Yini i-Pimavanserin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Pimavanserin iyimithi ekhethekile eyenzelwe ukusiza abantu abanesifo sikaParkinson abahlangabezana nama-hallucinations kanye nama-delusions. Uma wena noma othile omkhathalelayo ebhekene nalezi zimpawu eziyinselele, awuwedwa, futhi zikhona izindlela zokwelapha ezingenza umehluko wangempela.

Le mithi isebenza ngendlela ehlukile kunemithi yendabuko ye-antipsychotic, inikeza indlela enobumnene eyenzelwe ngqo abantu abanesifo sikaParkinson. Ukuqonda ukuthi isebenza kanjani nokuthi yini ongayilindela kungakusiza uzizwe uqiniseka kakhulu ngohambo lwakho lokwelashwa.

Yini i-Pimavanserin?

I-Pimavanserin iyimithi yomlomo engaphansi kwezigaba zemithi ebizwa ngokuthi ama-selective serotonin inverse agonists. Ngokungafani neminye imithi yezifo zengqondo, yenzelwe ngqo ukugxila ekushintsheni kwamakhemikhali obuchopho okubangela ama-hallucinations kanye nama-delusions esifweni sikaParkinson.

Le mithi yathuthukiswa ngemuva kokuthi abacwaningi bethola ukuthi imithi yendabuko ye-antipsychotic ngokuvamile yenza izimpawu zemoto zikaParkinson zibe zimbi kakhulu. I-Pimavanserin inikeza enye indlela ephephile ngoba ayivimbi ama-dopamine receptors, asevele ekhubazekile esifweni sikaParkinson.

Uzoyithola itholakala ngaphansi kwegama lomkhiqizo elithi Nuplazid, futhi iza ngamaphilisi omlomo owathatha ngomlomo. Le mithi ifundwe ngokukhethekile futhi yagunyazwa ngokuphazamiseka kwengqondo yesifo sikaParkinson, okuyenza ibe yindlela yokwelapha eqondiwe.

Yini i-Pimavanserin Esetshenziselwa Yona?

I-Pimavanserin isetshenziswa ikakhulukazi ukwelapha ama-hallucinations kanye nama-delusions avela kubantu abanesifo sikaParkinson. Lezi zimpawu, ezaziwa ngokuthi i-Parkinson's disease psychosis, zingaba buhlungu ngendlela emangalisayo kuzo zombili iziguli nemindeni yazo.

Ukucabanga okungamanga kungabandakanya ukubona abantu, izilwane, noma izinto ezingekho ngempela, kuyilapho imicabango eyiphutha ihlanganisa ukukholwa okungamanga okuzwakala kuyiqiniso ngempela kumuntu okuzwayo. Lezi zimpawu zithinta kufika ku-50% yabantu abanesifo sikaParkinson ngesikhathi esithile ohambweni lwabo.

Umuthi uvunyelwe ngokuqondile kulesi simo futhi awusetshenziselwa ezinye izinhlobo ze-psychosis noma izimo zempilo yengqondo. Udokotela wakho uzomisa umuthi kuphela uma unesifo sikaParkinson esiqinisekisiwe kanye nalezi zimpawu ezithile zengqondo.

Isebenza Kanjani I-Pimavanserin?

I-Pimavanserin isebenza ngokugxila kuma-serotonin receptors ebuchosheni bakho, ikakhulukazi ama-5-HT2A receptors. Lawa ma-receptors adlala indima ebalulekile ekubangeleni ukucabanga okungamanga kanye nemicabango eyiphutha ehambisana ne-Parkinson's disease psychosis.

Cabanga ngayo njengenkinobho yokusetha kabusha ngobumnene emisebenzini yobuchopho esibe ngaphezu kwamandla. Umuthi awucindezeli lonke uhlelo lwakho lwezinzwa njengoba imithi eqinile ye-antipsychotic ingase yenze. Kunalokho, ilungisa izindlela ezithile zobuchopho ezibangela izinkinga.

Le ndlela eqondiwe isho ukuthi i-pimavanserin ithathwa njengomuthi onamandla aphakathi nendawo. Inamandla ngokwanele ukuthi isebenze kahle ezimpawini ze-psychotic kodwa ithambile ngokwanele ukugwema ukwenza izimpawu zakho zemoto ze-Parkinson zibe zimbi njengokuthuthumela noma ukuqina.

