Yini i-Pimecrolimus: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Pimecrolimus iyikhambi elingaphandle elilawula amasosha omzimba elisiza ukulawula i-eczema kanye ne-atopic dermatitis ngokuthulisa ukusabela komzimba wakho. Ngokungafani nama-steroid creams, lo muthi oqokiwe usebenza ngokuvimba amaseli athile omzimba abangela ukuvuvukala, okwenza kube yindlela ethambile kodwa esebenzayo yokwelapha izimo zesikhumba ezibucayi.

Le cream ingeyodwa yezinhlobo zemithi ebizwa ngokuthi ama-calcineurin inhibitors, okusho ukuthi iqondisa imbangela ye-eczema flare-ups ngaphandle kwemiphumela yesikhathi eside ehambisana nokusetshenziswa kwe-steroid okude. Abantu abaningi bayithola ilusizo ikakhulukazi ekwelapheni izindawo ezibucayi njengobuso nentamo lapho ama-steroid creams angase abe lukhuni kakhulu.

Yini i-Pimecrolimus Esetshenziselwa Yona?

I-Pimecrolimus iphatha i-atopic dermatitis (eczema) ebuthaka kuya kokulingene kubantu abadala kanye nezingane ezineminyaka engaphezu kwengu-2 ubudala. Udokotela wakho uqoka lo muthi uma ezinye izindlela zokwelapha zingasebenzi kahle noma uma udinga inketho ephephile yesikhathi eside yokulawula i-eczema engapheli.

Lo muthi usebenza kahle kakhulu nge-eczema ebusweni bakho, entanyeni, nakwezinye izindawo ezibucayi lapho isikhumba sakho sincane khona. Isiza ukunciphisa izindawo ezibomvu, ezilumayo, ezivuvukele ezenza i-eczema ingakhululeki futhi iphazamise impilo yansuku zonke.

Abanye odokotela baphinda baqoke i-pimecrolimus ngaphandle kwethekithi lezinye izimo zesikhumba ezivuthayo njenge-seborrheic dermatitis noma i-vitiligo, nakuba lokhu kusetshenziswa kungagunyazwanga ngokusemthethweni yi-FDA. Umhlinzeki wakho wezempilo uzonquma ukuthi lo muthi ulungele isimo sakho sesikhumba esithile.

Isebenza Kanjani i-Pimecrolimus?

I-Pimecrolimus isebenza ngokuvimba ama-T-cells kanye nama-mast cells esikhumbeni sakho ekukhipheni amakhemikhali avuthayo abangela izimpawu ze-eczema. Cabanga ngayo njengokubeka ibhuleki elithambile ekusabeleni ngokweqile komzimba wakho ezintweni ezivame ukungakhathazi isikhumba esinempilo.

Lo muthi uthathwa njengokwelapha okunamandla aphakathi nendawo okuthambile kunezithako eziningi zokugcoba. Awuthambisi isikhumba sakho njengoba ama-steroids enza, okwenza kuphephe ukusetshenziswa isikhathi eside ezindaweni ezibucayi njengobuso bakho nasemaceleni amehlo akho.

Ngokuvamile uzoqala ukubona ngcono phakathi nezinsuku ezimbalwa kuya evikini lokusetshenziswa njalo, nakuba kungase kuthathe amasonto amaningana ukubona izinzuzo eziphelele. Umuthi uyaqhubeka nokusebenza ngisho nangemva kokuba izimpawu zakho zithuthuke, usiza ekuvikeleni ukuqubuka okusha uma usetshenziswa njengoba kuqondiswe.

Ngingawuthatha Kanjani I-Pimecrolimus?

Gcobisa ungqimba oluncane lwe-pimecrolimus cream ezindaweni ezithintekile kabili ngosuku, ekuseni nakusihlwa. Akudingeki ukuthi uyigcobe ngamandla - vele uyithambise ngobumnene esikhumbeni sakho size singene.

Geza izandla zakho ngamanzi ngaphambi nangemva kokugcoba ukhilimu, ngaphandle uma welapha izandla zakho. Gcobisa umuthi kuphela ezindaweni ezinama-eczema, ugweme isikhumba esinempilo ezungeze izindawo ezithintekile.

