Yini iSarilumab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

ISarilumab iyimithi kadokotela esiza ukunciphisa ukuvuvukala kubantu abanomdlavuza wamathambo kanye nezinye izimo ze-autoimmune. Inikezwa njengesijovo ngaphansi kwesikhumba, ngendlela efana nendlela abantu abanesifo sikashukela abazijova ngayo i-insulin.

Le mithi ingeyeqembu elibizwa ngokuthi ama-IL-6 inhibitors, asebenza ngokuvimba amasignali athile ohlelweni lwakho lomzimba oluzivikelayo abangela ubuhlungu emalungeni nokuvuvukala. Cabanga ngakho njengokwehlisa ivolumu ekuphenduleni komzimba wakho okusebenza ngokweqile.

Yini iSarilumab?

ISarilumab iyimithi ye-biologic eqondise i-interleukin-6 (IL-6), iphrotheni eqhuba ukuvuvukala emzimbeni wakho. Uma unomdlavuza wamathambo, uhlelo lwakho lomzimba oluzivikelayo lukhiqiza i-IL-6 eningi kakhulu, okuholela emalungeni abuhlungu, avuvukele.

Umuthi uza njengepeni elizaliswe ngaphambilini noma isirinji oyijova ngaphansi kwesikhumba njalo emavikini amabili. Yenziwa kusetshenziswa i-biotechnology ethuthukisiwe, okusho ukuthi yenziwe ngamaseli aphilayo kunamakhemikhali endabuko.

Udkt wakho ngokuvamile uzonquma i-sarilumab uma eminye imithi yomdlavuza ingazange inikeze ukukhululeka okwanele. Ithathwa njenge-targeted therapy ngoba igxila engxenyeni ethile yohlelo lomzimba oluzivikelayo kunokucindezela impendulo yakho yonke yomzimba.

ISarilumab isetshenziselwani?

ISarilumab isetshenziswa ikakhulukazi ukwelapha umdlavuza wamathambo ophakathi nendawo kuya koweqile kubantu abadala. Isiza ukunciphisa ubuhlungu emalungeni, ukuqina, nokuvuvukala okungenza imisebenzi yansuku zonke ibe yinselele.

Udkt wakho angase ancome i-sarilumab uma ungazange uphendule kahle ku-methotrexate noma eminye imithi yokuguqula isifo se-antirheumatic (DMARDs). Ingasetshenziswa yodwa noma ihlanganiswe ne-methotrexate ukuze kutholakale imiphumela engcono.

Lo muthi ufundelwa nezinye izimo zokuvuvukala, nakuba i-rheumatoid arthritis isaqhubeka nokuba yona esetshenziswa kakhulu. Udokotela wakho uzonquma ukuthi i-sarilumab ilungele yini isimo sakho esithile ngokusekelwe ezimpawini zakho kanye nomlando wakho wezokwelapha.

Isebenza Kanjani I-Sarilumab?

I-Sarilumab isebenza ngokuvimba ama-interleukin-6 receptors emzimbeni wakho. I-IL-6 ifana nesithunywa esitshela amasosha akho omzimba ukuthi akhe ukuvuvukala, ngisho nalapho kungadingeki.

Lapho i-sarilumab inamathisela kula ma-receptors, ivimbela i-IL-6 ekuthumeleni izimpawu zokuvuvukala. Lokhu kusiza ukunciphisa ukulimala kwamalunga, ubuhlungu, nokuvuvukala okuhambisana ne-rheumatoid arthritis.

Lo muthi uthathwa njengomuthi oqinile phakathi kokwelashwa kwe-biologic. Iqondiswe ngokuqondile kunezithako zama-steroid kodwa isinamandla ngokwanele ukuthinta kakhulu amasosha akho omzimba. Abantu abaningi baqala ukuqaphela ukuthuthuka phakathi kwamasonto angu-2-4 ngemuva kokuqala ukwelashwa.

Kufanele Ngiyithathe Kanjani I-Sarilumab?

I-Sarilumab inikezwa njenge-subcutaneous injection, okusho ukuthi uyayijova esicutshini esinamanzi ngaphansi kwesikhumba sakho. Umthamo ojwayelekile ungu-200mg njalo emavikini amabili, nakuba udokotela wakho angaqala ngo-150mg uma unezimo ezithile zempilo.

