Yini i-Quinupristin kanye ne-Dalfopristin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Quinupristin kanye ne-dalfopristin kuyinhlanganisela enamandla yama-antibiotic odokotela abawasebenzisela ukwelapha izifo ezingathi sína ezibangelwa amagciwane lapho amanye ama-antibiotic engasebenzi. Lo muthi ungowodidi olubizwa ngokuthi ama-streptogramins, futhi unikezwa ngomugqa we-IV (intravenous) ngqo emgudwini wakho wegazi.

Le nhlanganisela yama-antibiotic ngokuvamile igcinelwe izifo eziyinselele, ikakhulukazi lezo ezibangelwa amagciwane angamelanayo. Udokotela wakho uzoyicabangela ngokucophelela le ndlela yokwelapha lapho ebhekene nezinhlobo ezithile zezifo ezingathi sína ezibangelwa amagciwane ezidinga ukunakekelwa ngokushesha.

Yini i-Quinupristin kanye ne-Dalfopristin?

I-Quinupristin kanye ne-dalfopristin yinhlanganisela yama-antibiotic amabili asebenza ndawonye njengeqembu ukulwa nezifo ezibangelwa amagciwane. Cabanga ngayo njengokushaya okukodwa-kabili ngokumelene namagciwane ayingozi aye abonakala emelana nezinye izindlela zokwelapha.

Umuthi uza njengempushana abasebenzi basemtholampilo abayixuba namanzi ahlanzekile ngaphambi kokukunika ngomugqa we-IV. Le nhlanganisela isebenza kahle ikakhulukazi ekulweni namagciwane e-gram-positive, okuyizinhlobo zamagciwane abangela izifo eziningi ezingathi sína.

Leli antibiotic libhekwa njengomuthi onamandla, okusho ukuthi ngokuvamile lisetshenziswa lapho amanye ama-antibiotic athambile engasebenzi. Ithimba lakho lezempilo lizokuqapha ngokucophelela ngenkathi uthola lokhu kwelashwa.

Isetshenziselwani i-Quinupristin kanye ne-Dalfopristin?

Le nhlanganisela yama-antibiotic iphatha izifo ezingathi sína zesikhumba nezicubu ezithambile ezibangelwa amagciwane athile. Udokotela wakho angase akubhalele uma unezifo eziyinkimbinkimbi ezingaphendulanga kwamanye ama-antibiotic.

Umuthi usebenza kahle ikakhulukazi ekulweni nezinhlobo ezithile zamagciwane ezingabangela izifo ezisongela impilo. Nazi izimo eziyinhloko ezilashwayo:

• Izifo eziyinkimbinkimbi zesikhumba nesakhiwo sesikhumba
• Izifo ezibangelwa yi-Enterococcus faecium (uhlobo lwebhaktheriya elingamelani ne-vancomycin)
• Izifo ezibangelwa yi-Staphylococcus aureus (kuhlanganisa ezinye izinhlobo ezingamelani ne-methicillin)
• Izifo ezibangelwa yi-Streptococcus pyogenes

Umhlinzeki wakho wezempilo uzoqaphela ukuthi ngabe lo muthi ulungele yini ukutheleleka kwakho okuthile ngokusekelwe ezivivinyweni zaselabhorathri kanye nomlando wakho wezokwelapha. Lokhu kuqinisekisa ukuthi uthola ukwelashwa okufanele kakhulu isimo sakho.

Isebenza Kanjani I-Quinupristin kanye ne-Dalfopristin?

Le nhlanganisela yama-antibiotic isebenza ngokuvimbela amabhaktheriya ekwenzeni amaprotheni abawadingayo ukuze basinde futhi bande. Uma amabhaktheriya engakwazi ukukhiqiza lawa maprotheni abalulekile, ekugcineni ayafa, okuvumela izivikelo zomzimba wakho zemvelo ukuthi ziqede ukutheleleka.

Lezi zinto ezimbili zisebenza ndawonye ngendlela ehambisanayo, okusho ukuthi zisebenza kahle ndawonye kunanoma iyiphi yazo ingayodwa. I-Quinupristin kanye ne-dalfopristin zinamathela ezingxenyeni ezihlukene zomshini wokwenza amaprotheni webhaktheriya, okudala ukuvinjelwa okuphindwe kabili okunzima kakhulu ukuthi amabhaktheriya akunqobe.

