Yini i-Polymyxin B Injection: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Polymyxin B injection iyisidakamizwa esinamandla sokulwa namagciwane esisetshenziswa odokotela ukwelapha izifo ezingathi sína ezibangelwa amagciwane lapho ezinye izibulala-magciwane zingasebenzi. Lo muthi ungoweqembu elibizwa ngokuthi ama-antibiotics e-polymyxin, futhi wenzelwe ngqo ukulwa nezinhlobo ezithile zamagciwane ezingabangela izifo ezisongela impilo. Ngenkathi ithathwa njengomuthi onamandla onemiphumela engase ibe khona, isebenza njengenketho ebalulekile yokwelapha uma ubhekene nezifo ezinzima ezingamelani nezinye izindlela zokwelapha.

Yini i-Polymyxin B?

I-Polymyxin B iyi-antibiotic esebenza ngokudiliza udonga olungaphandle lwamagciwane athile, empeleni iwabhubhise ngaphandle nangaphakathi. Yilokho odokotela abakubiza ngokuthi i-antibiotic

Izinhlobo zezifo ezingase zidinge i-polymyxin B zihlanganisa umkhuhlane wamaphaphu, i-sepsis (ukutheleleka kwegazi), nezifo zomgudu womchamo ezibangelwa amagciwane athile afana ne-Pseudomonas aeruginosa, i-Acinetobacter, noma izinhlobo ezithile ze-E. coli. Lawa magciwane aye athuthukisa ukumelana nama-antibiotics amaningi avamile, okwenza i-polymyxin B ibe yindlela ebalulekile yokwelapha.

Kwezinye izimo, odokotela basebenzisa i-polymyxin B nasezifweni esiswini sakho noma izifo ezenzeka ngemva kokuhlinzwa. Isinqumo sokusebenzisa lo muthi sihlala siza ngemva kokucatshangelwa ngokucophelela kokutheleleka kwakho okuthile kanye nemiphumela yamasiko amagciwane.

Isebenza Kanjani I-Polymyxin B?

I-Polymyxin B isebenza ngokugxila kulwelwesi olungaphandle lwamagciwane, ikakhulukazi amagciwane e-gram-negative. Ihlanganisa nezingxenye odongeni lweseli lamagciwane olubizwa ngokuthi ama-lipopolysaccharides, okwenza udonga lweseli luwohloke futhi luvuze. Le nqubo ekugcineni ibulala amagciwane abangela ukutheleleka kwakho.

Lo muthi ubhekwa njengonamandla kakhulu emhlabeni wama-antibiotics. Ngenkathi lawa mandla ewenza asebenze kahle kumagciwane amelana nawo, futhi kusho ukuthi angathinta amaseli akho ngezinga elithile, yingakho odokotela bekuqapha eduze ngesikhathi sokwelashwa. Umuthi usebenza ngokushesha uma usufinyelele endaweni yokutheleleka ngegazi lakho.

Ngenxa yokuthi i-polymyxin B inamandla kakhulu, odokotela ngokuvamile bayisebenzisa kuphela uma kudingeka ngempela. Akuyona i-antibiotic yokuqala, kodwa iyithuluzi elinamandla eligcinelwe izimo lapho ama-antibiotics athambile engaphumelelanga.

Kufanele Ngiyithathe Kanjani I-Polymyxin B?

Umjovo we-Polymyxin B uhlala unikezwa ochwepheshe bezempilo esibhedlela noma endaweni yomtholampilo. Ngeke uthathe lo muthi ekhaya ngoba udinga ukuqapha ngokucophelela nokuphathwa okunembile. Umuthi ngokuvamile unikezwa ngomugqa we-IV (intravenous) ngqo emthanjeni wakho, okuvumela ukuthi ujikeleze emzimbeni wakho ngokushesha.

Iqembu lakho lezempilo lizokunika umjovo kancane kancane phakathi nehora elingu-1-2. Lokhu kunikezwa kancane kancane kusiza ukunciphisa ubungozi bemiphumela emibi futhi kuvumela umzimba wakho ukuthi ubhekane kangcono nomuthi. Isikhathi esiqondile nendlela kungahluka ngokuya ngesimo sakho esithile nokuthi umzimba wakho usabela kanjani ekwelashweni.

Ngesikhathi sokwelashwa, akudingeki ukhathazeke ngokuvinjelwa kokudla noma ukuthatha umuthi ngesikhathi sokudla ngoba unikezwa ngqo emsingeni wakho wegazi. Kodwa-ke, ukuhlala unamanzi kahle kubalulekile, ngakho-ke iqembu lakho lezempilo cishe lizokukhuthaza ukuthi uphuze uketshezi oluningi ngaphandle uma kunesizathu sezokwelapha sokuluvimbela.