Ungagcoba i-pimecrolimus esikhumbeni esihlanzekile, esomile nganoma yisiphi isikhathi sosuku, ngaphandle noma ngaphandle kokudla njengoba kungumuthi ogcotshwayo. Nokho, abantu abaningi bakuthola kuwusizo ukuyigcoba ngemva kokugeza lapho isikhumba sabo sisamanzi kancane ukusiza ukuvala umswakama.

Ungambozi izindawo eziphathwayo ngamabhandishi noma izingubo zokugqoka eziqinile ngaphandle uma udokotela wakho ekutshela ngqo ukuthi wenze njalo. Lo muthi usebenza kahle kakhulu lapho isikhumba sakho singaphefumula ngokwemvelo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Pimecrolimus?

Kufanele usebenzise i-pimecrolimus isikhathi eside njengoba udokotela wakho encoma, okuyinto ngokuvamile kuze kube yilapho izimpawu zakho ze-eczema zinyamalala ngokuphelele. Abantu abaningi babona ukuthuthuka okukhulu phakathi kwama-2-6 amasonto okusetshenziswa okuqhubekayo.

Ngokungafani nama-steroids agcotshwayo, i-pimecrolimus ingasetshenziswa ngokuphepha isikhathi eside ngaphandle kokubangela ukuthamba kwesikhumba noma eminye imiphumela emibi yesikhathi eside. Abanye abantu bayisebenzisa ngezikhathi ezithile izinyanga noma iminyaka ngisho nokuvimbela ukuqubuka kwe-eczema.

Udktela wakho angase ancome ukuyeka imithi uma isikhumba sakho sesihlanzekile bese uyiqala kabusha uma izimpawu zibuyela. Le ndlela ikusiza ukuthi usebenzise imithi encane edingekayo ukuze ugcine i-eczema yakho ilawulwa.

Yiziphi Izimo Ezingezinhle Zomuthi i-Pimecrolimus?

Abantu abaningi bayamukela kahle i-pimecrolimus, kodwa njenganoma imuphi umuthi, ingabangela imiphumela engemihle. Izindaba ezinhle ukuthi imiphumela engemihle engathi sína ayivamile, futhi iningi lezimo zithambile futhi zihambela.

Nazi izimo ezingezinhle ezivamile ongase uzithole lapho uqala lo muthi:

• Ukusha noma ukuluma endaweni yokusebenzisa (ngokuvamile kuthuthuka ezinsukwini ezimbalwa)
• Ukubomvu kwesikhumba noma ukucasuka
• Ukuluma okungase kube kubi okwesikhashana ngaphambi kokuthuthuka
• Ukufudumala kwesikhumba noma ukuluma
• Ikhanda
• Izimpawu ezinjengomkhuhlane noma umkhuhlane

Lezi zimo ezivamile ngokuvamile ziyanyamalala njengoba isikhumba sakho sijwayela umuthi. Uma ziqhubeka noma ziba zimbi ngemva kwesonto, xhumana nomhlinzeki wakho wezempilo ukuze uthole isiqondiso.

Imiphumela engemihle engavamile kodwa engathi sína idinga ukunakekelwa kwezempilo ngokushesha futhi ihlanganisa:

• Izimpawu zokutheleleka kwesikhumba (ukubomvu okukhulu, ukufudumala, i-pus, noma imigqa ebomvu)
• Ukungezwani komzimba okukhulu (ukuqubuka, ukuvuvukala, ubunzima bokuphefumula)
• Ukukhula kwesikhumba okungavamile noma izinguquko kuma-moles akhona
• Umkhuhlane oqhubekayo noma ama-lymph nodes avuvukile

Nakuba kungavamile kakhulu, kuye kwaba nemibiko yomdlavuza wesikhumba ne-lymphoma kubantu abasebenzisa ama-calcineurin inhibitors, nakuba ukuxhumana okuqondile kungakafakazelwa. Udktela wakho ulinganisa lezi zingozi ezincane ngokumelene nezinzuzo lapho enikeza lo muthi.

Ubani Ongafanele Athathwe i-Pimecrolimus?

I-Pimecrolimus ayilungile kuwo wonke umuntu, futhi izimo ezithile zenza kungaphephile ukuyisebenzisa. Udktela wakho uzobukeza umlando wakho wezokwelapha ngokucophelela ngaphambi kokunikeza lo muthi.