Umuthi ngokuvamile uthatha amasonto amaningana ukukhombisa imiphumela yawo ephelele. Ungase uqaphele ukuthuthuka kancane kancane ekuvamekeni nasekuqineni kokucabanga okungamanga kanye nemicabango eyiphutha njengoba amakhemikhali obuchopho bakho elungela ukwelashwa.

Kufanele Ngiyithathe Kanjani I-Pimavanserin?

Thatha i-pimavanserin ngendlela udokotela wakho ayala ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Ungayithatha nokudla noma ngaphandle kokudla, noma yikuphi okuzwakala kukhululekile esiswini sakho.

Gwinya ithebhulethi yonke ngengilazi yamanzi. Ungayichobozi, uhlafune, noma uhlukanise ithebhulethi, ngoba lokhu kungathinta indlela umuthi omuncwa ngayo emzimbeni wakho.

Abantu abaningi bakuthola kuwusizo ukuphuza i-pimavanserin kusihlwa, njengoba lesi sikhathi singasiza ekunciphiseni noma yikuphi ukulala emini. Kodwa-ke, udokotela wakho angase ancome uhlelo oluhlukile olusekelwe ezidingweni zakho ezithile kanye neminye imithi.

Uma uthatha eminye imithi ye-Parkinson, qhubeka uyithatha njengoba iqoshiwe. I-Pimavanserin yenzelwe ukusebenza kanye nokwelashwa kwakho okukhona, hhayi ukukushintsha.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Pimavanserin?

Ubude bokwelashwa nge-pimavanserin buhlukahluka kumuntu nomuntu futhi kuncike ekutheni usabela kahle kangakanani emuthini. Abanye abantu bangase badinge ukuyithatha izinyanga, kanti abanye bangase badinge ukwelashwa isikhathi eside.

Udokotela wakho uzohlola njalo ukuthi usabela kanjani emuthini nokuthi ngabe izinzuzo ziyaqhubeka yini ukwedlula noma yimaphi ama-side effects angaba khona. Lokhu kuhlolwa kuvame ukwenzeka njalo ezinyangeni ezimbalwa, ikakhulu ngonyaka wokuqala wokwelashwa.

Kubalulekile ukungayeki ukuthatha i-pimavanserin ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka ngokuphazima kungabangela ukuthi imibono yakho nokukhohlisa kubuye ngokushesha, okungaba buhlungu futhi kuphazamise impilo yakho yansuku zonke.

Uma wena nodokotela wakho ninquma ukuyeka umuthi, cishe uzo landela uhlelo oluqhubekayo lokunciphisa ukuze kuncishiswe noma yimaphi ama-withdrawal effects angaba khona.

Yiziphi Izinkinga Ezingaba Khona Ze-Pimavanserin?

Njengayo yonke imithi, i-pimavanserin ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi imild kuya esimweni esiphakathi nendawo futhi ivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini.

Nawa ama-side effects avamile ongase uwathole:

• Ukuvuvukala emilenzeni yakho, emaqakaleni, noma ezinyaweni (peripheral edema)
• Ukucasuka noma isisu esibuhlungu
• Ukudideka noma inkungu yengqondo
• Imibono (nakuba ngokuvamile ingabi nzima njengaphambi kokwelashwa)
• Ukukhathala noma ukulala
• Ukuqunjelwa
• Izifo zomgudu womchamo

Lezi zimo ezivamile ezibangelwa imithi ngokuvamile zithinta abantu abangaphansi kuka-10% abathatha imithi futhi ngokuvamile ziba ngaphansi kokuqashelwa ngokuhamba kwesikhathi.

Kukhona nemiphumela emibi engavamile kodwa ebucayi edinga ukunakekelwa kwezempilo ngokushesha. Lezi zinkinga ezingavamile zihlanganisa izinguquko zesigqi senhliziyo, ukusabela okukhulu komzimba, noma ukwanda okukhulu kokudideka.

