Yini i-Plecanatide: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Plecanatide iyimithi kadokotela esiza ukwelapha ukuqunjelwa okungamahlalakhona kanye ne-irritable bowel syndrome enokuqunjelwa (IBS-C). Lokhu kwelashwa okumnene kodwa okuphumelelayo kusebenza ngokukhuthaza amathumbu akho ukuthi akhiqize uketshezi olwengeziwe, oluthambisa indle futhi lwenza ukuhamba kwamathumbu kube lula futhi kube lula.

Yini i-Plecanatide?

I-Plecanatide iyimithi ye-peptide yokwenziwa elingisa i-hormone yemvelo emzimbeni wakho ebizwa ngokuthi i-guanylin. Ingaphansi kohlobo lwemithi ebizwa ngokuthi i-guanylate cyclase-C agonists, okuzwakala kuyinkimbinkimbi kodwa okusho ukuthi isiza amathumbu akho ukuthi asebenze ngempumelelo.

Le mithi iza njengemithi encane oyithatha ngomlomo kanye ngosuku. Ngokungafani namanye ama-laxatives anokhahlo angabangela ukuqaqamba noma ukuphuthuma, i-plecanatide isebenza ngobumnene ngezinqubo zomzimba wakho zemvelo ukuze ibuyisele ukusebenza kwamathumbu okujwayelekile.

I-FDA yavuma i-plecanatide ngo-2017 ngemuva kokuthi izifundo zomtholampilo zakhombisa ukuthi ingathuthukisa kakhulu imvamisa yokuhamba kwamathumbu futhi inciphise ukuzikhandla kubantu abanokuqunjelwa okungamahlalakhona.

Isetshenziselwani i-Plecanatide?

I-Plecanatide iphatha izimo ezimbili eziyinhloko ezithinta izigidi zabantu emhlabeni jikelele. Udokotela wakho angase akubhale uma ulwa nezinkinga zokugaya ukudla eziqhubekayo ezithinta impilo yakho yansuku zonke.

Ukusetshenziswa okuyinhloko kokuqunjelwa kwe-idiopathic okungamahlalakhona, okusho ukuqunjelwa kwesikhathi eside ngaphandle kwembangela ecacile. Lesi simo sihlanganisa ukuba nokuhamba kwamathumbu okungaphansi kwamathathu ngesonto, kanye nezimpawu ezinjengokuzikhandla, indle eqinile, noma ukuzwa sengathi awukwazi ukukhipha amathumbu akho ngokuphelele.

I-Plecanatide iphatha futhi i-irritable bowel syndrome enokuqunjelwa (IBS-C). Lesi simo sihlanganisa izimpawu zokuqunjelwa ezishiwo ngenhla nobuhlungu besisu, ukuqunjelwa, kanye nezinguquko emikhubeni yamathumbu eziqhubeke okungenani izinyanga ezintathu.

Isebenza kanjani i-Plecanatide?

I-Plecanatide isebenza ngokuvula ama-receptor athile emgqeni wakho wamathumbu abizwa ngokuthi ama-guanylate cyclase-C receptors. Uma la ma-receptor evuliwe, aqala uchungechunge lwezenzakalo ezandisa ukukhishwa kwamanzi emathunjini akho.

Lawa manzi engeziwe asiza ukuthambisa indle yakho futhi avuselele ukunyakaza kwamathumbu okwemvelo. Cabanga ngakho njengokusiza amathumbu akho ukuthi akhumbule ukuthi angasebenza kanjani kahle kunokuwaphoqa ukuthi enze ngokungajwayelekile.

Umuthi uthathwa njengomuthi olungile uma uqhathaniswa nezinketho ezingaphandle kwe-counter ezifana nezithasiselo ze-fiber, kodwa uthambile kunezithasiselo zokwelapha ezikhuthazayo. Abantu abaningi baqaphela ukuthuthuka ngesonto lokuqala lokwelashwa, nakuba abanye bengase badinge amasonto amabili ukuze bathole izinzuzo eziphelele.

Ngokungafani nezithasiselo ezikhuthazayo ezingase zilahlekelwe ukusebenza ngokuqhubeka kwesikhathi, i-plecanatide igcina izinzuzo zayo ngokuqhubeka nokuyisebenzisa futhi ngokuvamile ayibangeli ukuncika.

Kufanele Ngiyithathe Kanjani I-Plecanatide?

