Yini i-Selegiline: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Selegiline iyimithi kadokotela esiza ukuphatha izimpawu zesifo sikaParkinson ngokuvikela i-dopamine ebuchosheni bakho. Le mithi isebenza ngendlela ehlukile kwezinye izindlela zokwelapha i-Parkinson ngoba ivimba i-enzyme eqeda i-dopamine, ikhemikhali yobuchopho oyidingayo ukuze uhambe kahle futhi uhleleke.

Udkt wakho angase akunikeze i-selegiline uma imithi yakho yamanje ye-Parkinson ingasebenzi kahle njengoba yayinjalo. Ithathwa njengokwelashwa okusekelayo okungasiza ukwelula izinzuzo zomuthi wakho oyinhloko, ikunikeze amahora amahle engeziwe ngosuku.

Yini i-Selegiline?

I-Selegiline ingeyeqembu lemithi ebizwa ngokuthi ama-MAO-B inhibitors, okusho ukuthi ivimba i-enzyme ethile ebuchosheni bakho ebizwa ngokuthi i-monoamine oxidase B. Le enzyme ngokuvamile iqeda i-dopamine, kodwa uma unesifo sikaParkinson, usuvele unayo i-dopamine encane kunaleyo oyidingayo.

Cabanga nge-selegiline njengenduku yokuvikela i-dopamine yakho esele. Ngokuvimba i-enzyme ecekela phansi i-dopamine, ikhemikhali yobuchopho ebalulekile ihlala itholakala ukuze isize ukulawula ukunyakaza kwakho futhi kunciphise ukuthuthumela.

Umuthi uza ngamaphilisi ajwayelekile namaphilisi aqeda ngomlomo ancibilika olimini lwakho. Udkt wakho uzokhetha ifomu elingcono kakhulu ngokusekelwe ezidingweni zakho ezithile nokuthi ukwazi kangakanani ukugwinya amaphilisi.

Isetshenziselwani i-Selegiline?

I-Selegiline isetshenziswa ikakhulukazi ukwelapha isifo sikaParkinson, ikakhulukazi uma izimpawu zakho zingalawulwa ngokugcwele yi-levodopa ne-carbidopa kuphela. Isiza ukuphatha izimpawu zemoto ezifana nokuthuthumela, ukuqina, nokunyakaza okuhamba kancane okwenza imisebenzi yansuku zonke ibe yinselele.

Udkt wakho angase angeze i-selegiline ohlelweni lwakho lokwelapha lapho uqala ukuzwa izikhathi zokuthi

Ngesinye isikhathi odokotela banikeza i-selegiline ezigabeni zokuqala zesifo sikaParkinson. Kulezi zimo, kungasiza ukunciphisa ukuqhubeka kwezimpawu futhi kulibazise isidingo semithi eqinile efana ne-levodopa.

Lo muthi ungasiza futhi ukunciphisa ukuguquguquka kwezimpawu zakho usuku lonke. Abantu abaningi abanesifo sikaParkinson baqaphela ukuthi izimpawu zabo ziyahluka kakhulu ihora ngalinye, futhi i-selegiline ingasiza ukuthambisa lezi zinto eziphezulu nezaphansi.

Isebenza Kanjani I-Selegiline?

I-Selegiline isebenza ngokuvimba i-MAO-B, i-enzyme eqeda i-dopamine ebuchosheni bakho. Uma unesifo sikaParkinson, amaseli obuchopho akhiqiza i-dopamine ayafa kancane kancane, ngakho ukuvikela i-dopamine onayo manje kubalulekile ekuphatheni izimpawu.

Lo muthi uthathwa njengomuthi olungile ngokuqina uma kuziwa ekwelapheni isifo sikaParkinson. Awunamandla njenge-levodopa, evame ukubizwa ngokuthi iyigolide, kodwa iqondiswe kakhulu futhi inganikeza ukukhululeka okukhulu ezimpawini ezinemiphumela emincane.

