Yini i-Secukinumab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Secukinumab iyikhambi eliqondiwe elisiza ukulawula izimo ezinzima ze-autoimmune ezifana ne-psoriasis nezinhlobo ezithile ze-arthritis. Isebenza ngokuvimba iphrotheni ethile ohlelweni lwakho lomzimba lokuzivikela ekuguleni okubangela ukuvuvukala, inike umzimba wakho ithuba lokuphola futhi kunciphise izimpawu ezibuhlungu.

Lo muthi ungowesigaba esibizwa ngokuthi ama-monoclonal antibodies, okuyizinhlobo zamaprotheni aklanywe ngokukhethekile asebenza njengamathuluzi aqondile ohlelweni lwakho lomzimba lokuzivikela ekuguleni. Cabanga nge-secukinumab njengomhlahlandlela osizayo oqondisa kabusha impendulo yakho yomzimba yokuzivikela ekuguleni, okuvumela isikhumba sakho namalunga ukuthi azizwe ekhululekile.

Yini i-Secukinumab?

I-Secukinumab iyikhambi elinikezwa ngudokotela eliqondise i-interleukin-17A, iphrotheni eqhuba ukuvuvukala ezifweni ze-autoimmune. Udokotela wakho angase ancome lokhu kwelashwa lapho eminye imithi inganikezanga ukukhululeka okwanele ezimpawini zakho.

Umuthi uza ngomjovo owamukelayo ngaphansi kwesikhumba sakho noma nge-IV, kuye ngesimo sakho esithile kanye nohlelo lokwelashwa. Yenzelwe ukusebenza kancane kancane ngokuhamba kwesikhathi, isiza uhlelo lwakho lomzimba lokuzivikela ekuguleni ukuthi lithole ibhalansi engcono.

Ngokungafani neminye imithi ecindezela kabanzi uhlelo lwakho lomzimba lokuzivikela ekuguleni, i-secukinumab isebenza ngokunembe kakhulu. Igxila endleleni eyodwa ethile yokuvuvukala, okusho ukuthi imiphumela embalwa iyonke emzimbeni wakho ekwazi ukulwa nezifo.

Isetshenziselwani i-Secukinumab?

I-Secukinumab iphatha izimo eziningana ze-autoimmune lapho uhlelo lwakho lomzimba lokuzivikela ekuguleni luhlasela ngokungafanele izicubu ezinempilo. Udokotela wakho uzonquma ukuthi lo muthi ulungele yini isimo sakho esithile ngokusekelwe ezimpawini zakho nomlando wezokwelapha.

Izimo ezivame kakhulu eziphathwa nge-secukinumab zihlanganisa i-psoriasis emaphakathi kuya kakhulu, lapho kuvela khona iziqephu ezibomvu, ezinama-scaly esikhumbeni sakho. Abantu abaningi bathola ukuthuthuka okukhulu ekucaceni kwesikhumba sabo nokuncishiswa kokuluma ezinyangeni ezimbalwa nje beqala ukwelashwa.

Ezimweni ezihlobene namalunga, i-secukinumab ingasiza nge-psoriatic arthritis, ebangela ubuhlungu emalungeni nokuvuvukala kubantu abane-psoriasis. Kungase futhi kunqunywe i-ankylosing spondylitis, uhlobo lwe-arthritis oluthinta ikakhulukazi umgogodla wakho futhi olungabangela ukuqina nobuhlungu.

Ngokuvamile, udokotela wakho angase ancome i-secukinumab kwezinye izimo zokuvuvukala njenge-non-radiographic axial spondyloarthritis noma i-hidradenitis suppurativa. Lokhu ukusetshenziswa okukhethekile okudinga ukuhlolwa ngokucophelela kwesimo sakho sempilo.

Isebenza Kanjani I-Secukinumab?

I-Secukinumab isebenza ngokuvimba i-interleukin-17A, iphrotheni yomlayezo etshela amaseli akho omzimba ukuthi akhe ukuvuvukala. Lapho le phrotheni isebenza ngokweqile, ingabangela izimpawu ezibuhlungu, ezingakhululeki ozihlangabezana nazo ngezimo ze-autoimmune.

Lo muthi uthathwa njengokwelashwa okuqinile, okuhloswe ngakho okunganikeza ukukhululeka okukhulu kubantu abanezimpawu eziphakathi nendawo kuya kwezinkulu. Akuyona imithi emnene, kodwa iyithuluzi elikhethekile lezimo ezingazange ziphendule kahle kwezinye izindlela zokwelapha.