Thatha i-plecanatide ngendlela udokotela wakho ayichazayo, ngokuvamile ithebhulethi eyodwa engu-3-mg kanye ngosuku. Ungayithatha ngaphandle noma ngaphandle kokudla, kodwa ukuyithatha ngesikhathi esifanayo nsuku zonke kusiza ukugcina amazinga aqhubekayo emzimbeni wakho.

Gwinya ithebhulethi yonke ngengilazi yamanzi egcwele. Ungayichobozi, uyihlafune, noma uyiphule ithebhulethi, njengoba lokhu kungathinta indlela umuthi osebenza ngayo ohlelweni lwakho.

Uma unenkinga yokugwinya amaphilisi, ungachoboza ithebhulethi bese uyixuba nenani elincane le-applesauce noma amanzi. Sebenzisa le ngxube ngokushesha futhi ungayilondolozi kamuva.

Hlala unamanzi ngokwanele usuku lonke lapho uthatha i-plecanatide. Ukuphuza amanzi amaningi kusiza umuthi ukuthi usebenze ngempumelelo futhi kunciphisa ingozi yemiphumela emibi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Plecanatide?

Ubude bokwelashwa nge-plecanatide buyahlukahluka ngokuya ngesimo sakho somuntu ngamunye nokuphendula emuthini. Abantu abaningi abanezinkinga zokuqunjelwa okungapheli badinga ukwelashwa kwesikhathi eside ukuze bagcine ukusebenza kwamathumbu okuvamile.

Udktela wakho cishe uzoqala ngesikhathi sokuhlola samaviki ambalwa ukuze ahlulele ukuthi imithi ikusebenzela kahle kangakanani. Uma uthola ukuthuthuka okukhulu ezimpawini zakho, bangase bakuncome ukuthi uqhubeke nokwelashwa.

Abanye abantu abane-IBS-C bangase badinge ukwelashwa okuqhubekayo ukuze balawule isimo sabo ngempumelelo. Abanye bangase bakwazi ukunciphisa umthamo wabo noma baphumule emithini uma izimpawu zabo zithuthuka.

Ungayeki ukuthatha i-plecanatide ngokuzumayo ngaphandle kokubonisana nodokotela wakho, njengoba izimpawu zakho zokuqunjelwa zingase zibuye. Umhlinzeki wakho wezempilo uzokusiza ukuthi unqume uhlelo olungcono kakhulu lokwelashwa kwesikhathi eside lesimo sakho esithile.

Yiziphi Izimo Ezingezinhle Ze-Plecanatide?

Njengayo yonke imithi, i-plecanatide ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe uqiniseka ngokwelashwa kwakho.

Imiphumela emibi evame kakhulu ngokuvamile imnene futhi ihlobene nendlela yokusebenza yomuthi. Nansi imiphumela emibi ongase uyithole:

• Ukuqunjelwa yisisu (kuthinta cishe u-5% wabantu)
• Ubuhlungu besisu noma ukungakhululeki
• I-Flatulence (igesi)
• Ukuqubuka kwesisu
• Isicanucanu
• Ikhanda

Le miphumela emibi ejwayelekile ngokuvamile iyathuthuka njengoba umzimba wakho ujwayela umuthi, ngokuvamile ezinsukwini zokuqala zokwelashwa.

Imiphumela emibi engathi sína kodwa engavamile idinga ukunakekelwa kwezempilo ngokushesha. Nakuba kungavamile, kufanele uthinte udokotela wakho ngokushesha uma uthola:

• Ukuqunjelwa yisisu okukhulu noma okuqhubekayo okungathuthuki
• Izimpawu zokuphelelwa amanzi emzimbeni (isiyezi, umlomo owomile, ukuncipha komchamo)
• Ubuhlungu besisu obukhulu obuhlukile ezimpawini zakho ezijwayelekile
• Igazi esitulweni sakho
• Isicanucanu esikhulu noma ukuhlanza

Abantu abaningi bathola ukuthi ukuqala ngokuhambisana nokuhambisana kahle nokuthatha imithi ngokuqhubekayo kusiza ukunciphisa imiphumela emibi.

Ubani Ongafanele Athatha I-Plecanatide?

I-Plecanatide ayifanele wonke umuntu, futhi izimo ezithile zezokwelapha noma izimo zenza kungaphephile ukuyisebenzisa. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-plecanatide uma ngabe ungeminyaka engu-18 ubudala, njengoba ukuphepha nokusebenza kungakahlolwa ezinganeni nakubantu abasha. Lo muthi awunconyelwe uma ukhulelwe noma uncelisa ngaphandle kokuthi izinzuzo zicace ngaphezu kwezingozi.

