Yini i-Saxagliptin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Saxagliptin iyimithi kadokotela esiza abantu abanesifo sikashukela sohlobo 2 ukulawula amazinga kashukela wegazi labo. Ingaphansi kohlu lwemithi olubizwa ngokuthi ama-DPP-4 inhibitors, asebenza ngokusiza umzimba wakho ukuthi ukhiqize i-insulin eyengeziwe lapho ushukela wakho wegazi uphezulu futhi unciphisa inani likashukela isibindi sakho esikwenzayo.

Le mithi ivame ukunqunywa lapho ukudla nokuzivocavoca kuphela kunganele ukulawula ushukela wegazi, noma lapho eminye imithi yesifo sikashukela idinga ukwesekwa okwengeziwe. Abantu abaningi bathola ukuthi i-saxagliptin iyisengezo esinobumnene kodwa esisebenzayo ohlelweni lwabo lokulawula isifo sikashukela.

Yini i-Saxagliptin?

I-Saxagliptin iyimithi yomlomo yesifo sikashukela oyithatha ngomlomo, ngokuvamile kanye ngosuku. Yenzelwe ukusebenza nesistimu yomzimba yakho yokukhiqiza i-insulin yemvelo kunokuphoqa izinguquko ezinkulu kushukela wakho wegazi.

Cabanga nge-saxagliptin njengomsizi olusizo ku-pancreas yakho. Lapho ushukela wakho wegazi ukhuphuka ngemva kokudla, uthumela isignali ku-pancreas yakho ukuthi ikhiphe i-insulin eyengeziwe. Ngesikhathi esifanayo, utshela isibindi sakho ukuthi sinciphise ukukhiqizwa kwaso ushukela, okudala indlela elinganiselwe yokulawula ushukela wegazi.

Le mithi ithathwa njengomuthi wesifo sikashukela onamandla aphakathi nendawo. Ayinqeni njengemijovo ye-insulin, kodwa iqondiswe ngokuqondile kunokushintsha kwendlela yokuphila okulula kuphela. Abantu abaningi bayayibekezelela kahle ngoba isebenza ngobumnene nezinhlelo zomzimba wakho ezikhona.

Isetshenziselwani i-Saxagliptin?

I-Saxagliptin isetshenziswa ikakhulukazi ukwelapha isifo sikashukela sohlobo 2 kubantu abadala. Udokotela wakho angase ayinikeze lapho uhlelo lwakho lwamanje lokulawula isifo sikashukela ludinga ukwesekwa okwengeziwe ukuze kufinyelelwe imigomo yakho kashukela wegazi.

Nazi izimo eziyinhloko lapho i-saxagliptin iba usizo:

• Lapho ukudla nokuzivivinya kuphela kungalawuli ushukela wakho wegazi ngokwanele
• Njengokwengezwa ku-metformin lapho i-metformin yodwa inganele
• Ngokuhlangana neminye imithi yesifo sikashukela efana ne-insulin noma i-sulfonylureas
• Uma udinga umuthi ongeke ubangele ukukhuluphala okukhulu
• Uma ufuna inketho yansuku zonke evumelana kalula nomkhuba wakho

Umhlinzeki wakho wezempilo uzonquma ukuthi i-saxagliptin ilungile yini esimweni sakho esithile. Bazocabangela amazinga akho kashukela wegazi wamanje, eminye imithi oyithathayo, kanye nesithombe sakho sempilo esiphelele.

Isebenza Kanjani I-Saxagliptin?

I-Saxagliptin isebenza ngokuvimba i-enzyme ebizwa nge-DPP-4 ohlelweni lwakho lokugaya ukudla. Le enzyme ngokuvamile ichitha amahomoni awusizo alawula ushukela wegazi, ngakho-ke ngokuyivimba, i-saxagliptin ivumela la mahomoni emvelo ukuthi asebenze isikhathi eside futhi ngempumelelo.

