Yini i-Remdesivir: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Remdesivir iyimithi elwa namagciwane esiza umzimba wakho ukuthi ulwe nezifo ezithile ezibangelwa amagciwane ngokuvimbela amagciwane ukuthi azande. Ungase uyazi kangcono njengenye yezindlela zokwelapha ezisetshenziselwa i-COVID-19, nakuba ekuqaleni yayenzelwe ukwelapha ezinye izifo ezibangelwa amagciwane ezingathi sína. Le mithi isebenza ngokungenelela endleleni amagciwane azikopisha ngayo ngaphakathi kwamaseli akho, inikeze amasosha akho omzimba ithuba elingcono lokususa lesi sifo.

Yini i-Remdesivir?

I-Remdesivir iyisidakamizwa esilwa namagciwane esinikezwa ngudokotela esingaphansi kohlobo lwemithi ebizwa ngokuthi ama-nucleoside analogs. Cabanga ngayo njenge-decoy yama-molecular ekhohlisa amagciwane ukuthi ayisebenzise esikhundleni sezinto okufanele azakhe ukuze azale. Uma amagciwane ezama ukusebenzisa i-remdesivir ukwenza amakhophi awo, inqubo iyaphazamiseka futhi iyeka ukusebenza kahle.

Le mithi yaqala ukuthuthukiswa yi-Gilead Sciences ukwelapha isifo se-Ebola virus. Nokho, abacwaningi bathola ukuthi ingasebenza kahle nakwamanye amagciwane futhi, okuhlanganisa i-coronavirus ebangela i-COVID-19. Lesi sidakamizwa sathola imvume yokusetshenziswa ngokuphuthuma e-FDA ngo-2020 kanye nokugunyazwa okugcwele ngo-2021 ukwelapha i-COVID-19 ezigulini ezibhedlela.

I-Remdesivir ithathwa njengemithi elwa namagciwane enamandla amaphakathi. Nakuba inganamandla njengamanye ama-antivirals asetshenziselwa izimo ezihlukene, ikhombise izinzuzo eziqondakalayo ekunciphiseni isikhathi sokululama futhi mhlawumbe ivimbele izinkinga ezinzima ezigulini ezithile ezinayo i-COVID-19.

Isetshenziselwani i-Remdesivir?

I-Remdesivir isetshenziswa ikakhulukazi ukwelapha i-COVID-19 kubantu abadala neziguli zezingane ezingena esibhedlela noma ezingozini enkulu yesifo esibi. Le mithi ibonakale isebenza kahle kakhulu uma iqala ekuqaleni kwesifo, okungcono phakathi nezinsuku ezimbalwa zokuqala kwezimpawu.

Abahlinzeki bezempilo ngokuvamile banikeza i-remdesivir ezigulini ezinemiphumela ephakathi nendawo kuya kokubi kakhulu ye-COVID-19 futhi ezidinga umoya-mpilo owengeziwe noma okunye ukunakekelwa okusekelayo. Isetshenziswa futhi ezigulini ezithile eziphuma ngaphandle ezinengozi enkulu ezinokugula okungathi sína kuya kokulinganiselwe kwe-COVID-19 kodwa okungenzeka ukuthi zizoya ekuguleni okukhulu ngokusekelwe emlandweni wazo wezokwelapha kanye nezici eziyingozi.

Ngaphandle kwe-COVID-19, i-remdesivir ifundwe kwezinye izifo ezibangelwa amagciwane, nakuba lezi zinto ezisetshenziswayo zingavamile. Abanye odokotela baye bayisebenzisa ngaphandle kwesitifiketi sezifo ezinzima zokuphefumula (RSV) noma ezinye izifo ezibangelwa amagciwane ezingathi sína, ikakhulukazi ezigulini ezingakwazi ukumelana nezifo ezingase zingasabeli kahle ekwelashweni okujwayelekile.

Isebenza Kanjani I-Remdesivir?

I-Remdesivir isebenza ngokulingisa enye yezakhi zemvelo ezidingwa amagciwane ukuze akopishe izinto zawo zofuzo. Lapho igciwane lizama ukuzikopisha, ngokungaqondile lifaka i-remdesivir kulandelana kwalo kofuzo esikhundleni sengxenye efanele.

