeke futhi akhe imithambo emisha yegazi. Ngokuvimba lezi ziguquli, i-pazopanib ilambisa ithumba ngomsoco nomoya-mpilo oludingayo ukuze likhule.

Lokhu kwenza i-pazopanib ibe yimithi yomdlavuza ephakathi nendawo eqinile evame ukubekezeleleka kalula kune-chemotherapy yendabuko. Ngenkathi inamandla ngokwanele ukunciphisa ukuqhubeka komdlavuza, ngokuvamile ibangela imiphumela emibi embalwa kakhulu kunezindlela zokwelapha umdlavuza ezindala.

Kufanele Ngiyithathe Kanjani I-Pazopanib?

Thatha i-pazopanib njengoba nje udokotela wakho ekuyala, ngokuvamile kanye ngosuku esiswini esingenalutho. Lokhu kusho ukuyithatha okungenani ihora elilodwa ngaphambi kokudla noma amahora amabili ngemuva kokudla kwakho kokugcina.

Gwinya amaphilisi wonke ngamanzi - ungaqedi, uhlafune, noma uwaphule. Umuthi udinga ukumuncwa kahle, futhi ukuphula amaphilisi kungathinta ukuthi kungakanani okungena emzimbeni wakho.

Zama ukuthatha umthamo wakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo emzimbeni wakho. Abantu abaningi bakuthola kuwusizo ukuyithatha ekuseni, bese belinda okungenani ihora elilodwa ngaphambi kokudla kwasekuseni.

Gwema ama-grapefruit nejusi le-grapefruit ngenkathi uthatha i-pazopanib, ngoba lokhu kungakhuphula amazinga omuthi egazini lakho futhi kubangele imiphumela eminingi emibi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Pazopanib?

Ngokuvamile uzoqhubeka nokuthatha i-pazopanib uma nje isiza ukulawula umdlavuza wakho futhi uyayibekezelela kahle. Lokhu kungaba izinyanga noma ngisho neminyaka, kuye ngokuthi umzimba wakho uphendula kanjani.

Udokotela wakho uzoqapha inqubekela phambili yakho ngokuskena okuvamile nokuhlolwa kwegazi ukuze abone ukuthi umuthi usebenza kahle kangakanani. Bazobheka futhi noma yimiphi imiphumela emibi engase idinge ukulungiswa komthamo wakho noma ukuyeka ukwelashwa.

Isinqumo sokuqhubeka noma ukuyeka i-pazopanib sincike ezintweni eziningana: ukuthi umdlavuza wakho uzinzile noma uqhubeka, ukuthi uzizwa kanjani ngaphandle, nokuthi izinzuzo zidlula yini noma yimiphi imiphumela emibi oyitholayo.

Yini Imiphumela Emibi Ye-Pazopanib?

Abantu abaningi abathatha i-pazopanib bahlangabezana nemiphumela emibi, kodwa ngokuvamile iyalawuleka ngokunakekelwa okufanele nokuqapha. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi ulungiselele futhi wazi ukuthi ungaxhumana nini nethimba lakho lezempilo.

Nawa amanye emiphumela emibi evame kakhulu ongase uyithole:

• Ukuqunjelwa kanye nokuphazamiseka kwesisu
• Ukukhathala nokuzizwa ukhathele
• Ukucanuzela kwenhliziyo nokuncipha kwesifiso sokudla
• Umfutho wegazi ophezulu
• Ushintsho lombala wezinwele (ngokuvamile ziphenduka zibe mhlophe noma mpunga)
• Ukuqubuka kwesikhumba noma isikhumba esomile
• Ubuhlungu bemisipha namalunga

Le miphumela emibi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi, futhi udokotela wakho angasiza ekuphatheni ngemithi esekelayo.

Imiphumela emibi engavamile kodwa ebucayi idinga ukunakekelwa kwezempilo ngokushesha. Nakuba lokhu kungenzeki kuwo wonke umuntu, kubalulekile ukuyazi:

• Izinkinga ezinzima zesibindi (ukuphuzi kwesikhumba noma amehlo, umchamo omnyama)
• Ushintsho lwesigqi senhliziyo noma ubuhlungu besifuba
• Ukuphuma kwegazi okukhulu noma ukulimala okungavamile
• Izimpawu zamaqhubu egazi (ukuphefumula ngokushesha, ukuvuvukala komlenze)
• Ukuphendula kwesikhumba okukhulu noma izilonda zomlomo
• Izinkinga ze-thyroid (ukukhathala okukhulu, izinguquko zesibalo somzimba)

Ithimba lakho lezokwelapha lizokuqapha eduze ukuze libone le miphumela ngokuhlolwa kwegazi njalo nokuhlolwa. Imiphumela emibi eminingi iyaphathwa uma itholwa kusenesikhathi.

Ubani Ongafanele Athathwe I-Pazopanib?