Umphumela wokuvikela we-selegiline uhlala izinsuku eziningana ngemva kokuyithatha. Lokhu kusho ukuthi i-enzyme ihlala ivinjiwe ngisho nangemva kokuba umuthi ususukile egazini lakho, unikeza izinzuzo eziqhubekayo kunezinye izidakamizwa ze-Parkinson.

Ngokungafani neminye imithi ye-Parkinson ethatha indawo ye-dopamine elahlekile, i-selegiline isiza ukugcina ukukhiqizwa kwe-dopamine komzimba wakho. Le ndlela ingaba mnene emzimbeni wakho futhi ingase ibangele izinkinga ezimbalwa ngokuhamba kwesikhathi.

Kufanele Ngiyithathe Kanjani I-Selegiline?

Thatha i-selegiline ngendlela enqunywe ngayo udokotela wakho, ngokuvamile kanye noma kabili ngosuku ngokudla noma ngaphandle kokudla. Umthamo ojwayelekile wokuqala ngu-5mg kabili ngosuku, othathwa ngesidlo sasekuseni nesantambama ukuze kugwenywe izinkinga zokulala.

Uma uthatha amaphilisi aqhekekayo ngomlomo, wawabeke olwimini lwakho bese uwavumela ukuthi ancibilike ngokuphelele. Ungahlafuni, ungachobozi, noma ugwinye lawa maphilisi wonke, ngoba lokhu kungathinta ukuthi umuthi usebenza kahle kangakanani.

Isikhathi sibalulekile nge-selegiline ngoba singaphazamisa ukulala uma sithathwa sekwephuzile emini. Thatha umthamo wakho wokugcina ngaphambi kuka-2 PM ukuvimbela ukuqwasha noma ukungazinzi ngesikhathi sokulala.

Ungathatha i-selegiline ngokudla noma ngaphandle kokudla, kodwa ukuyithatha ngesnakhi esincane kungasiza ukunciphisa isisu esibuhlungu. Gwema ukuyithatha ngokudla okukhulu okunokudla okunothile nge-tyramine njengoshizi omdala, inyama elashwe, noma imikhiqizo evutshiwe.

Ungayeki ngokuzumayo ukuthatha i-selegiline ngaphandle kokukhuluma nodokotela wakho kuqala. Izimpawu zakho ze-Parkinson zingase zibe zimbi ngokushesha uma uyeka umuthi ngokuzumayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Selegiline?

Abantu abaningi abane-Parkinson's disease bathatha i-selegiline iminyaka eminingi njengengxenye yohlelo lwabo lokwelashwa oluhlala isikhathi eside. Umuthi usebenza kahle uma uthathwa njalo ngokuhamba kwesikhathi, usiza ukugcina amazinga e-dopamine aqinile ebuchosheni bakho.

Udokotela wakho uzobuyekeza njalo ukuthi i-selegiline isebenza kahle kangakanani kuwe ngokuqokwa okulandelayo. Bazohlola ukuthi izimpawu zakho zilawulwa kahle yini nokuthi ngabe kukhona yini ukulungiswa okudingekayo ohlelweni lwakho lokwelashwa.

Abanye abantu bangase badinge ukuthatha i-selegiline impilo yabo yonke, ikakhulukazi uma ithuthukisa kakhulu izinga labo lempilo nokulawulwa kwezimpawu. Lokhu kuvamile futhi kulindelekile ezimweni ezingapheli njenge-Parkinson's disease.

Ubude bokwelashwa buphinde buxhomeke ekutheni isimo sakho siqhubeka kanjani nokuthi ngabe eminye imithi iba yimpoqo yini. Udokotela wakho angase angeze ezinye izindlela zokwelapha noma alungise umthamo wakho we-selegiline njengoba izidingo zakho zishintsha ngokuhamba kwesikhathi.

Yiziphi Imiphumela Eceleni Ye-Selegiline?

