Yini i-Rasagiline: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Rasagiline iyimithi kadokotela esiza ukuphatha izimpawu zesifo sikaParkinson ngokuvimba i-enzyme eqeda i-dopamine ebuchosheni bakho. Le mithi emnene kodwa esebenzayo isebenza buthule ngemuva ukusiza ukugcina i-dopamine ubuchopho bakho obuyidingayo ukuze kube nokunyakaza okubushelelezi nokuxhumana.

Uma wena noma othile omkhathalelayo enikwe i-rasagiline, cishe ufuna imininingwane ecacile, eqotho mayelana nokuthi yini ongayilindela. Ake sihambe kukho konke okudingeka ukwazi ngale mithi ngendlela ezizwa iphatheka futhi iqinisekisa.

Yini i-Rasagiline?

I-Rasagiline ingeyeqembu lemithi ebizwa ngokuthi ama-MAO-B inhibitors, okusho ukuthi ivimba i-enzyme ethile ebuchosheni bakho ebizwa ngokuthi i-monoamine oxidase type B. Le enzyme ngokuvamile iqeda i-dopamine, isithunywa samakhemikhali esisiza ukulawula ukunyakaza nokuxhumana.

Ngokuvimba ngobumnene le enzyme, i-rasagiline isiza ukugcina i-dopamine etholakala ebuchosheni bakho. Cabanga ngayo njengokusiza ubuchopho bakho ukuthi bubambe i-dopamine obusenza, kunokuyiphoqa ukuthi ikhiqize okwengeziwe.

Le mithi ithathwa njengenketho yokwelashwa enamandla amaphakathi. Ayinamandla njenge-levodopa, kodwa inikeza ukusekelwa okuqhubekayo, okuqhubekayo abantu abaningi abakuthola kuwusizo ekuphatheni izimpawu zabo.

Isetshenziselwani i-Rasagiline?

I-Rasagiline ikakhulukazi inikezwa ukwelapha isifo sikaParkinson, kokubili njengokwelashwa okuzimele ezigabeni zokuqala kanye nokwelashwa okwengeziwe uma isetshenziswa neminye imithi. Udokotela wakho angase ayincomise uma uhlangabezana nobunzima bokunyakaza, ukuqina, noma ukuthuthumela okuhlobene nesifo sikaParkinson.

Ezigabeni zokuqala zesifo sikaParkinson, i-rasagiline ingasiza ukubambezela isidingo semithi enamandla ngenkathi inikeza ukukhululeka kwezimpawu. Lapho i-Parkinson iqhubeka, ivame ukuhlanganiswa ne-levodopa ukusiza ukuthambisa ukwehla nokukhuphuka okungenzeka ngaleyo mithi.

Abanye odokotela baphinda banikeze i-rasagiline ngaphandle kwemvume yezinye izimo ezihilela i-dopamine, nakuba lokhu kungavamile. Umhlinzeki wakho wezempilo uzoqaphela ukuthi lo muthi ulungile yini esimweni sakho esithile.

Isebenza Kanjani I-Rasagiline?

I-Rasagiline isebenza ngokuvimba ngokuqondile i-enzyme ye-MAO-B ebuchosheni bakho, okuyilena enomthwalo wokwehlisa i-dopamine. Uma le enzyme ivinjelwe, amazinga e-dopamine ahlala ezinzile usuku lonke.

Le nqubo yenzeka kancane kancane futhi ngobumnene. Ngeke uzizwe ngokushesha noma ushintsho olukhulu njengoba ungenza ngeminye imithi. Kunalokho, i-rasagiline inikeza ukusekelwa okuzinzile okwakhiwa ngokuhamba kwesikhathi.

Lo muthi ungase futhi ube nemiphumela ethile evikelayo emangqamuzaneni ezinzwa, nakuba abacwaningi besafunda ngalo leli thuba elingaba khona. Esikwaziyo ngokuqinisekile ukuthi kusiza ukugcina amazinga e-dopamine ngendlela esekela ukunyakaza okungcono nokuxhumana.

Kufanele Ngiyithathe Kanjani I-Rasagiline?

I-Rasagiline ivamise ukuthathwa kanye ngosuku, ngokuvamile ekuseni ngokudla noma ngaphandle kokudla. Umthamo ojwayelekile wokuqala uvame ukuba ngu-0.5 mg, okungenzeka ukuthi udokotela wakho awunyuse ube ngu-1 mg ngosuku ngokuya ngempendulo yakho nezidingo zakho.

Ungawuthatha lo muthi ngamanzi, futhi akukhathazi ukuthi usanda kudla yini. Kodwa-ke, abanye abantu bakuthola kulula ukukhumbula uma bewuthatha nge-breakfast noma enye inqubo yasekuseni ejwayelekile.

