Yini i-Safinamide: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Safinamide iyimithi kadokotela esiza ukuphatha izimpawu zesifo sikaParkinson uma isetshenziswa kanye neminye imithi. Ingowomndeni wemithi ebizwa ngokuthi ama-MAO-B inhibitors, asebenza ngokuvimba i-enzyme eqeda i-dopamine ebuchosheni bakho. Lokhu kusiza ukugcina amazinga angcono e-dopamine, angathuthukisa izinkinga zokunyakaza futhi anciphise izikhathi "ezingasebenzi" lapho imithi yakho eyinhloko ye-Parkinson ingasebenzi kahle.

Yini i-Safinamide?

I-Safinamide iyimithi entsha eyenzelwe ngqo ukusiza abantu abanesifo sikaParkinson. Isebenza njengokwelashwa okwengeziwe, okusho ukuthi uzoyithatha kanye nemithi yakho ye-Parkinson ekhona esikhundleni sokuyishintsha. Lo muthi unezenzo ezimbili eziyingqayizivele - awuvimbi nje kuphela i-enzyme ye-MAO-B kodwa futhi uthinta umsebenzi we-glutamate ebuchosheni bakho, okunganikeza izinzuzo ezengeziwe zokulawula ukunyakaza.

Lo muthi uthathwa njengenketho yokwelashwa enamandla aphakathi nendawo kuthuluzi le-Parkinson. Ayinamandla njenge-levodopa, kodwa inganikeza ngcono okukhulu ekusebenzeni kwansuku zonke nasezingeni lempilo. Odokotela abaningi bayayibhala lapho iziguli ziqala ukuzwa izikhathi "ezingasebenzi" ezivamile noma lapho imithi yazo yamanje idinga ukukhushulwa.

Isetshenziselwani i-Safinamide?

I-Safinamide isetshenziswa ikakhulukazi ukwelapha isifo sikaParkinson njengokwelashwa okwengeziwe ku-levodopa/carbidopa. Udokotela wakho angase ayincomise uma uhlangabezana nokuguquguquka kwemoto, okuyizikhathi lapho imithi yakho eyinhloko iphela khona futhi izimpawu zakho zibuyela. Lezi ziqephu "ezingasebenzi" zingakhungathekisa futhi zithinte imisebenzi yakho yansuku zonke kakhulu.

Umuthi ulusizo olukhulu ikakhulukazi kubantu abasesigabeni esiphakathi nendawo kuya kwesokugcina sesifo sikaParkinson. Ungasiza ukulungisa ukwehla nokukhuphuka kokulawulwa kwezimpawu usuku lonke. Ezinye iziguli zithola ukuthi kuyasiza ekunciphiseni i-dyskinesia, okuyizinyakazo ezingahleliwe ezingenzeka njengomphumela ohlangothini wokusebenzisa i-levodopa isikhathi eside.

Isebenza Kanjani I-Safinamide?

I-Safinamide isebenza ngokuvimba i-enzyme ebizwa nge-MAO-B, evame ukwehlisa i-dopamine ebuchosheni bakho. Ngokuvimbela le enzyme, i-dopamine eningi ihlala itholakala ukuthi amaseli akho obuchopho ayisebenzise. Lokhu kubaluleke kakhulu esifweni sikaParkinson, lapho amaseli akhiqiza i-dopamine elahleka kancane kancane ngokuhamba kwesikhathi.

Okuhlukanisa i-safinamide ukuthi isebenza kanjani okwesibili. Iphinde ivimbele iziteshi ze-sodium futhi inciphise ukukhishwa kwe-glutamate, okungasiza ukuvikela amaseli obuchopho futhi kuthuthukise ukulawulwa kokunyakaza. Lesi senzo esiphindwe kabili singase sichaze ukuthi kungani ezinye iziguli zithola izinzuzo ezingaphezu kwalokho ezikuthola kwamanye ama-inhibitors e-MAO-B.

Umuthi uthathwa njengonamandla ngokulinganisela uma uqhathaniswa nezinye izindlela zokwelapha isifo sikaParkinson. Awunamandla njenge-levodopa, kodwa unganikeza ngcono okukhulu uma usetshenziswa ngendlela efanele. Iziguli eziningi zibona ukuthuthuka kancane kancane ezingxenyeni zamasonto amaningana kunokushintsha okukhulu ngokushesha.

Kufanele Ngiyithathe Kanjani I-Safinamide?