Njengayo yonke imithi, i-selegiline ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ivame ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Nansi imiphumela emibi ongase uyithole, iqala ngaleyo evame kakhulu:

• Ukugula kwesisu nokungakhululeki kwesisu
• Isiyezi noma ukukhathala
• Ubunzima bokulala noma amaphupho acacile
• Umlomo owomile
• Ukuqaqamba kwekhanda
• Ukudideka noma ukucabanga
• Ukunyakaza okungazelelwe okwandayo

Le miphumela emibi ejwayelekile ivame ukunyamalala emasontweni ambalwa njengoba umzimba wakho ujwayela umuthi. Uma ziqhubeka noma ziba yinkinga, udokotela wakho angakwazi ukulungisa umthamo wakho noma isikhathi sokukusiza.

Imiphumela emibi engathi sína kodwa engavamile ingabandakanya izinguquko ezinzima zemizwa, ubuhlungu besifuba, noma ukwanda okungazelelwe kwengcindezi yegazi. Lokhu kudinga ukunakekelwa kwezempilo ngokushesha futhi kungenzeka ukuthi kwenzeke uma udla ukudla okuthile noma uthatha eminye imithi exhumana ne-selegiline.

Abanye abantu bahlangabezana nalokho okubizwa ngokuthi "umphumela we-cheese" uma bedla ukudla okuningi okunothile nge-tyramine ngenkathi bethatha i-selegiline. Lokhu kungabangela ukwanda okuyingozi kwengcindezi yegazi, nakuba kungavamile emithini evame ukusetshenziselwa isifo sikaParkinson.

Ubani Ongafanele Athathwe I-Selegiline?

Abantu abathile kufanele bagweme i-selegiline ngoba ingaxhumana ngendlela eyingozi neminye imithi noma izimo zezempilo. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha nemithi yamanje ngaphambi kokuyinika.

Akufanele uthathe i-selegiline uma njengamanje usebenzisa ama-antidepressants athile, ikakhulukazi ama-SSRI, ama-SNRI, noma ama-tricyclic antidepressants. Inhlanganisela ingabangela isimo esibi esibizwa nge-serotonin syndrome, esingaba yingozi empilweni.

Abantu abathatha imithi yokwelapha ubuhlungu ye-opioid efana ne-meperidine, i-tramadol, noma i-methadone kufanele futhi bagweme i-selegiline. Lezi zinhlanganisela zingabangela ukusabela okukhulu okuhlanganisa umkhuhlane ophezulu, ukuqina kwemisipha, kanye nezinguquko eziyingozi engcindezi yegazi.

Uma unesifo esibi sesibindi, udokotela wakho cishe uzokhetha omunye umuthi ngoba i-selegiline icutshungulwa yisibindi. Ngokufanayo, abantu abanesifo esibi sezinso bangase badinge ukulungiswa komthamo noma ukwelashwa okuhlukile.

Njalo tshela udokotela wakho ngayo yonke imithi oyithathayo, okuhlanganisa imithi etholakala ngaphandle kwemvume kadokotela, izithasiselo, kanye nemithi yezitshalo. Ngisho nemikhiqizo ebonakala ingenabungozi njenge-St. John's wort ingase ihlangane ngendlela eyingozi ne-selegiline.

Amagama e-Brand e-Selegiline

I-Selegiline itholakala ngaphansi kwamagama amaningi e-brand, i-Eldepryl iyilena eqashelwa kakhulu. Leli yigama lokuqala le-brand le-tablet ejwayelekile ye-selegiline odokotela abebelokhu beyibhala iminyaka eminingi.

I-Zelapar elinye igama le-brand, ikakhulukazi lama-tablet ancibilika ngomlomo ancibilika olimini lwakho. Lawa ma-tablet avame ukuba lula kubantu abanobunzima bokugwinya amaphilisi ngenxa yesifo sikaParkinson.

Izinhlobo ze-generic ze-selegiline zitholakala kabanzi futhi zisebenza ngempumelelo njengezinhlobo zegama le-brand. Umuthi wakho we-pharmacist angakutshela ukuthi iyiphi inguqulo oyitholayo futhi aphendule noma yimiphi imibuzo mayelana nokuhlukahluka phakathi kwama-brand.

