Yini iQuizartinib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Quizartinib iyimithi yomdlavuza eqondiswe ngqo eyenzelwe ukwelapha uhlobo oluthile lwe-acute myeloid leukemia (AML). Le mithi yomlomo isebenza ngokuvimba amaprotheni angajwayelekile asiza amaseli omdlavuza ukuthi akhule futhi ande emnkantshubeni wakho wamathambo.

Uma wena noma othandiweyo wakho unikezwe i-quizartinib, cishe ubhekene nokuxilongwa komdlavuza okuyinkimbinkimbi. Ngenkathi lokhu kungase kuzizwe kukhulu, ukuqonda ukuthi le mithi isebenza kanjani kungakusiza ukuthi uzizwe ulungiseleleke futhi uqiniseke ohambweni lwakho lokwelashwa.

Yini iQuizartinib?

I-Quizartinib iyimithi yomdlavuza kadokotela eyingxenye yeqembu lezidakamizwa ezibizwa ngokuthi ama-kinase inhibitors. Iqondisa ngqo futhi ivimbe iprotheni ebizwa ngokuthi i-FLT3, engase ibe ngaphezulu emdlavuzeni othile wegazi.

Le mithi iza njengamaphilisi omlomo, okusho ukuthi ungayithatha ngomlomo ekhaya kunokuthi udinge ukwelashwa ngemithambo emithanjeni esibhedlela. Lesi sidakamizwa sakhiwe ngqo kubantu abane-acute myeloid leukemia enoshintsho oluthile lofuzo olubizwa ngokuthi i-FLT3-ITD.

Udokotela wakho uzobe ehlolile amaseli akho omdlavuza ukuze aqinisekise ukuthi unalo lolu shintsho oluthile ngaphambi kokukuyalela i-quizartinib. Le ndlela yomuntu ngamunye isiza ukuqinisekisa ukuthi imithi izosebenza kahle kakhulu ohlotsheni lwakho oluthile lwe-leukemia.

Isetshenziselwani iQuizartinib?

I-Quizartinib isetshenziselwa ukwelapha abantu abadala abane-acute myeloid leukemia (AML) enoshintsho oluthile lofuzo olubizwa ngokuthi i-FLT3-ITD mutation. Le mithi ivamise ukunikezwa lapho i-leukemia yakho ibuye ngemva kokwelashwa kwangaphambilini noma ingazange isabele kahle kwezinye izindlela zokwelapha.

I-AML wuhlobo lomdlavuza wegazi oluthinta umnkantshubeni wakho wamathambo, lapho umzimba wakho wenza khona amaseli egazi. Uma unesimo esinjalo, umnkantshubeni wakho wamathambo ukhiqiza amaseli amaningi amhlophe egazi angajwayelekile angasebenzi kahle, ekhupha amaseli egazi anempilo.

Ushintsho lwe-FLT3-ITD lwenza amaseli omdlavuza akhule futhi aphindaphindeke ngokushesha. Cishe ama-25-30% abantu abane-AML banolu shintsho oluthile, yingakho ukuhlolwa kwezakhi zofuzo kubaluleke kakhulu ngaphambi kokuqala ukwelashwa.

Udkt wakho wezifo zomdlavuza angase futhi acabangele i-quizartinib uma ungafaneleki ukwelashwa ngamakhemikhali aqinile ngenxa yobudala bakho noma ezinye izimo zempilo. Lo muthi unikeza indlela eqondiwe engaba mnene emzimbeni wakho ngenkathi usalwa nomdlavuza ngempumelelo.

Isebenza Kanjani I-Quizartinib?

I-Quizartinib isebenza ngokuvimba iphrotheni ethile ebizwa ngokuthi i-FLT3 esebenza njengokuthi “inkinobho yokukhula” yamaseli omdlavuza. Lapho le phrotheni iguqulwa, ihlala ivuliwe ngaso sonke isikhathi, itshela amaseli omdlavuza ukuthi aqhubeke ekhula futhi ehlukana ngokushesha.

Cabanga ngayo njengemoto enesivinini esibambekile. Ushintsho lwe-FLT3 lugcina “isivinini” sicindezelwe phansi, okwenza amaseli omdlavuza aphindaphindeke ngaphandle kokulawulwa. I-Quizartinib isebenza njengokufaka amabhuleki, imisa le nqubo yokukhula engalawuleki.

