Yini i-Ramelteon: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Ramelteon iyikhambi lokulala elinikezwa ngudokotela elikusiza ukuthi ulale ngokusebenza nomjikelezo womzimba wakho wemvelo wokulala nokuphapama. Ngokungafani nezinye izindlela zokulala, lo muthi uqondise ngqo izamukeli ze-melatonin ebuchosheni bakho, okwenza kube yindlela enobumnene kubantu abahlushwa yi-insomnia.

Lo muthi ungowesigaba esibizwa ngokuthi ama-melatonin receptor agonists, futhi wenzelwe ukulingisa imiphumela ye-hormone yakho ye-melatonin. Ungase uyazi kangcono ngegama layo lomkhiqizo, i-Rozerem, futhi ilusizo ikakhulukazi kubantu abanobunzima bokulala kunokuhlala belele.

Yini i-Ramelteon Esetshenziselwa Yona?

I-Ramelteon ngokuyinhloko inikezwa ukwelapha i-insomnia, ikakhulukazi uhlobo lapho unobunzima bokulala. Udokotela wakho angase ancome lo muthi uma uzithola ulele isikhathi eside lapho uqala ukulala embhedeni ebusuku.

Lo muthi usebenza kahle kakhulu kubantu abanento ebizwa ngokuthi

Cabanga nge-melatonin njengoba kuyisignali yakho yomzimba yemvelo "yobuthongo." Lapho kusondela kusihlwa, ubuchopho bakho buvamise ukukhiqiza i-melatonin eningi, okutshela umzimba wakho ukuthi sekuyisikhathi sokulungiselela ukulala. I-Ramelteon empeleni ikhulisa leli siginali yemvelo ngokusebenzisa ama-receptors afanayo okufanele i-melatonin yakho iqondise kuwo.

Lo muthi ubhekwa njengosizo lokulala oluthambile ngoba usebenza nezinhlelo zomzimba wakho ezikhona kunokuthi uphoqe ukulala ngokuthulisa. Ngokuvamile kuthatha imizuzu engaba ngu-30 kuya ehora ukuthi iqale ukusebenza, futhi imiphumela yayo ingahlala amahora amaningi.

Ngingayithatha Kanjani I-Ramelteon?

Thatha i-ramelteon ngendlela eqondile udokotela wakho ayikuyala ngayo, ngokuvamile imizuzu engaba ngu-30 ngaphambi kokuba uhlele ukulala. Umthamo ojwayelekile ungu-8 mg, othathwa kanye ngosuku, kodwa udokotela wakho uzonquma inani elifanele lesimo sakho esithile.

Kufanele uthathe lo muthi esiswini esingenalutho noma ngesnakhi esilula. Gwema ukuwuthatha ngesikhathi noma ngemva nje kokudla okunamfutha amaningi, ngoba lokhu kunganciphisa ukuthi umuthi usebenza ngokushesha kangakanani. Ukudla okukhulu kungahlehlisa ukumuncwa kwe-ramelteon ngesikhathi esingafika ehora elilodwa.

Qiniseka ukuthi unesikhathi esingama-7 kuya kwangu-8 amahora sokulala ngaphambi kokuthatha i-ramelteon. Ukuyithatha uma ungenakuthola ukuphumula okugcwele ebusuku kungakushiya uzizwa uyaluza ngosuku olulandelayo. Futhi, gwema utshwala lapho uthatha lo muthi, ngoba kungakhuphula ukozela futhi kunciphise ukusebenza komuthi.

Ngingayithatha Isikhathi Esingakanani I-Ramelteon?

Ubude bokwelashwa nge-ramelteon buyahluka ngokuya ngesimo sakho somuntu ngamunye kanye nesincomo sikadokotela wakho. Abanye abantu bayayisebenzisa amasonto ambalwa nje ukuze baphumelele esikhathini esicindezelayo, kanti abanye bangayithatha izinyanga eziningana.

Ngokungafani neminye imithi yokulala, i-ramelteon ngokuvamile ayibangeli ukuncika ngokomzimba, okusho ukuthi mancane amathuba okuthi uzobhekana nezimpawu zokuhoxiswa lapho uyeka ukuyithatha. Kodwa-ke, kufanele usebenze nodokotela wakho ukuze unqume umugqa wesikhathi ongcono kakhulu wokwelashwa kwakho.

Udokotela wakho angase asikisele ukuqala ngesilingo sesikhashana ukuze abone ukuthi umuthi usebenza kahle kangakanani kuwe. Uma kuyasiza futhi ungaqali ukuzwa imiphumela emibi, bangase bancomise ukuqhubeka nokuyithatha isikhathi eside. Ukuhlolwa njalo nomhlinzeki wakho wezempilo kuzosiza ekuqinisekiseni ukuthi umuthi uqhubeka ukuba yisinqumo esifanele kuwe.

