Yini i-Revefenacin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Revefenacin iyimithi kadokotela esiza abantu abanesifo sokuvinjelwa komoya okungamahlalakhona (i-COPD) baphefumule kalula. Iyi-bronchodilator esebenza ngokukhulula imisipha ezungeze izindlela zakho zomoya, okwenza kube lula ukuthi umoya ungene futhi uphume emaphashini akho.

Le mithi iza njengesixazululo osiphefumulela ngomshini we-nebulizer. Udokotela wakho angase akubhalele i-revefenacin uma une-COPD futhi udinga ukwelashwa nsuku zonke ukuze ulawule izimpawu zakho zokuphefumula futhi unciphise ukuqubuka.

Yini i-Revefenacin?

I-Revefenacin ingeyeqembu lemithi ebizwa ngokuthi ama-long-acting muscarinic antagonists (LAMAs). Cabanga ngayo njengokhiye ovula izindlela zomoya eziqinile emaphashini akho, okuzivumela ukuthi zihlale zivulekile isikhathi eside ukuze ukwazi ukuphefumula ngokunethezeka okwengeziwe.

Le mithi yenzelwe ngqo abantu abane-COPD, isimo esihlanganisa i-chronic bronchitis kanye ne-emphysema. Ngokungafani nama-inhalers osizo asebenza ngokushesha ngesikhathi sezimo eziphuthumayo zokuphefumula, i-revefenacin iyimithi yokulondoloza oyisebenzisa nsuku zonke ukuvimbela izinkinga zokuphefumula ngaphambi kokuthi ziqale.

Le mithi imisha uma iqhathaniswa, yavunywa yi-FDA ngonyaka ka-2018. Yenzelwe ukuthi isetshenziswe kanye ngosuku, okungenza kube lula ukunamathela ohlelweni lwakho lokwelashwa uma kuqhathaniswa nemithi okudingeka ithathwe izikhathi eziningi ngosuku.

Isetshenziselwani i-Revefenacin?

I-Revefenacin isetshenziselwa ngqo ukwelapha isifo sokuvinjelwa komoya okungamahlalakhona (i-COPD) kubantu abadala. Isiza ukuphatha izimpawu zansuku zonke ze-COPD futhi inciphisa imvamisa yokuqubuka okungakuthumela esibhedlela.

Udokotela wakho angase akubhalele le mithi uma une-COPD ephakathi nendawo kuya kokubi kakhulu futhi uhlangabezana nobunzima bokuphefumula njalo. Ilusizo ikakhulukazi uma uzithola uphelelwa umoya ngesikhathi semisebenzi yansuku zonke efana nokuhamba, ukukhuphuka izitebhisi, noma nokugqoka izingubo.

Umuthi usebenza kahle kakhulu njengengxenye yohlelo olubanzi lokwelapha i-COPD. Lokhu kungabandakanya eminye imithi, ukuzivocavoca ukuphefumula, izinguquko zokuphila, kanye nokuhlolwa njalo nethimba lakho lokunakekelwa kwezempilo.

Isebenza Kanjani I-Revefenacin?

I-Revefenacin isebenza ngokuvimba ama-receptors athile emisipha yakho yomoya abizwa ngokuthi ama-muscarinic receptors. Uma lawa ma-receptor evinjelwe, imisipha ezungeze imigudu yakho yomoya iyakhululeka futhi ihlale ikhululekile cishe amahora angama-24.

Lokhu kuthathwa njengomuthi onamandla amaphakathi wokwelapha i-COPD. Ayinamandla ngokushesha njengama-inhalers okusindisa, kodwa inikeza ukukhululeka okuqhubekayo, okuhlala isikhathi eside okusiza ukuvimbela izinkinga zokuphefumula usuku lonke.

Umuthi uqala ukusebenza kungakapheli amahora ngemva komthamo wakho wokuqala, kodwa ungase ungazizwa izinzuzo ezigcwele izinsuku eziningana noma amasonto. Imigudu yakho yomoya kancane kancane iba ngaphansi kokuvuvukala futhi ivuleke kakhulu njengoba uqhubeka usebenzisa umuthi njalo.

Kufanele Ngiyithathe Kanjani I-Revefenacin?