Akufanele usebenzise i-pimecrolimus uma unezinye zalezi zimo:

• Ukungezwani okwaziwayo ne-pimecrolimus noma yiziphi izithako ezikukhilimu
• Izifo zesikhumba ezisebenzayo (amagciwane, amagciwane, noma isikhunta)
• Isistimu yokuzivikela emzimbeni ekhubazekile ngenxa yesifo noma imithi
• Umkhuhlane wesikhumba noma izilonda ezingaphambi komdlavuza endaweni yokwelashwa
• I-Netherton's syndrome (isimo sesikhumba esingavamile se-genetic)

Ukuqapha okukhethekile kuyadingeka uma ukhulelwe, uncelisa, noma uhlela ukukhulelwa. Ngenkathi izifundo zingakhombisanga imiphumela eyingozi, udokotela wakho uzohlola izinzuzo ngokumelene nezingozi ezingaba khona kuwe nomntwana wakho.

Izingane ezingaphansi kweminyaka emi-2 ubudala akufanele zisebenzise i-pimecrolimus, njengoba ukuphepha nokusebenza kungakaze kuqinisekiswe kulolu hlu lweminyaka. Ngaphezu kwalokho, abantu abanezifo ezithile ze-autoimmune bangase badinge ukuqapha okwengeziwe ngenkathi besebenzisa lo muthi.

Amagama Omkhiqizo we-Pimecrolimus

I-Pimecrolimus itholakala ngaphansi kwegama lomkhiqizo elithi Elidel emazweni amaningi, okuhlanganisa ne-United States. Leli yigama lomkhiqizo lokuqala lapho umuthi waqala ukugunyazwa futhi wathengiswa.

Amanye amazwe angase abe nezinhlobo ezivamile ezitholakalayo, kodwa isithako esisebenzayo sihlala sifana kungakhathaliseki ukuthi ngubani umenzi. Ikhemisi lakho ngokuvamile lizokhipha inguqulo eshibhile kakhulu yohlelo lwakho lomshuwalense.

Njalo hlola nekhemisi lakho uma ubona noma yikuphi ukungafani ekubukekeni noma ekupakisheni komuthi wakho, njengoba bengaqinisekisa ukuthi uthola ifomula efanele.

Ezinye izindlela ze-Pimecrolimus

Uma i-pimecrolimus ingasebenzi kahle kuwe noma ibangela imiphumela emibi, ezinye izindlela ezingasiza ukuphatha i-eczema yakho ngempumelelo. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho ngokusekelwe ezidingweni zakho ezithile.

Ezinye izinto ezivimbela i-calcineurin zihlanganisa i-tacrolimus (Protopic), esebenza ngendlela efanayo kodwa ingase ibe namandla kakhulu nge-eczema eqinile. Ama-steroid athambile anamandla ahlukahlukene ahlala eyingxenye yokwelapha evame ukunconywa nge-eczema, nakuba engalungile ukusetshenziswa isikhathi eside ezindaweni ezizwelayo.

Izinketho ezintsha zihlanganisa izinto ezivimbela i-topical JAK njenge-ruxolitinib (Opzelura) ye-eczema elula kuya kokulingene, kanye ne-crisaborole (Eucrisa), into evimbela i-PDE4 ethambile ikakhulukazi ezinganeni. Ezimweni ezinzima, udokotela wakho angase acabange ngemithi yomlomo noma i-biologics efana ne-dupilumab (Dupixent).

Ezinye izindlela ezingekho emthethweni zihlanganisa izinto ezithambisa umzimba ezinothile nge-ceramide, amalungiselelo e-colloidal oatmeal, kanye nezinto zokuhlanza ezithambile ezenzelwe isikhumba esizwelayo. Lezi zingasetshenziswa kanye nokwelashwa okubhalwe ngudokotela ukusekela ukuphulukiswa kwesikhumba sakho.

Ingabe i-Pimecrolimus Ingcono Kune-Tacrolimus?