I-Pazopanib ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo ezithile zingenza lo muthi ungaphephile noma ungasebenzi kahle.

Akufanele uthathe i-pazopanib uma unesifo sesibindi esibi, njengoba umuthi ungenza ukusebenza kwesibindi kube kubi kakhulu. Abantu abanezimo ezithile zenhliziyo, umfutho wegazi ophezulu ongagadiwe, noma izinkinga zokuphuma kwegazi zakamuva kungenzeka badinga ukugwema lokhu kwelashwa.

Uma ukhulelwe noma uncelisa, i-pazopanib ingamlimaza umntwana wakho futhi ayinconywa. Abesifazane abaneminyaka yokuzala kufanele basebenzise izindlela zokulawula inzalo ezisebenzayo ngesikhathi sokwelashwa kanye namasonto amaningana ngemuva kokuyeka umuthi.

Udkt wakho uzobheka neminye imithi oyithathayo, njengoba i-pazopanib ingasebenzisana nemithi eminingi, okuhlanganisa nemithi ethile yokunciphisa igazi, imithi yenhliziyo, ngisho nezithasiselo ezithile zamakhambi.

Amagama Omkhiqizo we-Pazopanib

I-Pazopanib ithengiswa ngaphansi kwegama lomkhiqizo elithi Votrient emazweni amaningi, okuhlanganisa ne-United States. Lolu uhlobo oluvamile ozohlangana nalo emakhemisi.

Amanye amazwe angase abe namagama omkhiqizo ahlukene noma izinhlobo ezivamile ezitholakalayo. Njalo qiniseka ukuthi uthola umuthi olungile ngokuxhumana nomphathi wakho wamaphilisi uma unemibuzo mayelana negama noma ukubukeka kwamaphilisi akho.

Ezinye izindlela ze-Pazopanib

Eminye imithi eminingana yokwelapha eqondiwe isebenza ngendlela efanayo ne-pazopanib ekwelapheni umdlavuza wezinso kanye nama-sarcoma ethishu athambile. Udkt wakho angase acabange lezi ezinye izindlela uma i-pazopanib ingakulungele noma iyeka ukusebenza ngempumelelo.

Umdlavuza wezinso, ezinye izindlela zihlanganisa i-sunitinib (Sutent), i-sorafenib (Nexavar), kanye nemithi emisha efana ne-cabozantinib (Cabometyx) noma i-nivolumab (Opdivo). Ngamunye unenzuzo yawo kanye nephrofayili yemiphumela emibi.

Ama-sarcoma ethishu athambile, izinketho zingase zihlanganise i-doxorubicin-based chemotherapy, i-ifosfamide, noma ezinye izindlela zokwelapha eziqondiwe njenge-trabectedin. Ukukhetha okungcono kuncike ohlotsheni lwakho oluthile lwe-sarcoma nempilo yonke.

Udokotela wakho we-oncologist uzokusiza ukuthi uqonde ukuthi kungani bencoma i-pazopanib ngaphezu kwalezi ezinye izindlela, bebheka uhlobo lwakho lomdlavuza, umlando wakho wezokwelapha, nezintandokazi zakho.

Ingabe i-Pazopanib Ingcono Kune-Sunitinib?

I-Pazopanib kanye ne-sunitinib yomibili imithi esebenzayo yokwelapha umdlavuza wezinso oqhubekayo, kodwa isebenza ngendlela ehlukile futhi inezinhlobo ezihlukene zemiphumela emibi. Akukho noyedwa othiwa “ungcono” kunomunye - kuncike esimweni sakho.

Izifundo zikhombisile ukuthi i-pazopanib kanye ne-sunitinib zisebenza ngendlela efanayo ekunciphiseni ukuqhubeka komdlavuza nokwelula ukusinda. Kodwa-ke, abantu abaningi bathola ukuthi i-pazopanib kulula ukuyibekezelela nsuku zonke, ngaphandle kokukhathala okuncane kanye nezilonda ezingaphakathi emlonyeni.

I-Sunitinib ithathwa ngemijikelezo enezikhawu, kanti i-pazopanib ithathwa ngokuqhubekayo. Abanye abantu bakhetha indlela eqhubekayo, kanti abanye bathanda ukuba nezikhefu zokwelashwa. Udokotela wakho uzocabangela indlela yakho yokuphila, ezinye izimo zempilo, kanye nezintandokazi zakho siqu lapho ekhetha phakathi kwazo.

Isinqumo sivame ukwehla emuthini ofanelana kangcono nempilo yakho kanye nemiphumela emibi ozizwa ukhululekile ukuyilawula.

Imibuzo Evame Ukubuzwa Mayelana ne-Pazopanib

Ingabe i-Pazopanib iphephile kubantu abanezifo zenhliziyo?