Uma i-remdesivir isifakiwe ezintweni zofuzo zegciwane, isebenza njengomgwaqo ovimbayo ovimbela igciwane ukuthi liqede inqubo yalo yokuziphinda. Lokhu ngempumelelo kumisa igciwane ekwenzeni amakhophi amasha awo, okwenza ukuthi uhlelo lwakho lomzimba lokuzivikela lunikeze impendulo eqinile futhi lususe ukutheleleka.

Umuthi uqondise ngqo i-enzyme ebizwa nge-RNA polymerase, ebalulekile kumagciwane amaningi ukuze azale. Ngokuvimba le enzyme, i-remdesivir inganciphisa noma imise ukuziphinda kwamagciwane ezinhlotsheni ezahlukene zamagciwane, nakuba isebenza kahle kakhulu kumagciwane athile e-RNA afana nama-coronaviruses.

Kufanele Ngiyithathe Kanjani I-Remdesivir?

I-Remdesivir itholakala kuphela njengomuthi we-intravenous (IV), okusho ukuthi kufanele inikezwe ngokuqondile emgombeni wakho nge-vein. Awukwazi ukuthatha lo muthi ngomlomo, futhi kufanele unikezwe endaweni yokunakekelwa kwezempilo efana nesibhedlela, isikhungo sokufaka umuthi, noma umtholampilo wabangaphandle.

Umuthi ngokuvamile unikezwa njengokufakwa kwe-IV okuhamba kancane ngemizuzu engama-30 kuya kwengama-120, kuye ngomthamo kanye nezimo zakho. Ithimba lakho lezempilo lizokuqapha eduze ngesikhathi nangemva kokufakwa ngakunye ukuze libheke noma yiziphi izindlela ezingezinhle noma imiphumela emibi.

Akudingeki ukuthi udle noma uphuze noma yini ekhethekile ngaphambi kokuthola i-remdesivir, nakuba ukuhlala unamanzi njalo kusiza uma ulwa nokutheleleka. Ithimba lakho lezokwelapha lizohlinzeka ngemiyalelo ethile mayelana nokudla nokuphuza ngokusekelwe esimweni sakho esiphelele kanye neminye imithi ongase uyithole.

Inqubo yokufakwa ngokwayo ivamise ukuba lula. Uzohlala kahle noma ulale embhedeni ngenkathi umuthi uconsa kancane emgqeni wakho we-IV. Iziguli eziningi zisebenzisa lesi sikhathi ukuze ziphumule, zifunde, noma zibuke ukuzijabulisa kumadivayisi azo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Remdesivir?

Inkambo ejwayelekile yokwelashwa nge-remdesivir ihlala izinsuku ezi-3 kuya kwezi-5, nakuba lokhu kungahluka ngokuya ngesimo sakho esithile nokuthi usabela kanjani emuthini. Udokotela wakho uzonquma ubude obuqondile bokwelashwa ngokusekelwe ezintweni ezinjengobunzima bokugula kwakho, impilo yakho yonke, nokuthi ululama ngokushesha kangakanani.

Ezigulini ezibhedlela ezinomkhuhlane i-COVID-19, inkambo yokwelashwa ejwayelekile ivamise ukuba yizinsuku ezi-5. Kodwa-ke, uma ukhombisa ukuthuthuka okukhulu, udokotela wakho angase anqume ukuqeda ukwelashwa ngemva kwezinsuku ezi-3 nje. Kwezinye izimo lapho ukululama kuhamba kancane noma kuvela izinkinga, ukwelashwa kungase kunwetshwe ngaphezu kwezinsuku ezi-5.

Iziguli eziphathwa ngaphandle kwesibhedlela ezithola i-remdesivir ngokuvamile zithola inkambo yokwelashwa yezinsuku ezi-3. Lesi sikhathi esifushane sivame ukwanele kubantu abaphathwa ekuqaleni kokugula kwabo futhi abangabi nazimpawu ezinzima.

Iqembu lakho lezempilo lizohlola intuthuko yakho nsuku zonke futhi lingashintsha uhlelo lokwelapha njengoba kudingeka. Bazocabangela izinto ezinjengamazinga akho omoya-mpilo, ukuthuthuka kwezimpawu, nesimo sonke somtholampilo lapho benquma ukuthi ngabe baqhubeka noma baqede yini inkambo ye-remdesivir.