Zama ukuthatha i-rasagiline ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga azinzile ohlelweni lwakho. Uma uyithatha neminye imithi ye-Parkinson, udokotela wakho uzohlinzeka ngemiyalelo ethile yokuhlela isikhathi ukuze uthuthukise indlela asebenza ngayo ndawonye.

Njalo gwinya ithebhulethi yonke kunokuyichoboza noma ukuyihlafuna. Lokhu kuqinisekisa ukuthi umuthi ukhululwa ngendlela efanele ohlelweni lwakho.

Kufanele Ngiyithathe Isikhathi Eside Kangakanani I-Rasagiline?

I-Rasagiline ngokuvamile imithi yesikhathi eside ozoqhubeka uyithatha uma nje isiza izimpawu zakho. Abantu abaningi abanesifo iParkinson bayayithatha izinyanga noma iminyaka, njengoba yenzelwe ukunikeza ukusekelwa okuqhubekayo kunokulungisa okusheshayo.

Udokotela wakho uzoqapha ukuthi imithi ikusebenzela kahle kangakanani ngesikhathi sokuhlolwa okuvamile. Bazobheka ukuthi izimpawu zakho zisabela kanjani nokuthi ngabe uhlangabezana nemiphumela emibi edlula izinzuzo.

Abanye abantu bathatha i-rasagiline iminyaka eminingi ngemiphumela emihle, kanti abanye bangadinga ukulungiswa ohlelweni lwabo lokwelashwa njengoba isimo sabo sishintsha. Okubalulekile ukugcina ukuxhumana okuvulekile nethimba lakho lezempilo mayelana nendlela ozizwa ngayo.

Yiziphi Imiphumela Emibi ye-Rasagiline?

Njengayo yonke imithi, i-rasagiline ingabangela imiphumela emibi, yize abantu abaningi beyibekezelela kahle. Ukuqonda ukuthi okulindelekile kungakusiza uzizwe ulungiseleleke futhi uqiniseke ngemithi yakho.

Imiphumela emibi evame kakhulu ivame ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi:

• Ukucabuka kwekhanda
• Ubuhlungu emalungeni noma ukuqina
• Ukungagayeki kahle kokudla noma isisu esibuhlungu
• Izimpawu ezinjengomkhuhlane
• Ukucindezeleka noma izinguquko zemizwa
• Isiyezi
• Umlomo owomile

Le miphumela emibi yansuku zonke ngokuvamile ayidingi ukuyeka imithi, kodwa kufanele uxoxe ngayo nodokotela wakho uma iba yisicefe noma iqhubeka.

Imiphumela emibi engavamile kodwa ebucayi ingenzeka, yize ithinta abantu abambalwa:

• Iziqephu ezingazelelwe zokulala ngesikhathi semisebenzi yansuku zonke
• Ukucabanga okungamanga noma ukudideka
• Ukuphendula kwesikhumba okukhulu noma ukuqubuka
• Izifiso ezingavamile noma ukuziphatha (ukugembula, ukuthenga, ukudla)
• Ushintsho olukhulu lomfutho wegazi
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile

Uma uhlangabezana nanoma yimaphi alawa maphumelelo abucayi kakhulu, xhumana nomhlinzeki wakho wezempilo ngokushesha. Bangasiza ekunqumeni ukuthi ngabe umuthi udinga ukulungiswa noma ukuyekiswa.

Ngokuvamile kakhulu, i-rasagiline ingasebenzisana nokudla okuthile okuqukethe i-tyramine eningi (njengoshizi omdala noma inyama elashwe) noma eminye imithi ukubangela ukwanda okuyingozi komfutho wegazi. Udokotela wakho uzohlinzeka ngemihlahlandlela ethile yokudla uma kudingeka.

Ubani Ongafanele Athathe I-Rasagiline?

I-Rasagiline ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyibhala. Izimo ezithile kanye nemithi kungenza i-rasagiline ingaphephile noma ingasebenzi kahle.

Akufanele uthathe i-rasagiline uma njengamanje usebenzisa ama-antidepressants athile, ikakhulukazi ama-MAOI, ama-SSRI, noma ama-SNRI. Inhlanganisela ingabangela ukusebenzisana okuyingozi okuthinta umfutho wegazi lakho kanye ne-chemistry yobuchopho.

Abantu abanezifo zesibindi ezinzima kufanele bagweme i-rasagiline ngoba isibindi sisebenzisa lo muthi. Udokotela wakho angase ayalele ukuhlolwa komsebenzi wesibindi ngaphambi kokuqala ukwelashwa ukuze aqinisekise ukuthi kuphephile kuwe.