Ungajova i-sarilumab ethangeni lakho, engalweni engenhla, noma esiswini. Shintshanisa izindawo zokujova njalo ukuze uvimbele ukucasuka kwesikhumba. Umuthi kufanele ube sezingeni lokushisa legumbi lapho uwujova, ngakho-ke wukhiphe esiqandisini imizuzu engu-30-60 ngaphambi kwesikhathi.

Akudingeki ukuthi uthathe i-sarilumab nokudla ngoba ijovwa esikhundleni sokugwinywa. Kodwa-ke, kubalulekile ukuyijova ngosuku olufanayo njalo emavikini amabili ukuze kugcinwe amazinga aqhubekayo ohlelweni lwakho.

Udokotela wakho noma umhlengikazi uzokufundisa ukuthi uzijova kanjani wena. Abantu abaningi bakuthola kulula kunalokho abebelindele, futhi amapeni agcwaliswe ngaphambili enza inqubo iqonde ngqo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Sarilumab?

I-Sarilumab ngokuvamile iyindlela yokwelapha yesikhathi eside ye-rheumatoid arthritis. Abantu abaningi baqhubeka beyithatha uma nje isiza izimpawu zabo futhi ingabangeli imiphumela emibi.

Udkt wakho uzoqapha impendulo yakho ezinyangeni ezimbalwa zokuqala ukuze abone ukuthi umuthi usebenza kahle kangakanani. Uma uthola ukuthuthuka okukhulu, cishe uzoqhubeka nokujova njalo.

Abanye abantu bangase badinge ukuthatha i-sarilumab iminyaka eminingi ukuze balondoloze ukulawulwa kwezimpawu zabo. Kodwa-ke, umhlinzeki wakho wezempilo uzobuyekeza njalo ukwelashwa kwakho ukuze aqinisekise ukuthi iseyona inketho engcono kakhulu kuwe.

Ungayeki ukuthatha i-sarilumab ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Izimpawu zakho zingase zibuye uma uyeka umuthi ngokuzumayo.

Yiziphi Imiphumela Emibi ye-Sarilumab?

Njengayo yonke imithi, i-sarilumab ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini okufanele uyibheke kungakusiza ukuthi uzizwe uqiniseka ngokwengeziwe ngokwelashwa kwakho.

Nansi imiphumela emibi evame kakhulu ongase uyithole:

• Ukuphendula endaweni yokujova njengobubomvu, ukuvuvukala, noma ubuhlungu obuncane
• Ukutheleleka okuphezulu kwemigudu yokuphefumula njengomkhuhlane noma ukutheleleka kwama-sinus
• Ikhanda elivame ukuba lincane kuya phakathi nendawo
• Amazinga e-cholesterol andile, okuzoqashwa udokotela wakho
• Ama-enzyme esibindi andisiwe, atholwe ngezivivinyo zegazi

Le miphumela emibi evamile ngokuvamile iyalawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Abanye abantu bangase bathole imiphumela emibi engathi sína kodwa engavamile edinga ukunakekelwa kwezempilo ngokushesha:

• Ukutheleleka okungathi sína okungase kube yingozi ekuphileni
• Ukuphendula okukhulu komzimba okunezingxaki zokuphefumula noma ukuvuvukala
• Ukwehla okukhulu kwamaseli egazi amhlophe noma ama-platelet
• Izinkinga zesibindi ezibangela ukuphuzi kwesikhumba noma amehlo
• Ukugqoboka kwamathumbu, nakuba lokhu kungavamile kakhulu

Nakuba le miphumela emibi ingavamile, kubalulekile ukuxhumana nomhlinzeki wakho wezempilo ngokushesha uma uhlangabezana nanoma yiziphi izimpawu ezikhathazayo.

Ubani Ongafanele Athole i-Sarilumab?

I-Sarilumab ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinikeza. Izimo ezithile noma izimo zenza lo muthi ube yingozi.

Akufanele uthathe i-sarilumab uma unezinye zalezi zimo:

• Izifo ezisebenzayo, okuhlanganisa i-tuberculosis noma i-hepatitis B
• Isifo sesibindi esibi noma ama-enzyme esibindi aphakeme kakhulu
• Ukubala okuncane kakhulu kwamangqamuzana amhlophe egazi noma ama-platelet
• Ukungezwani komzimba okwaziwayo ne-sarilumab noma yiziphi izithako zayo
• Imithi yokugoma ephilayo ehlelelwe amasonto ambalwa alandelayo

Udokotela wakho uzosebenzisa ukuqapha okwengeziwe uma unomlando wezifo eziphindaphindayo, ukuhlinzwa kwamuva, noma ezinye izifo zesimiso somzimba sokuzivikela.

