Yini i-Plazomicin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Plazomicin iyisibulala-magciwane esinamandla esisetshenziswa odokotela ukwelapha izifo ezinzima ezibangelwa amagciwane lapho ezinye izibulala-magciwane zingasebenzi. Lo muthi ungoweqembu elibizwa ngokuthi ama-aminoglycosides, okuyizidakamizwa ezinamandla zokulwa nezifo ezinikezwa nge-IV esibhedlela. Uma udokotela wakho encoma i-plazomicin, kungenxa yokuthi ubhekene nesifo esinzima esibangelwa amagciwane esidinga lokhu kwelashwa okukhethekile ukukusiza ukuthi ululame.

Yini i-Plazomicin?

I-Plazomicin uhlobo olusha lwe-aminoglycoside antibiotic olwenzelwe ukulwa namagciwane asevele amelana neminye imithi. Isebenza ngokuvimbela amagciwane ayingozi ekwenzeni amaprotheni awadingayo ukuze asinde futhi azale emzimbeni wakho. Lo muthi njalo unikezwa njenge-intravenous infusion, okusho ukuthi ungena ngqo egazini lakho ngomthambo.

Lo muthi wenzelwe ngqo ukubhekana nezinye zezifo ezinzima kakhulu ezibangelwa amagciwane ezingasabeli ezibulala-magciwane ezijwayelekile. Cabanga ngayo njengethuluzi elikhethekile elisetshenziswa odokotela uma bedinga okuthile okuqinile futhi okuqondiwe kunezibulala-magciwane ezivamile.

Isetshenziselwani i-Plazomicin?

I-Plazomicin iphatha izifo eziyinkimbinkimbi zamathumbu kanye nezifo zegazi ezibangelwa amagciwane athile amelana nemithi. Udokotela wakho uzonquma lo muthi lapho izivivinyo zaselabhorethri zikhombisa ukuthi amagciwane abangela ukutheleleka kwakho amelana nezinye izibulala-magciwane. Lezi zifo zingaba zimbi futhi zibeke ukuphila engozini ngaphandle kokwelashwa okufanele.

Izimo ezivamile lapho odokotela besebenzisa i-plazomicin zihlanganisa izifo eziyinkimbinkimbi zezinso, izifo ezinzima zesinye eziye zasabalala, nezifo zegazi ezibangelwa amagciwane athile afana ne-carbapenem-resistant Enterobacteriaceae. Lawa amagciwane aqinile ngokukhethekile aye athuthukisa izindlela zokusinda ezibulala-magciwane ezijwayelekile.

Isebenza Kanjani i-Plazomicin?

I-Plazomicin ithathwa njenge-antibiotic eqinile esebenza ngokuhlasela amagciwane emgogodleni wawo. Ibopha ezingxenyeni ezithile zamaseli amagciwane abizwa ngokuthi ama-ribosomes, afana namafektri amancane enza amaprotheni. Lapho i-plazomicin ivimba lawa mafektri amaprotheni, amagciwane awakwazi ukwenza amaprotheni abalulekile abawadingayo ukuze asinde futhi azale.

Okuhlukanisa i-plazomicin ukuthi ikwazi ukunqoba izindlela eziningi zokuzivikela ezisetshenziswa amagciwane ukumelana namanye ama-antibiotics. Amagciwane amaningi aye athuthukisa ama-enzyme angahlukanisa ama-antibiotics amadala e-aminoglycoside, kodwa i-plazomicin yakhelwe ukumelana nalezi zivikelo zamagciwane. Lokhu kuyinika ithuba elihle lokulwa nezifo ezingakwazi ukusingathwa amanye ama-antibiotics.

Kufanele Ngiyithathe Kanjani I-Plazomicin?

I-Plazomicin ihlale inikezwa njenge-infusion ye-intravenous esibhedlela noma endaweni yezokwelapha ngabasebenzi bezempilo abaqeqeshiwe. Awukwazi ukuthatha lo muthi ekhaya noma ngomlomo. Umuthi uhlanganiswa nesixazululo esingenazo izinto ezingcolile futhi unikezwa kancane nge-IV line ngemizuzu engama-30 kuya emahoreni amabili, kuye ngesimo sakho esithile.