Lo muthi ubhekwa njengokwelashwa okuqondiwe okuqinile nokuphumelelayo. Ngokungafani nokwelashwa ngamakhemikhali okwesintu okuthinta wonke amaseli ahlukana ngokushesha, i-quizartinib iqondisa ngqo iphrotheni eguquliwe kumaseli akho omdlavuza, okungasho imiphumela emibi embalwa kumaseli anempilo.

Uma usuthatha umuthi, uhamba ngegazi lakho futhi ufike emnkantsheni lapho amaseli e-leukemia ekhula khona. Ngokuvimba iphrotheni ye-FLT3, kungasiza ukunciphisa inani lamaseli omdlavuza futhi kuvumele umnkantshe wakho ukuthi uqale ukukhiqiza amaseli egazi anempilo futhi.

Kufanele Ngiyithathe Kanjani I-Quizartinib?

Kufanele uthathe i-quizartinib ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Umuthi uza ngamaphilisi owagwinya wonke ngengilazi yamanzi egcwele.

Ungathatha i-quizartinib ngaphandle kokudla noma ngemva kokudla, kodwa zama ukuba nokuvumelana nokukhetha kwakho. Uma uvame ukuyithatha ekuseni, qhubeka ukwenza kanjalo kuyo yonke imithi yakho. Lokhu kusiza ukugcina amazinga aqhubekayo omuthi emzimbeni wakho.

Ungachobozi, uhlafune, noma uqhekeze amaphilisi, ngoba lokhu kungathinta indlela umuthi omuncwa ngayo. Uma unenkinga yokugwinya amaphilisi, khuluma neqembu lakho lezempilo mayelana namaqhinga angasiza, kodwa ungalokothi ushintshe amaphilisi ngokwawo.

Kubalulekile ukuthatha i-quizartinib cishe ngesikhathi esifanayo nsuku zonke ukuze kugcinwe amazinga aqhubekayo egazini lakho. Ukusetha i-alamu yansuku zonke noma ukuyixhuma emsebenzini ojwayelekile njengokuxubha amazinyo kungakusiza ukuthi ukhumbule.

Gcina imithi yakho ekamelweni lokushisa, kude nomswakama nokushisa. Yigcine esitsheni sayo sokuqala futhi kude nezingane nezilwane ezifuywayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Quizartinib?

Ubude bokwelashwa nge-quizartinib buhlukahluka kakhulu kumuntu nomuntu futhi kuncike ekutheni umzimba wakho usabela kahle kangakanani emuthini. Udokotela wakho uzoqapha inqubekela phambili yakho ngokuhlolwa kwegazi njalo kanye nokuhlolwa komnkantsha wamathambo ukuze anqume ubude obufanele.

Abantu abaningi baqhubeka nokuthatha i-quizartinib izinyanga eziningana kuya eminyakeni, uma nje ilawula ngempumelelo i-leukemia yabo futhi imiphumela emibi ihlala ilawuleka. Ezinye iziguli zingayithatha unomphela njengokwelashwa kokugcinwa ukuze zigcine umdlavuza wazo ekuxolelweni.

Udokotela wakho we-oncologist uzoqapha njalo ukuthi ngabe imithi iyasebenza yini ngokuhlola ukubalwa kwamaseli egazi lakho futhi efuna amaseli e-leukemia emnkantshweni wamathambo akho. Uma umdlavuza wakho usabela kahle, cishe uzoqhubeka nokwelashwa isikhathi eside.

Ungalokothi uyeke ukuthatha i-quizartinib ngokuzumayo noma ushintshe isimiso sakho sokulinganisa ngaphandle kokubonisana neqembu lakho lezempilo. Noma ngabe uzizwa ungcono, imithi ingase isalwa ngempela namaseli omdlavuza angabangeli izimpawu okwamanje.

Ziyini Imiphumela Eceleni ye-Quizartinib?

Njengayo yonke imithi yomdlavuza, i-quizartinib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi ingalawulwa ngokuqapha okufanele nokunakekelwa okusekelayo okuvela eqenjini lakho labanakekeli bezempilo.

Nawa amanye emiphumela emibi evame kakhulu ongase uyithole ngenkathi uthatha i-quizartinib:

• Ukucasuka nokuhlanza
• Ukuqunjelwa noma ukuqina kwesisu
• Ukukhathala nobuthakathaka
• Ukuncipha kwesifiso sokudla
• Ubuhlungu bemisipha namalunga
• Ikhanda
• Isiyezi
• Ushintsho ekunambithekeni

Le miphumela emibi ejwayelekile ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Ithimba lakho labanakekeli bezempilo linganikeza amasu nemithi yokusiza ukulawula lezi zimpawu ngempumelelo.