Lokhu kuthathwa njenge-antibiotic eqinile ngoba ingangena ezivikelweni zamabhaktheriya eziye zakha ukumelana neminye imithi. Kodwa-ke, leli qiniso futhi lisho ukuthi lidinga ukuqapha ngokucophelela ngesikhathi sokwelashwa.

Kufanele Ngiyithathe Kanjani I-Quinupristin kanye ne-Dalfopristin?

Uzothola lo muthi kuphela esibhedlela noma endaweni yomtholampilo ngomugqa we-IV. Ithimba lezempilo lizokulungisela futhi likunikeze wona, ngakho akudingeki ukhathazeke ngokuzithathela wona.

Umuthi uvame ukunikezwa njalo ngamahora angu-8 noma angu-12, kuye ngesimo sakho esithile nokuthi umzimba wakho usabela kanjani. Ukufakwa ngakunye kuvame ukuthatha imizuzu engaba ngu-60, lapho uzoqashwa khona nganoma yiziphi izindlela zokuphendula.

Akudingeki ukuthi ugweme ukudla noma ukuphuza ngenkathi uthola lo muthi, nakuba ithimba lakho lezempilo lingase libe nezincomo ezithile ezisekelwe ohlelweni lwakho lonke lokwelashwa. Umugqa we-IV wenza ukuthi umuthi ungene ngqo egazini lakho, udlule ngokuphelele ohlelweni lwakho lokugaya ukudla.

Kufanele Ngithathe Isikhathi Esingakanani I-Quinupristin kanye ne-Dalfopristin?

Ubude bokwelashwa buvame ukusuka ezinsukwini eziyi-7 kuya kweziyi-14, kuye ngobukhulu bokutheleleka kwakho nokuthi usabela kahle kangakanani emuthini. Udokotela wakho uzoqapha inqubekela phambili yakho futhi alungise ubude njengoba kudingeka.

Ezinye izifo ezingase zidinge izikhathi zokwelashwa ezimfushane, kuyilapho izifo ezingathi sína noma eziyinkimbinkimbi zingase zidinge izifundo ezinde. Ithimba lakho lezempilo lizosebenzisa izivivinyo zaselabhorethri nokuthuthuka kwakho komtholampilo ukuze linqume ubude obufanele kuwe.

Kubalulekile ukuqeda lonke uhlelo lokwelashwa, ngisho noma uqala ukuzizwa ungcono ngaphambi kokuthi luqede. Ukuyeka ama-antibiotics ngaphambi kwesikhathi kungavumela amagciwane ukuthi abuye futhi angase akhe ukumelana nomuthi.

Yiziphi Imiphumela Eceleni ye-Quinupristin kanye ne-Dalfopristin?

Njengayo yonke imithi, i-quinupristin kanye ne-dalfopristin ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi iyaphathwa, futhi ithimba lakho lezempilo lizokuqapha eduze ngesikhathi sokwelashwa.

Nawa amanye imiphumela emibi evame kakhulu ongase uyithole:

• Ubuhlungu, ukucasuka, noma ukuvuvukala endaweni ye-IV
• Ukuluma kwemisipha nobuhlungu emalungeni
• Isicanucanu nokuhlanza
• Ukuqunjelwa
• Ikhanda
• Ukuqubuka noma ukusabela kwesikhumba

Abanye abantu bangase babe nemiphumela emibi engathi sína kodwa engavamile. Ithimba lakho lezempilo lizobheka izimpawu zalezi futhi lithathe isinyathelo esifanele uma zenzeka:

• Ukungezwani komzimba okukhulu
• Ushintsho lomsebenzi wesibindi
• Ushintsho lwesigqi senhliziyo
• Ubuhlungu obukhulu bemisipha noma ubuthakathaka
• Ukuphefumula kanzima

Uma ubona noma yiziphi izimpawu ezingavamile noma uzizwa ukhathazekile ngendlela ozabela ngayo emuthini, unganqikazi ukutshela ithimba lakho lezempilo ngokushesha. Zikhona ukuqinisekisa ukuphepha kwakho nokunethezeka ngesikhathi sokwelashwa.

Ubani Ongafanele Athole i-Quinupristin ne-Dalfopristin?

Lo muthi awulungelwe wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwubhala. Ezinye izimo noma izimo zingenza le antibiotic ingafaneleki esimweni sakho.