Isenzo sokuvimba senzeka kancane kancane, yingakho ungase ungaboni izinguquko ngokushesha lapho uqala ukwelashwa. Uhlelo lwakho lomzimba lokuzivikela emzimbeni ludinga isikhathi sokuzivumelanisa nokulinganisela okusha, futhi abantu abaningi baqala ukubona ukuthuthuka phakathi kwamasonto angu-12 kuya kwangu-16.

Ngenxa yokuthi i-secukinumab iqondise indlela ethile, ayicindezeli lonke uhlelo lwakho lomzimba lokuzivikela emzimbeni njengeminye imithi. Kodwa-ke, ingase isathinte ikhono lakho lokulwa nezifo ezithile, ngakho udokotela wakho uzokuqapha ngokucophelela ngesikhathi sokwelashwa.

Kufanele Ngiyithathe Kanjani I-Secukinumab?

I-Secukinumab inikezwa njengomjovo, ngaphansi kwesikhumba sakho (subcutaneous) noma nge-IV (intravenous), kuye ngesimo sakho kanye nokunconywa kukadokotela. Ithimba lakho lezempilo lizokufundisa inqubo efanele yokujova uma uzobe uzijova ekhaya.

Ukuze uthole imijovo engaphansi kwesikhumba, ungafaka umuthi ethangeni lakho, engalweni engenhla, noma esiswini, ujikelezisa izindawo zokujova ukuvimbela ukucasuka. Umuthi kufanele ube sezingeni lokushisa legumbi lapho uwujova, ngakho uwukhiphe esiqandisini cishe imizuzu engama-30 ngaphambi komthamo wakho ohleliwe.

Akudingeki ukuthi uthathe i-secukinumab nokudla, futhi azikho izithiyo ezithile zokudla ngenkathi usebenzisa lo muthi. Kodwa-ke, ukugcina ukudla okunempilo, okulinganiselayo kungasekela impumelelo yakho yokwelashwa iyonke futhi kusize umzimba wakho ukuthi usabele kahle emuthini.

Uma wamukela ukumnika kwe-IV, lokhu kuzokwenziwa ehhovisi likadokotela wakho noma esikhungweni sokumnika. Inqubo ngokuvamile ithatha cishe ihora elilodwa, futhi uzoqashwa ngesikhathi nangemva kokumnika ukuze uqinisekise ukuthi uyakubekezelela ukwelashwa kahle.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Secukinumab?

I-Secukinumab ngokuvamile iyindlela yokwelashwa yesikhathi eside, njengoba izimo ezilashwayo zingamahlala-khona futhi zidinga ukuphathwa okuqhubekayo. Udokotela wakho uzosebenza nawe ukunquma ubude obufanele ngokuya ngokuthi usabela kahle kangakanani emuthini kanye nanoma yimaphi imiphumela emibi oyitholayo.

Abantu abaningi baqala ngesigaba sokulayisha, bathola imijovo kaningi emasontweni ambalwa okuqala noma izinyanga. Ngemva kwalesi sikhathi sokuqala, cishe uzoshintshela ekulinganiseni ukugcinwa, okungase kube njalo njalo ngemva kwamasonto ama-4, 8, noma ama-12 kuye ngesimo sakho esithile.

Udokotela wakho uzohlola njalo inqubekela phambili yakho ngokuhlolwa komzimba, ukuhlolwa kwegazi, kanye nezingxoxo mayelana nokuthi uzizwa kanjani. Uma umuthi usebenza kahle futhi uwubekezelela ngaphandle kwemiphumela emibi ebalulekile, ungaqhubeka nokwelashwa iminyaka eminingi.

Abanye abantu bangase bakwazi ukunciphisa imvamisa yabo yokulinganisa ngokuhamba kwesikhathi uma isimo sabo silawulwa kahle. Nokho, ukuyeka i-secukinumab ngokuzumayo kungaholela ekubuyeni kwezimpawu, ngakho noma yiziphi izinguquko ohlelweni lwakho lokwelashwa kufanele zenziwe kancane kancane ngaphansi kokugadwa kwezokwelapha.

Yiziphi Imiphumela Emibi Ye-Secukinumab?