Yiziphi Izimo Ezingezinhle Ze-Remdesivir?

Abantu abaningi bayamukela kahle i-remdesivir, kodwa njengayo yonke imithi, ingabangela imiphumela emibi kwabanye abantu. Izindaba ezinhle ukuthi imiphumela emibi engathí sina ayivamile, futhi iqembu lakho lezempilo lizokuqapha ngokucophelela ngesikhathi sokwelashwa.

Nawa amanye amiphumela emibi ejwayelekile ongase uyithole, futhi ukuqonda lokhu kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi ungakhathazeki ngokuphathelene nokwelashwa kwakho:

• Ukucasuka: Lesi yisimo esibi esibikiwe kaningi, esithinta cishe umuntu oyedwa kwabayishumi. Ngokuvamile kulula futhi kuvame ukulawulwa ngemithi elwa nokucasuka uma kudingeka.
• Ukwenyuka kwama-enzyme esibindi: Ukuhlolwa kwegazi kungakhombisa ukwanda okwesikhashana kwama-marker omsebenzi wesibindi, okuvame ukubuyela kokujwayelekile ngemuva kokuphela kokwelashwa.
• Ukuphendula kwendawo yokufaka umjovo: Abanye abantu bazwa ubuhlungu obuncane, ukuvuvukala, noma ububomvu endaweni ye-IV.
• Ikhanda: Lokhu kwenzeka ngamaphesenti amancane eziguli futhi ngokuvamile kulula noma kulukhuni.
• Ukukhathala: Ungase uzizwe ukhathele kunokujwayelekile, yize lokhu kungahlobana nesifo sakho esingaphansi.

Le miphumela emibi ejwayelekile ngokuvamile iyalawuleka futhi ivame ukuzixazulula yona. Iqembu lakho lezempilo linolwazi lokusiza iziguli ngalezi zinkinga zesikhashana.

Kukhona nemiphumela emibi engavamile kodwa engathí sina ukuthi iqembu lakho lezokwelapha lizoyibheka ngokucophelela. Ngenkathi lokhu kungavamile, kubalulekile ukukwazi:

• Ukuphendula komzimba: Ukuphendula komzimba okukhulu akuvamile kodwa kungabandakanya ubunzima bokuphefumula, ukuvuvukala ebusweni noma emqaleni, noma ukuqubuka okusabalalele.
• Izinkinga zezinso: Ezimweni ezingavamile, i-remdesivir ingase ithinte ukusebenza kwezinso, yingakho odokotela bakho bezobheka ukusebenza kwezinso zakho ngokuhlolwa kwegazi.
• Ukwelashwa kwesibindi: Ngenkathi ukunyuka okuncane kwama-enzyme esibindi kuvamile, izinkinga ezinkulu zesibindi azivamile kakhulu kodwa kungenzeka.
• Ukuphendula kokufakwa: Ezinye iziguli zingase zibe nezimpawu ezinjengomkhuhlane, ama-chills, noma izinguquko zomfutho wegazi ngesikhathi sokufakwa.

Ithimba lakho lezempilo liqeqeshwe kahle ukubona nokuphatha lezi zinkinga ezingavamile uma zenzeka. Bazobe beqapha izimpawu zakho ezibalulekile nemiphumela yelabhorethri kuyo yonke imithi yakho ukuze babambe noma yiziphi izinkinga ekuqaleni.

Ubani Ongafanele Athathwe I-Remdesivir?

I-Remdesivir ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Zikhona izimo ezithile lapho izingozi zingase zidlule izinzuzo, futhi ukwelashwa okuhlukile kungaba kufaneleka kakhulu.

Akufanele uthole i-remdesivir uma wazi ukuthi unokungezwani komzimba emuthini noma kunoma iyiphi yezingxenye zawo. Uma uke waba nokuphendula komzimba ku-remdesivir esikhathini esidlule, qiniseka ukuthi wazisa ithimba lakho lezempilo ngokushesha.