Imiphumela emibi engathi sína ingenzeka, nakuba ingavamile. Kubalulekile ukuyazi lezi ukuze ukwazi ukufuna ukunakekelwa kwezempilo ngokushesha uma kudingeka:

• Izinkinga zesigqi senhliziyo (ukwelulwa kwe-QT)
• Izifo ezinzima ngenxa yokubala okuncane kwamangqamuzana amhlophe egazi
• Ukuphuma kwegazi noma ukulimala ngenxa yokubala okuncane kwamaplatelet
• Izinkinga zesibindi
• Ukugcinwa kwamanzi nokuvuvukala
• Ukuphefumula kanzima
• Ukuphendula kwesikhumba okukhulu

Udokotela wakho uzokuqapha eduze ngezivivinyo zegazi ezivamile nokuqapha inhliziyo ukuze ubambe noma yimiphi imiphumela emibi engathi sína kusenesikhathi. Abantu abaningi bangaqhubeka nokwelashwa ngokuphepha ngaphansi kokuqondiswa kwezokwelapha okufanele.

Imiphumela emibi engavamile kodwa engathi sína ingabandakanya izinkinga zenhliziyo ezinzima, izifo ezisongela impilo, noma i-tumor lysis syndrome (lapho amaseli omdlavuza ewohloka ngokushesha kakhulu). Nakuba lezi zinkinga zingavamile, ithimba lakho lezokwelapha lizobheka izimpawu zokuqala zokuxwayisa futhi lisenze ngokushesha uma zenzeka.

Ubani Ongafanele Athatha i-Quizartinib?

I-Quizartinib ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ingabe iyona ndlela efanele kuwe. Abantu abanezimo ezithile zenhliziyo kungenzeka bangafaneleki kule mithi ngenxa yemiphumela yayo engaba khona esigqi senhliziyo.

Akufanele uthathe i-quizartinib uma wazi ukuthi unokungezwani komzimba nemithi noma yiziphi izithako zayo. Udokotela wakho uzophinda aqaphele ngoku-oda uma unezinkinga ezinkulu zesibindi noma izinso, njengoba lezi zitho zisiza ukucubungula imithi.

Abantu abanezinkinga ezithile zesigqi senhliziyo, ikakhulukazi labo abane-long QT syndrome, kungenzeka bangakwazi ukuthatha i-quizartinib ngokuphepha. Udokotela wakho cishe uzoqhuba i-electrocardiogram (ECG) ngaphambi kokuqala ukwelashwa ukuze ahlolisise isigqi senhliziyo yakho.

Ukukhulelwa nokuncelisa ibele kuyizinto ezibalulekile okufanele zicatshangelwe. I-Quizartinib ingalimaza ingane engakazalwa, ngakho-ke ukuthatha izindlela zokuvimbela ukukhulelwa ezisebenzayo kubalulekile ngesikhathi sokwelashwa nangesikhathi esithile ngemuva kokuyeka imithi. Uma uncelisa, uzodinga ukuxoxa ngezinketho zokondla ezinye nethimba lakho lezempilo.

Udokotela wakho uzophinda acabangele isimo sakho sempilo esiphelele, eminye imithi oyithathayo, nanoma yimuphi umlando wokutheleleka okukhulu ngaphambi kokubhala i-quizartinib. Lokhu kuhlola ngokucophelela kusiza ukuqinisekisa ukuthi imithi iphephile futhi ifanele isimo sakho esithile.

Igama Lomkhiqizo le-Quizartinib

I-Quizartinib itholakala ngaphansi kwegama lomkhiqizo elithi Vanflyta e-United States nakwamanye amazwe. Leli yigama lezentengiso ozolibona ebhodleleni lakho lemithi kanye nokupakishwa kwemithi.

Imithi yathuthukiswa yi-Daiichi Sankyo futhi yathola imvume evela e-FDA yokwelapha i-FLT3-ITD positive AML. Uma udokotela wakho ebhala i-quizartinib, ikhemisi ngokuvamile lizoyikhipha njenge-Vanflyta ngaphandle kokuthi lichaze ngenye indlela.