Akufanele uthole lo muthi uma wazi ukuthi une-allergy ku-quinupristin, dalfopristin, noma iyiphi ingxenye yomuthi. Ithimba lakho lezempilo lizobuza mayelana nokusabela okwedlule kwe-allergy kuma-antibiotics ngaphambi kokuqala ukwelashwa.

Abantu abanezimo ezithile zezokwelapha bangase badinge izinyathelo zokuphepha ezikhethekile noma ezinye izindlela zokwelapha. Udokotela wakho uzocabangela lezi zinto ngokucophelela:

• Isifo sesibindi noma izinkinga zomsebenzi wesibindi
• Ukuphazamiseka kwesigqi senhliziyo
• Izifo zemisipha noma izinkinga zemisipha zangaphambilini ezivela emithini
• Ukukhulelwa noma ukuncelisa (kudinga ukuhlolwa okucophelelayo kobungozi-inzuzo)
• Isifo sezinso (singase sidinge ukulungiswa komthamo)

Umhlinzeki wakho wezempilo uzobuyekeza nayo yonke imithi oyithathayo njengamanje, njengoba eminye imithi ingasebenzisana ne-quinupristin ne-dalfopristin. Lokhu kubuyekezwa okuphelele kuqinisekisa ukuphepha kwakho ngesikhathi sokwelashwa.

Amagama Omkhiqizo we-Quinupristin ne-Dalfopristin

Igama lomkhiqizo lalesi sihlanganisela somuthi yi-Synercid. Leli yigama okungenzeka ukuthi uzolibona emarekhodini esibhedlela nasemalebula emithi ngesikhathi sokwelashwa kwakho.

Abahlinzeki bezempilo bavame ukusebenzisa kokubili igama elivamile (quinupristin ne-dalfopristin) negama lomkhiqizo (Synercid) ngokushintshana. Zombili zibhekisela kuso sonke isihlanganisela somuthi esifanayo, ngakho-ke ungadideki uma uzwa amagama ahlukene esetshenziswa.

Ezinye izindlela ze-Quinupristin ne-Dalfopristin

Ezinye izibulala-magciwane ezingase zicatshangelwe njengezinye izindlela, kuye ngokutheleleka kwakho kanye nesimo sakho sezempilo. Udokotela wakho uzokhetha ngokusekelwe ohlotsheni lwebhaktheriya olubangela ukutheleleka kwakho kanye nezici zakho zempilo.

Ezinye izibulala-magciwane ezingase zicatshangelwe zihlanganisa:

• Linezolid (ngokutheleleka okumelana ne-gram-positive)
• Daptomycin (ngokutheleleka okuthile kwesikhumba nezicubu ezithambile)
• Tigecycline (ngokutheleleka okuyinkimbinkimbi)
• Vancomycin (ngohlobo oluthile lwebhaktheriya elingamelani)
• Clindamycin (ngokutheleleka okuthile kwesikhumba)

Ukukhetha okunye kuncike ezintweni eziningi, okuhlanganisa amabhaktheriya athintekayo, umlando wakho wezokwelapha, nokuthi usabele kahle kangakanani kwezinye izindlela zokwelapha. Ithimba lakho lezempilo lizokhetha inketho efanele kakhulu isimo sakho esiyingqayizivele.

Ingabe i-Quinupristin ne-Dalfopristin ingcono kune-Vancomycin?

Noma ngabe i-quinupristin ne-dalfopristin ingcono kune-vancomycin kuncike ngokuphelele ekuthelelekeni kwakho kanye namabhaktheriya akubangelayo. Zombili ziyizibulala-magciwane ezinamandla ezisetshenziselwa ukutheleleka okungathi sína, kodwa zisebenza ngezindlela ezahlukene futhi zilwa nezinhlobo ezahlukene zamabhaktheriya.

I-Quinupristin ne-dalfopristin ingase ithandwe uma kubhekanwa ne-vancomycin-resistant enterococci (VRE), uhlobo lwebhaktheriya olungasabeli ku-vancomycin. Kulezi zimo, le nhlanganisela inikeza inketho yokwelapha esebenzayo lapho i-vancomycin ihlulekile.

Nokho, i-vancomycin ingase ibe yindlela engcono yezinye izinhlobo eziningi zokutheleleka, ikakhulukazi lezo ezibangelwa amabhaktheriya azwelayo kuyo. Udokotela wakho uzosebenzisa izivivinyo zaselabhorethri ukunquma ukuthi yimaphi amabhaktheriya abangela ukutheleleka kwakho nokuthi yiziphi izibulala-magciwane ezizosebenza kahle kuwo.