Abantu abanezifo ezinzima zezinso badinga ukucatshangelwa okukhethekile, njengoba i-remdesivir icutshungulwa ngezinso. Uma ukusebenza kwezinso zakho kukhubazekile kakhulu, udokotela wakho angase akhethe ukwelashwa okuhlukile noma alungise umthamo ngokucophelela ngokuqapha okuseduze.

Izimo ezithile zidinga ukuqapha okwengeziwe, futhi udokotela wakho uzokala izingozi nezinzuzo ngokucophelela uma unezimo ezithile:

• Isifo sesibindi esibi: Njengoba i-remdesivir ingathinta ukusebenza kwesibindi, abantu abanezinkinga zesibindi ezikhona badinga ukuqashwa ngokucophelela.
• Ukukhulelwa: Ngenkathi i-remdesivir ingasetshenziswa ngesikhathi sokukhulelwa lapho izinzuzo zidlula izingozi, lesi sinqumo sidinga ukucatshangelwa ngokucophelela.
• Ukuncelisa: Ukuphepha kwe-remdesivir ngesikhathi sokuncelisa akukamiswanga ngokugcwele, ngakho udokotela wakho uzokusiza ukuthi uhlole izinketho.
• Ukugula okuthuthuke kakhulu: Kwezinye izimo lapho isiguli sigula kakhulu, izinzuzo ezingaba khona zingase zilinganiselwe.

Iqembu lakho lezempilo lizobuyekeza zonke lezi zinto futhi lixoxe ngendlela engcono kakhulu yokwelapha isimo sakho esithile. Banolwazi ekwenzeni lezi zinqumo futhi bazokuqondisa kulo lonke le nqubo.

Amagama Omkhiqizo we-Remdesivir

I-Remdesivir ithengiswa ngaphansi kwegama lomkhiqizo elithi Veklury yi-Gilead Sciences. Lona ukuphela kwenguqulo yegama lomkhiqizo etholakalayo emazweni amaningi, okuhlanganisa ne-United States.

Ungase futhi uzwe abahlinzeki bezempilo bekhuluma ngayo kalula njengokuthi "remdesivir" noma ngegama layo langaphambilini lokuhlola elithi "GS-5734," nakuba leli gama elingemuva lingavamile ukusetshenziswa emithini yezokwelapha manje. Uma uthola lo muthi, ilebula ngokuvamile lizokhombisa "Veklury" njengegama lomkhiqizo.

Izinhlobo ezivamile ze-remdesivir ziya zitholakala emazweni athile, kodwa e-United States, i-Veklury isahlala iyindlela eyinhloko esetshenziswa ezibhedlela nakwizikhungo zezempilo.

Ezinye izindlela zokwelapha i-Remdesivir

Ezinye izindlela eziningana zokwelapha ziyatholakala ze-COVID-19 kanye nezinye izifo ezibangelwa amagciwane, futhi udokotela wakho uzokhetha inketho engcono kakhulu ngokusekelwe ezimweni zakho ezithile. Ukukhethwa kokwelashwa kuncike ezintweni ezinjengokuthi isifo sakho siqale nini, izinto eziyingozi, nezimpawu zakho zamanje.

Ukwelashwa kwe-COVID-19, ezinye izindlela zokwelapha zihlanganisa i-Paxlovid (nirmatrelvir-ritonavir), okuyimithi yomlomo engathathwa ekhaya ezimeni ezilula kuya kweziphakathi. Kukhona futhi i-molnupiravir (Lagevrio), enye i-antiviral yomlomo engase icatshangelwe ezimweni ezithile.

Ukwelashwa ngama-antibody e-monoclonal kwake kwasetshenziswa ku-COVID-19, nakuba amaningi engasebenzi kahle ezinhlobonhlobo zamanje zegciwane. Udokotela wakho uzokwazi ukuthi yiziphi izindlela zokwelapha ezinconywa njengamanje ngokusekelwe eziqondisweni zakamuva kanye nezinhlobo zamagciwane ezisabalalayo.

Kwezinye izifo ezibangelwa amagciwane, ezinye izindlela zokwelapha zingahlanganisa imithi ehlukene ye-antiviral eqondene negciwane elibangela ukugula kwakho. Ithimba lakho lezempilo lizoxoxa ngazo zonke izinketho ezitholakalayo futhi likusize uqonde ukuthi kungani lincoma indlela ethile yokwelapha.