Kufanele uthathe i-revefenacin ngendlela eqondile udokotela wakho ayikunikeza ngayo, ngokuvamile kanye ngosuku usebenzisa umshini we-nebulizer. Umuthi uza ngamabhodlela amancane aqukethe umthamo olinganiselwe ngaphambili womuthi oluketshezi.

Nansi indlela yokusebenzisa i-revefenacin ngendlela efanele:

1. Geza izandla zakho kahle ngaphambi kokubamba umuthi
2. Susa ibhodlela elilodwa esikhwameni se-foil ngaphambi nje kokusetshenziswa
3. Thela konke okuqukethwe enkomishini yakho ye-nebulizer
4. Xhuma i-nebulizer ku-compressor yakho bese uphefumula ngokujwayelekile ngomlomo
5. Qhubeka kuze kube yilapho wonke umuthi usuphelile (ngokuvamile imizuzu engu-8-15)

Ungawuthatha lo muthi ngaphandle noma ngaphandle kokudla, futhi asikho isidingo sokugwema ukudla ngaphambi noma ngemva komthamo wakho. Isikhathi esikusebenzela kangcono ngokuvamile silungile, kodwa zama ukuwuthatha ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo ohlelweni lwakho.

Hlanza izinto zakho ze-nebulizer ngemva kokuzisebenzisa ngakunye ngokulandela imiyalelo yomkhiqizi. Lokhu kuvimbela ukwakheka kwamagciwane futhi kuqinisekisa ukuthi imithi isebenza ngempumelelo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Revefenacin?

I-Revefenacin ngokuvamile iyimithi yesikhathi eside okudingeka uyithathe nsuku zonke isikhathi esinconywe ngaso udokotela wakho. Abantu abaningi abane-COPD badinga ukusebenzisa imithi yokugcina njengale ngokungapheli ukuze balawule izimpawu zabo.

Udokotela wakho uzoqapha ukuthi imithi isebenza kahle kangakanani kuwe ngokuhlolwa okuvamile kanye nokuhlolwa komsebenzi wamaphaphu. Uma ukuphefumula kwakho kuthuthuka kakhulu noma uma uhlangabezana nemiphumela emibi, udokotela wakho angase alungise uhlelo lwakho lokwelapha.

Ungayeki ukuthatha i-revefenacin ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Izimpawu zakho ze-COPD zingase zibuye noma zibe zimbi uma uyeka imithi ngokuzumayo. Uma udinga ukuyeka nganoma yisiphi isizathu, udokotela wakho uzokusiza ukuthi wenze kanjalo ngokuphepha.

Yiziphi Imiphumela Emibi Ye-Revefenacin?

Abantu abaningi bayayithanda i-revefenacin, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathi sína ayivamile, futhi abantu abaningi bathola kuphela izimpawu ezithambile ezithuthuka njengoba umzimba wabo ujwayela imithi.

Imiphumela emibi evamile ongase uyithole ihlanganisa:

• Ukhwehlela (okungase kubonakale kuyahlekisa emithini yokuphefumula)
• Ukutheleleka kwepheshana eliphezulu lokuphefumula njengomkhuhlane
• Ikhanda
• Ubuhlungu emhlane
• Ukuqunjelwa

Lezi zimpawu zivame ukuba mnene futhi zesikhashana. Uma ziqhubeka noma ziba yizihlupho, khuluma nodokotela wakho ngezindlela zokuzilawula.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Xhumana nodokotela wakho ngokushesha uma uhlangabezana nobunzima bokuchama, ubuhlungu emehlweni noma izinguquko embonweni, ukusabela okukhulu komzimba, noma izinkinga zokuphefumula eziba zimbi ngemva kokusebenzisa imithi.

Abanye abantu bangase babe nokusabela okungaqondakali lapho ukuphefumula kwabo kuba kubi nakakhulu ngemuva kokusebenzisa umuthi. Lokhu akuvamile kodwa kubucayi - yeka ukusebenzisa i-revefenacin ngokushesha futhi uthinte umhlinzeki wakho wezempilo uma lokhu kwenzeka.

Ubani Ongafanele Athathe I-Revefenacin?

I-Revefenacin ayilungile kuwo wonke umuntu. Akufanele usebenzise lo muthi uma unokungezwani komzimba ne-revefenacin noma yiziphi izithako zayo, noma uma unomoya ophezulu njengesimo sakho esiyinhloko sokuphefumula.

