Yini i-Ramucirumab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Ramucirumab iyikhambi lomdlavuza eliqondiwe elisiza ukunciphisa ukukhula kwesimila ngokuqeda ukuhlinzekwa kwegazi okondla amaseli omdlavuza. Yilokho odokotela abakubiza ngokuthi i-monoclonal antibody - okuyiphrotheni eyenziwe e-lab elenza njengohlelo lomzimba lwakho lokuzivikela emzimbeni ukulwa nezinto ezithile emdlavuzeni.

Lo muthi usebenza ngendlela ehlukile emithini yendabuko ye-chemotherapy. Esikhundleni sokuhlasela wonke amaseli ahlukanisa ngokushesha, i-ramucirumab iqondisa ngqo amaprotheni asiza izimila ukudala imithambo emisha yegazi, okuyindlela eqondile yokwelashwa komdlavuza.

Yini i-Ramucirumab Esetshenziselwa Yona?

I-Ramucirumab iphatha izinhlobo eziningi zomdlavuza othuthukile, ikakhulukazi lapho ezinye izindlela zokwelapha zingasebenzi njengoba bekulindelekile. Udokotela wakho we-oncologist unquma lo muthi ezimweni ezithile lapho ukuvimba ukukhula kwemithambo yegazi kungasiza ukulawula ukuqhubeka komdlavuza.

Imidlavaza emikhulu i-ramucirumab eyelapha ihlanganisa umdlavuza wesisu othuthukile, izinhlobo ezithile zomdlavuza wamaphaphu, nomdlavuza we-colorectal oye wasabalala kwezinye izingxenye zomzimba. Ivame ukusetshenziswa kanye neminye imithi yomdlavuza kunokuthi isetshenziswe yodwa.

Udokotela wakho angase ancome i-ramucirumab uma umdlavuza wakho uqhubekile naphezu kokwelashwa kwangaphambilini, noma njengengxenye yohlelo lokwelapha oluhlanganisiwe. Isimo ngasinye sihlukile, futhi udokotela wakho we-oncologist uzokuchazela ngqo ukuthi kungani lo muthi ulungela uhlelo lwakho oluthile lokwelapha.

Isebenza Kanjani i-Ramucirumab?

I-Ramucirumab ivimba iphrotheni ebizwa nge-VEGFR-2 esetshenziswa izimila ukukhulisa imithambo emisha yegazi. Cabanga ngayo njengokuqeda imigqa yokuhlinzeka enikeza amaseli omdlavuza izakhamzimba abazidingayo ukuze zikhule futhi zisabalale.

Lo muthi ubhekwa njengokwelashwa okuqondiwe okuphakathi nendawo. Akuyona into enokhahlo emzimbeni wakho wonke njenge-chemotherapy yendabuko, kodwa iseyikhambi elinamandla elidinga ukuqashwa ngokucophelela yithimba lakho lezempilo.

Umuthi usebenza ngokubopha kuma-receptors athile kumaseli emithambo yegazi, uwavimbela ukuthi angatholi izimpawu zokukhula. Lokhu kusiza ukulambisa imithombo yegazi ama-tumor ayidingayo, okunganciphisa ukukhula kwawo nokusabalala kwawo.

Kufanele Ngiyithathe Kanjani I-Ramucirumab?

I-Ramucirumab inikezwa kuphela nge-IV infusion ehhovisi likadokotela wakho noma esikhungweni se-infusion. Awukwazi ukuthatha lo muthi ekhaya - idinga ukugadwa kwezokwelapha ngobuchwepheshe njalo uma uwuthola.

I-infusion ngokuvamile ithatha imizuzu engaba ngu-60 ngomthamo wakho wokuqala, futhi ithimba lakho lezempilo lizokuqapha eduze ngalesi sikhathi. Uma ukubekezelela kahle ukufakwa kokuqala, imithamo yesikhathi esizayo inganikezwa ngemizuzu engama-30.

Akudingeki ukuthi wenze izinguquko ezikhethekile ekudleni ngaphambi kokufakwa kwakho, kodwa ukuhlala unamanzi ngokwanele ngokuphuza amanzi amaningi ezinsukwini eziholela ekwelashweni kwakho kungasiza umzimba wakho ukuthi ubhekane kangcono nomuthi. Ithimba lakho lezempilo lizokunikeza imiyalelo ethile mayelana nokudla nokuphuza ngaphambi kokuhlangana kwakho.

Ngaphambi kokufakwa ngakunye, cishe uzothola imithi yangaphambi kokwelashwa ukusiza ukuvimbela ukusabela komzimba. Lokhu kungabandakanya ama-antihistamines noma eminye imithi yokwenza ukwelashwa kwakho kube lula.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Ramucirumab?