Ingabe i-Remdesivir ingcono kune-Paxlovid?

I-Remdesivir ne-Paxlovid zombili ziyindlela yokwelapha i-COVID-19 esebenzayo, kodwa zisetshenziswa ezimweni ezihlukene kunokuba zibe ngabancintisana ngqo. Ukukhetha okuthi "kungcono" kuncike ngokuphelele ezimweni zakho ezithile, isikhathi sokugula, nezici zezempilo zomuntu ngamunye.

I-Paxlovid inezinzuzo ezithile ezigulini ezithile ngoba ithathwa ngomlomo ekhaya, okwenza kube lula kubantu abangadingi ukulaliswa esibhedlela. Isebenza kahle kakhulu uma iqala zingakapheli izinsuku ezi-5 zokuqala kwezimpawu futhi ibonise imiphumela eqinile ekuvikeleni ukugula okukhulu ezigulini eziyingozi.

I-Remdesivir, ngakolunye uhlangothi, ngokuvamile igcinelwe iziguli ezilaliswe esibhedlela noma eziyingozi kakhulu yokugula okukhulu. Ingasetshenziswa kamuva ekuhambeni kokugula kune-Paxlovid futhi inerekhodi elide lokusetshenziswa ezigulini ezilaliswe esibhedlela.

Udokotela wakho uzocabangela izici eziningana lapho ekhetha phakathi kwale mithi. Lokhu kuhlanganisa ukuthi sekunesikhathi esingakanani unezimpawu, ukuthi ulaliswe esibhedlela yini, ezinye izimo zakho zezokwelapha, nokuthi yimiphi eminye imithi oyithathayo engase ihlangane nanoma iyiphi indlela yokwelapha.

Zombili le mithi inezinzuzo eziqinisekisiwe, futhi isinqumo phakathi kwazo kufanele senziwe ngaso sonke isikhathi ngokubonisana nomhlinzeki wakho wezempilo ongahlola isimo sakho somuntu ngamunye.

Imibuzo Evame Ukubuzwa Mayelana ne-Remdesivir

Q1. Ingabe i-Remdesivir iphephile kubantu abanesifo sikashukela?

Yebo, i-remdesivir ngokuvamile iphephile kubantu abanesifo sikashukela, futhi ukuba nesifo sikashukela akukuvimbeli ukuthi uthole lo muthi. Eqinisweni, abantu abanesifo sikashukela bavame ukuba sengozini enkulu ye-COVID-19 ebucayi, ngakho izinzuzo zokwelashwa nge-antiviral njenge-remdesivir zingase zibaluleke kakhulu.

Ithimba lakho lezempilo lizogada amazinga akho kashukela egazini ngesikhathi sokwelashwa, njengoba ukugula nemithi ethile kungathinta ukulawulwa kwe-glucose yegazi. Bazosebenza nawe ukuze baphathe imithi yakho yesifo sikashukela ne-insulin njengoba kudingeka ngenkathi uthola i-remdesivir.

Qiniseka ukuthi wazisa ithimba lakho lezokwelapha ngemithi yakho yesifo sikashukela nokulawulwa kwakho kwamuva kashukela egazini ukuze bakwazi ukukunikeza ukunakekelwa okuhle kakhulu okuhleliwe ngesikhathi sokwelashwa kwakho.

Q2. Kufanele ngenzeni uma ngithola i-Remdesivir eningi ngengozi?

Njengoba i-remdesivir inikezwa ochwepheshe bezempilo endaweni yezokwelapha elawulwayo, ukweqisa ngengozi akuvamile kakhulu. Umuthi ulinganiswa ngokucophelela futhi unikezwa ngamaphampu e-IV infusion alawula izinga nenani eliphelele olitholayo.

Uma ukhathazekile ngomthamo wakho noma uqaphela noma yiziphi izimpawu ezingavamile ngesikhathi noma ngemva kokufakwa kwakho, tshela ithimba lakho lezempilo ngokushesha. Bangahlola amarekhodi akho emithi futhi bakuqaphele nganoma yiziphi izimpawu zemiphumela emibi.