Ukukhulelwa nokuncelisa ngamabele kudinga ukucatshangelwa okukhethekile. Nakuba i-sarilumab ingakaze ifundwe kabanzi kwabesifazane abakhulelwe, udokotela wakho uzolinganisela izinzuzo nezingozi ezingaba khona uma uhlela ukukhulelwa noma usuvele ulindele.

Amagama Omkhiqizo we-Sarilumab

I-Sarilumab ithengiswa ngaphansi kwegama lomkhiqizo elithi Kevzara e-United States nakwamanye amazwe amaningi. Leli yigama lomkhiqizo elilodwa elitholakalayo njengamanje ngalo muthi.

I-Kevzara yenziwa yi-Sanofi ne-Regeneron Pharmaceuticals. Umuthi uza ngamapeni agcwaliswe ngaphambilini kanye nemijovo yokuzijova kalula ekhaya.

Ngokungafani neminye imithi, akukabi khona inguqulo ejwayelekile ye-sarilumab etholakalayo okwamanje. Lokhu kusho ukuthi i-Kevzara okwamanje iyona kuphela inketho uma udokotela wakho ekunikeza i-sarilumab.

Ezinye Izindlela ze-Sarilumab

Uma i-sarilumab ingakulungele, eminye imithi eminingi ye-biologic ingelapha i-rheumatoid arthritis ngempumelelo. Udokotela wakho angase acabangele lezi ezinye izindlela ngokusekelwe ezidingweni zakho ezithile kanye nomlando wezokwelapha.

Ezinye izinto ezivimbela i-IL-6 zihlanganisa i-tocilizumab (Actemra), esebenza ngendlela efana ne-sarilumab kodwa inikezwa njengokufakwa noma umjovo. Izinto ezivimbela i-TNF ezifana ne-adalimumab (Humira) noma i-etanercept (Enbrel) ziqondisa izindlela ezihlukene zokuvuvukala.

Izinto ezivimbela i-JAK ezifana ne-tofacitinib (Xeljanz) noma i-baricitinib (Olumiant) yimithi yomlomo engaba lula ukuyithatha kwabanye abantu. Ama-DMARDs endabuko afana ne-methotrexate noma i-sulfasalazine aqhubeka ebalulekile njengezinketho zokwelapha, ikakhulukazi kubantu abasaqala ukwelashwa kwe-arthritis.

Umhlinzeki wakho wezempilo uzokusiza ukhethe inketho engcono kakhulu ngokusekelwe ezimpawini zakho, ezinye izimo zempilo, kanye nezintandokazi zokwelapha.

Ingabe i-Sarilumab Ingcono Kune-Tocilizumab?

I-Sarilumab ne-tocilizumab zombili ziyizinto ezivimbela i-IL-6, okusho ukuthi zisebenza ngezindlela ezifanayo kakhulu ukunciphisa ukuvuvukala. Ukuziqhathanisa ngokuqondile kungaba nzima ngoba azizange zihlolwe ngqo ezifundweni ezinkulu.

Zombili lezi zithako zisebenza kahle kakhulu ekwelapheni i-rheumatoid arthritis, futhi abantu abaningi benza kahle nganoma iyiphi inketho. Ukukhetha kuvame ukwehla ezintweni ezingokoqobo njengendlela umuthi onikezwa ngayo nezintandokazi zakho.

I-Sarilumab itholakala kuphela njengomjovo ozifakelwa njalo emavikini amabili, kuyilapho i-tocilizumab inganikezwa njengokufakwa njalo ngemva kwamasonto amane noma umjovo wamasonto onke. Abanye abantu bakhetha ukulula komjovo ozifakelwa, kuyilapho abanye bethanda ukuthatha imithi engavamile yokufakwa.

Udokotela wakho uzocabangela isimo sakho esithile, okuhlanganisa neminye imithi oyithathayo nanoma yimaphi imiphumela emibi oyitholile, ukusiza ukunquma ukuthi iyiphi inketho engasebenza kangcono kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Sarilumab

Ingabe i-Sarilumab Iphephile Kubantu Abanezifo Zenhliziyo?

