Yini i-Secretin (Indlela Yokufaka Ngemithambo): Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Secretin iyisidakamizwa se-hormone esenziwe ngendlela yokwenziwa esinikezwa ngemithambo esisiza odokotela ukuthi bathole izinkinga nge-pancreas yakho kanye ne-gallbladder. Umzimba wakho ngokwemvelo wenza i-secretin emathunjini akho amancane, kodwa inguqulo yezokwelapha yenziwe ngendlela ekhethekile ukuthi iqale i-pancreas yakho ukuthi ikhiphe amajusi okugaya ukuze odokotela bakwazi ukubona ukuthi lezi zitho zisebenza kahle kangakanani.

Lesi sidakamizwa sisetshenziswa ikakhulukazi ngesikhathi sokuhlolwa kwezokwelapha okukhethekile, hhayi njengokwelashwa okuvamile ongakuthatha ekhaya. Cabanga ngakho njengethuluzi lokuxilonga elisiza ithimba lakho lezempilo ukuthi lithole umbono ocacile wempilo yesistimu yakho yokugaya ukudla.

Yini i-Secretin Esetshenziselwa Yona?

I-Secretin isebenza njengosizo lokuxilonga ukusiza odokotela ukuthi bahlole ukuthi i-pancreas yakho kanye ne-gallbladder yakho zisebenza kahle kangakanani. Inhloso enkulu ukukhuthaza i-pancreas yakho ukuthi ikhiqize futhi ikhiphe ama-enzyme ayo okugaya kanye noketshezi olucebile nge-bicarbonate.

Odokotela bavame ukusebenzisa i-secretin ngesikhathi senqubo ebizwa ngokuthi i-secretin-enhanced magnetic resonance cholangiopancreatography (MRCP). Leli gama elihle lichaza i-MRI scan ekhethekile ethatha izithombe ezinemininingwane yemigudu yakho ye-bile kanye nemigudu ye-pancreatic. Lapho i-secretin inikezwa ngesikhathi salolu vivinyo, yenza lezi zakhiwo zibonakale kakhulu ekucabangeni, okusiza odokotela ukuthi babone ukuvinjelwa, ukuvuvukala, noma ezinye izinkinga.

Abahlinzeki bezempilo futhi basebenzisa i-secretin ukuhlola isimo esibizwa ngokuthi i-Zollinger-Ellison syndrome. Le nkinga engavamile ibangela izimila ku-pancreas yakho noma emathunjini amancane akhiqiza i-asidi yesisu eningi kakhulu. Ukuhlolwa kwe-secretin kungasiza ukuqinisekisa lokhu kuxilongwa ngokukala ukuthi umzimba wakho usabela kanjani ku-hormone.

Isebenza Kanjani i-Secretin?

I-Secretin isebenza ngokulingisa i-hormone yomzimba wakho yemvelo etshela i-pancreas yakho ukuthi isebenze. Uma udla, amathumbu akho amancane ngokuvamile akhipha i-secretin ukuze itshele i-pancreas yakho ukuthi ikhiqize amajusi okugaya asiza ukwehlisa ukudla.

Inguqulo yokwenziwa yenza umsebenzi ofanayo kodwa endaweni elawulwayo, yezokwelapha. Ngemizuzu nje ngemva kokuthola umjovo we-IV, i-pancreas yakho iqala ukukhipha uketshezi olucacile, olune-alkaline olucebile nge-bicarbonate. Lolu ketshezi lusiza ukungathathi hlangothi i-asidi yesisu futhi luqukethe ama-enzyme agaya amafutha, amaprotheni, nama-carbohydrate.

Lo muthi uthathwa njenge-ejenti yokuxilonga enamandla aphakathi nendawo. Akuthambile njengodayi abathile abahlukile, kodwa futhi akunamandla njengemithi ye-chemotherapy. Imiphumela ivame ukuba yesikhashana futhi iyaphela emahoreni ambalwa njengoba umzimba wakho uqhubekisa futhi uqeda i-hormone yokwenziwa.

Ngingayithatha kanjani i-Secretin?