Uma udla, amathumbu akho akhipha amahomoni abizwa ngokuthi ama-incretins athumela isignali emzimbeni wakho ukuthi ukhiqize i-insulin. I-Saxagliptin isiza la mahomoni ukuthi ahlale esebenza isikhathi eside, okusho ukuthi umzimba wakho ungasabela ngendlela efanele emazingeni kashukela wegazi akhuphukayo.

Lo muthi ubhekwa njengomuthi wesifo sikashukela onamandla aphakathi nendawo. Unomusa kune-insulin noma i-sulfonylureas ngoba usebenza kuphela lapho ushukela wakho wegazi uphakeme. Lapho ushukela wakho wegazi ujwayelekile, i-saxagliptin inemiphumela emincane, okunciphisa ingozi yezigameko eziyingozi zikashukela wegazi ophansi.

Ubuhle bale ndlela ukuthi isebenza nesigqi somzimba wakho esingokwemvelo. Awuphoqi umzimba wakho ukuthi usebenze isikhathi esengeziwe njalo, umane nje uwanikeza amathuluzi angcono okwenza umsebenzi wawo uma kudingeka.

Kufanele Ngiyithathe Kanjani I-Saxagliptin?

I-Saxagliptin ngokuvamile ithathwa kanye ngosuku, nokudla noma ngaphandle kokudla. Abantu abaningi bakuthola kulula ukuyithatha ngesikhathi esifanayo nsuku zonke ukuze bagcine amazinga aqhubekayo ohlelweni lwabo.

Ungathatha i-saxagliptin ngamanzi, ubisi, noma ijusi. Ngokungafani neminye imithi, ayidingi isikhathi esikhethekile sokudla. Kodwa-ke, ukuyithatha nokudla kungasiza uma uhlangabezana nokungakhululeki esiswini, nakuba lokhu kungavamile.

Nakhu okusebenza kahle kakhulu kubantu abaningi:

• Khetha isikhathi esifanayo nsuku zonke, njengasekuseni noma kusihlwa
• Gwinya ithebhulethi yonke ngenkomishi yamanzi egcwele
• Ungayichobozi noma uyihlafune ithebhulethi
• Uma uyithatha nokudla, noma yisiphi isidlo esivamile silungile
• Qhubeka nokuyithatha ngisho noma uzizwa kahle, njengoba ukuphathwa kwesifo sikashukela kuqhubeka

Udokotela wakho uzoqala ngomthamo ofanele ngokuya ngokusebenza kwezinso zakho nezinye izinto zezempilo. Abantu abaningi baqala ngama-2.5 mg noma ama-5 mg kanye ngosuku, futhi lokhu kuvame ukuhlala umthamo wesikhathi eside.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Saxagliptin?

I-Saxagliptin ngokuvamile iyimithi yesikhathi eside ozoqhubeka nokuyithatha uma nje isiza ukuphatha isifo sikashukela sakho ngempumelelo. Uhlobo 2 lwesifo sikashukela yisimo esingamahlalakhona esidinga ukuphathwa okuqhubekayo, ngakho-ke abantu abaningi bahlala emithini yabo yesifo sikashukela unomphela.

Udokotela wakho uzoqapha amazinga kashukela egazini lakho nempilo yonke njalo ukuze aqinisekise ukuthi i-saxagliptin iyaqhubeka nokuba yisinqumo esifanele kuwe. Ngokuvamile bazohlola amazinga akho e-A1C njalo ezinyangeni ezintathu kuya kweziyisithupha ukuze babone ukuthi uhlelo lwakho lokuphatha isifo sikashukela lusebenza kahle kangakanani.

Abanye abantu bangase badinge ukulungisa imithi yabo yesifo sikashukela ngokuhamba kwesikhathi. Lokhu akusho ukuthi i-saxagliptin isiyekile ukusebenza, kodwa kunalokho ukuthi isifo sikashukela singashintsha futhi sithuthuke. Ithimba lakho lezempilo lizosebenza nawe ukwenza noma yikuphi ukulungiswa okudingekayo ukuze ugcine ushukela wakho wegazi ebangeni elinempilo.