Ithimba lakho lezokwelapha lilandela izinqubo eziqinile zokuphepha kwemithi, okuhlanganisa ukuhlola kabili imithamo nokusebenzisa amasistimu kagesi ukuvimbela amaphutha. Baqeqeshwe ukuqaphela nokuphatha noma yiziphi izinkinga ezihlobene nemithi ezingase zenzeke.

Q3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Remdesivir?

Ukuphuthelwa umthamo we-remdesivir akunakwenzeka njengoba inikezwa endaweni yokunakekelwa kwezempilo lapho ithimba lakho lezokwelapha liphatha isimiso sakho sokwelashwa. Kodwa-ke, uma umthamo ulibaziseka ngenxa yezinkinga zokuhlela noma izizathu zezokwelapha, ithimba lakho lezokwelapha lizothatha isinqumo sendlela engcono kakhulu yokuqhubeka.

Bangase balungise isimiso sakho sokwelashwa ukuze baqinisekise ukuthi uthola inkambo ephelele yemithi, noma bangase balungise isikhathi ngokuya ngesimo sakho somtholampilo nokuphendula ekwelashweni. Into ebalulekile ukuthi izinqumo mayelana nemithamo ephuthelwe noma elibazisekile zenziwa ngabahlinzeki bakho bezempilo.

Uma unezinkathazo mayelana nesimiso sakho sokwelashwa noma uma udinga ukushiya isikhungo nganoma yisiphi isizathu ngesikhathi sokwelashwa kwakho, xoxa lokhu nethimba lakho lezokwelapha ukuze bakwazi ukuhlela ngokufanele.

Q4. Ngingayeka nini ukuthatha i-Remdesivir?

Isinqumo sokuyeka ukwelashwa nge-remdesivir kufanele senziwe njalo yithimba lakho lezokwelapha ngokusekelwe esimweni sakho somtholampilo nokuphendula ekwelashweni. Iziguli eziningi ziqeda inkambo ebekwe ngaphambilini yezinsuku ezi-3 kuya kwezi-5, kodwa lokhu kungahluka ngokuya ngezimo zomuntu ngamunye.

Udokotela wakho uzocabangela izinto ezinjengokuthuthuka kwezimpawu zakho, amazinga omoya-mpilo, imiphumela yelabhorethri, nesimo somtholampilo esiphelele lapho enquma ukuthi uzoqhubeka yini noma uqede ukwelashwa. Bangase bayeke ukwelashwa ngaphambi kwesikhathi uma ululama kahle, noma balwelise uma udinga ukwesekwa okwengeziwe.

Ungakhathazeki ngokwenza lesi sinqumo wena uqobo - ithimba lakho lezokwelapha lizokuqondisa kulo lonke le nqubo futhi lichaze ukucabanga kwabo nganoma yiziphi izinguquko ohlelweni lwakho lokwelashwa. Banolwazi lokuphatha le mithi futhi bazoqinisekisa ukuthi uthola inani elifanele lokwelashwa ngesimo sakho.

Q5. Ngingashayela ngemva kokuthola i-Remdesivir?

I-Remdesivir ngokwayo ngokuvamile ayikuthinti ukukwazi kwakho ukushayela, kodwa ukugula kwakho okuyisisekelo nezinye izinto ezihlobene nokwelashwa kwakho kungase kuthinte ukuphepha kwakho ngemuva kwesondo. Okubaluleke kakhulu ukuthi ngabe uphilile ngokwanele ukushayela ngokuphepha, hhayi ngqo umuthi ngokwawo.

Uma uthola i-remdesivir njengesiguli esingagcini esibhedlela, ungezwa ukhathele noma ungazizwa kahle ngenxa yokugula kwakho ngegciwane, okungase kuthinte isikhathi sakho sokusabela nokwahlulela kwakho. Abanye abantu futhi baba nemiphumela emincane engemihle efana nekhanda elibuhlungu noma isicanucanu okungase kwenze ukushayela kungafaneleki.

Ithimba lakho lezempilo lizohlinzeka ngesiqondiso mayelana nokuqala kabusha imisebenzi ejwayelekile ngokusekelwe esimweni sakho esiphelele nentuthuko yokululama kwakho. Bazocabangela izinto ezinjengamandla akho, ukunyamalala kwezimpawu, nanoma imiphi eminye imithi oyithathayo engase ithinte ikhono lakho lokushayela ngokuphepha.