Udokotela wakho uzodinga ukwazi ngezinye izimo zempilo ngaphambi kokukuchazela i-revefenacin. Qiniseka ikakhulukazi ukuthi uyasho uma une:

• I-glaucoma ye-narrow-angle
• I-prostate enwetshiwe noma ubunzima bokuchama
• Izinkinga zezinso
• Ukuphazamiseka kwesigqi senhliziyo
• Ukuphazamiseka kokuthuthumela

Lezi zimo akusho ngempela ukuthi awukwazi ukusebenzisa i-revefenacin, kodwa udokotela wakho angase adinge ukukuqapha eduze noma alungise uhlelo lwakho lokwelashwa.

Uma ukhulelwe, uhlela ukukhulelwa, noma uncelisa, xoxa ngalokhu nodokotela wakho. Kukhona imininingwane elinganiselwe mayelana nokuphepha kwe-revefenacin ngesikhathi sokukhulelwa, ngakho-ke udokotela wakho uzolinganisela izinzuzo nezingozi ezingaba khona.

Igama Lomkhiqizo Le-Revefenacin

I-Revefenacin ithengiswa ngaphansi kwegama lomkhiqizo elithi Yupelri. Leli njengamanje yilona kuphela igama lomkhiqizo elitholakala ngalo muthi e-United States.

I-Yupelri iza ngama-vials asetshenziswa kanye aqukethe ama-micrograms angu-175 e-revefenacin kusisombululo esingu-3 mL. I-vial ngayinye yenzelwe ukusetshenziswa kanye futhi kufanele ilahlwe ngemuva kokuvulwa, ngisho noma ungasawusebenzisi wonke umuthi.

Umuthi ukhiqizwa yi-Mylan Pharmaceuticals futhi utholakala ngemiyalelo kadokotela kuphela. Akukabi bikho inguqulo ejwayelekile etholakalayo, njengoba umuthi usamusha.

Ezinye Izindlela Zokwelapha Nge-Revefenacin

Uma i-revefenacin ingakulungele, kunemithi eminingi ye-COPD esebenza ngezindlela ezifanayo. Udokotela wakho angase acabange ngeminye imithi elwa ne-muscarinic antagonists (LAMAs) esebenza isikhathi eside njenge-tiotropium (Spiriva) noma i-umeclidinium (Incruse Ellipta).

Abanye abantu benza ngcono ngemithi ehlanganisiwe ehlanganisa kokubili i-LAMA kanye ne-long-acting beta-agonist (LABA). Lezi zinhlanganisela, njenge-umeclidinium/vilanterol (Anoro Ellipta) noma i-glycopyrrolate/formoterol (Bevespi Aerosphere), zingahlinzeka ngokuqondisa izimpawu okubanzi.

Udokotela wakho angase futhi acabange ngezinhlanganisela zokwelapha ezintathu ezihlanganisa i-inhaled corticosteroid kanye ne-LAMA ne-LABA. Ukukhetha kuncike ezimpawini zakho ezithile, ukuthi i-COPD yakho inzima kangakanani, nokuthi usabela kahle kangakanani ekwelashweni okuhlukene.

Umuthi ngamunye unenzuzo yawo kanye nemiphumela engaba khona. Udokotela wakho uzokusiza ukuthi uthole indlela yokwelapha esebenza kahle kakhulu esimweni sakho esithile.

Ingabe i-Revefenacin Ingcono Kune-Tiotropium?

Kokubili i-revefenacin ne-tiotropium ziyimithi ye-COPD esebenzayo eyingxenye yeqembu elifanayo lemithi (LAMAs). Zisebenza ngezindlela ezifanayo kodwa zinezinto ezibalulekile ezingenza enye ikufaneleke kakhulu kunenye.

I-Revefenacin ithathwa kanye ngosuku nge-nebulizer, kuyilapho i-tiotropium ithathwa kanye ngosuku nge-dry powder inhaler (nakuba inguqulo ye-nebulizer nayo iyatholakala). Uma unzima ukusebenzisa ama-inhalers noma ukhetha ukwelashwa nge-nebulizer, i-revefenacin ingase ikulungele kakhulu.

Yomibili imithi inokusebenza okufanayo ekuthuthukiseni ukusebenza kwamaphaphu nokunciphisa ukuqubuka kwe-COPD. Ukukhetha phakathi kwazo kuvame ukwehla ekuthandeni komuntu siqu, ikhono lakho lokusebenzisa amadivayisi ahlukene okulethwa, nokuthi uyibekezelela kahle kangakanani imithi ngayinye.