Kokubili i-pimecrolimus ne-tacrolimus yizinto ezivimbela i-calcineurin ezisebenza ngendlela efanayo, kodwa zinezinye izinto ezibalulekile ezihlukile ezenza ngamunye afaneleke kakhulu ezimweni ezihlukene. Akukho noyedwa

Yebo, i-pimecrolimus iphephile ezinganeni ezineminyaka engaphezu kwemi-2 ubudala uma isetshenziswa njengoba kuqondiswe udokotela wezingane. Umuthi uye wafundwa ngokukhethekile ezinganeni futhi uvame ukukhethwa ngaphezu kwama-steroid atholakala ngaphandle ezinganeni ezincane ngoba awenzi isikhumba sibe sincane noma uphazamisa ukukhula.

Izingane zingase zizwele kakhulu emuzweni wokuqala wokusha, ngakho-ke kubalulekile ukuzilungiselela lokhu kungakhululeki kwesikhashana. Ukuqala ngezilinganiso ezincane bese ukhuphula kancane indawo yokusebenzisa kungasiza ukunciphisa ukucasuka kokuqala.

Ngingenzani Uma Ngisebenzisa I-Pimecrolimus Engakanani Ngengozi?

Uma ngengozi usebenzisa i-pimecrolimus eningi, ungangeni ekuqhumeni - lo muthi awumuncwa kalula egazini lakho ngamanani ayingozi. Vele usule ukhilimu owedlulele ngendwangu ehlanzekile, emanzi bese uqhubeka neshejuli yakho yokusebenzisa ejwayelekile.

Ukwenza okungaphezu kokuqondisiwe ngeke kusize i-eczema yakho iphole ngokushesha futhi kungase kwandise ingozi yemiphumela emibi efana nokusha noma ukucasuka. Uma uhlangabezana nokusha okukhulu, ububomvu, noma ezinye izimpawu ezikhathazayo ngemva kokusebenzisa okuningi, xhumana nomhlinzeki wakho wezempilo ukuze uthole isiqondiso.

Ngingenzani Uma Ngedlula Umthamo We-Pimecrolimus?

Uma udlula umthamo, sebenzisa umuthi ngokushesha lapho ukhumbula, ngaphandle uma sekuyisikhathi esiseduze sokusebenzisa kwakho okulandelayo okuhleliwe. Kulokho, weqa umthamo owedluliwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungasebenzisi umuthi owengeziwe ukuze ubuyisele umthamo owedluliwe, ngoba lokhu kungandisa ingozi yemiphumela emibi. Ukuqina kubaluleke kakhulu kunokuhlelwa kwesikhathi okuphelele, ngakho-ke gxila ekubuyeleni emsebenzini wakho ojwayelekile.

Ngingayeka nini ukuthatha i-Pimecrolimus?

Ngokuvamile ungaqeda ukusebenzisa i-pimecrolimus uma izimpawu zakho ze-eczema zinyamale ngokuphelele futhi isikhumba sakho sibuyele esimweni esijwayelekile. Lokhu kuvame ukuthatha amasonto ama-2-6 okusetshenziswa okuqhubekayo, kodwa umugqa wesikhathi uyahlukahluka kumuntu ngamunye.

Ungayeki ngokuphazima kweso uma usabona ngcono - qhubeka usebenzisa imithi kuze kube yilapho isikhumba sakho sesihlanzeke ngokuphelele. Udokotela wakho angase ancome ukunciphisa kancane kancane ukuvama kokusebenzisa kunokuyeka kungazelelwe ukuvimbela ukuqubuka.

Ngingasebenzisa i-Moisturizer nge-Pimecrolimus?

Yebo, kufanele uqhubeke usebenzisa i-moisturizer ethambile, engenamvini ngenkathi welapha i-eczema yakho nge-pimecrolimus. Ukuthambisa isikhumba kuyingxenye ebalulekile yokuphathwa kwe-eczema futhi kusiza imithi ukuthi isebenze ngempumelelo.

Sebenzisa i-moisturizer yakho ngemuva kokuthi ukhilimu we-pimecrolimus usuncelwe, ngokuvamile ulinda imizuzu engaba ngu-15-30 phakathi kokusebenzisa. Le ndlela yokubeka izendlalelo isiza ukuvala umswakama futhi isekela inqubo yokwelapha yesikhumba sakho.