I-Sarilumab ingasetshenziswa kubantu abanezifo zenhliziyo, kodwa idinga ukuqapha ngokucophelela. Umuthi ungakhuphula amazinga e-cholesterol, okungase kuthinte ingozi yakho yenhliziyo nemithambo yegazi.

Udkt wenu uzohlola amazinga akho e-cholesterol njalo futhi angase anikeze imithi yokwehlisa i-cholesterol uma kudingeka. Bazophinde baqaphe impilo yakho yonke yenhliziyo ngesikhathi sokwelashwa.

Uma unenhliziyo ehlulekayo enkulu noma izinkinga zenhliziyo zakamuva, umhlinzeki wakho wezempilo uzolinganisela izinzuzo ze-sarilumab nezingozi ezingaba khona. Ukuxhumana okuvulekile nodokotela wakho wenhliziyo kanye nodokotela wama-rheumatologist kubalulekile.

Kufanele Ngenzeni Uma Ngizisebenzisa Ngengozi I-Sarilumab Eningi Kakhulu?

Uma ngengozi ujova i-sarilumab eningi kunaleyo ebekiwe, xhumana nomhlinzeki wakho wezempilo noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini.

Ukweqisa kwe-sarilumab kungandisa ingozi yakho yokutheleleka okukhulu noma eminye imiphumela emibi. Udokotela wakho angase afune ukukuqapha eduze noma alungise isimiso sakho sokwelashwa.

Ukuvimbela ukweqisa ngengozi, hlola kabili umthamo wakho ngaphambi kokujova futhi ungalokothi uthathe imithamo eyengeziwe ukuze "ubambe" uma uphuthelwe owodwa.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Sarilumab?

Uma uphuthelwa umjovo wakho we-sarilumab ohleliwe, wuthathe ngokushesha lapho ukhumbula, bese ubuyela esimisweni sakho esijwayelekile. Ungaphindi imithamo noma uthathe imijovo emibili eduze.

Uma sekudlule izinsuku ezimbalwa ngemuva komthamo wakho ophuthelwe, xhumana nomhlinzeki wakho wezempilo ukuze uthole isiqondiso. Bangase bancomise ukulungisa isimiso sakho noma bakuqaphe eduze.

Ukusetha izikhumbuzi ocingweni lwakho noma ekhalendeni kungakusiza ukuthi ukhumbule isimiso sakho somjovo. Abanye abantu bakuthola kuwusizo ukujova ngosuku olufanayo lwesonto njalo emavikini amabili.

Ngingayeka Nini Ukuthatha I-Sarilumab?

Kufanele uyeke kuphela ukuthatha i-sarilumab ngaphansi kokuqondisa kukadokotela wakho. Ukuyeka ngokuphazima imithi kungabangela ukuthi izimpawu zakho ze-arthritis zibuye, ngezinye izikhathi zibe zimbi kakhulu kunakuqala.

Umhlinzeki wakho wokunakekelwa kwezempilo angase ancome ukuyeka i-sarilumab uma uba nemiphumela emibi engathi sína, izifo, noma uma isimo sakho singena ekuxolelweni kwesikhathi eside. Bazokwenza uhlelo lokukuqapha ngokucophelela ngesikhathi sokushintshwa kokwelashwa.

Abanye abantu bangase bakwazi ukunciphisa umthamo wabo noma bandise isikhathi phakathi kwemijovo esikhundleni sokuyeka ngokuphelele. Udokotela wakho uzosebenza nawe ukuthola indlela ezigcina izimpawu zakho zilawulwa ngemithi encane ngangokunokwenzeka.

Ngingakwazi Ukuthola Imigomo Ngesikhathi Ngithatha I-Sarilumab?

Ungathola imigomo eminingi ngenkathi uthatha i-sarilumab, kodwa imigomo ebukhoma kufanele igwenywe ngoba ingase ibangele izifo kubantu abanezinhlelo zokuzivikela ezicindezelwe.

Udokotela wakho uzoncoma ukuthola imigomo ebalulekile efana nemijovo yomkhuhlane, imigomo yepneumonia, kanye nemigomo ye-COVID-19 ngaphambi kokuqala i-sarilumab. Le migomo isebenza kahle kakhulu lapho uhlelo lwakho lokuzivikela lungacindezelwe.

Njalo tshela noma yimuphi umhlinzeki wokunakekelwa kwezempilo okunikeza imigomo ukuthi uthatha i-sarilumab. Bazoqinisekisa ukuthi imigomo iphephile futhi ifanele isimo sakho.