I-Pazopanib ingayithinta inhliziyo yakho nomfutho wegazi, ngakho-ke abantu abanezifo zenhliziyo ezikhona badinga ukuqashwa ngokucophelela. Udokotela wakho uzohlola impilo yenhliziyo yakho ngaphambi kokuqala ukwelashwa futhi angase ayalele izivivinyo zenhliziyo njenge-echocardiogram noma i-EKG.

Uma unezinkinga zenhliziyo ezithambile, ungase ukwazi ukuthatha i-pazopanib ngokuqashwa okuseduze futhi mhlawumbe imithi yenhliziyo ukuze ulawule umfutho wegazi. Kodwa-ke, ukuhluleka kwenhliziyo okukhulu noma ukuhlaselwa yinhliziyo kwakamuva ngokuvamile kwenza i-pazopanib ibe yingozi kakhulu.

Ithimba lakho le-cardio-oncology lizosebenzisana ukuze linqume ukuthi ngabe izinzuzo zokwelashwa komdlavuza zidlula izingozi zenhliziyo esimweni sakho esithile.

Ngingenzani uma ngiphuthelwa ngengozi ukuthatha i-Pazopanib eningi kakhulu?

Uma ngengozi uthatha i-pazopanib eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi uzizwa yini izimpawu - ukuthola iseluleko sezokwelapha ngokushesha ngaso sonke isikhathi kuyindlela ephephe kunazo zonke.

Ukunatha i-pazopanib eningi kakhulu kungadala imiphumela emibi efana nokwehla okukhulu kwengcindezi yegazi, izinkinga zesigqi senhliziyo, noma ukulimala kwesibindi. Le miphumela ingase ingaveli ngokushesha, ngakho ukuqapha kwezokwelapha kubalulekile ngisho noma uzizwa kahle.

Letha ibhodlela lakho lemithi esibhedlela noma ulibeke uma ushayela ucingo, ukuze abahlinzeki bezempilo bazi kahle ukuthi yini nokuthi ungakanani okuthathile.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Pazopanib?

Uma ugeqa umthamo futhi sekudlule amahora angaphansi kwangu-12 kusukela ngesikhathi sakho esivamile, yithathe ngokushesha lapho ukhumbula. Uma sekudlule amahora angaphezu kwangu-12, weqa umthamo ogeqiwe bese uthatha umthamo wakho olandelayo ngesikhathi esivamile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ogeqiwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi engathi sína. Kungcono ukweqa umthamo owodwa kunokuphinda.

Uma uvame ukukhohlwa imithamo, khuluma nethimba lakho lezempilo ngamasu okukusiza ukuthi ukhumbule, njengama-alamu ocingo, abahleli bamaphilisi, noma izinhlelo zokusebenza ze-smartphone ezenzelwe izikhumbuzi zemithi.

Ngingayeka Nini Ukuthatha I-Pazopanib?

Kufanele uyeke kuphela ukuthatha i-pazopanib ngaphansi kwesiqondiso sikadokotela wakho. Ngisho noma uzizwa ungcono noma uhlangabezana nemiphumela emibi, ukuyeka kungazelelwe ngaphandle kokuqashwa kwezokwelapha kungavumela umdlavuza wakho ukuthi ukhule ngokushesha.

Udokotela wakho uzoncoma ukuyeka i-pazopanib uma umdlavuza wakho uqhubeka naphezu kokwelashwa, uma uba nemiphumela emibi engathi sína engakwazi ukulawulwa, noma uma okunye ukwelashwa kuba okufanele kakhulu isimo sakho.

Ngezinye izikhathi udokotela wakho angase amise ukwelashwa okwesikhashana ukuze uvumele umzimba wakho ukuthi ululame emiphumeleni emibi, bese uqala kabusha ngomthamo ophansi. Le ndlela ingakusiza ukuthi uqhubeke nokuzuza emithini ngenkathi uhlala ukhululekile.

Ngingakwazi Yini Ukuphuza Utshwala Ngenkathi Ngithatha I-Pazopanib?

Kungcono ukugwema utshwala noma uphuze amanani amancane kakhulu ngenkathi uthatha i-pazopanib. Kokubili utshwala kanye ne-pazopanib kungathinta isibindi sakho, futhi ukukuhlanganisa kwandisa ingozi yokulimala kwesibindi.

Utshwala bungase futhi bunyuse eminye yemiphumela emibi ye-pazopanib, njengokucasuka, isiyezi, nokukhathala. Uma ukhetha ukuphuza ngezikhathi ezithile, zilinganisele esiphuzweni esisodwa futhi unake indlela ozizwa ngayo.

Njalo xoxa ngokusebenzisa utshwala nethimba lakho lezempilo, njengoba linganikeza iseluleko esiqondene nawe ngokusekelwe ekuhlolweni komsebenzi wesibindi sakho kanye nesimo sempilo yakho esiphelele.