Thatha i-safinamide ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku ngaphandle noma ngaphandle kokudla. Umuthi uza ngesimo samaphilisi futhi kufanele ugwinywe wonke ngamanzi. Akudingeki ukuthi uyithathe nobisi noma okunye ukudla okuthile, okwenza kube lula ukukufaka emsebenzini wakho wansuku zonke.

Odokotela abaningi baqala iziguli ngomthamo ophansi futhi bawukhulise kancane kancane ngokuya ngokuthi usabela kahle kangakanani futhi ukubekezelela kanjani umuthi. Yithathe ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo ohlelweni lwakho. Uma uyithatha ekuseni, namathela emithini yasekuseni kuyo yonke indlela yakho yokwelashwa.

Ungathatha i-safinamide ngaphandle kokudla noma ngemva kokudla, kodwa zama ukuba nokuzimisela ngokukhetha kwakho. Abanye abantu bathola ukuthi ukuyithatha ngokudla kusiza ekuvikeleni isisu esibuhlungu, kanti abanye bakhetha ukuyithatha esiswini esingenalutho. Akukho imikhawulo ethile yokudla, kodwa ukugcina ukudla okunempilo kungasekela uhlelo lwakho lokwelashwa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Safinamide?

I-Safinamide ngokuvamile iyindlela yokwelapha yesikhathi eside ozoqhubeka nayo uma nje inikeza izinzuzo futhi uyayibekezelela kahle. Abantu abaningi abanesifo sikaParkinson badinga ukuthatha imithi yabo unomphela, njengoba lesi simo siqhubeka futhi singelapheki. Udokotela wakho uzoqapha impendulo yakho futhi alungise uhlelo lwakho lokwelashwa njengoba kudingeka ngokuhamba kwesikhathi.

Izinzuzo eziphelele ze-safinamide zingathatha amasonto amaningana ukuthi zivele. Ezinye iziguli zibona ngcono ngaphakathi kwenyanga yokuqala, kanti ezinye zingadinga izinyanga ezintathu ukuba zithole imiphumela ephelele. Lokhu kuqala kancane kujwayelekile futhi akusho ukuthi imithi ayisebenzi.

Udokotela wakho uzohlola njalo ukuthi i-safinamide iyaqhubeka yini nokusiza esimweni sakho esithile. Uma izimpawu zakho zikaParkinson zishintsha noma uma uhlangabezana nemiphumela emibi enezinkinga, bangase balungise umthamo wakho noma bacabange ezinye izindlela zokwelapha. Ungayeki ukuthatha i-safinamide ngokuzumayo ngaphandle kokubonisana nomhlinzeki wakho wezempilo, ngoba lokhu kungase kubhebhethekise izimpawu zakho.

Yiziphi Imiphumela Eceleni Ye-Safinamide?

Njengayo yonke imithi, i-safinamide ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ngokuvamile imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi. Ukuqonda okulindelekile kungakusiza ukuthi uzizwe ulungile futhi uzethembile ngokuqondene nokwelashwa kwakho.

Nawa imiphumela emibi ebikwa njalo ukuthi iziguli ziyayithola:

• Ukugula kwesisu nokungakhululeki kwesisu
• Isiyezi noma ukukhathala
• Ukucabanga
• Ukuhlupheka ukulala noma amaphupho acacile
• Ukwanda kokunyakaza okungahleliwe (i-dyskinesia)
• Ukukhathala noma ukudinwa
• Ukuqina kwesisu
• Umlomo owomile

Le miphumela evamile ngokuvamile iyalawuleka futhi ingancipha ngokuhamba kwesikhathi. Ukuthatha imithi ngokudla kungasiza ukunciphisa isicanucanu, futhi ukuhlala unamanzi kahle kungasiza ngomlomo owomile nokuqina kwesisu.

Imiphumela engavamile kodwa ebucayi kakhulu idinga ukunakekelwa kwezempilo ngokushesha. Ngenkathi lokhu kwenzeka ngesilinganiso esincane seziguli, kubalulekile ukuyazi:

• Umfutho wegazi ophezulu kakhulu, ikakhulukazi uma udla ukudla okunama-tyramine amaningi
• Iziqephu ezingazelelwe zokuwela ebuthongweni ngesikhathi semisebenzi yansuku zonke
• Ukucabanga noma ukudideka
• Ushintsho olukhulu lwemizwa noma ukucindezeleka
• Ubuhlungu besifuba noma izinkinga zesigqi senhliziyo
• Ukuphendula kwesikhumba okukhulu noma ukuqubuka
• Izimpawu zezinkinga zesibindi njengesikhumba esiphuzi noma amehlo

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nanoma iyiphi yale miphumela emibi kakhulu. Bangasiza ukunquma ukuthi imithi idinga ukulungiswa noma ukuyekiswa.

