Sacituzumab govitecan-hziy (indlela ye-intravenous)
Imikhiqizo etholakalayo
Trodelvy
Mayelana naleli khambi
Isicathulo se-Sacituzumab govitecan-hziy sisetshenziswa ekwelapheni lomdlavuza webele ongathathi hlangothi (triple-negative) osedume (metastatic) noma ongenakususwa ngokuhlinzwa (unresectable locally advanced). Linikwa iziguli ezithole ukwelashwa okungaphezu kwesibili lomdlavuza, okuhlanganisa nokwelashwa okungenani okukodwa sesifo esidume. Isicathulo se-Sacituzumab govitecan-hziy sisetshenziswa futhi ekwelapheni lomdlavuza webele oqaphela ama-hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative osedume (metastatic) noma ongenakususwa ngokuhlinzwa (unresectable locally advanced) kubantu abatholwe ukwelashwa kwe-endocrine kanye nokwelashwa okungenani okubili sesifo esidume. Isicathulo se-Sacituzumab govitecan-hziy sisetshenziswa futhi ekwelapheni lomdlavuza we-urothelial (umdlavuza we-bladder kanye nomdlavuza wendlela yokuphuma kwesisu) osedume noma ongenakususwa ngokuhlinzwa kubantu abatholwe eminye imithi yomdlavuza (eg, imithi ye-immunotherapy, imithi yomdlavuza ehlanganisa i-platinum). I-Sacituzumab govitecan-hziy iyingxenye yeqembu lemithi ebizwa ngokuthi yi-antineoplastics (imithi yomdlavuza). Iphazamisa ukukhula kwamaseli omdlavuza, aqedwa ekugcineni. Njengoba ukukhula kwamaseli avamile kungathinteka futhi yimithi, ezinye izinto zingase zenzeke. Ezinye zalezi zingaba nzima futhi kufanele zibikwe kudokotela wakho. Lolu lwemi lusetshenziswa kuphela yi- noma ngaphansi kokunakekelwa ngokushesha kudokotela wakho. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma ukhetha ukusebenzisa le mishini, kufanele kuqhathaniswe ingozi yokusebenzisa le mishini nezinzuzo eziyolethwa yiyo. Lo ngumqondo owenzayo wena nodokotela wakho. Ngale mishini, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma iyiphi impendulo engavamile noma ebangelwa uketshezi kule mishini noma kwezinye izidakamizwa. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zoketshezi, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenaso iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Akwenziwanga ucwaningo olufanele mayelana nobudlelwano bobudala nemiphumela yokubeka i-sacituzumab govitecan-hziy kubantwana. Ukuphepha nokuphumelela akukaqiniswa. Ucwaningo olufanele oluqediwe kuze kube manje alubonisi izinkinga ezikhethekile zabantu abadala ezingakhawulela ukusetshenziswa kwe-sacituzumab govitecan-hziy kubantu abadala. Ayikho izifundo ezanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mishini ngesikhathi uncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mishini ngesikhathi uncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye, kwezinye izimo izidakamizwa ezimbili ezahlukene zingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha kungase kudingeke. Uma uthola le mishini, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imishini ehlaliswe ngezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mishini nanoma iyiphi imishini elandelayo ngokuvamile akunconywa, kodwa kungase kudingeke kwezinye izimo. Uma kokubili imishini ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma kokubili imishini. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma ngesikhathi sokudla izinhlobo ezithile zokudla ngoba kungenzeka kube khona ukusebenzisana. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemishini yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mishini. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Imithi esetshenziswa ekwelapheni umdlavuza inamandla kakhulu futhi ingaba nemiphumela eminingi emibi. Ngaphambi kokuthola le mithi, qiniseka ukuthi uyayiqonda yonke imingcipheko nezinzuzo. Kubalulekile ukuthi usebenzisane eduze nodokotela wakho phakathi nokwelashwa kwakho. Udokotela noma omunye ochwepheshe bezempilo oqeqeshwe ngokucophelela uyokunika le mithi esikhungweni sezokwelapha. Inikezwa ngenhlanzi ebekwe kwenye yezinzwa zakho. Imithi kufanele inikezwe kancane, ngakho-ke inhlanzi kuzofanele ihlale ibekwe okungenani amahora amathathu ngenxa yomthamo wokuqala, bese kuba amahora angu-1 noma angu-2 ngemithamo elandelayo. Ukugonywa kuvame ukwenziwa kanye ngesonto ngezinsuku 1 no-8 kwesikhathi sokwelashwa sezinsuku ezingu-21. I-Sacituzumab govitecan-hziy ivame ukubangela isicanucanu nokugabha. Noma kunjalo, kubalulekile kakhulu ukuthi uqhubeke uthola le mithi ngisho noma uqala ukuzwa ubuhlungu. Ungathola eminye imithi ezosiza ngesicanucanu nokugabha. Buza udokotela wakho ngezinye izindlela zokunciphisa le miphumela. Ungathola futhi amanzi engeziwe neminye imithi (eg., imithi yokwelapha uketshezi, imithi yokwelapha ubushushu, ama-steroids) ukusiza ukuvimbela imiphumela emibi engathandeki evela ekugonyweni. Le mithi kufanele inikezwe ngesikhathi esibekiwe. Uma uphuthelwa umthamo, shayela udokotela wakho, umhlinzeki wezempilo ekhaya, noma ikliniki yokwelashwa ukuze uthole imiyalo.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.