Abanye abantu bangase babe nokuwa noma izinkinga zokulinganisela, nakuba kuvame ukuba nzima ukutshela ukuthi lokhu kuvela emuthini noma isifo sikaParkinson esingaphansi. Uma uqaphela ukuwa okwengeziwe noma izinkinga zokulinganisela, xoxa ngalokhu nodokotela wakho ngokushesha.

Ubani Ongafanele Athole I-Pimavanserin?

I-Pimavanserin ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinikeza. Akufanele uthathe lo muthi uma wazi ukuthi unokungezwani komzimba ne-pimavanserin noma yiziphi izithako zawo.

Abantu abanezimo ezithile zenhliziyo badinga ukucatshangelwa okukhethekile. Uma unomlando wezinkinga zesigqi senhliziyo, ukuhluleka kwenhliziyo, noma uthatha imithi ethinta isigqi senhliziyo, udokotela wakho uzodinga ukukuqapha eduze noma angase akhethe ukwelashwa okuhlukile.

Umuthi futhi udinga ukuqapha uma unezifo ezinzima zezinso noma zesibindi, njengoba umzimba wakho ungase ungawuqedi kahle. Udokotela wakho angase adinge ukulungisa umthamo wakho noma akuqaphe kaningi kulezi zimo.

Ukukhulelwa nokuncelisa kubalulekile futhi. Nakuba kukhona idatha elinganiselwe emiphumeleni ye-pimavanserin ngesikhathi sokukhulelwa, kufanele uxoxe ngezingozi nezinzuzo nodokotela wakho uma ukhulelwe noma uhlela ukukhulelwa.

Igama Lomkhiqizo Le-Pimavanserin

I-Pimavanserin ithengiswa ngaphansi kwegama lomkhiqizo elithi Nuplazid e-United States. Leli njengamanje yilona kuphela igama lomkhiqizo elitholakalayo lalo muthi, njengoba lisavikelwe ngamalungelo obunikazi.

Uma uthatha umuthi wakho, uzobona "Nuplazid" kulebula lebhodlela, kanye negama elivamile elithi pimavanserin. Womabili la magama abhekisela emuthini ofanayo, ngakho ungakhathazeki uma ubona elilodwa emithini yakho.

Amaphilisi ngokuvamile amhlophe noma amhlophe kancane futhi eza emaphaketheni e-blister ukusiza ukugcina ukuzinza kwawo. Iphakethe ngalinye liqukethe ukuhlinzekwa kwenyanga yomuthi uma uthathwa njengoba kunqunywe.

Ezinye izindlela zikaPimavanserin

Uma i-pimavanserin ingasebenzi kahle kuwe noma ibangela imiphumela engathandeki, zikhona ezinye izindlela zokwelapha ezitholakalayo. Kodwa-ke, ezinye izindlela ziza nezinto okufanele zicatshangelwe kanye nezingozi ezingaba khona.

I-quetiapine enomthamo ophansi ngezinye izikhathi isetshenziswa njengenye indlela, nakuba ingenza izimpawu zemoto zibe zimbi kwabanye abantu abanesifo sikaParkinson. I-Clozapine enye inketho esebenzayo kodwa idinga ukuqapha igazi njalo ngenxa yemiphumela emibi engaba khona.

Ezinye izinyanga zingase zincomise ukunciphisa noma ukulungisa imithi yakho yamanje ye-Parkinson uma inegalelo ezimpawini ze-psychotic. Le ndlela idinga ibhalansi eqaphelisisayo ukuze kugcinwe umsebenzi wemoto ngenkathi kuncishiswa izimpawu zengqondo.

Izindlela ezingezona imithi nazo zingaba usizo njengokwelashwa okwengezayo. Lokhu kungase kuhlanganise ukuguqulwa kwemvelo, ukuthuthukiswa kwenhlanzeko yokulala, kanye namasu e-cognitive behavioral therapy.

Ingabe i-Pimavanserin ingcono kune-Quetiapine?

I-Pimavanserin ne-quetiapine zisebenza ngendlela ehlukile futhi zinezinzuzo nezingozi ezihlukile. I-Pimavanserin yenzelwe ngqo i-Parkinson's disease psychosis futhi mancane amathuba okuthi yenze izimpawu zakho zemoto zibe zimbi.