Ubude bokwelashwa nge-ramucirumab buhlukahluka kakhulu kumuntu nomuntu futhi kuncike ekutheni umdlavuza wakho usabela kahle kangakanani nokuthi umzimba wakho uyawubekezelela kanjani umuthi. Abanye abantu bayawuthola izinyanga eziningana, kanti abanye bangase bawudinge isikhathi eside.

Udokotela wakho we-oncologist uzohlela izithombe ezivamile nokuhlolwa kwegazi ukuze aqaphe ukuthi ukwelashwa kusebenza kahle kangakanani. Lokhu kuhlolwa kusiza ukunquma ukuthi ngabe uzoqhubeka, ulungise, noma umise umuthi ngokuya ngempendulo yomdlavuza wakho.

Ukwelashwa ngokuvamile kuqhubeka kuze kube yilapho umdlavuza wakho uqhubeka, imiphumela emibi iba nzima kakhulu ukuphatha, noma wena nodokotela wakho ninquma ukuthi sekuyisikhathi sokuzama indlela ehlukile. Lesi sinqumo senziwa ngaso sonke isikhathi ndawonye ngokusekelwe empilweni yakho yonke kanye nemigomo yokwelashwa.

Ziyini Imiphumela Eceleni Ye-Ramucirumab?

Njengayo yonke imithi yomdlavuza, i-ramucirumab ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyithola ngendlela efanayo. Ithimba lakho lokunakekelwa kwezempilo lizokuqapha ngokucophelela futhi lisize ukuphatha noma yiziphi izinkinga eziphakamayo.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa ukukhathala, ukuncipha kwesifiso sokudla, kanye nezinguquko emfutheni wegazi lakho. Abantu abaningi baphawula nokuvuvukala ezandleni zabo noma ezinzwaneni zabo, okuvame ukulawuleka ngokunakekelwa okufanele.

Nansi imiphumela emibi evame kakhulu ethinta abantu abaningi abathatha i-ramucirumab:

• Umfutho wegazi ophezulu ongase udinge imithi
• Ukukhathala noma ukuzizwa ukhathele kakhulu kunokujwayelekile
• Ukuncipha kwesifiso sokudla nokulahlekelwa isisindo okungenzeka
• Ukukhathazeka
• Ukuvuvukala ezandleni, ezinzwaneni, noma emilenzeni
• Ukuqunjelwa noma izinguquko ekuhambeni kwamathumbu
• Isicanucanu ngaphandle kokuhlanza

Le miphumela emibi ejwayelekile ivame ukulawuleka ngokunakekelwa okusekelayo kanye nemithi uma kudingeka. Ithimba lakho lokunakekelwa kwezempilo linolwazi lokusiza iziguli ukuthi ziqondise lezi zinselelo.

Kukhona nemiphumela emibi engavamile kodwa ebucayi edinga ukunakekelwa kwezempilo ngokushesha. Nakuba lokhu kungenzeki kubantu abaningi, kubalulekile ukwazi ukuthi yini okufanele uyibheke ukuze uthole usizo ngokushesha uma kudingeka.

Imiphumela emibi ebucayi edinga ukunakekelwa kwezempilo ngokushesha ihlanganisa:

• Ukuphuma igazi okukhulu noma yikuphi emzimbeni wakho
• Amaqhubu egazi angadala ubuhlungu besifuba noma ukuphefumula kanzima
• Ukuphendula okukhulu komzimba ngesikhathi sokufakwa komuthi
• Izinkinga zokuphola kwamanxeba uma udinga ukuhlinzwa
• Izifo ezinzima ngenxa yokwehla kwamaseli amhlophe egazi
• Izinkinga zezinso ezivela ekuhlolweni kwegazi

Iqembu lakho lezempilo lizokugada ngokucophelela ukuze libone le miphumela emibi ngokusebenzisa ukuhlolwa kwegazi njalo nokuhlolwa. Abantu abaningi ababi nazo lezi zinkinga ezinzima, kodwa ukwazi ukuthi yini okufanele uyibheke kusiza ekuqinisekiseni ukuthi uthola ukunakekelwa ngokushesha uma kudingeka.

Ubani Ongafanele Athathe I-Ramucirumab?

I-Ramucirumab ayifanele wonke umuntu, futhi udokotela wakho we-oncologist uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuncoma lo muthi. Izimo ezithile zezempilo noma izimo zenza lo muthi ube yingozi kakhulu ukuthi usetshenziswe ngokuphepha.