Yini Imiphumela Eceleni ye-Ramelteon?

Abantu abaningi bayamukela kahle i-ramelteon, kodwa njenganoma imuphi umuthi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathi sína ayivamile, futhi abantu abaningi bazwa kuphela imiphumela emincane ethuthukayo njengoba umzimba wabo ujwayela umuthi.

Nansi imiphumela emibi evame kakhulu ongase uyizwe:

• Ukozela emini noma ukukhathala
• Isiyezi, ikakhulukazi lapho usukuma ngokushesha
• Isicanucanu noma isisu esibuhlungu
• Ukukhathwa yikhanda
• Ukwanda kokungalali kwezinye izimo
• Amaphupho angavamile noma acacile
• Ukucindezeleka okuncane noma izinguquko zemizwa

Le miphumela evamile ngokuvamile iyazinzisa phakathi nezinsuku ezimbalwa kuya evikini njengoba umzimba wakho ujwayela umuthi. Uma ziqhubeka noma ziba yinkinga, yazisa udokotela wakho ukuze akwazi ukulungisa uhlelo lwakho lokwelashwa.

Kukhona neminye imiphumela emibi engavamile kodwa engathi sína okufanele uyiqaphele. Nakuba lokhu kungenzeki kubantu abaningi, kubalulekile ukukubona:

• Ukusabela okukhulu komzimba ngokuqumbuka kobuso, izindebe, noma umphimbo
• Ukuziphatha okuyinkimbinkimbi kokulala njengokuhamba ulele noma ukushayela ulele
• Ukuwohloka kokucindezeleka noma imicabango yokuzibulala
• Isiyezi esikhulu noma ukudideka
• Ushintsho lwama-hormone, ikakhulukazi oluthinta amazinga e-testosterone
• Izinkinga zesibindi, nakuba lokhu kungavamile kakhulu

Uma uhlangabezana nanoma yimiphi yale miphumela engathi sína, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezimo eziphuthumayo. Abantu abaningi abahlangabezani nalezi zinkinga, kodwa ukwaziswa kukusiza ukuthi uhlale uphephile.

Ubani Ongafanele Athole i-Ramelteon?

I-Ramelteon ayifanele wonke umuntu, futhi kunezimo eziningana lapho udokotela wakho angase ancome omunye umuthi wokulala esikhundleni salokho. Ukuphepha kwakho kuyinto eza kuqala, ngakho kubalulekile ukuxoxa ngomlando wakho wezokwelapha ophelele ngaphambi kokuqala lokhu kwelashwa.

Akufanele uthathe i-ramelteon uma unesifo sesibindi esibi noma ukwehluleka kwesibindi. Isibindi sakho sisebenzisa lo muthi, futhi uma ungasebenzi kahle, i-ramelteon ingakwazi ukwakheka emazingeni ayingozi ohlelweni lwakho. Ngisho nezinkinga zesibindi ezincane zingase zidinge ukulungiswa komthamo noma ukwelashwa okuhlukile.

Abantu abathatha imithi ethile kufanele futhi bagweme i-ramelteon. Lokhu kuhlanganisa izithiyo eziqinile ze-CYP1A2 njenge-fluvoxamine, engakwazi ukukhuphula kakhulu amazinga e-ramelteon egazini lakho. Uma uthatha i-rifampin noma eminye imithi ethinta ama-enzyme esibindi, udokotela wakho uzodinga ukucabangela ngokucophelela ukuthi i-ramelteon iphephile yini kuwe.

Abesifazane abakhulelwe nabancelisayo ngokuvamile kufanele bagweme i-ramelteon ngaphandle kwalapho izinzuzo zicacile ukwedlula izingozi. Umuthi ungadlulela obisini lwebele, futhi imiphumela yawo ezinganeni ezisakhula ayiqondakali ngokugcwele. Njalo xoxa ngezinhlelo zakho zokukhulelwa noma isimo sakho sokukhulelwa samanje nodokotela wakho.

Izingane nentsha engaphansi kweminyaka engu-18 akufanele ithathe i-ramelteon, njengoba ukuphepha kwayo nokusebenza kahle kungakahlolwa emaqenjini eminyaka emincane. Abantu abadala kungenzeka badinge imithamo ephansi noma ukuqapha okucophelelayo ngenxa yokucutshungulwa kwemithi okuhamba kancane.