Ungayeki ukuthatha i-saxagliptin ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Noma ngabe uzizwa umuhle, ushukela wakho wegazi ungaqala ukukhuphuka uze ufike emazingeni ayingozi ngaphandle kokuphathwa kwemithi okufanele.

Yiziphi Imiphumela Eceleni ye-Saxagliptin?

Abantu abaningi bayakwazi ukumelana ne-saxagliptin kahle, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathí sina ayivamile, futhi abantu abaningi ababi nayo imiphumela emibi nhlobo.

Nansi imiphumela emibi evame kakhulu abanye abantu abayitholayo:

• Ukukhathazeka ikhanda
• Izifo eziphezulu zokuphefumula (njengomkhuhlane)
• Izifo zomgudu womchamo
• Ubuhlungu besisu noma ukungakhululeki
• Isicanucanu

Le miphumela emibi ejwayelekile ivame ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Uma ziqhubeka noma ziba yinkinga, yazisa umhlinzeki wakho wezempilo.

Kukhona imiphumela emibi embalwa kodwa engathi sína edinga ukunakekelwa kwezempilo ngokushesha:

• Ubuhlungu obukhulu emalungeni obungathuthuki
• Izimpawu ze-pancreatitis (ubuhlungu obukhulu besisu obungase buye emhlane wakho)
• Ukungezwani komzimba (ukuqubuka, ukuluma, ukuvuvukala, ubunzima bokuphefumula)
• Izimpawu zokuhluleka kwenhliziyo (ukuqubuka emilenzeni, ukuphefumula kanzima, ukukhathala okungavamile)
• Ukuphendula kwesikhumba okukhulu noma ukuqhekeka

Ngenkathi le miphumela emibi engathi sína ingavamile, kubalulekile ukuyazi futhi uthinte udokotela wakho ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu.

Ubani Ongafanele Athole I-Saxagliptin?

I-Saxagliptin ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Kunezimo ezithile lapho lo muthi kufanele ugwenywe noma usetshenziswe ngokuqapha okwengeziwe.

Akufanele uthathe i-saxagliptin uma une:

• Isifo sikashukela sohlobo 1 (ivunyelwe kuphela uhlobo 2)
• Umlando wokungezwani komzimba okukhulu ku-saxagliptin noma imithi efanayo
• I-diabetic ketoacidosis (inkinga enkulu yesifo sikashukela)
• Isifo sezinso esibi (udokotela wakho angase adinge ukulungisa umthamo noma akhethe omunye umuthi)

Udokotela wakho uzosebenzisa i-saxagliptin ngokuqapha okwengeziwe uma une:

• Umlando wokuhluleka kwenhliziyo
• Izinkinga zezinso (ngisho nezincane zingadinga ukulungiswa komthamo)
• Umlando we-pancreatitis
• Amathambo e-gall noma izinkinga ze-gallbladder
• Umlando wezinkinga ezinzima zamalunga

Njalo tshela udokotela wakho ngazo zonke izimo zakho zezokwelapha nemithi ngaphambi kokuqala i-saxagliptin. Lokhu kubasiza ukuthi banqume ukuthi iyona ekhethekile futhi esebenza kahle kakhulu ekuphathweni kwesifo sakho sikashukela.

Igama Lomkhiqizo le-Saxagliptin

I-Saxagliptin itholakala ngaphansi kwegama lomkhiqizo elithi Onglyza. Ungase futhi uyithole ihlanganiswe neminye imithi yesifo sikashukela ngaphansi kwamanye amagama omkhiqizo.

Inhlanganisela ye-saxagliptin ne-metformin ithengiswa njenge-Kombiglyze XR. Leli thebhulethi elihlanganisiwe lingaba lula kubantu abadinga womabili lawo machiza, njengoba kunciphisa inani lamaphilisi okudingeka uwathathe nsuku zonke.