I-Secretin inikezwa kuphela ochwepheshe bezempilo endaweni yezokwelapha ngomugqa we-intravenous (IV). Ngeke uthathe lo muthi ekhaya noma uzinike wona.

Ngaphambi kwenqubo yakho, udokotela wakho cishe uzokucela ukuthi uzile ukudla amahora angu-8 kuya kwangu-12. Lokhu kusho ukuthi akukho ukudla noma iziphuzo ngaphandle kokuthatha amanzi amancane. Isisu esingenalutho sisiza ukuqinisekisa ukuthi imiphumela yokuhlolwa inembile futhi kunciphisa ingozi yesicanucanu ngesikhathi senqubo.

Ngesikhathi sokuhlolwa, umhlengikazi noma uchwepheshe uzofaka i-catheter encane ye-IV emthanjeni engalweni yakho. I-secretin bese ifakwa kancane ngalo mugqa we-IV. Kuzodingeka ulale unganyakazi ngesikhathi sokuthwebula izithombe zokuhlolwa, okuthatha imizuzu engama-30 kuya kwengama-60.

Ngemva kokuthola i-secretin, ungase uzwe umuzwa ofudumele noma ukukhanya okuncane. Lokhu kujwayelekile futhi kuvame ukudlula ngokushesha. Ithimba lakho lezempilo lizokuqapha kuyo yonke inqubo ukuze liqinisekise ukuthi uzizwa ukhululekile futhi usabela kahle emuthini.

Ngingayithatha isikhathi esingakanani i-Secretin?

I-Secretin isetshenziswa kanye kuphela ngenqubo ngayinye yokuxilonga, hhayi njengokwelashwa okuqhubekayo. Umuthi unikezwa njengomjovo owodwa osebenza ngesikhathi sokuhlolwa kwakho.

Imiphumela ye-secretin ivamise ukuhlala amahora ama-2 kuya kwama-4 ngemuva komjovo. Ngesikhathi lesi, i-pancreas yakho izoqhubeka nokukhiqiza uketshezi lokugaya ukudla olusiza odokotela ukuthi babone izakhiwo zakho zangaphakathi ngokucacile ekuhlolweni kokuthwebula izithombe.

Uma udinga ukuphinda ukuhlolwa esikhathini esizayo, udokotela wakho angase ayale enye inqubo ethuthukiswe yi-secretin. Kodwa-ke, ngokuvamile akudingeki imithamo eminingi ngesikhathi esisodwa sokuhlolwa ngaphandle uma kunconywe ngokuqondile ngumhlinzeki wakho wezempilo.

Yiziphi Imiphumela Eceleni ye-Secretin?

Abantu abaningi bayayibekezelela kahle i-secretin, kodwa njenganoma imuphi umuthi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi ukusabela okungathi sína akuvamile, futhi imiphumela eminingi emibi imnene futhi yesikhashana.

Nansi imiphumela emibi evame kakhulu ongase uyithole ngesikhathi noma ngemuva nje kokuthola i-secretin:

• Ukucasuka okuncane noma ukungakhululeki kwesisu
• Umuzwa ofudumele noma ukubomvu ebusweni nasentanyeni yakho
• Isiyezi esincane noma ukuzwa ukukhanya ekhanda
• Ukwanda kwesikhashana kwesilinganiso senhliziyo
• Ukucasuka okuncane esiswini sakho

Le miphumela ivamise ukuqala ngemizuzu embalwa ngemuva kokuthola umjovo futhi ngokuvamile iyaphela phakathi kwemizuzu engama-30 kuya kwengama-60. Ithimba lakho lezempilo lizokugada eduze futhi linganikeza izinyathelo zokunethezeka uma kudingeka.

Imiphumela emibi engavamile kodwa engathi sína ingabandakanya ukusabela okukhulu komzimba, nakuba lokhu kungavamile. Izimpawu zokusabela okukhulu komzimba zihlanganisa ubunzima bokuphefumula, ukuvuvukala okukhulu ebusweni bakho noma emqaleni, ukuqubuka okubanzi, noma isiyezi esikhulu. Uma kukhona okwenzekayo, ithimba lakho lezokwelapha lizosabela ngokushesha ngokwelashwa okufanele.