Amagama Omkhiqizo we-Ramelteon

I-Ramelteon yaziwa kakhulu ngegama layo lomkhiqizo elithi Rozerem, elikhiqizwa yi-Takeda Pharmaceuticals. Leli yigama lomkhiqizo lokuqala lapho imithi yaqala ukugunyazwa futhi yathengiswa.

Njengamanje, i-Rozerem yigama eliyinhloko lomkhiqizo ozohlangana nalo emakhemisi amaningi nasezindaweni zezokwelapha. Izinhlobo ezivamile ze-ramelteon nazo ziyatholakala, eziqukethe isithako esifanayo esisebenzayo kodwa singavela kubakhiqizi abahlukene futhi ngokuvamile zibiza ngaphansi kwenguqulo yegama lomkhiqizo.

Lapho udokotela wakho ekunika i-ramelteon, angase abhale igama elivamile noma igama lomkhiqizo emiyalelweni yakho. Umuthi wakho ungakusiza ukuthi uqonde ukuthi ngabe uthola inguqulo yegama lomkhiqizo noma ejwayelekile, futhi zombili kufanele zisebenze kahle ngezinkinga zakho zokulala.

Ezinye izindlela ze-Ramelteon

Uma i-ramelteon ingasebenzi kahle kuwe noma ibangela imiphumela engathandeki, kunezinketho eziningana ezingase zicatshangelwe udokotela wakho. Enye nanye indlela esebenza ngendlela ehlukile, ngakho-ke ukuthola okufanele ngokuvamile kuhilela ukuzama izindlela ezahlukene.

Izithasiselo ze-Melatonin ziyindlela yemvelo abantu abaningi abazama kuqala. Ngenkathi zitholakala ngaphandle kwe-counter, azihambisani njenge-ramelteon kadokotela, futhi ukusebenza kwazo kungahluka. Abanye abantu bayazithola ziwusizo ezinkingeni zokulala ezimnene noma i-jet lag.

Eminye imithi yokulala kadokotela ihlanganisa i-zolpidem (Ambien), i-eszopiclone (Lunesta), ne-zaleplon (Sonata). Le mithi isebenza ngendlela ehlukile ku-ramelteon ngokuthinta ama-GABA receptors ebuchosheni bakho. Zivame ukusebenza ngokushesha kodwa zingaba nengozi enkulu yokuncika nokuzizwa ubuthuntu ekuseni.

I-Suvorexant (Belsomra) enye inketho entsha esebenza ngokuvimba ama-orexin receptors, ahilelekile ekuvukeni. Njengo-ramelteon, yenzelwe ukusebenza nezinqubo zakho zokulala zemvelo kunokuphoqa ukuthuliswa.

Izindlela ezingezona zokwelapha nazo zifanele ukucatshangelwa. Ukwelashwa kokuziphatha kwengqondo ngokuqina (CBT-I) kunokwesekwa okunamandla kocwaningo futhi kungahlinzeka ngezinzuzo ezihlala isikhathi eside. Ukuthuthukiswa kwenhlanzeko yokulala, amasu okuphumula, nokubhekana nokucindezeleka okuyisisekelo noma ukukhathazeka konke kungasiza ekuthuthukiseni ikhwalithi yokulala.

Ingabe i-Ramelteon Ingcono Kune-Melatonin?

I-Ramelteon kanye nezithasiselo ze-melatonin zisebenza ezindleleni ezifanayo ebuchosheni bakho, kodwa kunezingxenye ezibalulekile ezingenza enye ifaneleke kakhulu esimweni sakho kunenye.

I-Ramelteon iyimithi kadokotela eyenzelwe ngqo futhi yahlolwa ukwelapha ukuqwasha. Inamandla futhi iqhubeka ngaphezu kwezithasiselo ze-melatonin ezithengiswa ngaphandle kwekhawunta, futhi idlule ezivivinyweni zomtholampilo eziqinile zokufakazela ukuphepha kwayo nokusebenza kwayo.

Izithasiselo ze-melatonin ezithengiswa ngaphandle kwekhawunta zihluka kakhulu ngekhwalithi kanye nomthamo. Eminye imikhiqizo iqukethe i-melatonin eningi kakhulu noma encane kakhulu kunalokho okushiwo amalebula ayo, futhi isikhathi semiphumela yayo asibikezeleki. I-Ramelteon, njengoba iyimithi kadokotela, inezilawuli eziqinile zekhwalithi kanye nokulinganisa okuqhubekayo.

Ezindabeni zokulala ezithambile, ngezikhathi ezithile noma i-jet lag, izithasiselo ze-melatonin zingase zanele futhi nakanjani azibizi. Kodwa-ke, uma une-insomnia engapheli ethinta kakhulu impilo yakho yansuku zonke, imiphumela ethembeke kakhulu ye-ramelteon kanye nokuqondiswa kwezokwelapha kungase kufaneleke izindleko ezengeziwe nomzamo.