Iqembu lakho lezokwelapha lizogada ukusebenza kwezinso zakho, ukuzwa, nokuphendula okuphelele emuthini ngesikhathi sokwelashwa kwakho. Bazolungisa umthamo noma isikhathi uma kudingeka ngokuya ngokuthi umzimba wakho ubhekana kanjani nomuthi.

Kufanele Ngithathe Isikhathi Esingakanani I-Polymyxin B?

Ubude bokwelashwa kwakho nge-polymyxin B buxhomeke ohlotsheni nasekubeni sibi kokutheleleka kwakho, kanye nokuthi umzimba wakho usabela ngokushesha kangakanani emuthini. Izifundo eziningi zokwelashwa zithatha phakathi kwezinsuku eziyi-7 kuya kweziyi-14, kodwa lokhu kungahluka kakhulu ngokuya ngesimo sakho somuntu ngamunye.

Udokotela wakho uzoqapha izimpawu zakho zokutheleleka ngokuhlolwa kwegazi nokunye ukuhlolwa ukuze anqume ukuthi kuphephile nini ukuyeka umuthi. Bazofuna izimpawu zokuthi amagciwane ayaqedwa nokuthi umzimba wakho uyaphola kahle. Ezinye izifo zingase zidinge izifundo ezimfushane zezinsuku eziyi-5-7, kanti izifo ezingathi sína noma eziyinkimbinkimbi zingase zidinge izikhathi zokwelashwa ezinde.

Kubalulekile ukuqeda lonke uhlelo lokwelashwa, ngisho noma uqala ukuzizwa ungcono ngaphambi kokuthi luqede. Ukuyeka ngokushesha kungavumela amagciwane ukuthi asinde futhi angase athuthukise ukumelana okwengeziwe kuma-antibiotics. Iqembu lakho lezempilo lizokwenza noma yiziphi izinqumo mayelana nokushintsha noma ukuyeka ukwelashwa kwakho ngokusekelwe entuthukweni yakho nemiphumela yokuhlolwa.

Ziyini Imiphumela Eceleni ye-Polymyxin B?

Njengemithi eminingi enamandla, i-polymyxin B ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ivamise ukulawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi noma ngemva kokuphela kokwelashwa.

Nansi imiphumela emibi ongase uyithole, futhi kubalulekile ukukhumbula ukuthi ithimba lakho lezempilo likuqapha eduze ukuze libambe futhi lilungise noma yiziphi izinkinga ngokushesha:

Imiphumela emibi evamile ihlanganisa:

• Ubuhlungu, ububomvu, noma ukuvuvukala endaweni yokujova
• Isicanucanu noma isisu esibuhlungu
• Isiyezi noma ukuzizwa unovalo
• Ikhanda
• Ukuqubuka kwesikhumba noma ukuluma
• Ubuthakathaka bemisipha noma ukukhathala

Imiphumela emibi engathi sína edinga ukunakekelwa kwezempilo ngokushesha ihlanganisa:

• Izinkinga zezinso (izinguquko ekuchameni, ukuvuvukala emilenzeni noma ezinyaweni)
• Ushintsho lokuzwa noma ukukhala ezindlebeni
• Ukungezwani komzimba okukhulu (ubunzima bokuphefumula, ukuqubuka okukhulu, ukuvuvukala ebusweni noma emqaleni)
• Izimpawu zemizwa (ukudideka, ukuquleka, isiyezi esikhulu)
• Ubuthakathaka bemisipha noma ukukhubazeka okukhulu

Ithimba lakho lezempilo likuqapha eduze ukuze lithole le miphumela engathi sína, ikakhulukazi ukusebenza kwezinso nokushintsha kokuzwa, okuyizona eziyingozi kakhulu. Bazohlola njalo umsebenzi wegazi lakho futhi babuze nganoma yiziphi izimpawu oziphilayo.

Imiphumela eminingi emibi ingeyesikhashana futhi iyanyamalala ngemva kokuphela kokwelashwa. Nokho, ezimweni ezingavamile, eminye imiphumela ekuzweni noma ekusebenzeni kwezinso ingase iqhubeke, yingakho odokotela besebenzisa le mithi kuphela uma kudingeka ngempela.

Ubani Ongafanele Athole i-Polymyxin B?

Abantu abathile akufanele bathole umjovo we-polymyxin B, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwunika. Okubaluleke kakhulu ukuthi ngabe uke waba nokusabela komzimba ku-polymyxin B noma ama-antibiotics afanayo esikhathini esidlule.