Abanye abantu bangase babe nomfutho wegazi ophansi ngemuva kokuthola i-secretin, okungabangela imizwa yobuthakathaka noma ukuquleka. Yingakho uzoqashwa kuyo yonke inqubo kanye nesikhashana ngemuva kwalokho.

Ubani Ongafanele Athole I-Secretin?

I-Secretin ayiphephile kuwo wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuncoma lolu vivinyo. Abantu abanezimo ezithile noma izinto abazwelana nazo kufanele bagweme i-secretin noma bayisebenzise ngokucophelela okwengeziwe.

Akufanele uthole i-secretin uma unokungezwani komzimba ne-secretin uqobo noma yiziphi izithako zayo. Uma uke waba nokusabela ngaphambilini kulo muthi, qiniseka ukuthi utshela umhlinzeki wakho wezempilo ngaphambi kwanoma iyiphi inqubo.

Abantu abanezimo zenhliziyo ezinzima, umfutho wegazi ophezulu ongagadiwe, noma ukuhlaselwa yinhliziyo kwamuva kungenzeka bangabi ngabazali abafanelekayo bokuhlolwa kwe-secretin. Umuthi ungalithinta okwesikhashana izinga lokushaya kwenhliziyo nomfutho wegazi, okungaba yingozi uma unezinkinga zenhliziyo ezikhona.

Uma ukhulelwe noma uncelisa, xoxa ngobungozi nezinzuzo nodokotela wakho. Ngenkathi i-secretin ingakabonakali ilimaza izingane ezisakhula, ngokuvamile isetshenziswa kuphela uma imininingwane yokuxilonga ibalulekile empilweni yakho.

Iziguli ezinokugula okukhulu kwezinso noma isibindi zingase zidinge ukulungiswa komthamo noma izindlela zokuhlola ezingezinye. Lezi zitho zisiza ukucubungula nokususa imithi emzimbeni wakho, ngakho-ke izinkinga ngomsebenzi wezinso noma isibindi zingathinta ukuthi i-secretin isebenza kanjani noma ukuthi ihlala isikhathi esingakanani ohlelweni lwakho.

Amagama e-Secretin Brand

I-Secretin itholakala ngaphansi kwegama lomkhiqizo elithi ChiRhoStim e-United States. Le yindlela esetshenziswa kakhulu ye-secretin yokwenziwa ezinqubweni zokuxilonga.

I-ChiRhoStim yenziwa ngokuqondile ukusetshenziswa kwezokwelapha futhi iza njengempushana exutshwe namanzi angenazinzwa ngaphambi kokujova. Umuthi utholakala kuphela ngabahlinzeki bezempilo futhi awukwazi ukuthengwa ukuze usetshenziswe ekhaya.

Ezinye izikhungo zezokwelapha zingase zibhekisele kule nqubo ngamagama ahlukene, njengokuthi

Kukhona ezinye izivivinyo ezingahlola ukusebenza kwamanyikwe, nakuba ngasinye sinokwazisa kwazo kanye nemikhawulo yazo. Udokotela wakho uzokhetha inketho engcono kakhulu ngokusekelwe ezimpawini zakho ezithile kanye nomlando wakho wezokwelapha.

I-Endoscopic ultrasound (EUS) inikeza izithombe ezinemininingwane yamanyikwe akho ngaphandle kokudinga ukukhuthazwa kwamahomoni. Le nqubo isebenzisa ithumbu elincanyana, eliguquguqukayo elinokuhlola kwe-ultrasound ukuhlola amanyikwe akho ngaphakathi kwendlela yakho yokugaya ukudla.

I-MRI ejwayelekile noma ukuskena kwe-CT kungakhombisa nokungajwayelekile kwamanyikwe, nakuba kungase kunganikezi imininingwane eminingi mayelana nokusebenza njengokutadisha okuthuthukiswe yi-secretin. Lezi zivivinyo zivame ukusetshenziswa lapho i-secretin ingafaneleki noma ingatholakali.