Izinhlobo ezijwayelekile ze-quizartinib azikatholakali okwamanje, njengoba umuthi usamusha futhi uvikelwe ngamalungelo obunikazi. Lokhu kusho ukuthi i-Vanflyta okwamanje iyona kuphela uhlobo lwe-quizartinib olutholakala ukuze lunikezwe ngudokotela.

Ezinye Izindlela Zokwelapha Nge-Quizartinib

Imithi eminingi ehlukile iyatholakala yokwelapha i-FLT3-positive AML, ngalinye linendlela ehlukile yokusebenza kanye nemiphumela emibi. Udokotela wakho we-oncologist uzosiza ekunqumeni ukuthi iyiphi inketho engase ibe ngcono esimweni sakho esithile.

I-Midostaurin (Rydapt) ngomunye umuthi ovimbela i-FLT3 ovame ukusetshenziswa ngokuhlangana ne-chemotherapy ye-FLT3-positive AML esanda kutholakala. Isebenza ngendlela efana ne-quizartinib kodwa ivame ukusetshenziswa ekuqaleni kokwelashwa.

I-Gilteritinib (Xospata) ngomunye umuthi oqondiswe ngqo we-FLT3-positive AML osetshenziswa lapho lesi sifo sibuyele noma singasabeli kwezinye izindlela zokwelapha. Ivimba amaprotheni amaningi abamba iqhaza ekukhuleni kwamaseli omdlavuza.

Izindlela zokwelapha ngendlela ye-chemotherapy yendabuko zisaqhubeka ziyizinketho ezibalulekile zokwelapha, ikakhulukazi kubantu abanempilo eyanele yokubekezelela ukwelashwa okunamandla. Lokhu kungase kuhlanganise ukuhlanganiswa kwe-cytarabine kanye ne-anthracyclines.

Ukufakelwa kwamaseli esiqu kungase kucatshangelwe ezigulini ezithile, ikakhulukazi abantu abasebancane abanempilo enhle. Lokhu kwelashwa okunamandla kungenzeka kuphulukise i-AML kodwa kudinga ukukhethwa kwesiguli ngokucophelela nokulungiselela.

Udokotela wakho uzocabangela izinto ezinjengobudala bakho, impilo yonke, ukwelashwa kwangaphambilini, kanye nezici ezithile zofuzo lwe-leukemia yakho lapho encoma ezinye izindlela zokwelapha ezingezona i-quizartinib.

Ingabe i-Quizartinib Ingcono Kune-Midostaurin?

Kokubili i-quizartinib kanye ne-midostaurin ziyizinto ezivimbela i-FLT3 ezisebenzayo, kodwa zivame ukusetshenziswa ezimweni ezihlukene kunokuba ziqhathaniswe ngokuqondile. Ukukhetha okungcono kuncike ezimweni zakho ezithile, umlando wokwelashwa, nokuthi i-leukemia yakho isabele kanjani ekwelashweni kwangaphambilini.

I-Midostaurin ivame ukusetshenziswa njengengxenye yokwelashwa kokuqala kwe-FLT3-positive AML esanda kutholwa, ngokuvamile ihlanganiswe ne-chemotherapy ejwayelekile. Kuye kwakhonjiswa ukuthi ithuthukisa ukusinda uma ingezwa ekwelashweni okuvamile.

Ngakolunye uhlangothi, i-Quizartinib isetshenziswa ikakhulukazi ku-relapsed noma refractory FLT3-positive AML. Yenzelwe izimo lapho i-leukemia ibuye ngemva kokwelashwa noma ingaphendulanga kahle kwezinye izindlela zokwelapha.

Ngokuqondene nokusebenza kahle, yomibili imithi ikhombise izinzuzo ezinkulu ezivivinyweni zomtholampilo. I-Quizartinib ikhombise umsebenzi oqinile ikakhulukazi ngokumelene nezinguquko ezithile ze-FLT3 futhi ingase ibe namandla amaningi kwezinye izifundo zaselabhorethri.

Amaphrofayili emiphumela emibi ahlukile phakathi kwemithi emibili. Ngenkathi zombili zingabangela imiphumela emibi efanayo ejwayelekile efana nesicanucanu nokukhathala, zingase zibe nezingozi ezihlukene zezinkinga ezinzima njengezinkinga zesigqi senhliziyo noma izifo.