Noma ngabe uthola igama lomkhiqizo noma inguqulo ejwayelekile, isithako esisebenzayo nokusebenza kahle kuyafana. Uhlelo lwakho lomshuwalense nekhemisi kungase kuthinte ukuthi iyiphi inguqulo oyitholayo, kodwa zombili izinketho zisebenza kahle ngokulinganayo ekuphatheni ushukela wegazi.

Ezinye Izindlela ze-Saxagliptin

Uma i-saxagliptin ingakulungele, kunezinye izindlela eziningi zemithi yesifo sikashukela esebenza ngezindlela ezifanayo noma ezihlukene. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho ngokusekelwe ezidingweni zakho ezithile nesimo sempilo.

Ezinye izinto ezivimbela i-DPP-4 ezisebenza ngendlela efana ne-saxagliptin zihlanganisa:

• Sitagliptin (Januvia)
• Linagliptin (Tradjenta)
• Alogliptin (Nesina)

Amanye amakilasi emithi yesifo sikashukela okungenzeka ukuthi udokotela wakho angawacabangela ahlanganisa:

• Metformin (ngokuvamile ukwelashwa kokuqala)
• Ama-GLP-1 receptor agonists (njenge-semaglutide noma i-liraglutide)
• Ama-SGLT-2 inhibitors (njenge-empagliflozin noma i-canagliflozin)
• Ama-Sulfonylureas (njenge-glipizide noma i-glyburide)
• I-Insulin (yokuphathwa kwesifo sikashukela esithuthukisiwe)

Enye indlela engcono kakhulu incike kuphrofayela yakho yezempilo, eminye imithi oyithathayo, kanye nemigomo yakho yokuphatha isifo sikashukela. Umhlinzeki wakho wezempilo uzosebenza nawe ukuthola inketho esebenza kahle kakhulu futhi ebekezelelekayo.

Ingabe i-Saxagliptin ingcono kune-Sitagliptin?

Kokubili i-saxagliptin ne-sitagliptin ziyizithiyo ze-DPP-4 ezisebenza ngendlela efanayo kakhulu ukuphatha isifo sikashukela sohlobo 2. Akukho mithi enye engcono kakhulu kunenye, njengoba zombili ziyizinketho ezisebenzayo ezinenzuzo efanayo kanye namaphrofayili emiphumela emibi.

Umehluko omkhulu phakathi kwale mithi mncane. I-Sitagliptin itholakale isikhathi eside futhi inemininingwane eminingi yocwaningo. I-Saxagliptin ingase ibe nephrofayili ehlukile kancane yemiphumela emibi, ngocwaningo oluthile oluphakamisa imiphumela ehlukene empilweni yenhliziyo, nakuba zombili zithathwa njengeziphephile.

Ukukhetha kukadokotela wakho phakathi kwale mithi kuvame ukuncika ku:

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• Ukusebenza kwakho kwezinso (ukulungiswa kwemithamo kungahluka)
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• Eminye imithi oyithathayo
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• Umshwalense wakho kanye nezindleko zemithi
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• Izimo zakho zempilo ezithile kanye nezici eziyingozi
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• Ukuthi usebenze kahle kangakanani kweminye imithi yesifo sikashukela
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Zombili le mithi ithathwa kanye ngosuku futhi isebenza kahle ngokuhlanganiswa nezinye izindlela zokwelapha isifo sikashukela. Inketho

Kodwa-ke, lokhu akusho ukuthi i-saxagliptin ayiphephile ngokuzenzakalelayo kubantu abanezifo zenhliziyo. Udokotela wakho uzohlola izinzuzo zokulawula ushukela wegazi ngokumelene nezingozi ezingaba khona zenhliziyo. Bazokuqapha ngokucophelela futhi bangase bakuncome ukuhlolwa okujwayelekile komsebenzi wenhliziyo uma unokukhathazeka nganoma yini ye-cardiovascular.

Uma unesifo senhliziyo, qiniseka ukuthi uxoxa lokhu ngokucophelela nomhlinzeki wakho wezempilo. Bangase bakhethe umuthi ohlukile wesifo sikashukela noma bathathe izinyathelo ezengeziwe zokuqapha impilo yakho yenhliziyo ngenkathi uthatha i-saxagliptin.