Isithako esisebenzayo siyafana kungakhathaliseki igama le-brand, ngakho ukushintsha phakathi kwabakhiqizi abahlukene ngokuvamile akuthinti ukuthi umuthi usebenza kahle kangakanani kuwe.

Ezinye izindlela ze-Selegiline

Uma i-selegiline ingakulungele, eminye imithi eminingi ingasiza ekuphatheni izimpawu zesifo sikaParkinson. Udokotela wakho angase acabangele i-rasagiline, okuyi-MAO-B inhibitor entsha esebenza ngendlela efana ne-selegiline kodwa ingase ibe nemiphumela emincane.

Ama-dopamine agonists afana ne-pramipexole noma i-ropinirole asebenza ngendlela ehlukile ngokuvuselela ngokuqondile ama-dopamine receptors ebuchosheni bakho. Le mithi ingaba ezinye izindlela eziphumelelayo, ikakhulukazi ezigabeni zokuqala zesifo sikaParkinson.

Ama-COMT inhibitors afana ne-entacapone noma i-tolcapone enye inketho esiza ukwelula imiphumela ye-levodopa. Lezi zisebenza ngokuvimba i-enzyme ehlukile echitha i-levodopa ngaphambi kokuthi ifinyelele ebuchosheni bakho.

Udktela wakho angase futhi acabangele i-amantadine, enezindlela eziningi zokusiza ngezimpawu ze-Parkinson futhi ingaba usizo ikakhulukazi ekunciphiseni ukunyakaza okungahleliwe okubangelwa eminye imithi.

Enye indlela engcono kakhulu incike ezimpawini zakho ezithile, eminye imithi oyithathayo, nokuthi umzimba wakho usabela kanjani ekwelashweni okuhlukene. Udktela wakho uzosebenza nawe ukuthola inhlanganisela esebenza kahle kakhulu.

Ingabe i-Selegiline ingcono kune-Rasagiline?

Kokubili i-selegiline ne-rasagiline zingama-MAO-B inhibitors asebenza ngezindlela ezifanayo, kodwa zomehluko obalulekile. I-Rasagiline iyimithi entsha engase ibangele imiphumela emibi embalwa nokuxhumana kwemithi kuno-selegiline.

I-Selegiline isetshenziswe isikhathi eside futhi inokucwaninga okuningi okusekela ukusebenza kwayo, ikakhulukazi uma ihlanganiswe ne-levodopa. Itholakala futhi ngezindlela eziningi, okuhlanganisa amaphilisi aqeda ngomlomo abanye abantu abawathola elula ukuwathatha.

I-Rasagiline ingase ingabangi izinkinga zokulala ngoba ayihlakazi ibe yizinto ezinjenge-amphetamine emzimbeni wakho. Lokhu kuyenza ibe yindlela engcono kubantu abazwela emiphumeleni yokuvuselela.

Akukho emithini okuthiwa “ingcono” kunenye. Ukukhetha phakathi kwazo kuncike ekuphenduleni kwakho ngakunye, iphrofayili yomphumela, nokuthi yimiphi eminye imithi oyithathayo.

Udktela wakho uzocabangela izinto ezinjengobudala bakho, ukusebenza kwezinso, ezinye izimo zempilo, nokuphendula kwemithi yangaphambilini lapho enquma phakathi kwalezi zinketho ezimbili.

Imibuzo Evame Ukubuzwa Mayelana ne-Selegiline

Q1. Ingabe i-Selegiline iphephile kubantu abanezifo zenhliziyo?

I-Selegiline ngokuvamile iphephile kubantu abanezifo zenhliziyo, kodwa udktela wakho uzokuqapha eduze uma unezimo zenhliziyo nemithambo yegazi. Imithi ingase ngezikhathi ezithile ibangele izinguquko emfuthe yegazi noma isigqi senhliziyo, ikakhulukazi lapho uqala ukwelashwa.