Akufanele uthole i-ramucirumab uma ukhulelwe noma uhlela ukukhulelwa, njengoba kungalimaza kakhulu umntwana osakhula. Abesifazane abangakhulelwa badinga ukusebenzisa izindlela zokuvimbela inzalo ngesikhathi sokwelashwa nangemva kwezinyanga eziningana.

Abantu abahlinzwe ngokushesha, abaphuza igazi eliningi, noma abanezinkinga ezinzima zokujiya kwegazi ngokuvamile abakwazi ukuthola i-ramucirumab. Udokotela wakho uzophinda aqaphele uma unomfutho wegazi ophezulu ongagadiwe noma izinkinga zenhliziyo ezinzima.

Ezinye izimo ezingenza i-ramucirumab ingafaneleki zihlanganisa isifo sezinso esibi, ukuhlaselwa yinhliziyo noma unhlangothi olusanda kwenzeka, noma umlando wezinkinga ezinkulu zokuphuma igazi. Ithimba lakho lezempilo lizohlola zonke lezi zici ngaphambi kokuqala ukwelashwa.

Amagama Omkhiqizo we-Ramucirumab

I-Ramucirumab ithengiswa ngaphansi kwegama lomkhiqizo elithi Cyramza. Leli yigama lomkhiqizo elilodwa elitholakala ngalo muthi, njengoba kuyidrugi ekhethekile eyenziwa ngumkhiqizi oyedwa.

Uma uthola ukwelashwa kwakho, ibhodlela lomuthi lizobhalwa ngokuthi i-Cyramza, kodwa ithimba lakho lezokwelapha lizovame ukulibiza ngegama elivamile, i-ramucirumab. Womabili la magama abhekisela emuthini ofanayo.

Ezinye izindlela ze-Ramucirumab

Eminye imithi eminingi isebenza ngendlela efana ne-ramucirumab ngokugxila ekukhuleni kwemithambo yegazi emithanjeni. Udokotela wakho we-oncologist angase acabange lezi ezinye izindlela uma i-ramucirumab ingafaneleki esimweni sakho noma uma udinga indlela yokwelashwa ehlukile.

I-Bevacizumab ngomunye umuthi olwa ne-angiogenic osebenza ngokuvimba i-VEGF kunokuba i-VEGFR-2. Isetshenziselwa izinhlobo eziningi zomdlavuza ezifanayo futhi ingase ibe yindlela ongayikhetha kuye ngokuthi ukuxilongwa kwakho kanye nomlando wokwelashwa kwakho.

Ezinye izindlela zokwelapha ezihloswe ngazo njenge-aflibercept noma i-regorafenib nazo zingase zicatshangelwe ezinhlotsheni ezithile zomdlavuza. Udokotela wakho we-oncologist uzokhetha inketho engcono kakhulu ngokusekelwe ohlotsheni lomdlavuza wakho, ukwelashwa kwangaphambilini, kanye nesimo sempilo yakho esiphelele.

Ukukhetha phakathi kwale mithi kuncike ezintweni eziningi, okuhlanganisa ukuthi yimiphi imidlavuza evunyelwe ukuyelapha, ukuthi isebenzisana kanjani neminye imithi oyithathayo, kanye nezici zakho eziyingozi zokuthola imiphumela emibi.

Ingabe i-Ramucirumab ingcono kune-Bevacizumab?

Kokubili i-ramucirumab ne-bevacizumab yimithi ephumelelayo elwa ne-angiogenic, kodwa isebenza ngendlela ehlukile kancane futhi isetshenziselwa izimo ezihlukene. Akukho noyedwa othi “ungcono” ngokujwayelekile - ukukhetha kuncike ohlotsheni lomdlavuza wakho kanye nomlando wokwelashwa kwakho.

I-Ramucirumab ivimba ngokuqondile i-VEGFR-2 receptor, kuyilapho i-bevacizumab ivimba iphrotheni ye-VEGF ehlanganisa naleyo receptor. Lo mahluko endleleni yokusebenza ungenza enye ifaneleke kakhulu kunenye esimweni sakho esithile.

Ngesifo somdlavuza wesisu, i-ramucirumab ibonise izinzuzo ezithile eziyenze yaba yindlela ekhethwayo ezimweni eziningi. Kodwa-ke, i-bevacizumab ingase ibe ngcono kwezinye izinhlobo zomdlavuza noma izimo lapho i-ramucirumab ingafaneleki.