Eminye imithi engahambisani kahle ne-rasagiline ihlanganisa:

• I-Meperidine (pethidine) neminye imithi yokwelapha ubuhlungu ye-opioid
• I-Dextromethorphan (etholakala emithini yokukhwehlela)
• I-St. John's wort
• I-Tramadol
• Ama-antibiotics athile afana ne-linezolid

Njalo tshela udokotela wakho ngayo yonke imithi, izithasiselo, kanye nemikhiqizo yamakhambi oyithathayo. Lokhu kufaka phakathi imithi etholakala ngaphandle kwe-oda engase ibonakale ingenangozi kodwa ingasebenzisana ne-rasagiline.

Amagama Omkhiqizo we-Rasagiline

I-Rasagiline itholakala ngaphansi kwegama lomkhiqizo elithi Azilect, okuyilona okubhalwa kakhulu. Izinhlobo ezivamile ze-rasagiline nazo ziyatholakala futhi zisebenza ngendlela efanayo nomuthi wegama lomkhiqizo.

Ikhemisi lakho lingase libe nophawu lomkhiqizo noma inguqulo ejwayelekile, kuye ngokuthi umshwalense wakho uhlanganisa ini nezintandokazi zakho. Zombili ziqukethe isithako esifanayo esisebenzayo futhi ziyasebenza ngokulinganayo.

Uma ushintsha phakathi kwezinhlobo zomkhiqizo nezivamile, noma phakathi kwabakhiqizi abahlukene abavamile, yazisa udokotela wakho. Nakuba kungavamile, abanye abantu baqaphela umehluko omncane endleleni abazizwa ngayo, futhi udokotela wakho angasiza ukuqapha impendulo yakho.

Ezinye izindlela zokwelapha i-Rasagiline

Eminye imithi eminingi ingelapha isifo sikaParkinson uma i-rasagiline ingakulungele noma iyeka ukusebenza ngempumelelo. Udokotela wakho angase acabangele lezi ezinye izindlela zokwelapha ngokusekelwe ezimpawini zakho ezithile kanye nomlando wakho wezokwelapha.

Ezinye izithiyo ze-MAO-B zihlanganisa i-selegiline, esebenza ngendlela efana ne-rasagiline kodwa ithathwa kabili ngosuku. Abanye abantu benza ngcono ngomunye kunomunye, ngokuvamile ngenxa yamaphrofayili emiphumela emibi noma izintandokazi zesikhathi.

Ama-dopamine agonists afana ne-pramipexole, ropinirole, noma i-rotigotine (etholakala njengesichibi) asebenza ngendlela ehlukile ngokuqondile ngokuvuselela izamukeli ze-dopamine. Lezi zingaba ezinye izindlela eziphumelelayo, ikakhulukazi ekuqaleni kwesifo sikaParkinson.

Ngezimpawu ezithuthukisiwe, i-levodopa isahlala iyindlela yokwelapha yegolide. Ivame ukuhlanganiswa ne-carbidopa ukunciphisa imiphumela emibi futhi ithuthukise ukusebenza kahle. Udokotela wakho angase akuncome lokhu uma i-rasagiline yodwa inganikezi ukulawulwa okwanele kwezimpawu.

Ingabe i-Rasagiline ingcono kune-Selegiline?

Kokubili i-rasagiline ne-selegiline ziyizithiyo ze-MAO-B ezisebenza ngendlela efanayo, kodwa zinezinto ezibalulekile ezingenza enye ikufaneleke kakhulu kunenye.

I-Rasagiline ithathwa kanye ngosuku, kuyilapho i-selegiline ivame ukuthathwa kabili ngosuku. Lokhu kungenza i-rasagiline ilungele abantu abaningi, ikakhulukazi labo asebevele bephatha imithi eminingi.

Ezinye izifundo zikhomba ukuthi i-rasagiline ingase ibe nokusebenzisana okuncane nokudla okuqukethe i-tyramine, nakuba yomibili imithi ngokuvamile idinga ukuqwashisa okuthile ngokudla. I-Rasagiline nayo ivame ukuba nomphumela oqagelwayo kubantu abaningi.

I-Selegiline isitholakala isikhathi eside futhi inemininingwane yokuphepha yesikhathi eside, okuyilokho odokotela abathile abakuthandayo. Nokho, i-rasagiline ivame ukubangela ukuphazamiseka okuncane kokulala njengoba ingahlukaniswa ibe yizinhlanganisela ezinjenge-amphetamine.

Udokotela wakho uzocabangela umsebenzi wakho wansuku zonke, eminye imithi, nezintandokazi zomuntu siqu lapho ekhetha phakathi kwalezi zinketho. Akukho noyedwa ongcono ngokuqondile - kuncike kulokho okusebenzela kangcono isimo sakho somuntu ngamunye.

Imibuzo Evame Ukubuzwa Mayelana ne-Rasagiline

Ingabe i-Rasagiline iphephile kubantu abanezifo zenhliziyo?

