Yini i-Saxagliptin kanye ne-Metformin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Saxagliptin kanye ne-metformin kuyisithako esihlanganisiwe esisiza ukuphatha isifo sikashukela sohlobo 2 ngokusebenza ngezindlela ezimbili ezihlukene zokulawula amazinga kashukela egazini. Lo muthi oqokiwe uhlanganisa ukwelashwa okubili okufakazelwe kwesifo sikashukela emthini owodwa olula, okwenza kube lula ukuthi unamathele ohlelweni lwakho lokwelashwa.

Uma uqokiwe lo muthi, cishe uyazibuza ukuthi usebenza kanjani nokuthi yini ongayilindela. Ake sihambe kukho konke okudingeka ukwazi ngalo muthi wesifo sikashukela ngendlela ezizwakala ilawuleka futhi icacile.

Yini i-Saxagliptin kanye ne-Metformin?

I-Saxagliptin kanye ne-metformin ngumuthi oqokiwe oqukethe izithako ezimbili ezisebenzayo ezisebenza ndawonye ukusiza ukulawula ushukela wegazi kubantu abanesifo sikashukela sohlobo 2. Cabanga ngakho njengendlela yeqembu lapho umuthi ngamunye ubhekana noshukela wegazi ngendlela ehlukile.

I-Saxagliptin ingeyeqembu lemithi ebizwa ngokuthi ama-DPP-4 inhibitors, asiza umzimba wakho ukuthi ukhiqize i-insulin eyengeziwe lapho ushukela wegazi lakho uphakeme. I-Metformin ivela eqenjini elibizwa ngokuthi ama-biguanides, futhi isiza ukunciphisa inani likashukela isibindi sakho esikwenzayo ngenkathi futhi isiza umzimba wakho ukuthi usebenzise i-insulin ngempumelelo.

Lo muthi ohlanganisiwe utholakala njengamaphilisi owathatha ngomlomo, ngokuvamile kabili ngosuku ngokudla. Udokotela wakho ukunikeza lokhu lapho imithi eyodwa inganikezi ukulawulwa okwanele kukashukela wegazi yodwa.

Yini i-Saxagliptin kanye ne-Metformin Esetshenziselwa Yona?

Lo muthi wenzelwe ngqo ukwelapha isifo sikashukela sohlobo 2 kubantu abadala lapho ukudla nokuzivivinya kuphela kunganele ukulawula amazinga kashukela egazini. Ilusizo ikakhulukazi kubantu abadinga ngaphezu kohlobo olulodwa lomuthi wesifo sikashukela ukuze bafinyelele emigomweni yabo kashukela wegazi.

Udktela wakho angase akunike le nhlanganisela uma ubuthatha i-metformin yodwa kodwa usenawo amazinga kashukela egazi aphakeme. Isetshenziswa futhi uma udinga imithi yomibili kodwa ufuna ukuthola lula lokuthatha iphilisi elilodwa esikhundleni sezimbili ezihlukene.

Umuthi usebenza kahle kakhulu njengengxenye yohlelo oluphelele lokuphatha isifo sikashukela oluhlanganisa ukudla okunempilo, ukuzivocavoca umzimba njalo, nokuphatha isisindo uma kufanele. Akuhloselwe ukushintsha lezi zindlela ezibalulekile zokuphila kodwa kunalokho ukusebenza kanye nazo.

Isebenza Kanjani I-Saxagliptin ne-Metformin?

Le nhlanganisela yomuthi isebenza ngezindlela ezimbili ezihlukene ukusiza ukugcina ushukela wakho wegazi ebangeni elinempilo. Ingxenye ye-saxagliptin isiza amanyikwe akho ukuthi akhiphe i-insulin eningi lapho ushukela wakho wegazi ukhuphuka ngemva kokudla, kuyilapho futhi kunciphisa inani le-glucose isibindi sakho esikhiqizayo.

Ingxenye ye-metformin ngokuyinhloko isebenza ngokunciphisa inani likashukela isibindi sakho esikwenzayo futhi sikhiphe egazini lakho. Futhi isiza imisipha yakho kanye namaseli amafutha ukuthi abe sensitive kakhulu ku-insulin, okusho ukuthi angasebenzisa i-glucose ngempumelelo.

Ngokuhlanganyela, le mithi emibili inikeza lokho odokotela abakubiza ngokuthi izinga

Zama ukuthatha imithamo yakho cishe ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo omuthi emzimbeni wakho. Abantu abaningi bakuthola kuwusizo ukuxhumanisa ukuthatha imithi yabo nokudla okuvamile, njengesidlo sasekuseni nesidlo sakusihlwa, ukuze basungule isimiso esiqhubekayo.