Udkt wakho uzocabangela izidingo zakho ezithile, eminye imithi oyithathayo, kanye nempilo yakho yonke lapho enquma ukuthi imuphi umuthi ongcono kakhulu kuwe. Abanye abantu benza ngcono ngomuthi owodwa kunomunye, futhi kujwayelekile ukuzama izinketho ezahlukene ukuze uthole okusebenzayo.

Imibuzo Evame Ukubuzwa Mayelana Ne-Revefenacin

Q1. Ingabe i-Revefenacin iphephile ezigulini zenhliziyo?

I-Revefenacin ngokuvamile ingasetshenziswa ngokuphepha ngabantu abanezifo zenhliziyo, kodwa udokotela wakho uzodinga ukukuqapha eduze. Umuthi ngezinye izikhathi ungabangela izinguquko esigqi senhliziyo, nakuba lokhu kungavamile.

Uma unesifo senhliziyo, qiniseka ukuthi udokotela wakho uyazi ngayo yonke imithi yakho yenhliziyo ngaphambi kokuqala i-revefenacin. Bangase bafune ukuhlola isigqi senhliziyo yakho kaningi noma balungise uhlelo lwakho lokwelashwa ukuze baqinisekise ukuphepha kwakho.

Q2. Kufanele ngenzeni uma ngiphuthelwa ngengozi ngisebenzisa i-Revefenacin eningi kakhulu?

Uma ngengozi usebenzisa ngaphezu komthamo wakho obekiwe we-revefenacin, ungapheli amandla. Xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha ukuze uthole isiqondiso sokuthi wenzeni ngokulandelayo.

Izimpawu zokweqisa zingabandakanya umlomo owomile kakhulu, ubunzima bokuchama, umbono ongacacile, noma ukushaya kwenhliziyo okusheshayo. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, funa usizo lwezokwelapha ngokushesha. Ukweqisa okuningi okungahlosiwe akubangeli izinkinga ezinkulu, kodwa ngaso sonke isikhathi kungcono ukuphepha.

Q3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Revefenacin?

Uma uphuthelwa umthamo we-revefenacin, yithathe ngokushesha lapho ukhumbula ngalo lolo suku. Uma sekuyisikhathi somthamo wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe. Lokhu kungakhuphula ingozi yakho yemiphumela emibi ngaphandle kokuhlinzeka ngezinzuzo ezengeziwe. Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma usebenzise uhlelo lokusebenza lokukhumbuza imithi.

Q4. Ngingayeka nini ukuthatha i-Revefenacin?

Kufanele uyeke kuphela ukuthatha i-revefenacin uma udokotela wakho ekutshela ukuthi kuphephile ukwenza kanjalo. Lokhu kuvamile ukwenzeka uma izimpawu zakho ze-COPD zithuthuka kakhulu, uma uhlangabezana nemiphumela engemihle engabekezeleleki, noma uma udokotela wakho efuna ukuzama indlela ehlukile yokwelapha.

I-COPD yisimo esingamahlalakhona esivame ukudinga ukwelashwa kwesikhathi eside. Noma ngabe uzizwa ungcono ngenkathi uthatha i-revefenacin, ukuyeka imithi kungase kubangele ukuthi izimpawu zakho zibuye. Njalo xoxa nganoma yikuphi ukukhathazeka mayelana nokuqhubeka nokwelashwa nomhlinzeki wakho wezempilo.

Q5. Ngingahamba Nge-Revefenacin?

Yebo, ungahamba nge-revefenacin, kodwa uzodinga ukuhlela kusengaphambili. Umuthi udinga ukugcinwa esiqandisini kuze kube yilapho usulungele ukuwusebenzisa, ngakho-ke uzodinga ukwenza amalungiselelo okulondoloza okufanele ngesikhathi sokuhamba.

Ukuhamba ngomoya, pakisha imithi yakho emthwalweni wakho ohamba nawo kanye nekhophi kadokotela wakho. Ungasusa izitsha ngazinye esiqandisini izinsuku eziyi-7, okufanele zanele uhambo oluningi. Uma uhamba isikhathi eside kunaleso, uzodinga ukuqinisekisa ukugcinwa esiqandisini lapho uya khona.