Kufanele ngenzeni uma ngithatha i-Saxagliptin eningi ngengozi?

Uma ngengozi uthatha i-saxagliptin eningi kunaleyo ebekiwe, ungangeni ekuqeqesheni. Ukuthatha umthamo ophindwe kabili ngezikhathi ezithile akunakwenzeka ukuthi kubangele ukulimala okukhulu, kodwa kufanele usaxhumane nomhlinzeki wakho wezempilo noma isikhungo sokulawula ubuthi ukuze uthole isiqondiso.

Ziqaphele izimpawu ezinjengokucasuka, ukuhlanza, ubuhlungu besisu, noma ukukhathala okungavamile. Ngenkathi i-saxagliptin ingavamile ukubangela ushukela wegazi ophansi oyingozi yodwa, ukuthatha okuningi kakhulu kungaholela kulezi zimpawu, ikakhulukazi uma uthatha eminye imithi yesifo sikashukela.

Shayela udokotela wakho, usokhemisi, noma isikhungo sokulawula ubuthi (1-800-222-1222 e-US) uma ukhathazekile ngokuthatha okuningi kakhulu. Bangakunikeza isiqondiso esiqondile esisekelwe ekutheni uthathe okungakanani kanye nesimo sakho sempilo.

Ungazami ukwenza

Ukushiya umthamo ngezikhathi ezithile akuyona ingozi, kodwa zama ukugcina ukuqina ukuze uthole ukuphathwa okungcono kakhulu kwesifo sikashukela. Cabangela ukusetha isikhumbuzi sansuku zonke ocingweni lwakho noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule uhlelo lwakho lwemithi.

Ngingayeka nini ukuthatha i-Saxagliptin?

Kufanele uyeke kuphela ukuthatha i-saxagliptin ngaphansi kokuqondisa komhlinzeki wakho wezempilo. Noma ngabe amazinga akho kashukela egazi athuthuke kakhulu, lokhu kungenzeka ngenxa yokuthi umuthi uyasebenza, hhayi ngoba awusawudingi.

Udokotela wakho angase acabangele ukunciphisa noma ukuyeka i-saxagliptin uma wenze izinguquko ezinkulu zokuphila eziye zathuthukisa ukulawulwa kwesifo sikashukela, uma uhlangabezana nemiphumela engemihle, noma uma befuna ukuzama indlela ehlukile yemithi.

Abanye abantu bangakwazi ukunciphisa imithi yabo yesifo sikashukela ngokulahlekelwa isisindo esikhulu, ukudla okuthuthukisiwe, nokuzivocavoca njalo. Kodwa-ke, lesi sinqumo kufanele senziwe ngaso sonke isikhathi ngokubambisana nethimba lakho lezempilo, ngokuqapha ngokucophelela amazinga akho kashukela egazi ngazo zonke izinguquko zemithi.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Saxagliptin?

Ukusetshenziswa kotshwala ngokulinganisela kuvamile ukwamukeleka ngenkathi kuthathwa i-saxagliptin, kodwa kufanele uxoxe ngalokhu nodokotela wakho. Utshwala bungathinta amazinga kashukela egazi, futhi ukuhlanganiswa nemithi yesifo sikashukela kudinga ukuqapha okuthile.

Uma ukhetha ukuphuza utshwala, kwenze ngokulinganisela futhi ngaso sonke isikhathi ngokudla. Utshwala bunganciphisa amazinga kashukela egazi, ikakhulukazi uma kuhlanganiswe nemithi yesifo sikashukela, ngakho qapha ushukela wakho wegazi ngokucophelela ezinsukwini lapho uphuza khona.

Qaphela ukuthi utshwala bungafihla izimpawu zikashukela ophansi, okwenza kube nzima ukuqaphela uma ushukela wakho wegazi wehla kakhulu. Uma uthatha eminye imithi yesifo sikashukela kanye ne-saxagliptin, ingozi kashukela ophansi ngotshwala ingase ibe phezulu.