Ubani Ongafanele Athathwe I-Safinamide?

I-Safinamide ayiphephile kuwo wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo ezithile zezokwelapha nemithi kungasebenzisana ngendlela eyingozi ne-safinamide, ngakho-ke kubalulekile ukuhlinzeka ngolwazi olugcwele ngesimo sakho sempilo.

Abantu abanezimo ezinjalo ngokuvamile kufanele bagweme i-safinamide noma bayisebenzise ngokuqapha okukhulu:

• Isifo sesibindi esibi noma ukwehluleka kwesibindi
• Umlando wezinkinga ze-retinal noma i-macular degeneration
• Isifo sezinso esibi
• Umlando we-psychosis noma izimo ezinzima zempilo yengqondo
• Umfutho wegazi ophezulu ongagadiwe
• Umlando wokushaywa unhlangothi noma isifo senhliziyo esibalulekile

Udktela wakho uzodinga ukwazi ngayo yonke imithi oyithathayo, njengoba i-safinamide ingasebenzisana nezigaba eziningana zemithi. Lokhu kufaka phakathi imithi kadokotela, imithi etholakala ngaphandle kwemvume kadokotela, kanye nezithasiselo zemvelo.

Ukukhulelwa nokuncelisa ngamabele kudinga ukucatshangelwa okukhethekile. Ngenkathi kukhona idatha elinganiselwe ekusetshenzisweni kwe-safinamide ngesikhathi sokukhulelwa, udokotela wakho uzokala izinzuzo ezingaba khona ngokumelene nezingozi ezingenzeka. Uma uhlela ukukhulelwa noma uncelisa, xoxa ngalokhu nomhlinzeki wakho wezempilo ngaphambi kokuqala ukwelashwa.

Amagama Omkhiqizo we-Safinamide

I-Safinamide itholakala ngaphansi kwegama lomkhiqizo elithi Xadago e-United States nakwamanye amazwe amaningi. Lena yindlela ejwayelekile kakhulu ebekwe ngayo ukuthi cishe uzohlangana nayo ekhemisi lakho. Umuthi ukhiqizwa yizinkampani eziningana zemithi ngaphansi kwezivumelwano zokulayisensa.

Kwezinye izifunda, i-safinamide ingase itholakale ngaphansi kwamagama omkhiqizo ahlukene noma njengezinhlobo ezivamile. Umkhemisi wakho angakusiza ukuthi ubone ukwakheka okuthile okutholayo futhi aqinisekise ukuthi uthola umuthi ofanele. Hlala uhlola nomhlinzeki wakho wezempilo uma ubona noma yiziphi izinguquko ekubukekeni noma ekupakisheni komuthi wakho.

Ezinye izindlela ze-Safinamide

Uma i-safinamide ingakulungele noma inganikezi izinzuzo ezanele, imithi eminingana ehlukile ingasiza ekuphatheni izimpawu zesifo sikaParkinson. Udokotela wakho angase acabange ezinye izithiyo ze-MAO-B, ama-dopamine agonists, noma izithiyo ze-COMT kuye ngezidingo zakho ezithile nomlando wezokwelapha.

Ezinye izithiyo ze-MAO-B zifaka i-selegiline ne-rasagiline, esebenza ngendlela efanayo ne-safinamide kodwa inezinhlobo ezihlukene zemiphumela emibi. Ama-dopamine agonists afana ne-pramipexole ne-ropinirole aqondisa ngqo ama-dopamine receptors futhi angaba ukwelashwa okusebenzayo okwengeziwe. Izithiyo ze-COMT ezifana ne-entacapone zisiza ukwelula imiphumela ye-levodopa ngokuvimbela ukuhlakazeka kwayo.

Ukukhetha okunye kuncike ezimpawini zakho ngazinye, eminye imithi oyithathayo, kanye nokubekezelelana kwakho nemiphumela ehlukene. Udokotela wakho uzosebenza nawe ukuthola inhlanganisela ephumelela kakhulu yokwelashwa ngesimo sakho esithile.

Ingabe i-Safinamide ingcono kune-Rasagiline?