I-Quetiapine, ngenkathi isebenza kahle ngamaphupho nenkohliso, ngezinye izikhathi ingenza ukuthuthumela, ukuqina, nezinkinga zokunyakaza zibe zimbi ngoba ithinta ama-dopamine receptors. Lokhu kwenza i-pimavanserin ibe yindlela ephephe kakhulu kubantu abaningi abanesifo sikaParkinson.

Noma kunjalo, i-quetiapine isetshenziswe isikhathi eside futhi inemininingwane ebanzi yocwaningo etholakalayo. Futhi ngokuvamile ibiza kancane kune-pimavanserin, okungaba yinto ebalulekile okufanele icatshangelwe kwabanye abantu.

Udokotela wakho uzokusiza ukuthi ulinganise lezi zici ngokusekelwe ezimpawini zakho ezithile, umlando wakho wezokwelapha, kanye nokuphendula komuntu ngamunye ekwelashweni. Akukho impendulo eyodwa elingana wonke umuntu, futhi okusebenza kahle kakhulu kuyahlukahluka kumuntu nomuntu.

Imibuzo Evame Ukubuzwa Mayelana ne-Pimavanserin

Ingabe i-Pimavanserin iphephile kubantu abane-Dementia?

I-Pimavanserin ivunyelwe ngokuqondile i-Parkinson's disease psychosis, hhayi i-psychosis ehlobene ne-dementia. Uma une-dementia kanye ne-Parkinson's disease, udokotela wakho uzodinga ukuhlola ngokucophelela ukuthi lo muthi ulungele yini isimo sakho.

Umuthi uphethe isixwayiso sebhokisi elimnyama mayelana nengozi eyengeziwe yokufa ezigulini ezindala ezinokugula okuhlobene ne-dementia. Lokhu akusho ukuthi umuthi awuphephile kuwo wonke umuntu, kodwa kudinga ukucatshangelwa nokuqapha ngokucophelela.

Ngingenzani uma ngiphuzile i-Pimavanserin eningi ngengozi?

Uma ngengozi uphuza i-pimavanserin eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuphuza okuningi kungakhuphula ingozi yakho yezinkinga zesigqi senhliziyo neminye imiphumela emibi engathi sína.

Ungalindi ukubona ukuthi uzizwa ulungile yini. Noma ngabe awuziboni izimpawu ngokushesha, kubalulekile ukufuna iseluleko sezokwelapha ngokushesha. Gcina ibhodlela lakho lomuthi unawe uma ushayela noma uvakashela egumbini eliphuthumayo.

Ngingenzani uma ngiphuthelwa umthamo we-Pimavanserin?

Uma uphuthelwa umthamo, uwuphuze ngokushesha lapho ukhumbula, ngaphandle kwalapho sekuyisikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho lokulinganisa olujwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ubuyisele umthamo owuphuthelwe, njengoba lokhu kungakhuphula ingozi yakho yemiphumela engemihle. Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule.

Ngingayeka nini ukuthatha i-Pimavanserin?

Kufanele uyeke kuphela ukuthatha i-pimavanserin ngaphansi kwesiqondiso sikadokotela wakho. Isinqumo sokuyeka ngokuvamile sincike ekutheni izimpawu zakho zilawulwa kahle kangakanani nokuthi ngabe uhlangabezana nemiphumela engemihle ekhathazayo.

Udkt wakho cishe uzofuna ukunciphisa kancane kancane umthamo wakho kunokuyeka kungazelelwe. Le nqubo yokunciphisa isiza ekuvikeleni ukuthi imibono yakho nokukhohlisa kubuye ngokuphazima kweso, okungaba buhlungu futhi kuphazamise.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Pimavanserin?

Kungcono ukugwema utshwala ngenkathi uthatha i-pimavanserin, njengoba ingakhuphula ukozela nokudideka. Utshwala bungase futhi buqhubekisele phambili izinkinga zokulinganisela ezivamile kakade esifweni sikaParkinson.

Uma ukhetha ukuphuza ngezikhathi ezithile, xoxa ngalokhu nodokotela wakho kuqala. Bangakusiza ukuthi uqonde izingozi futhi banikeze isiqondiso semikhawulo ephephile ngokusekelwe empilweni yakho yonke neminye imithi.