Ithimba lakho lezempilo lizokuqapha eduze ngesikhathi se-infusion ngayinye ukuze libheke noma yiziphi izindlela zokuphendula noma imiphumela emibi. Uhlelo lokulinganisa ngokuvamile luhlanganisa ukuthola umuthi kanye ngosuku, nakuba udokotela wakho ezoqoka isikhathi esiqondile esisekelwe ekusebenzeni kwezinso zakho kanye nobukhulu besifo sakho. Akudingeki ukhathazeke ngokuyithatha nokudla ngoba iya ngqo emithanjeni yakho yegazi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Plazomicin?

Ubude bokwelashwa nge-plazomicin buvame ukusuka ezinsukwini ezi-4 kuya kweziyi-14, kuye ngohlobo nobukhulu besifo sakho. Udokotela wakho uzoqoka ubude obuqondile ngokusekelwe ekutheni uphendula kahle kangakanani ekwelashweni kanye nemiphumela yelabhorethri ekhombisa ukuthi isifo siya ngokuphola. Abanye abantu bangase badinge izifundo ezimfushane, kanti abanye abanezifo eziyinkimbinkimbi bangase badinge ukwelashwa isikhathi eside.

Kubalulekile ukuqeda lonke uhlelo lokwelashwa, ngisho noma uqala ukuzizwa ungcono ngaphambi kokuba luqede. Ukuyeka ama-antibiotics ngaphambi kwesikhathi kungavumela amagciwane ukuba asinde futhi athathe ukumelana, okwenza izifo zesikhathi esizayo zibe nzima ukuzelapha. Ithimba lakho lezokwelapha lizobheka intuthuko yakho ngokusebenzisa ukuhlolwa kwegazi nokuhlolwa komtholampilo ukuqinisekisa ukuthi ukwelashwa kusebenza ngempumelelo.

Yiziphi Imiphumela Eceleni Ye-Plazomicin?

Njengayo yonke imithi enamandla, i-plazomicin ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungele kakhulu futhi wazi ukuthi ungawazisa nini ithimba lakho lezempilo nganoma yikuphi ukukhathazeka.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa isicanucanu, isifo sohudo, nobuhlungu obuncane noma ukucasuka endaweni ye-IV lapho kunikezwa khona umuthi. Le miphumela ivamise ukulawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela ukwelashwa.

Imiphumela emibi kakhulu ingathinta izinso zakho nokuzwa, yingakho ithimba lakho lezokwelapha lizokubheka eduze ngokuhlolwa kwegazi okujwayelekile nokuhlolwa kokuzwa. Nansi imiphumela emibi ebalulekile okufanele uyazi:

• Izinkinga zezinso, ezingase zivele njengoshintsho ekuchameni noma ukuvuvukala
• Ushintsho lokuzwa, okuhlanganisa ukukhala ezindlebeni noma ubunzima bokuzwa
• Isiyezi noma izinkinga zokulinganisela
• Isifo sohudo esibi esingase sibonise ukutheleleka kwesibili
• Ukungezwani komzimba, nakuba lokhu kungavamile

Ithimba lakho lezempilo lizokwenza ukuhlolwa kwegazi okujwayelekile ukuze lihlole ukusebenza kwezinso zakho futhi lingase lenze izivivinyo zokuzwa ukuze libambe noma yiziphi izinkinga ngokushesha. Uma uqaphela noma yiziphi izimpawu ezikhathazayo, kubalulekile ukutshela umhlengikazi wakho noma udokotela ngokushesha ukuze bakwazi ukulungisa ukwelashwa kwakho uma kudingeka.

Ubani Ongafanele Athole I-Plazomicin?

I-Plazomicin ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ingabe iyona engakufanela yini isimo sakho esithile. Abantu abaziwa ukuthi banezinto abazwelana nazo kuma-antibiotic e-aminoglycoside akufanele bathole i-plazomicin, njengoba lokhu kungase kubangele ukusabela okukhulu komzimba.

Udokotela wakho uzophinda aqaphele kakhulu uma unezimo ezithile zempilo. Labo abanezinkinga zezinso ezikhona ngaphambili, ukulahlekelwa ukuzwa, noma izifo zokulinganisela bangase badinge ezinye izindlela zokwelapha noma ukuqapha ngokucophelela uma i-plazomicin idingeka. Abesifazane abakhulelwe kanye nomama abancelisayo badinga ukucatshangelwa okukhethekile, njengoba umuthi ungase ukwazi ukuthinta kokubili umama nomntwana.