Ngaphambi kokuqala lo muthi, yidla ukudla okulula noma ukudla okulula ukuze usize ukuvimbela ukuphatheka kabi kwesisu. Ukudla okulula esiswini sakho, njengama-toast, ama-crackers, noma iyogathi, kusebenza kahle uma ukhathazekile ngesicanucanu.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Saxagliptin ne-Metformin?

Uhlobo 2 lukashukela isimo sesikhathi eside, ngakho-ke abantu abaningi badinga ukuthatha lo muthi iminyaka eminingi noma ngisho unomphela ukuze bagcine ukulawulwa okuhle kukashukela wegazi. Udokotela wakho uzohlola njalo amazinga kashukela wegazi lakho nempilo yonke ukuze anqume ukuthi lo muthi uqhubeka yini ukuba yisinqumo esifanele kuwe.

Ngezinyanga zakho zokuqala ezimbalwa kulolu hlobo lomuthi, cishe uzoba nokuhlolwa okuvamile nokuhlolwa kwegazi ukuze uqiniseke ukuthi kusebenza kahle futhi akubangeli zinkinga. Ngemuva kwalokho, abantu abaningi banemithi yabo yesifo sikashukela ebuyekezwa njalo ezinyangeni ezintathu kuya kweziyisithupha.

Udokotela wakho angase alungise umthamo wakho noma akuqhubekisele emithini ehlukene ngokuhamba kwesikhathi njengoba izidingo zomzimba wakho zishintsha. Lokhu kuvamile ngokuphelele futhi akusho ukuthi umuthi awusebenzi - kusho nje ukuthi uhlelo lwakho lokwelapha lulungiswa kahle ngesimo sakho sempilo yamanje.

Yiziphi Imiphumela Eceleni ye-Saxagliptin ne-Metformin?

Njengayo yonke imithi, i-saxagliptin ne-metformin kungabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ivamise ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini emasontweni ambalwa okuqala.

Nansi imiphumela emibi ongase uyithole, ukhumbula ukuthi izinkinga ezihlobene nesisu zivame kakhulu:

• Ukugula noma ukungakhululeki kwesisu okuncane
• Ukuqunjelwa noma izitulo ezixekile
• Ikhanda elibuhlungu
• Izifo ezingaphezulu zokuphefumula njengomkhuhlane
• Ukunambitheka kwensimbi emlonyeni wakho
• Ukuncipha kwesifiso sokudla

Le miphumela eseceleni ejwayelekile ivamise ukuba yesikhashana futhi ilawuleke. Ukuthatha imithi nokudla kanye nokuqala ngemithamo emincane kungasiza ekunciphiseni izinkinga zesisu.

Manje, ake sikhulume ngeminye imiphumela eseceleni engavamile kodwa ebucayi edinga ukunakekelwa kwezempilo ngokushesha:

• Ubuhlungu obukhulu besisu obungapheli
• Ukugula okuqhubekayo nokuhlanza
• Ubuhlungu obungavamile bemisipha noma ubuthakathaka
• Ukuphefumula kanzima noma ukuphefumula ngokushesha
• Ukuphendula kwesikhumba okukhulu noma ukuqubuka
• Izimpawu zezinkinga zezinso njengoshintsho ekuchameni

Ngenkathi le miphumela emibi ingavamile, kubalulekile ukuyibona kusenesikhathi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezempilo eziphuthumayo.

Kukhona futhi isimo esingavamile kakhulu kodwa esibi esibizwa ngokuthi i-lactic acidosis engenzeka nge-metformin. Lokhu kwenzeka lapho i-lactic acid yakheka egazini lakho ngokushesha kunokuba umzimba wakho ungayisusa. Izimpawu zokuxwayisa zihlanganisa ubuhlungu obungavamile bemisipha, ukungaphefumuli kahle, ubuhlungu besisu, isiyezi, nokuzizwa ubuthakathaka kakhulu noma ukhathele.

Ubani Ongafanele Athole i-Saxagliptin ne-Metformin?

Le mithi ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Abantu abanezimo ezithile zezempilo noma izimo kufanele bagweme le mithi ehlanganisiwe ngokuphelele.