Njengazo zonke izidakamizwa, i-secukinumab ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi evame kakhulu ongase uyithole ngokuvamile imnene futhi iyaphathwa. Lezi zimpendulo zansuku zonke zivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini emasontweni okuqala okwelashwa.

• Ukuphendula kwendawo yokujova njengobubomvu, ukuvuvukala, noma ubuhlungu obuncane
• Ukutheleleka okuphezulu kwemigudu yokuphefumula njengomkhuhlane noma ukutheleleka kwama-sinus
• Ikhanda elivame ukuba mnene kuya esimweni esiphakathi nendawo
• Ukuqunjelwa noma isisu esincane
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile

Le miphumela emibi ejwayelekile ngokuvamile iyazixazulula yona futhi ayidingi ukuyeka umuthi. Udokotela wakho angase ancome izindlela zokuphatha lezi zinto uma ziba yinkinga.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Nakuba lezi zimpendulo zingenzeki kubantu abaningi, kubalulekile ukuzibona kusenesikhathi ukuze uthole ukunakekelwa okusheshayo.

• Ukutheleleka okungathi sína okungase kuvele kalula ngenxa yemiphumela yamasosha omzimba
• Izimpawu zesifo samathumbu esivuvukalayo njengobuhlungu obukhulu besisu noma izitulo ezinegazi
• Ukuphendula komzimba okuhlanganisa ubunzima bokuphefumula, ukuvuvukala, noma ukuqubuka okukhulu
• Ushintsho olungavamile emoyeni noma ekuziphatheni
• Umkhuhlane oqhubekayo noma izimpawu zokutheleleka ezingathuthuki

Uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína, xhumana nodokotela wakho ngokushesha. Bangasiza ekutholeni ukuthi izimpawu zihlobene yini nomuthi wakho futhi balungise uhlelo lwakho lokwelashwa uma kudingeka.

Imiphumela emibi engavamile kodwa engathi sína ihlanganisa ukuvuselelwa kwe-tuberculosis noma i-hepatitis B kubantu abake batheleleka ngaphambili. Udokotela wakho uzohlola lezi zimo ngaphambi kokuqala i-secukinumab futhi akuqaphe ngesikhathi sokwelashwa.

Ubani Ongafanele Athathe I-Secukinumab?

I-Secukinumab ayilungelwe wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuncoma lokhu kwelashwa. Ezinye izimo zempilo noma izimo zenza lo muthi ungabi nawo umphumela noma ungasebenzi kahle.

Akufanele usebenzise i-secukinumab uma unokutheleleka okusebenzayo, okungathi sína okungakalashwa okwamanje. Ngenxa yokuthi lo muthi uthinta amasosha akho omzimba, ukulwa nokutheleleka okukhona kuba yinselele enkulu futhi kungaba yingozi.

Abantu abanomlando we-tuberculosis noma i-hepatitis B badinga ukuhlolwa okukhethekile ngaphambi kokuqala i-secukinumab. Lokhu kutheleleka kungase kuphinde kusebenze uma amasosha akho omzimba eshintshiwe, ngakho-ke udokotela wakho uzohlola lezi zimo futhi angase ancome ukwelashwa kokuvimbela kuqala.

Uma ukhulelwe noma uhlela ukukhulelwa, xoxa lokhu ngokuningiliziwe nodokotela wakho. Ngenkathi i-secukinumab ingakahlolisiswa kakhulu ekukhulelweni, ngokuvamile kunconywa ukuyigwema ngaphandle uma izinzuzo zizwela izingozi.

Omama abancelisa izingane nabo kufanele babe nengxoxo enemininingwane nomhlinzeki wabo wezempilo. Inani elincane lomuthi lingase lidlulele obisini lwebele, futhi imiphumela ezinganeni ezincelisayo ayiqondakali ngokugcwele.

Abantu abanezifo zamathumbu ezivuvukalayo njengesifo sikaCrohn noma i-ulcerative colitis badinga ukuqashwa ngokucophelela, njengoba i-secukinumab ingase iqhubekisele phambili lezi zimo kwezinye izimo. Udokotela wakho uzohlola izinzuzo ngokumelene nezingozi ngokuya ngesimo sakho esithile.

Amagama Omkhiqizo we-Secukinumab

I-Secukinumab itholakala ngaphansi kwegama lomkhiqizo elithi Cosentyx, elikhiqizwa yi-Novartis. Leli yigama eliyinhloko lomkhiqizo ozolibona lapho udokotela wakho ebhala lo muthi.