Ngaphezu kwalokho, abantu abathatha eminye imithi ethile kungenzeka bangabi ngabantu abafanelekayo ekwelashweni nge-plazomicin. Ithimba lakho lezempilo lizobuyekeza yonke imithi yakho yamanje kanye nomlando wakho wezokwelapha ukuze liqinisekise ukuthi le antibiotic iphephile kuwe.

Amagama Omkhiqizo we-Plazomicin

I-Plazomicin itholakala ngaphansi kwegama lomkhiqizo elithi Zemdri e-United States. Leli yigama lezentengiso ozolibona emarekhodini emithi esibhedlela kanye nemibhalo yomshuwalense. Igama elivamile, i-plazomicin, libhekisela esithakweni esisebenzayo somuthi.

Njengoba lokhu kuyimithi ekhethekile yesibhedlela, ngeke uyithole emakhemisi ajwayelekile. Itholakala kuphela ngezibhedlela kanye nezikhungo zezempilo ezikhethekile eziphatha izifo ezingathi sína ezidinga ama-antibiotic e-intravenous.

Ezinye izindlela ze-Plazomicin

Lapho i-plazomicin ingeyona inketho efanele noma ingatholakali, odokotela banokwelashwa okuningi okuhlukile kwezifo zamagciwane ezingamelani. Enye indlela ethile incike ohlotsheni lwebhaktheriya olubangela ukutheleleka kwakho kanye nama-antibiotic lawo amabhaktheriya azwelayo.

Ezinye izibulala-magciwane ze-aminoglycoside ezifana ne-amikacin noma i-gentamicin zingaba ezinye izindlela uma amagciwane ezwelayo kule mithi. Kwezinye izifo, ukwelashwa okuhlanganisiwe kusetshenziswa izibulala-magciwane eziningi ngasikhathi sinye kungasebenza. Izibulala-magciwane ezintsha ezifana ne-meropenem-vaborbactam noma i-ceftazidime-avibactam nazo ziyizindlela ezingenye zokwelapha izifo ezithile zamagciwane ezingamelani.

Udokotela wakho uzokhetha indlela engcono kakhulu ngokusekelwe emiphumeleni yamasiko ekhombisa ukuthi yiziphi izibulala-magciwane ezizosebenza ngokumelene nesifo sakho esithile. Le ndlela yomuntu ngamunye iqinisekisa ukuthi uthola ukwelashwa okuphumelela kakhulu ngenkathi kunciphisa imiphumela engadingekile.

Ingabe i-Plazomicin Ingcono Kune-Amikacin?

I-Plazomicin ne-amikacin zombili ziyizibulala-magciwane ze-aminoglycoside, kodwa ngasinye sinamathuba akhethekile ezimweni ezihlukene. I-Plazomicin intsha futhi yakhelwe ukunqoba izindlela zokumelana ezenza i-amikacin ingasebenzi kahle emagciwaneni athile. Lokhu kwenza i-plazomicin ibaluleke kakhulu ekwelapheni izifo ezibangelwa amagciwane amelana ne-amikacin kanye nezinye izibulala-magciwane ze-aminoglycosides ezindala.

Nokho,

I-Plazomicin idinga ukucatshangelwa ngokucophelela uma unezinkinga zezinso, njengoba ama-antibiotic e-aminoglycoside angase athinte ukusebenza kwezinso. Udokotela wakho uzohlola impilo yezinso zakho ngokusebenzisa izivivinyo zegazi ngaphambi kokuqala ukwelashwa futhi angase alungise umthamo noma imvamisa yokuphatha ngokusekelwe ekutheni izinso zakho zisebenza kahle kangakanani.

Uma unezinkinga zezinso ezilula, ungase ukwazi ukuthola i-plazomicin ngokuqapha okuseduze futhi mhlawumbe ngemithamo ephansi. Kodwa-ke, uma unesifo sezinso esibi, udokotela wakho angase akhethe i-antibiotic ehlukile ephephe kakhulu ezinso zakho. Isinqumo sincike ekulinganiseni izinzuzo zokwelapha ukutheleleka kwakho okungathi sína ngokumelene nezingozi ezingaba khona ekusebenzeni kwezinso zakho.