Akufanele uthathe le mithi uma unesifo sikashukela sohlobo 1 noma i-diabetic ketoacidosis, njengoba yenzelwe ngokuqondile ukuphathwa kwesifo sikashukela sohlobo 2. Akunconywa futhi uma unokungezwani ne-saxagliptin, metformin, noma ezinye izithako emithini.

Nansi izimo ezithile zezempilo ezenza le mithi ingafaneleki noma idinga ukuqapha okukhethekile:

• Isifo sezinso noma ukuncipha komsebenzi wezinso
• Isifo sesibindi noma ama-enzyme esibindi aphakeme
• Umlando we-pancreatitis (ukuqubuka kwamanyikwe)
• Ukuhluleka kwenhliziyo okudinga imithi
• Ukutheleleka okukhulu noma ukugula
• Umlando we-lactic acidosis

Udkt wakho uzophinda aqaphele ngokuqoka lo muthi uma uhlelelwe ukuhlinzwa noma ezinye izinqubo zezokwelapha ezidinga umbala ohlukile, njengoba kungase kudingeke ukuthi uyeke okwesikhashana lo muthi ngalezo zikhathi.

Uma ukhulelwe, uhlela ukukhulelwa, noma uncelisa, xoxa ngalokhu nodokotela wakho. Ngenkathi i-metformin ngezinye izikhathi isetshenziswa ngesikhathi sokukhulelwa, ukuphepha kwe-saxagliptin ngesikhathi sokukhulelwa akukatholakali ngokugcwele, ngakho ukwelashwa okuhlukile kungase kube kufanelekile.

Amagama Omkhiqizo we-Saxagliptin kanye ne-Metformin

Igama elivamile lomkhiqizo walo muthi ohlanganisiwe yi-Kombiglyze XR, okuyinguqulo yokukhishwa okwandisiwe ovame ukuyithatha kanye ngosuku. Kukhona futhi nenguqulo yokukhishwa okuvamile ethathwa kabili ngosuku.

Ungase futhi ubone izinguqulo ezivamile zale nhlanganisela, equkethe izithako ezifanayo ezisebenzayo kodwa ezenziwe izinkampani ezahlukene zemithi. Izinguqulo ezivamile zisebenza kahle njengemithi yegama lomkhiqizo futhi zivame ukubiza kancane.

Ikhemisi lakho lingase lithathele indawo ngenguqulo ejwayelekile ngaphandle uma udokotela wakho ecela ngokuqondile igama lomkhiqizo. Lokhu kuvamile futhi kuphephile - izithako ezisebenzayo nokusebenza kahle kuhlala kufana.

Ezinye izindlela ze-Saxagliptin kanye ne-Metformin

Uma le nhlanganisela ingasebenzi kahle kuwe noma ibangela imiphumela engathandeki, kukhona izindlela eziningi zokwelapha ezitholakalayo. Udokotela wakho angakusiza ukuthi uthole umuthi ofanele noma inhlanganisela esebenza kahle kakhulu esimweni sakho esithile.

Ezinye izinhlanganisela ze-DPP-4 inhibitor kanye ne-metformin zihlanganisa i-sitagliptin kanye ne-metformin (Janumet) noma i-linagliptin kanye ne-metformin (Jentadueto). Lezi zisebenza ngendlela efanayo kodwa zingase zibekezelelwe kangcono ngabanye abantu.

Uma ungakwazi ukuthatha i-metformin ngenxa yezinkinga zezinso noma imiphumela emibi, udokotela wakho angase akubhalele i-saxagliptin yodwa noma ayihlanganise neminye imithi yesifo sikashukela efana ne-insulin noma ama-SGLT2 inhibitors.

Kubantu abathanda imithi ejovwayo, ama-GLP-1 receptor agonists afana ne-semaglutide noma i-liraglutide angaba ezinye izindlela ezinhle ezivame ukunikeza ukulawulwa okungcono ushukela wegazi futhi kungase kusize ekunciphiseni isisindo.

Ingabe i-Saxagliptin kanye ne-Metformin Ingcono Kune-Sitagliptin kanye ne-Metformin?

Kokubili i-saxagliptin kanye ne-metformin (Kombiglyze) kanye ne-sitagliptin kanye ne-metformin (Janumet) imithi efana kakhulu esebenza ngezindlela eziqhathanisekayo. Zombili zingama-DPP-4 inhibitors ahlanganiswe ne-metformin, futhi ucwaningo lubonisa ukuthi zinempumelelo efanayo ekwehliseni amazinga kashukela egazini.