Kokubili i-safinamide ne-rasagiline ziyizithiyo ze-MAO-B ezisetshenziselwa ukwelapha isifo sikaParkinson, kodwa zinezinye izinto ezibalulekile ezihlukile. I-Safinamide intsha futhi inendlela yokusebenza ephindwe kabili, ivimba kokubili i-MAO-B futhi ithinte izindlela ze-glutamate. I-Rasagiline isebenza ikakhulukazi ngokuvinjelwa kwe-MAO-B futhi isetshenziswe isikhathi eside, inikeza odokotela okuhlangenwe nakho okwengeziwe ngemiphumela yayo.

Ucwaningo luphakamisa ukuthi i-safinamide ingase isebenze kangcono ekunciphiseni isikhathi

Uma unesifo senhliziyo esingesibi, esilawulwa kahle, i-safinamide ingase isaba yindlela yokwelapha ngokuqapha ngokucophelela. Udokotela wakho cishe uzofuna ukuhlola umfutho wegazi lakho njalo futhi angase ancome ukugwema ukudla okunothile nge-tyramine, okungabangela ukunyuka okuyingozi komfutho wegazi uma kuhlanganiswe nezinto ezivimbela i-MAO-B.

Kufanele ngenzeni uma ngiphuzile i-Safinamide eningi ngengozi?

Uma ngengozi uphuza i-safinamide eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukuphuza i-safinamide eningi kungabangela imiphumela emibi engathi sína ehlanganisa umfutho wegazi ophezulu ngokuyingozi, isicanucanu esibi, ukudideka, nezinkinga zenhliziyo.

Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini - ukungenelela kusenesikhathi kubalulekile ekweqiseni imithi. Gcina ibhodlela lemithi unawe uma ufuna usizo ukuze abahlinzeki bezempilo bazi kahle ukuthi yini nokuthi ungakanani okuyiphuzile. Uma uhlangabezana nezimpawu ezinzima njengobuhlungu besifuba, ubunzima bokuphefumula, noma ukudideka, shayela izinsiza eziphuthumayo ngokushesha.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Safinamide?

Uma uphuthelwa umthamo we-safinamide, yiphuzeni ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho yokulinganisa ejwayelekile. Ungalokothi uphuze imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi.

Zama ukuphuza i-safinamide ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo ohlelweni lwakho. Ukusetha i-alamu yansuku zonke noma ukusebenzisa umhleli wamaphilisi kungakusiza ukuthi ukhumbule imithamo yakho. Uma uvame ukukhohlwa imithamo, khuluma nodokotela wakho ngamasu okuthuthukisa ukunamathela emithini.

Ngingayeka nini ukuphuza i-Safinamide?

Kufanele uyeke ukuthatha i-safinamide ngaphansi kwesiqondiso sikadokotela wakho kuphela. Ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho ze-Parkinson zibe zimbi ngokushesha, okungaba yingozi futhi kuthinte kakhulu izinga lempilo yakho. Udokotela wakho ngokuvamile uzoncoma ukunciphisa umthamo kancane kancane kunokuyeka kungazelelwe.

Kunezizathu eziningana zokuthi kungani udokotela wakho engase ancome ukuyeka i-safinamide, okuhlanganisa imiphumela emibi engathi sína, ukungasebenzi kahle, noma isidingo sokushintshela emuthini ohlukile. Bazosebenza nawe ukuthuthukisa uhlelo oluphephile lokushintsha emuthini ngenkathi kugcinwa ukulawulwa okwanele kwezimpawu ngeminye imithi.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Safinamide?

Utshwala bungasebenzisana ne-safinamide futhi bungase luqhubekisele phambili imiphumela ethile emibi efana nesiyezi, ukozela, nokudideka. Nakuba amanani amancane otshwala angase amukeleke kwabanye abantu, kubalulekile ukuxoxa ngokusebenzisa utshwala nodokotela wakho ngaphambi kokuphuza ngenkathi uthatha i-safinamide.

Utshwala bungase futhi buthinte izimpawu zakho ze-Parkinson futhi bungase luphazamise ukusebenza kwemithi yakho. Abanye abantu bathola ukuthi utshwala benza ukuthi ukuthuthumela kwabo kube kubi kakhulu noma kuthinte ibhalansi yabo nokuxhumana kwabo. Udokotela wakho angakusiza ukuthi uqonde ukuthi utshwala bungayithinta kanjani uhlelo lwakho oluthile lokwelapha nempilo yakho yonke.