I-Rasagiline ingasetshenziswa ngokuphepha kubantu abaningi abanezifo zenhliziyo, kodwa idinga ukuqapha okucophelelayo. Imithi ingase ngezinye izikhathi ithinte umfutho wegazi nesigqi senhliziyo, ngakho udokotela wakho uzofuna ukubukeza umlando wakho wenhliziyo ngokucophelela.

Uma unesifo senhliziyo esilawulwa kahle, i-rasagiline ingase isaba yindlela ongayikhetha ngaphansi kokuqondiswa okufanele kwezokwelapha. Udokotela wakho angase ancome ukuhlolwa okuningi noma ukuqapha okwengeziwe kwenhliziyo lapho uqala imithi.

Abantu abanomfutho wegazi ophezulu ongagadiwe noma abahlaselwe yinhliziyo yamuva kungenzeka badinge ukugwema i-rasagiline noma bayisebenzise ngokuqapha okukhulu. Hlala uxoxa ngomlando wakho ophelele wenhliziyo nomhlinzeki wakho wezempilo ngaphambi kokuqala noma iyiphi imithi emisha.

Ngingenzani uma ngiphuthelwa ngithatha i-Rasagiline eningi kakhulu?

Uma ngengozi uthatha i-rasagiline eningi kakhulu kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kakhulu kungabangela izinguquko eziyingozi zomfutho wegazi, ikhanda elibuhlungu eliqinile, noma ezinye izimpawu ezinzima.

Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini – thola iseluleko sezokwelapha ngokushesha. Ukuba nebhodlela lomuthi nawe kungasiza abahlinzeki bezempilo ukuthi banqume ngqo ukuthi ungakanani owuthathile futhi banikeze ukwelashwa okufanele.

Ukuvimbela ukweqisa ngengozi, cabangela ukusebenzisa umhleli wamaphilisi noma ukusetha izikhumbuzi zocingo. Uma unakekela umuntu onezinkinga zenkumbulo, basize ukuthi basungule inqubo yokuthatha imithi ephephile.

Ngingenzani Uma Ngeqe Umthamo We-Rasagiline?

Uma weqa umthamo we-rasagiline, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo. Kulokho, weqa umthamo oweqiwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo oweqiwe. Lokhu kungakhuphula ingozi yakho yemiphumela engemihle ngaphandle kokunikeza inzuzo eyengeziwe.

Uma uvame ukukhohlwa imithamo, zama ukuxhumanisa imithi yakho nenqubo yansuku zonke njengokuxubha amazinyo akho noma ukudla ibhulakufesi. Ukuqina kusiza ukugcina amazinga aqinile emithi ohlelweni lwakho.

Ngingayeka Nini Ukuthatha I-Rasagiline?

Kufanele uyeke kuphela ukuthatha i-rasagiline ngaphansi kwesiqondiso sikadokotela wakho. Ukuyeka kungazelelwe ngeke kubangele izimpawu zokuhoxisa eziyingozi, kodwa izimpawu zakho ze-Parkinson zingase zibuye noma zibe zimbi ngaphandle kokusekelwa komuthi.

Udokotela wakho angase ancome ukuyeka i-rasagiline uma uhlangabezana nemiphumela emibi ebalulekile, uma ingasawusizi izimpawu zakho, noma uma ushintshela endleleni yokwelapha ehlukile.

Abanye abantu banganciphisa kancane umthamo wabo ngaphambi kokuyeka ngokuphelele, kanti abanye bangayeka ngokushesha ngokuya ngesincomo sikadokotela wabo. Okubalulekile ukuba nohlelo olukhona lokulawula izimpawu zakho ngesikhathi sokuguquka.

Ngingakwazi Yini Ukuphuza Utshwala Ngenkathi Ngithatha I-Rasagiline?

Ukusetshenziswa kotshwala okulinganiselwe kuvamile ukwamukeleka ngenkathi uthatha i-rasagiline, kodwa kufanele uxoxe ngalokhu nodokotela wakho kuqala. Utshwala bungasebenzisana nemithi kanye nezimpawu zesifo sikaParkinson ngezindlela ezihlukahlukene kumuntu nomuntu.

Abanye abantu bathola ukuthi utshwala bunyusa izimpawu zabo zokunyakaza noma ukwandisa isiyezi uma kuhlangene ne-rasagiline. Abanye bangase baqaphele ukuthi ukubekezelelana kwabo okuvamile kotshwala kushintshile selokhu baqala umuthi.

Uma udokotela wakho evuma ukusetshenziswa kotshwala ngezikhathi ezithile, qala ngezilinganiso ezincane ukuze ubone ukuthi umzimba wakho usabela kanjani. Njalo qinisekisa ukuphepha kwakho futhi gwema utshwala uma uqaphela noma yikuphi ukusebenzisana okukhathazayo noma izimpawu ezikhulayo.