Izivivinyo zegazi ezilinganisa ama-enzyme e-pancreatic afana ne-lipase ne-amylase zingabonisa izinkinga ze-pancreatic, kodwa azinikezi imininingwane enemininingwane yesakhiwo enikezwa izivivinyo zokucabanga. Lezi zivame ukusetshenziswa njengamathuluzi okuqala okuhlola.

Ngesifo esisolisayo se-Zollinger-Ellison, odokotela bangase basebenzise ezinye izivivinyo zokukhuthaza amahomoni noma balinganise izimpawu ezithile zegazi esikhundleni sokuhlolwa kwe-secretin.

Ingabe i-Secretin Ingcono Kunezinye Izivivinyo Zokusebenza Kwe-Pancreatic?

Ukucabanga okuthuthukiswe yi-Secretin kunikeza izinzuzo eziyingqayizivele ezenza kube yindlela ekhethwayo ezimweni ezithile zokuxilonga. Inzuzo enkulu ukuthi inikeza kokubili ulwazi lwesakhiwo kanye nokusebenza mayelana namanyikwe akho esivivinyweni esisodwa.

Ngokungafani nezivivinyo zokucabanga ezijwayelekile, ukukhuthazwa kwe-secretin kubonisa ukuthi amanyikwe akho asebenza kahle kangakanani, hhayi nje ukuthi abukeka kanjani. Lolu lwazi olusebenzayo lubalulekile ekuxilongeni izimo ezinjenge-pancreatitis engapheli, lapho amanyikwe angase abukeke ejwayelekile kodwa asebenze kabi.

Uma kuqhathaniswa nezinqubo ezingena kakhulu njenge-endoscopic retrograde cholangiopancreatography (ERCP), i-secretin-enhanced MRCP ithwala izingozi ezimbalwa. I-ERCP ihlanganisa ukufaka isikophu ngomlomo wakho ungene endleleni yakho yokugaya ukudla, okunezingozi eziphakeme zezinkinga ezinjenge-pancreatitis noma ukopha.

Noma kunjalo, ukuhlolwa kwe-secretin akusona ngaso sonke isikhathi esingcono kakhulu. Ezimweni ezithile, ukuhlolwa kwegazi okulula noma izithombe ezijwayelekile kungahlinzeka ngolwazi olwanele. Udokotela wakho uzocabangela izimpawu zakho, umlando wezokwelapha, kanye nolwazi oluthile oludingekayo ukuze enze ukuxilongwa okulungile.

Imibuzo Evame Ukubuzwa Mayelana ne-Secretin

Ingabe i-Secretin iphephile kubantu abanesifo sikashukela?

I-Secretin ngokuvamile iphephile kubantu abanesifo sikashukela, kodwa amazinga kashukela wakho egazini azodinga ukuqapha okwengeziwe ngesikhathi nangemva kwenqubo. Umuthi ungase uthinte okwesikhashana indlela umzimba wakho oqhubula ngayo i-glucose.

Uma uthatha imithi yesifo sikashukela, udokotela wakho angase alungise isimiso sakho sokulinganisa ngosuku lokuhlolwa, ikakhulukazi njengoba uzodinga ukuzila ukudla ngaphambi kwalokho. Qiniseka ukuthi uxoxa ngohlelo lwakho lokuphatha isifo sikashukela nethimba lakho lezempilo ngaphambi kwenqubo.

Abantu abanesifo sikashukela esilawulwa kahle bavame ukubekezelela i-secretin ngaphandle kwezinkinga. Kodwa-ke, uma ushukela wakho wegazi ubengazinzile muva nje, udokotela wakho angase afune ukuhlehlisa ukuhlolwa kuze kube yilapho isifo sikashukela sakho silawulwa kangcono.

Ngingenzani uma ngithola i-Secretin eningi ngengozi?

Ukweqisa kwe-Secretin akuvamile kakhulu ngoba umuthi unikezwa kuphela ochwepheshe bezempilo abaqeqeshiwe ezindaweni zezokwelapha ezilawulwayo. Ukulinganisa kubalwa ngokucophelela ngokuya ngesisindo somzimba wakho nokuhlolwa okuthile okwenziwayo.