Udokotela wakho uzoba nokuqapha okukhethekile mayelana nokunika i-polymyxin B uma unezinkinga zezinso ezikhona, njengoba le mithi ingase iqhubekisele phambili ukusebenza kwezinso. Bazophinda bacabangele ngokucophelela izingozi uma unezinkinga zokuzwa noma umlando wezifo zokukhathala kwemisipha njenge-myasthenia gravis.

Uma ukhulelwe noma uncelisa, udokotela wakho uzokala izinzuzo ngokumelene nezingozi ezingaba khona ngokucophelela kakhulu. Ngenkathi i-polymyxin B ingase idingeke ezifweni ezinzima, bazokuqapha wena nomntwana wakho ngokucophelela uma ukwelashwa kudingeka.

Abantu abathatha eminye imithi ethile, ikakhulukazi leyo engathinta ukusebenza kwezinso noma ukuzwa, bangadinga ukuqapha okukhethekile noma ukulungiswa kwemithamo. Ithimba lakho lezempilo lizobukeza yonke imithi yakho ukuqinisekisa ukwelashwa okuphephile.

Amagama Omkhiqizo we-Polymyxin B

Igama elivamile lomkhiqizo we-polymyxin B injection yi-Poly-Rx. Kodwa-ke, le mithi iyatholakala njengomuthi ojwayelekile, okusho ukuthi ungayithola ngaphansi kwegama layo elijwayelekile elithi

Ngenkathi i-polymyxin B ivame ukusetshenziselwa izifo ezingamelani nemithi, ngezinye izikhathi kukhona ezinye izindlela zama-antibiotics ezingase zisebenze esimweni sakho esithile. Lezi zindlela ezihlukile zincike ohlotsheni lwebhaktheriya olubangela ukutheleleka kwakho kanye namaphethini abo okumelana.

Ezinye izindlela zama-antibiotics odokotela abangase bazicabange zihlanganisa i-colistin (efana kakhulu ne-polymyxin B), ezinye izindlela ezintsha zama-antibiotics e-beta-lactam, noma ukwelashwa okuhlanganisiwe kusetshenziswa ama-antibiotics amaningi ndawonye. Kwezinye izimo, i-tigecycline noma ama-antibiotics amasha afana ne-ceftazidime-avibactam angase abe yizinketho.

Ukukhethwa kwe-antibiotic kuhlala kuncike emiphumeleni yakho ethile yesiko le-bacterial kanye nokuhlolwa kokuzwela. Udokotela wakho uzokhetha umuthi ofanele kakhulu ngokusekelwe kulokho okungenzeka ukuthi kusebenze ngokumelene nokutheleleka kwakho okuthile ngenkathi kubangela imiphumela emibi embalwa.

Ngezinye izikhathi, ukwelashwa okuhlanganisiwe kusetshenziswa i-polymyxin B kanye namanye ama-antibiotics kuphumelela kakhulu kunokusebenzisa i-antibiotic eyodwa kuphela. Ithimba lakho lezempilo lizinquma indlela engcono kakhulu ngokusekelwe ezimweni zakho.

Ingabe i-Polymyxin B Ingcono Kune-Colistin?

I-Polymyxin B ne-colistin zama-antibiotics afana kakhulu angawomndeni ofanayo futhi asebenza ngezindlela ezicishe zifane. Zombili zithathwa njengezisebenza kahle ngokumelene namagciwane anegram-negative, futhi ukukhetha phakathi kwazo kuvame ukwehla ekutholakaleni nasekukhetheni kukadokotela wakho.

Ezinye izifundo zikhomba ukuthi i-polymyxin B ingase ibe lula ezinso uma iqhathaniswa ne-colistin, kodwa yomibili imithi inezingozi ezifanayo futhi idinga ukuqapha ngokucophelela. Umehluko kumaphrofayili emiphumela emibi mncane, futhi yomibili imithi ithathwa njengezinketho ezifanele zokutheleleka okumelana nemithi.

Ukukhetha kukadokotela wakho phakathi kwala ma-antibiotics amabili kungase kuncike ezintweni ezinjengokusebenza kwakho kwezinso, imiphumela yamasiko ebhaktheriya, noma ukuthi imuphi umuthi otholakala kalula endaweni yakho yokwelapha. Zombili ziyizindlela zokwelapha ezisebenzayo zokutheleleka okukhulu okumelana.

Kwezinye izimo, udokotela wakho angase ashintshe kusuka komunye aye komunye ngokusekelwe endleleni ozabela ngayo ekwelashweni noma uma imiphumela emibi iqala. Into ebalulekile ukuthi uthola ukwelashwa okufanele ukutheleleka kwakho, kungakhathaliseki ukuthi yimuphi umuthi othize we-polymyxin osetshenziswayo.