I-Cosentyx iza ngezindlela ezahlukene, okuhlanganisa imijovo egcwaliswe ngaphambili kanye namapeni e-autoinjector okusetshenziswa ekhaya, kanye namavial okufakwa ngomthambo ezindaweni zomtholampilo. Udokotela wakho uzokhetha ifomula efanele kakhulu ngokuya ngesimo sakho kanye nohlelo lokwelashwa.

Uma ukhuluma ngalo muthi neqembu lakho lezempilo noma usokhemisi, ungaqoka ukulibiza nganoma yiliphi igama - i-secukinumab noma i-Cosentyx. Zombili zibhekisela esithakweni esifanayo esisebenzayo kanye nomuthi.

Ezinye Izindlela Zokwelapha Nge-Secukinumab

Eminye imithi eminingi isebenza ngendlela efana ne-secukinumab ekwelapheni izifo ezizimele. Udokotela wakho angase acabangele lezi ezinye izindlela uma i-secukinumab ingafaneleki esimweni sakho noma uma ungasabeli kahle kuyo.

Ezinye izithiyo ze-IL-17 zihlanganisa i-ixekizumab (Taltz) kanye ne-brodalumab (Siliq), ezisebenza ngezindlela ezifanayo kodwa ezingase zibe nemiphumela emibi ehlukile. Le mithi iqondise indlela efanayo yokuvuvukala kodwa ingase ithandwe kangcono ngabanye abantu.

Izithiyo ze-TNF ezifana ne-adalimumab (Humira), etanercept (Enbrel), kanye ne-infliximab (Remicade) ezinye izigaba zemithi ye-biologic engelapha izimo ezifanayo. Lezi zisebenza ngokuvimba iphrotheni ehlukile yokuvuvukala ebizwa ngokuthi i-tumor necrosis factor.

Kubantu abane-psoriasis ngokuqondile, izithiyo ze-IL-23 ezifana ne-ustekinumab (Stelara), guselkumab (Tremfya), kanye ne-risankizumab (Skyrizi) zinikeza enye indlela eqondiwe. Le mithi isebenza ngaphezulu enqubweni yokuvuvukala uma iqhathaniswa ne-secukinumab.

Imithi yesistimu yendabuko efana ne-methotrexate, cyclosporine, noma ama-retinoid omlomo angase futhi acabangelwe, ikakhulukazi kubantu abakhetha ukwelashwa okungekona okwe-biologic noma abanezizathu ezithile zezokwelapha zokugwema imithi ye-biologic.

Ingabe i-Secukinumab Ingcono Kune-Adalimumab?

I-Secukinumab kanye ne-adalimumab (Humira) yomibili imithi esebenza kahle kakhulu, kodwa isebenza ngezindlela ezihlukene futhi ingase ifaneleke kangcono kubantu abahlukene. Akukho muthi ongaphezu kwamanye - ukukhetha okungcono kuncike esimweni sakho esithile, umlando wezokwelapha, kanye nokusabela komuntu ngamunye.

Nge-psoriasis, ucwaningo luphakamisa ukuthi i-secukinumab ingahle inikeze ukucaca kwesikhumba okungcono kancane kwabanye abantu uma kuqhathaniswa ne-adalimumab. Kodwa-ke, i-adalimumab isitholakala isikhathi eside futhi inocwaningo oluningi olusekela ukusebenza kwayo ezimweni eziningi.

Mayelana nemiphumela emibi, yomibili imithi ingakhuphula ingozi yokutheleleka, kodwa ingase ibe namaphethini ahlukene emiphumeleni emibi. I-Secukinumab ingase ingabi maningi amathuba okubangela ezinye izindlela zokuzivikela emzimbeni ezingenzeka ngama-TNF inhibitors afana ne-adalimumab.

Udokotela wakho uzocabangela izinto ezifana nokuxilongwa kwakho okuthile, izimpendulo zokwelashwa zangaphambilini, ezinye izimo zempilo, nezintandokazi zomuntu siqu lapho ekhetha phakathi kwale mithi. Abantu abaningi benza kahle kunoma yikuphi ukwelashwa, futhi isinqumo sivame ukwehla ezintweni zomuntu ngamunye kunokuthi esinye sibe ngcono ngokusobala kunomunye.