Udaktela wakho we-oncologist uzocabangela izinto ezifana nohlobo lomdlavuza wakho, ukwelashwa kwangaphambilini, iphrofayili yemiphumela emibi, kanye nempilo yakho yonke lapho ekhetha phakathi kwalawo mithi. Ukukhetha okuthi "kungcono" ngaso sonke isikhathi yilokho okungenzeka kakhulu ukuthi kuzosiza isimo sakho esithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Ramucirumab

Ingabe i-Ramucirumab iphephile kubantu abanezifo zenhliziyo?

I-Ramucirumab idinga ukucatshangelwa ngokucophelela uma unezifo zenhliziyo, njengoba ingathinta umfutho wegazi futhi ingase ikhulise ingozi yamaqhubu egazi. Udokotela wakho wenhliziyo kanye ne-oncologist bazosebenzisana ukunquma ukuthi izinzuzo zidlula yini izingozi esimweni sakho esithile.

Uma unomlando wezinkinga zenhliziyo, ithimba lakho lezempilo lizokuqapha eduze ngesikhathi sokwelashwa. Bangase balungise imithi yakho yenhliziyo noma bathathe izinyathelo ezengeziwe zokuvikela impilo yakho yenhliziyo nemithambo yegazi ngenkathi wamukela i-ramucirumab.

Ngingenzani uma ngisebenzisa i-Ramucirumab eningi ngengozi?

Njengoba i-ramucirumab inikezwa kuphela ochwepheshe bezempilo ezindaweni zezokwelapha, ukweqisa ngengozi akunakwenzeka. Umuthi ulinganiswa ngokucophelela futhi unikezwa yizisebenzi zezokwelapha eziqeqeshiwe ezilandela imithetho eqinile.

Uma ukhathazekile ngomthamo wakho noma uthola izimpawu ezingavamile ngemuva kokufakwa, xhumana nethimba lakho lezempilo ngokushesha. Bangahlola isimo sakho futhi banikeze ukunakekelwa okufanele uma kudingeka.

Ngingenzani uma ngiphuthelwa umthamo we-Ramucirumab?

Uma uphuthelwa ukufakwa kwe-ramucirumab okuhleliwe, xhumana nehhovisi likadokotela wakho we-oncologist ngokushesha ngangokunokwenzeka ukuze uhlele kabusha. Ungazami ukwenza umthamo ophuthelwe ngokwenza kabili - udokotela wakho uzonquma indlela engcono yokubuyela emgqeni ngohlelo lwakho lokwelashwa.

Ukuphuthelwa umthamo owodwa ngokuvamile akulithinti ngokuphawulekayo ukwelashwa kwakho, kodwa kubalulekile ukugcina isimiso esiqhubekayo ngangokunokwenzeka ukuze uthole imiphumela emihle. Ithimba lakho lokunakekelwa kwezempilo lizosebenza nawe ukuthola isikhathi sokuqokwa esisha esihambisana nesimiso sakho.

Ngingayeka nini ukuthatha i-Ramucirumab?

Ungayeka ukuthatha i-ramucirumab lapho i-oncologist yakho inquma ukuthi ayisazuzi, lapho imiphumela emibi iba nzima kakhulu ukuyilawula, noma lapho unquma ukuthi ukwelashwa akusahambisani nemigomo yakho. Lesi sinqumo kufanele senziwe ngaso sonke isikhathi kanye nethimba lakho lokunakekelwa kwezempilo.

Udokotela wakho uzohlola njalo ukuthi imithi isebenza kahle kangakanani ngokuskena kanye nokuhlolwa kwegazi. Uma umdlavuza wakho uqhubeka noma uma uhlangabezana nemiphumela emibi engathi sína, bangase bancomise ukuyeka i-ramucirumab futhi bahlole ezinye izindlela zokwelapha.

Ngingakwazi yini ukuthola imithi yokugoma ngenkathi ngithatha i-Ramucirumab?

Ungathola imithi yokugoma eminingi ngenkathi uthatha i-ramucirumab, kodwa kufanele ugweme imithi yokugoma ephilayo ngesikhathi sokwelashwa. I-oncologist yakho izohlinzeka ngesiqondiso esiqondile mayelana nokuthi yimiphi imithi yokugoma ephephile nokuthi ingahlelwa nini.

Kubaluleke kakhulu ukuhlala usesikhathini ngemithi yokugoma umkhuhlane kanye nemithi yokugoma i-COVID-19 ngenkathi uthola ukwelashwa komdlavuza, ngoba lokhu kungakusiza ukuthi uzivikele lapho amasosha akho omzimba engase abe sengozini. Hlala uxoxa ngezinhlelo zokugoma nethimba lakho lokunakekelwa kwezempilo ngaphambi kokuthola noma yiziphi izibhamu.