Izimo ezithile zezokwelapha ezenza i-plecanatide ingafaneleki zihlanganisa:

• Ukuvinjelwa kwamathumbu okwaziwayo noma okusolwayo
• Isifo samathumbu esivuvukalayo esibi (Isifo sikaCrohn noma i-ulcerative colitis)
• Isifo sezinso esibi
• Umlando wokuhuda okukhulu noma izimo zokuhuda ezingapheli
• Ukungezwani ne-plecanatide noma yiziphi izithako zayo

Xhumana nodokotela wakho mayelana nazo zonke izimo zakho zezokwelapha, ikakhulukazi uma unomlando wezinkinga zezinso, izimo zamathumbu avuvukalayo, noma uthatha eminye imithi engase ihlangane ne-plecanatide.

Amagama Omkhiqizo we-Plecanatide

I-Plecanatide itholakala ngaphansi kwegama lomkhiqizo elithi Trulance e-United States. Okwamanje le yilona kuphela uhlobo lomkhiqizo olutholakalayo, nakuba izinhlobo ezivamile zingase zitholakale esikhathini esizayo.

I-Trulance yenziwa yi-Bausch Health Companies futhi iza ngamaphilisi angu-3-mg. Lo muthi ngokuvamile uhlanganiswa yizinhlelo eziningi zomshuwalense, nakuba ukuhlinzekwa kungase kuhluke kuye ngohlelo lwakho oluthile kanye nesidingo sezokwelapha.

Uma izindleko zikhathaza, buza udokotela wakho mayelana nezinhlelo zokusiza iziguli noma izinhlelo zokunciphisa amakhemisi ezingase zisize ukunciphisa izindleko zakho eziphumayo.

Ezinye izindlela ze-Plecanatide

Eminye imithi eminingi ingelapha ukuqunjelwa okungapheli kanye ne-IBS-C uma i-plecanatide ingakulungele. Udokotela wakho angase acabangele lezi ezinye izindlela ngokusekelwe ezimpawini zakho ezithile kanye nomlando wezokwelapha.

Eminye imithi kadokotela esezingeni elifanayo ihlanganisa i-linaclotide (Linzess) kanye ne-lubiprostone (Amitiza). Lezi zisebenza ngezindlela ezihlukile kancane kodwa zinomphumela ofanayo ekusebenzeni kwamathumbu.

Izinketho ezingathengwa ngaphandle kwemvume kadokotela ezinganconywa udokotela wakho zihlanganisa:

• I-Polyethylene glycol (MiraLAX)
• Izithasiselo ze-psyllium fiber
• I-Docusate sodium (Colace)
• I-Bisacodyl (Dulcolax)

Umhlinzeki wakho wezempilo uzosiza ekunqumeni ukuthi iyiphi inketho yokwelapha efaneleka kakhulu isimo sakho esithile nezimpawu.

Ingabe i-Plecanatide ingcono kune-Linaclotide?

Kokubili i-plecanatide ne-linaclotide ziyindlela yokwelapha ephumelelayo yokuqunjelwa okungamahlalakhona kanye ne-IBS-C, kodwa zinezinye izinto ezihlukile ezingenza enye ifaneleke kakhulu kuwe kunenye.

I-Plecanatide ingase ibangele isifo sohudo esingesibi kangako uma siqhathaniswa ne-linaclotide, okuyenza ibe yindlela engcono kubantu abazwela kulo mphumela ongahle.

Ucwaningo lomtholampilo luphakamisa ukuthi i-plecanatide inesenzakalo esiphansi sesifo sohudo esikhawulela ukwelashwa.

I-Linaclotide, ngakolunye uhlangothi, isitholakala isikhathi eside futhi inemininingwane eminingi yomtholampilo esekela ukusetshenziswa kwayo. Itholakala futhi ngamandla amaningi okulinganisa, okuvumela izinketho zokulinganisa eziguquguqukayo.

Ukukhetha phakathi kwale mithi kuvame ukwehla ekuphenduleni kwakho ngakunye, ukubekezelelana nomphumela ongahle, kanye nokucatshangelwa kwezindleko. Udokotela wakho uzokusiza ukuthi unqume ukuthi iyiphi inketho efaneleka kakhulu esimweni sakho esithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Plecanatide

Ingabe i-Plecanatide iphephile kubantu abanesifo sikashukela?