Imibuzo Evame Ukubuzwa Mayelana ne-Quinupristin ne-Dalfopristin

Ingabe i-Quinupristin ne-Dalfopristin iphephile kubantu abanezifo zenhliziyo?

Lo muthi udinga ukuqashwa ngokucophelela kubantu abanezifo zenhliziyo, ikakhulukazi labo abanezinkinga zokushaya kwenhliziyo. Inhlanganisela ingase ithinte ukushaya kwenhliziyo, ngakho-ke ithimba lakho lezempilo lizobheka ngokucophelela ukusebenza kwenhliziyo yakho ngesikhathi sokwelashwa.

Uma unomlando wezinkinga zenhliziyo, udokotela wakho uzohlola izinzuzo zokwelapha ukutheleleka kwakho ngokumelene nezingozi ezingase zibe khona enhliziyweni yakho. Bangase basebenzise imishini eyengeziwe yokuqapha futhi balungise uhlelo lwakho lokwelapha ngokufanele ukuze bakugcine uphephile.

Kufanele Ngenzeni Uma Ngizwa Ubuhlungu Obukhulu Bemisipha Ngesikhathi Sokwelashwa?

Ubuhlungu obukhulu bemisipha bungaba umphumela ongemuhle ongadinga ukunakekelwa kwezempilo ngokushesha. Uma uzwa ubuhlungu obukhulu bemisipha, ubuthakathaka, noma ubuhlungu obubonakala bungajwayelekile noma bunzima, yazisa ithimba lakho lezempilo ngokushesha.

Ithimba lakho lezokwelapha lingase lidingeke ukuthi lilungise ukwelashwa kwakho noma linikeze imithi eyengeziwe yokuphatha lezi zimpawu. Ungazami ukuzama ukubhekana nobuhlungu obukhulu bemisipha, ngoba lokhu kungase kubonise ukusabela okungathi sína okudinga ukunakekelwa ngokushesha.

Kwenziwani Uma Ngiphuthelwa Umthamo We-Quinupristin kanye ne-Dalfopristin?

Njengoba uzothola lo muthi esibhedlela noma endaweni yezokwelapha, ithimba lakho lezempilo liphatha isikhathi sawo wonke imithamo. Banezinhlelo zokwenza isiqiniseko sokuthi uthola imithi yakho ngesikhathi esifanele.

Uma ngasizathu simbe umthamo ulibala ngenxa yezinqubo zezokwelapha noma ezinye izimo, ithimba lakho lezempilo lizolungisa isikhathi ngendlela efanele. Akudingeki ukhathazeke ngokulahlekelwa imithamo njengoba ochwepheshe abaqeqeshiwe bephatha uhlelo lwakho lokwelashwa.

Ngingayeka Nini Ukuthatha i-Quinupristin kanye ne-Dalfopristin?

Akufanele uyeke lo muthi wedwa, ngisho noma uzizwa ungcono kakhulu. Udokotela wakho uzonquma ukuthi kuphephile nini ukuyeka ukwelashwa ngokuya ngentuthuko yakho yezokwelapha kanye nemiphumela yokuhlolwa kwelabhorethri.

Ukunqamula ama-antibiotics ngaphambi kwesikhathi kungavumela amagciwane ukuthi abuye futhi kungenzeka ukuthi akhe ukumelana nomuthi. Ithimba lakho lokunakekelwa kwezempilo lizokulandela intuthuko yakho futhi likwazise uma usuqedele lonke uhlelo lokwelashwa oludingekayo ukuze ululame.

Ngingathola Eminye Imithi Ngesikhathi Ngithatha i-Quinupristin ne-Dalfopristin?

Imithi eminingi inganikezwa ngokuphepha kanye ne-quinupristin ne-dalfopristin, kodwa eminye idinga izinyathelo zokuphepha ezikhethekile noma ukulungiswa kwesikhathi. Ithimba lakho lokunakekelwa kwezempilo lizobuyekeza yonke imithi yakho ukuze livimbele ukusebenzisana okuyingozi.

Eminye imithi ethinta isigqi senhliziyo noma ukusebenza kwesibindi ingase idinge ukuqapha okukhethekile noma ukulungiswa komthamo. Ithimba lakho lezokwelapha lizoxhumanisa zonke izindlela zakho zokwelapha ukuze liqinisekise ukuthi zisebenza ngokuphepha nangempumelelo ekululameni kwakho.