Uma i-secretin eningi inikezwa ngengozi, ungezwa imiphumela emibi enamandla njengokucasuka okukhulu, izinguquko ezinkulu zomfutho wegazi, noma ukuqaqamba kwesisu okude. Ithimba lakho lezokwelapha linganikeza ngokushesha ukunakekelwa okusekelayo futhi likuqaphe eduze.

Izindaba ezinhle ukuthi i-secretin icutshungulwa futhi ikhishwe emzimbeni wakho ngokushesha, ngakho-ke noma ngabe ukweqisa kwenzekile, imiphumela izoba yesikhashana. Abahlinzeki bakho bezempilo banemithi nokwelashwa okutholakalayo ukuphatha noma yiziphi izindlela ezimbi ezingathi sína.

Ngingenzani uma ngiphuthelwa umthamo we-Secretin?

Lo mbuzo awusebenzi ngempela ku-secretin njengoba kungewona umuthi owuthatha njalo ekhaya. I-Secretin inikezwa kanye kuphela ngesikhathi sokuhlolwa okuthile kokuxilonga ezikhungweni zezokwelapha.

Uma uphuthelwa isikhathi sakho esihleliwe sokuhlolwa kwe-secretin, vele shayela ihhovisi likadokotela wakho ukuze ulungiselele kabusha. Akukho ngozi ekubambezeleni ukuhlolwa izinsuku ezimbalwa noma amasonto, ngaphandle uma unezimpawu ezinzima ezidinga ukuhlolwa ngokushesha.

Udokotela wakho uzokwazisa ukuthi ukuhlolwa kudingeka kuqedwe ngokushesha kangakanani ngokuya ngesimo sakho sezokwelapha esithile. Ezimweni eziningi, ukuhlela kabusha ngeke kuthinte ukunemba kwemiphumela noma uhlelo lwakho lokwelashwa.

Ngingayeka nini ukuthatha i-Secretin?

Akudingeki ukhathazeke ngokuyeka i-secretin ngoba akuyona imithi eqhubekayo. Imiphumela iyaphela ngokwemvelo emahoreni ambalwa ngemuva komjovo owodwa onikezwe ngesikhathi senqubo yakho yokuxilonga.

Umzimba wakho uzosusa le hormone yokwenziwa ngezinso zakho nesibindi, njengoba nje ucubungula eminye imithi. Akukho ukunciphisa noma ukunciphisa kancane kancane okudingekayo.

Uma udinga ukuhlolwa okulandelayo esikhathini esizayo, inqubo ngayinye ye-secretin iphathwa njengomcimbi ohlukile, owodwa. Akukho mphumela oqongelelwe noma isidingo sokucabangela imithamo yangaphambilini lapho kuhlelwa ukuhlolwa okuzayo.

Ngingashayela ngemuva kokuthola i-Secretin?

Abantu abaningi bangashayela ngemuva kokuthola i-secretin, kodwa kufanele ulinde kuze kube yilapho noma yikuphi ukugajuka noma ukukhathala kuqeda ngokuphelele. Umuthi ungase uthinte okwesikhashana umfutho wegazi nenhliziyo yakho, okungase kukwenze uzizwe ungazinzile.

Hlela ukuhlala esikhungweni sezokwelapha okungenani imizuzu engama-30 ngemuva kwenqubo yakho ukuze abasebenzi baqinisekise ukuthi uzizwa uzinzile futhi uqaphile. Uma uhlangabezana nanoma yikuphi ukugajuka okuqhubekayo, isicanucanu, noma ubuthakathaka, lungiselela omunye umuntu ukuthi akuqhubele ekhaya.

Abanye abantu bazizwa bekhathele ngemva kwale nqubo, ikakhulukazi uma kwadingeka bazile ukudla ngaphambili noma uma lolu vivinyo lwalicindezela. Lalela umzimba wakho futhi unganqikazi ukucela usizo ngezokuthutha uma ungezwa kahle.