Imibuzo Evame Ukubuzwa Nge-Secukinumab

Ingabe i-Secukinumab iphephile kubantu abanesifo sikashukela?

I-Secukinumab ngokuvamile ithathwa njengephephile kubantu abanesifo sikashukela, futhi ukuba nesifo sikashukela akukuvimbeli ngokuzenzakalelayo ukusebenzisa lo muthi. Kodwa-ke, udokotela wakho uzokuqapha eduze ngoba kokubili isifo sikashukela kanye ne-secukinumab kungathinta ikhono lomzimba wakho lokuzivikela ekulweni nezifo.

Abantu abanesifo sikashukela bangase babe nengozi enkulu yokuthola izifo ngenkathi bethatha i-secukinumab, ngakho-ke kubalulekile ukugcina ukulawulwa okuhle kukashukela wegazi futhi ulandele uhlelo lwakho lokuphatha isifo sikashukela ngokucophelela. Ithimba lakho lokunakekelwa kwezempilo lizosebenzisana ukuqinisekisa ukuthi zombili izimo ziphathwa kahle.

Ngingenzani uma ngizifaka i-Secukinumab eningi ngengozi?

Uma ngengozi uzifaka i-secukinumab eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma umhlinzeki wezempilo ngokushesha, ngisho noma uzizwa kahle. Ngenkathi izindlela ezimbi ezingathi sína ezivela ekweqiseni zingavamile, udokotela wakho udinga ukwazi ukuze akwazi ukukuqapha ngendlela efanele.

Ungazami ukulungisa ngokususa umthamo wakho olandelayo noma ukuwunciphisa ngokwakho. Udokotela wakho uzokweluleka ngendlela yokuqhubeka nesimiso sakho somthamo esivamile futhi angase afune ukukubona ukuze uhlolwe noma uqashwe ngaphezulu.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Secukinumab?

Uma weqa umthamo we-secukinumab, yithathe ngokushesha lapho ukhumbula, bese uqhubeka nesimiso sakho esivamile. Ungaphindi kabili imithamo noma uzame ukulungisa umthamo ongekho ngokuthatha imithi eyengeziwe.

Xhumana nehhovisi likadokotela wakho ukuze libazise ngomthamo ongekho, ikakhulukazi uma sekudlule izinsuku ezingaphezu kwezimbili ngesikhathi sakho esihleliwe. Bangase bafune ukulungisa isimiso sakho somthamo esizayo ukuze ubuyele emgqeni ngokuphepha.

Ngingayeka Nini Ukuthatha I-Secukinumab?

Kufanele uyeke kuphela ukuthatha i-secukinumab ngaphansi kwesiqondiso sikadokotela wakho, njengoba ukuyeka kungazelelwe kungaholela ekubuyeleni kwezimpawu zakho. Isinqumo sokuyeka ukwelashwa sincike ezintweni ezifana nokuthi imithi isebenza kahle kangakanani, imiphumela emibi oyitholayo, kanye nezinguquko empilweni yakho yonke.

Udokotela wakho angase ancome ukuyeka i-secukinumab uma uthola imiphumela emibi engathi sína, uma isimo sakho singena ekuxolelweni kwesikhathi eside, noma uma ezinye izinkinga zempilo zenza ukuqhubeka nokwelashwa kungaphephile. Bazosebenza nawe ukuthuthukisa uhlelo lokushintsha ngokuphepha emithini uma kudingeka.

Ngingakwazi Ukuthola Imigomo Ngenkathi Ngithatha I-Secukinumab?

Ungathola imigomo eminingi ejwayelekile ngenkathi uthatha i-secukinumab, kodwa kufanele ugweme imigomo ebukhoma njengomgomo womkhuhlane wamakhala noma umgomo we-shingles obukhoma. Udokotela wakho uzobuyekeza umlando wakho wokugoma futhi ancome ukugoma okufanele ngaphambi kokuqala ukwelashwa.

Kubaluleke kakhulu ukuhlala unolwazi lwakamuva ngemigomo efana nomgomo waminyaka yonke womkhuhlane kanye nemigomo ye-COVID-19, ngoba lokhu kungakusiza ukuthi uzivikele ezifweni ngenkathi amasosha akho omzimba elungiswa yi-secukinumab. Njalo yazisa abahlinzeki bezempilo ukuthi uthatha i-secukinumab ngaphambi kokuthola imigomo.