Udokotela wakho angakusiza ukuthi ulinganise izinzuzo nobubi benketho ngayinye ngokusekelwe kumaphethini akho okulala athile, eminye imithi oyithathayo, kanye nesithombe sakho sempilo esiphelele. Ngezinye izikhathi abantu baqala ngezithasiselo ze-melatonin bese beya ku-ramelteon uma bedinga okuthile okuqinile.

Imibuzo Evame Ukubuzwa Mayelana ne-Ramelteon

Q1. Ingabe i-Ramelteon iphephile ukusetshenziswa isikhathi eside?

I-Ramelteon ibonakala iphephe kakhulu ukusetshenziswa isikhathi eside kunezinye izidakamizwa zokulala ngoba ayibangeli ukuncika ngokomzimba noma ukubekezelelana. Izifundo zikhombisile ukuthi abantu bangayithatha izinyanga ngaphandle kokudinga imithamo ephezulu ukuze bagcine ukusebenza.

Kodwa-ke, ukusetshenziswa isikhathi eside kufanele ngaso sonke isikhathi kubhekwe udokotela wakho. Bazofuna ukuqapha ukuthi umuthi uqhubeka kanjani ukusebenza kahle kuwe futhi baqaphele noma yimaphi imiphumela emisha engemihle. Ukuhlolwa okuvamile kusiza ukuqinisekisa ukuthi i-ramelteon ihlala iyona ndlela engcono kakhulu yokukhathazeka kwakho ngokulala.

Q2. Kufanele ngenzeni uma ngiphuzile i-Ramelteon eningi ngengozi?

Uma ngengozi uphuza i-ramelteon eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ngenkathi ukweqisa kungavamile, ukuphuza okuningi kungabangela ukozela ngokweqile, ukudideka, noma ezinye izimpawu ezikhathazayo.

Ungazami ukuhlala uvukile noma uphuze i-caffeine ukuze ulwe nemiphumela. Kunalokho, iya endaweni ephephile lapho ungaphumula khona futhi ube nomuntu okukuqaphayo. Uma uhlangabezana nezimpawu ezinzima njengobunzima bokuphefumula noma ukudideka okukhulu, funa ukunakekelwa kwezempilo eziphuthumayo ngokushesha.

Q3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Ramelteon?

Uma uphuthelwa umthamo wakho we-ramelteon ngesikhathi sokulala, vele weqe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile ngobusuku obulandelayo. Ungathathi umthamo ophindwe kabili ukuze ulungise lowo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela engemihle.

Ukuphuza i-ramelteon phakathi kwamabili noma ekuseni kungakushiya uzizwa ubuthuntu ngosuku olulandelayo. Kungcono ukuba nobusuku obubodwa obunzima bokulala kunokubeka engozini ukozela ngosuku olulandelayo ngenxa yemithi engahlelwanga kahle.

Q4. Ngingayeka nini ukuphuza i-Ramelteon?

Ngokuvamile ungaqeda ukuphuza i-ramelteon lapho wena nodokotela wakho nivumelana ngokuthi ukulala kwakho kuthuthuke ngokwanele kangangokuthi awusadingi ukusekelwa ngemithi. Ngokungafani neminye imithi yokulala, i-ramelteon ngokuvamile ayidingi inqubo yokunciphisa kancane kancane.

Isikhathi siyahluka kumuntu ngamunye. Abanye abantu basebenzisa i-ramelteon amasonto ambalwa nje ukuze badlule esikhathini esicindezelayo, kanti abanye bangazuza ekwelashweni isikhathi eside. Udokotela wakho uzokusiza ukuthi ubone ukuthi usukulungele nini ukuzama ukulala ngaphandle kwemithi.

Q5. Ngingayithatha i-Ramelteon neminye imithi?

I-Ramelteon ingasebenzisana neminye imithi eminingi, ngakho-ke kubalulekile ukutshela udokotela wakho ngakho konke okuthathayo, okuhlanganisa nemithi etholakala ngaphandle kwemvume kadokotela kanye nezithasiselo. Eminye imithi ingenza i-ramelteon ingasebenzi kahle, kanti eminye ingakhuphula imiphumela yayo ezingeni eliyingozi.

Ama-antidepressants, ama-blood thinners, kanye nama-antibiotics athile angezinye zemithi engasebenzisana ne-ramelteon. Udokotela wakho uzobukeza uhlu lwakho oluphelele lwemithi futhi enze noma yiziphi izinguquko ezidingekayo ukuze akugcine uphephile ngenkathi elapha izinkinga zakho zokulala ngempumelelo.