Kufanele Ngenzeni Uma Ngithola Imiphumela Eceleni evela ku-Plazomicin?

Njengoba i-plazomicin inikezwa endaweni yesibhedlela, uzokwazi ukufinyelela ngokushesha ekunakekelweni kwezokwelapha uma kwenzeka imiphumela emibi. Tshela umhlengikazi wakho noma udokotela ngokushesha uma uhlangabezana nanoma yiziphi izimpawu ezikhathazayo njengokushintsha kokuzwa, isiyezi, ubuhlungu obungavamile, noma ubunzima bokuphefumula. Ungalindi ukubona ukuthi izimpawu ziyathuthuka zodwa.

Ithimba lakho lezokwelapha liqeqeshwe ukubona nokuphatha imiphumela emibi evela kulo muthi. Bangase balungise umthamo wakho, bashintshe izinga lokufakwa, noma banikeze ezinye izindlela zokwelapha ukusiza ukuphatha noma yimiphi imiphumela emibi oyitholayo. Kwezinye izimo, bangase badinge ukushintshela kwenye i-antibiotic uma imiphumela emibi iba mibi.

Kwenziwani Uma Ngiphuthelwa Umthamo we-Plazomicin?

Njengoba i-plazomicin inikezwa esibhedlela ochwepheshe bezempilo, imithamo ephuthelwe ayivamile. Ithimba lakho lezokwelapha lilandela isimiso esiqinile ukuze liqinisekise ukuthi uthola umthamo ngamunye ngesikhathi esifanele. Uma umthamo ulibaziseka ngenxa yezinqubo zezokwelapha noma eminye imisebenzi yesibhedlela, ithimba lakho lezempilo lizolungisa isimiso ngokufanele.

Uma ukhathazekile ngesikhathi sokuthatha imithamo yakho, zizwe ukhululekile ukubuza umhlengikazi wakho noma udokotela wakho mayelana nohlelo lwakho lwemithi. Bangakuchazela ukuthi uzothola nini umthamo ngamunye futhi basize ukubhekana nanoma yikuphi ukukhathazeka onakho mayelana nesikhathi sokwelashwa kwakho.

Ngingayeka nini ukuthatha i-Plazomicin?

Akufanele neze uyeke ukwelashwa nge-plazomicin ngokwakho, ngisho noma uzizwa ungcono kakhulu. Udokotela wakho uzonquma ukuthi uyeka nini umuthi ngokusekelwe ezintweni eziningana, okuhlanganisa ukuthi usabela kanjani ekwelashweni, imiphumela yokuhlolwa kwegazi, nokuthi ngabe ukutheleleka kuqediwe ngokuphelele yini.

Ukuyeka ukwelashwa ngama-antibiotic ngaphambi kwesikhathi kungavumela amagciwane ukuthi asinde futhi kungenzeka ukuthi athuthukise ukumelana, okwenza ukutheleleka okuzayo kube nzima ukukwelapha. Ithimba lakho lezokwelapha lizobheka intuthuko yakho futhi likwazise ukuthi kuphephile nini ukuqeda inkambo yokwelashwa. Lesi sinqumo sisekelwe ebufakazini bezokwelapha bokuthi ukutheleleka kulungiswe ngokugcwele.

Ingabe i-Plazomicin ingasebenzisana neminye imithi?

Yebo, i-plazomicin ingasebenzisana neminye imithi eminingana, yingakho udokotela wakho ezobuyekeza yonke imithi yakho yamanje ngaphambi kokuqala ukwelashwa. Eminye imithi ingandisa ingozi yezinkinga zezinso noma ukulahlekelwa ukuzwa uma ihlanganiswe ne-plazomicin, kanti eminye ingase ithinte ukuthi ama-antibiotic asebenza kahle kangakanani.

Imithi ejwayelekile engasebenzisana ihlanganisa ama-diuretics athile, amanye ama-antibiotics, neminye imithi yokwelapha ubuhlungu. Ithimba lakho lezempilo lizophatha ngokucophelela noma yimiphi imithi edingekayo oyithathayo futhi lingase lilungise imithamo noma isikhathi sokunciphisa ukusebenzisana. Njalo yazisa ithimba lakho lezokwelapha ngayo yonke imithi, izithasiselo, kanye nemithi yezitshalo oyithathayo, ngisho noma ibonakala ingahlobene nokutheleleka kwakho.