Ukukhetha phakathi kwale mithi kuvame ukuncika ezintweni zomuntu ngamunye njengemiphumela emibi, ukulula kokulinganisa, izindleko, kanye nomshwalense. Abanye abantu bayakubekezelela okunye kangcono kunokunye, nakuba iningi labantu lenza kahle nganoma iyiphi inketho.

Udokotela wakho uzocabangela isimo sakho sempilo esithile, eminye imithi oyithathayo, kanye nezintandokazi zakho siqu lapho unquma phakathi kwalezi zinketho. Zombili zithathwa njengeziphephile nezisebenzayo zokwelashwa kokuqala kwesifo sikashukela sohlobo 2.

Imibuzo Evame Ukubuzwa Mayelana ne-Saxagliptin kanye ne-Metformin

Q1. Ingabe i-Saxagliptin kanye ne-Metformin Iphephile Kubantu Abanezifo Zenhliziyo?

Ngokuvamile, le nhlanganisela ithathwa njengephephile kubantu abanezifo zenhliziyo, futhi i-metformin ingase inikeze ezinye izinzuzo zokuvikela inhliziyo. Nokho, udokotela wakho uzofuna ukukuqapha eduze uma unesifo senhliziyo noma ezinye izimo zenhliziyo ezinzima.

Umuthi ngokuvamile awubangeli izinkinga zenhliziyo kubantu abanempilo, kodwa kubalulekile ukutshela udokotela wakho nganoma yiziphi izimo zenhliziyo onazo. Bangase balungise umthamo wakho noma bakhethe imithi ehlukile uma unehluleka kwenhliziyo okuthuthukile.

Umbuzo 2. Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi I-Saxagliptin ne-Metformin Ngokweqile?

Uma ngengozi uthatha umuthi omningi kakhulu, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukuthatha i-metformin eningi kakhulu kungaholela esimweni esibucayi esibizwa nge-lactic acidosis, esidinga ukunakekelwa kwezokwelapha ngokushesha.

Qaphela izimpawu ezinjengobuhlungu obungavamile bemisipha, ubunzima bokuphefumula, ubuhlungu besisu, isiyezi, noma ukuzizwa ubuthakathaka kakhulu. Ungalindi ukuthi izimpawu zivele ngaphambi kokufuna usizo - shayela udokotela wakho ngokushesha uma uthathe okuningi kunokuba kunqunywe.

Umbuzo 3. Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Saxagliptin ne-Metformin?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, kodwa kuphela uma kungasondeli emthamweni wakho olandelayo ohleliwe. Uma sekuyisikhathi somthamo wakho olandelayo, weqa lowo ophuthelwe futhi uqhubeke neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni.

Umbuzo 4. Ngingayeka Nini Ukuthatha I-Saxagliptin ne-Metformin?

Kufanele uyeke kuphela ukuthatha lo muthi ngaphansi kwesiqondiso sikadokotela wakho. Uhlobo 2 lukashukela yisimo sempilo yonke, ngakho abantu abaningi badinga ukuqhubeka nokuthatha imithi yesifo sikashukela unomphela ukuze bagcine ukulawulwa okuhle kukashukela wegazi.

Udokotela wakho angase alungise imithi yakho ngokuhamba kwesikhathi ngokusekelwe emazingeni akho kashukela wegazi, imiphumela emibi, noma izinguquko empilweni yakho. Uma ukhathazekile ngokuthatha imithi isikhathi eside, xoxa ngemizwa yakho nodokotela wakho - bangakusiza ukuthi uqonde izinzuzo futhi babhekane nanoma yikuphi ukukhathazeka.

Q5. Ngingawuphuza utshwala ngenkathi ngithatha i-Saxagliptin ne-Metformin?

Ungawuthatha utshwala ngezikhathi ezithile, ngamanani amancane ngenkathi uthatha lo muthi, kodwa kubalulekile ukuqaphela. Utshwala bungakhuphula ingozi yakho yokuthuthukisa i-lactic acidosis, ikakhulukazi uma uphuza kakhulu noma uphuza ngobuningi.

Uma uphuza, phuza utshwala ngokudla futhi uzilinganisele esiphuzweni esisodwa ngosuku uma ungumuntu wesifazane noma iziphuzo ezimbili ngosuku uma ungumuntu wesilisa. Njalo xoxa ngokusebenzisa kwakho utshwala nodokotela wakho, njengoba bengakunikeza isiqondiso esiqondene nawe esisekelwe empilweni yakho yonke.