Udokotela wakho we-oncologist uzocabangela umlando wakho wokwelashwa, isimo sakho samanje sempilo, nezici ezithile ze-leukemia yakho lapho ekhetha phakathi kwale mithi. Isinqumo asikhona sokuthi iyiphi

Abantu abanezinkinga ezithile zokushaya kwenhliziyo kungenzeka bangabi ngabazongenela i-quizartinib, kodwa labo abanezimo zenhliziyo ezilawulwa kahle bangase bakwazi ukuyithatha ngokuphepha ngokuqapha okufanele.

Kufanele ngenzeni uma ngithatha i-Quizartinib eningi ngengozi?

Uma ngengozi uthatha i-quizartinib eningi kunaleyo ebekiwe, xhumana nomhlinzeki wakho wezempilo noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini, ngoba ukunakekelwa kwezokwelapha okusheshayo kubalulekile.

Ukuthatha i-quizartinib eningi kungakhuphula ingozi yakho yemiphumela emibi engathi sína, ikakhulukazi izinkinga zokushaya kwenhliziyo. Ithimba lakho lezokwelapha lingase lifune ukukuqapha eduze futhi lingase lenze ezinye izivivinyo ezinjenge-electrocardiogram.

Ukuvimbela ukweqisa ngengozi, gcina imithi yakho esitsheni sayo sokuqala ngokulebula okucacile, futhi cabanga ukusebenzisa umhleli wamaphilisi uma uthatha imithi eminingi. Ungalokothi uphinde izilinganiso uma uphuthelwa eyodwa.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Quizartinib?

Uma uphuthelwa umthamo we-quizartinib, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma ungaqiniseki ngesikhathi, xhumana nomhlinzeki wakho wezempilo ukuze uthole isiqondiso.

Ukusetha izikhumbuzi zansuku zonke ocingweni lwakho noma ukuxhumanisa imithi yakho nomsebenzi ojwayelekile kungakusiza ukuthi ukhumbule ukuthatha i-quizartinib ngokuqhubekayo. Ukulinganisa okuqhubekayo kubalulekile ekugcineni amazinga asebenzayo ohlelweni lwakho.

Ngingayeka nini ukuthatha i-Quizartinib?

Kufanele uyeke kuphela ukuthatha i-quizartinib lapho i-oncologist yakho inquma ukuthi kufanelekile ukwenza kanjalo. Lesi sinqumo sizosekelwa ekutheni imithi ilawula kahle kangakanani i-leukemia yakho nokuthi ngabe uhlangabezana nemiphumela emibi elawulekayo.

Abanye abantu bangase badinge ukuthatha i-quizartinib izinyanga noma iminyaka, kanti abanye bangase bashintshele kwezinye izindlela zokwelapha noma bafinyelele ekuthetheleleni isikhathi eside. Udokotela wakho uzosebenzisa ukuhlolwa kwegazi okujwayelekile kanye nokuhlolwa komnkantsha wamathambo ukuze aqondise lezi zinqumo.

Ungayeki ukuthatha i-quizartinib ngokwakho, ngisho noma uzizwa ungcono. Umuthi usengase ulwe ngempumelelo namaseli omdlavuza, futhi ukuyeka kungazelelwe kungavumela i-leukemia yakho ukuthi ibuye noma ibe yimbi.

Ngingathatha Eminye Imithi Ngesikhathi Ngithatha i-Quizartinib?

Imithi eminingi ingasebenzisana ne-quizartinib, ngakho-ke kubalulekile ukutshela umhlinzeki wakho wezempilo ngayo yonke imithi, izithasiselo, kanye nemikhiqizo yamakhambi oyithathayo. Ezinye izindlela zokusebenzisana zingathinta ukuthi i-quizartinib isebenza kahle kangakanani noma zikhuphule ingozi yakho yemiphumela emibi.

Imithi ethile ethinta isigqi senhliziyo kufanele isetshenziswe ngokucophelela okukhulu noma igwenywe ngokuphelele ngenkathi uthatha i-quizartinib. Udokotela wakho uzobuyekeza uhlu lwakho lwemithi ngokucophelela futhi kungase kudingeke ukuthi alungise noma ashintshe ezinye izindlela zokwelapha.

Njalo hlola nomhlinzeki wakho wezempilo ngaphambi kokuqala noma iyiphi imithi emisha, okuhlanganisa imithi etholakala ngaphandle kwemvume kadokotela kanye nezithasiselo. Bangakusiza ukuthi uqonde ukusebenzisana okungenzeka futhi baqinisekise ukuthi ukwelashwa kwakho kuhlala kuphephile futhi kuphumelela.