Yebo, i-plecanatide ngokuvamile iphephile kubantu abanesifo sikashukela. Umuthi awuthinti amazinga kashukela egazini ngokuqondile, futhi ucwaningo alukaze lubonise noma yikuphi ukusebenzisana okukhathazayo phakathi kwe-plecanatide nemithi evamile yesifo sikashukela.

Kodwa-ke, uma uba nohudo njengomphumela ohlangothini, lokhu kungase kuthinte ukulawulwa kukashukela wakho wegazi noma ukumuncwa kwemithi. Qaphela ushukela wakho wegazi eduze uma uqala i-plecanatide futhi uthinte udokotela wakho uma ubona izinguquko ezingavamile.

Kufanele ngenzeni uma ngithatha i-Plecanatide eningi ngengozi?

Uma ngengozi uthatha i-plecanatide eningi kunomthamo wakho obekiwe, thintana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yokuhudo olukhulu nokuphelelwa amanzi emzimbeni.

Qaphela izimpawu zokuphelelwa amanzi emzimbeni njengokugajuka, umlomo owomile, ukuncipha komchamo, noma ukuzizwa unovalo. Phuza uketshezi oluningi futhi funa ukwelashwa uma uba nohudo olukhulu noma oluqhubekayo.

Ungazami ukuthi "ukwenza" umthamo owengeziwe ngokuqaqa umthamo wakho olandelayo ohleliwe. Qala kabusha isimiso sakho somthamo esijwayelekile njengoba uqondiswe ngumhlinzeki wakho wezempilo.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Plecanatide?

Uma uphuthelwa umthamo we-plecanatide, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe futhi uqhubeke nesimiso sakho somthamo esijwayelekile.

Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela engemihle. Uma uvame ukukhohlwa imithamo, cabanga ukusetha isikhumbuzi sansuku zonke noma ukuthatha imithi ngesikhathi esifanayo nsuku zonke.

Ukuphuthelwa imithamo ngezikhathi ezithile ngeke kukulimaze, kodwa zama ukuthatha i-plecanatide ngokuqhubekayo ukuze uthole imiphumela engcono kakhulu ekuphatheni izimpawu zakho zokuqunjelwa.

Ngingayeka nini ukuthatha i-Plecanatide?

Ungayeka ukuthatha i-plecanatide lapho udokotela wakho enquma ukuthi kufanelekile, ngokuvamile lapho izimpawu zakho zokuqunjelwa zithuthuke kakhulu futhi ngokuqhubekayo. Kodwa-ke, abantu abaningi abane-constipation engapheli badinga ukwelashwa okuqhubekayo ukuze bagcine umsebenzi wamathumbu ojwayelekile.

Ungayeki ukuthatha i-plecanatide ngaphandle kokuxhumana nodokotela wakho kuqala, njengoba izimpawu zakho zingase zibuye. Umhlinzeki wakho wezempilo angase ancome ukunciphisa kancane kancane noma asikisela izinguquko zokuphila ukusiza ukugcina ukuthuthuka kwakho.

Uma ufuna ukuxoxa ngokuyeka imithi, khuluma nodokotela wakho ngezinkathazo zakho futhi nisebenzisane ukuthuthukisa uhlelo olugcina impilo yakho yokugaya ukudla.

Ngingayithatha i-Plecanatide nezinye izidakamizwa zokuthambisa isisu?

Ngokuvamile, akufanele uthathe i-plecanatide nezinye izidakamizwa zokuthambisa isisu ngaphandle uma udokotela wakho ekuncoma ngqo. Ukuhlanganisa izidakamizwa zokuthambisa isisu kungandisa ingozi yakho yokuhuda, ukushoda kwamanzi emzimbeni, kanye nokungalingani kwama-electrolyte.

Uma njengamanje uthatha eminye imithi yokuqunjelwa, xoxa nodokotela wakho ngendlela yokushintshela ngokuphepha ku-plecanatide. Bangase bancomise ukuyeka ezinye izidakamizwa zokuthambisa isisu ngaphambi kokuqala i-plecanatide noma basikisele uhlelo lwesikhathi oluthile.

Njalo yazisa umhlinzeki wakho wezempilo ngayo yonke imithi nezithasiselo ozithathayo ukuze ugweme ukusebenzisana okungase kube yingozi.