Imibuzo Evame Ukubuzwa Mayelana ne-Polymyxin B

Q1. Ingabe i-Polymyxin B iphephile kubantu abanezifo zezinso?

I-Polymyxin B idinga ukuqapha okwengeziwe kubantu abanezifo zezinso ngoba ingase yenze ukusebenza kwezinso kube kubi kakhulu. Kodwa-ke, odokotela ngezinye izikhathi basayibhala ngezifo ezinzima lapho izinzuzo zidlula izingozi. Uma unezinkinga zezinso, udokotela wakho cishe uzolungisa umthamo wakho futhi aqaphe ukusebenza kwezinso zakho eduze kakhulu ngesikhathi sokwelashwa.

Ithimba lakho lezempilo lizohlola umsebenzi wegazi lakho njalo ukuze liqinisekise ukuthi izinso zakho ziwusingatha kahle umuthi. Bangase futhi baqinisekise ukuthi uhlala kahle emanzini futhi ugweme eminye imithi engase iqhubeke nokucindezela izinso zakho ngesikhathi sokwelashwa.

Q2. Kufanele ngenzeni uma ngithola i-Polymyxin B eningi ngengozi?

Njengoba i-polymyxin B inikezwa kuphela ochwepheshe bezempilo ezindaweni zemitholampilo, ukweqisa ngengozi akuvamile kakhulu. Uma ukhathazekile ngomthamo wakho noma uhlangabezana nezimpawu ezingavamile ngesikhathi sokwelashwa, yazisa ithimba lakho lezempilo ngokushesha. Bangahlola isimo sakho futhi banikeze ukunakekelwa okufanele uma kudingeka.

Ithimba lakho lezokwelapha liqapha umthamo wakho ngokucophelela futhi liwulungise ngokusekelwe esisindweni sakho, ukusebenza kwezinso, nokuphendula ekwelashweni. Baqeqeshwe ukubona izimpawu zemiphumela yemithi futhi bazothatha isinyathelo esifanele uma kuvela izinkinga.

Q3. Kumele Ngenzeni Uma Ngeqe Umthamo We-Polymyxin B?

Njengoba i-polymyxin B inikezwa ochwepheshe bezempilo esibhedlela noma endaweni yezokwelapha, ngeke ube nesibopho sokuhlela imithamo yakho. Ithimba lakho lezempilo lilawula uhlelo lwakho lwemithi futhi liqinisekisa ukuthi uthola imithamo ngesikhathi esifanele.

Uma kukhona ukubambezeleka emthamweni wakho ohleliwe ngenxa yezinqubo zezokwelapha noma ezinye izimo, ithimba lakho lezempilo lizolungisa uhlelo lwakho lokwelashwa ngokufanele. Bazoqinisekisa ukuthi uthola lonke uhlelo lokwelashwa oludingwa yisifo sakho.

Q4. Ngingayeka Nini Ukuthatha I-Polymyxin B?

Akufanele neze uyeke ukwelashwa nge-polymyxin B ngokwakho, ngisho noma uzizwa ungcono. Isinqumo sokuyeka ukwelashwa senziwa njalo yithimba lakho lezempilo ngokusekelwe ezimpawini zakho zokutheleleka, ukuthuthuka kwemitholampilo, kanye nokuqedwa kohlelo olubekiwe.

Udokotela wakho uzoqapha inqubekela phambili yakho ngokusebenzisa ukuhlolwa kwegazi nokuhlolwa ngokomzimba ukuze anqume ukuthi kuphephile nini ukuyeka umuthi. Ukuyeka ngaphambi kwesikhathi kungavumela amagciwane ukuthi asinde futhi kungenzeka ukuthi athuthukise ukumelana okwengeziwe, okwenza ukutheleleka okuzayo kube nzima ukukwelapha.

Q5. Ngingakwazi Ukuthuthukisa Ukumelana Ne-Polymyxin B?

Ngenkathi ukumelana kwamagciwane ne-polymyxin B kungathuthuka, kusavamile uma kuqhathaniswa nokumelana namanye ama-antibiotics. Kodwa-ke, lesi esinye sezizathu zokuthi odokotela bagcine lo muthi ezifweni ezinzima futhi baqinisekise ukuthi uqedela lonke uhlelo lokwelashwa.

Ukuthatha umuthi ngendlela eqondile njengoba ubekiwe nokuqedela lonke uhlelo lokwelashwa kusiza ekuvikeleni ukuthuthukiswa kokumelana. Ithimba lakho lezempilo lisebenzisa i-polymyxin B ngokucophelela ukuze ligcine ukusebenza kwayo ezigulini zesikhathi esizayo ezingase ziyidinge ngezifo ezisongela impilo.