Uma unesifo senhliziyo, udokotela wakho angase akuqale ngomthamo ophansi bese ewunyusa kancane kancane. Bazofuna futhi ukukubona njalo ezinyangeni ezimbalwa zokuqala ukuze bahlole ukuthi inhliziyo yakho isabela kanjani emuthini.

Xhumana nodokotela wakho ngokushesha uma uzwa ubuhlungu besifuba, ukushaya kwenhliziyo okungajwayelekile, noma ukuphefumula kanzima okungajwayelekile ngenkathi uthatha i-selegiline. Lezi zimpawu zingase zikhombe ukuthi isimo senhliziyo yakho sidinga ukuqashwa okuseduze noma ukulungiswa kokwelashwa.

Q2. Kufanele Ngenzeni Uma Ngiphuzile I-Selegiline Engaphezu Kakhulu Ngengozi?

Uma ngengozi uphuza i-selegiline eningi kakhulu, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa kahle. Izimpawu zokweqisa umthamo kungenzeka zingaveli ngokushesha kodwa zingabandakanya ikhanda elibuhlungu elibuhlungu, ubuhlungu besifuba, noma izinguquko eziyingozi emfutheni wegazi.

Ungazami ukuzenza uhlanze noma uthathe eminye imithi ukuze ulwe nokweqisa umthamo. Kunalokho, qoqa ibhodlela lakho lomuthi bese uya egumbini eliphuthumayo eliseduze uma udokotela wakho ekuncoma.

Gcina uhlu lwazo zonke izidakamizwa zakho nawe, okuhlanganisa umthamo oqondile we-selegiline owawuphuze. Lolu lwazi luzosiza ochwepheshe bezokwelapha ukuthi banikeze ukunakekelwa okungcono kakhulu uma udinga ukwelashwa okuphuthumayo.

Q3. Kufanele Ngenzeni Uma Ngedlula Umthamo We-Selegiline?

Uma udlula umthamo we-selegiline, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekusihlwa noma kusihlwa. Ukuthatha i-selegiline sekwephuze kakhulu emini kungaphazamisa ukulala kwakho.

Uma sekudlule u-2 PM lapho ukhumbula umthamo wakho owuphuthelwe, weqe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile. Ungaphindi umthamo ukuze ulungise lowo owuphuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi.

Ukudlula umthamo ngezikhathi ezithile ngeke kukulimaze, kodwa zama ukugcina isimiso esiqhubekayo sokulawula izimpawu ezingcono kakhulu. Cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule.

Q4. Ngingayeka Nini Ukuthatha I-Selegiline?

Ungayeki ukuthatha i-selegiline ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Izimpawu zakho ze-Parkinson zizokwanda ngokushesha uma uyeka umuthi ngokungazelele, futhi ungase uhlangabezane nemiphumela efana nokuhoxiswa.

Udokotela wakho uzokusiza ukuthi unciphise kancane umthamo wakho emasontweni amaningana uma ukuyeka i-selegiline kudingeka. Le nqubo yokunciphisa kancane isiza ekuvikeleni ukubuya okungazelelwe kwezimpawu futhi ivumela umzimba wakho ukuthi ujwayele.

Isinqumo sokuyeka i-selegiline ngokuvamile senzeka lapho imiphumela emibi iba yinkinga kakhulu noma lapho ezinye izindlela zokwelapha ziba zifaneleka kakhulu esimweni sakho. Udokotela wakho uzosebenza nawe ukuthola enye indlela engcono ngaphambi kokuyeka i-selegiline.

Q5. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Selegiline?

Kungcono ukukhawulela ukusetshenziswa kotshwala ngenkathi uthatha i-selegiline, njengoba utshwala bungenza imiphumela emibi ethile ibe mibi njengokugajwa nokudideka. Amanani amancane otshwala ngokuvamile alungile, kodwa gwema ukuphuza kakhulu noma ukuphuza ngokweqile.

Qaphela ikakhulukazi iwayini elibomvu notshwala, ngoba lokhu kuqukethe i-tyramine, engasebenzisana ne-selegiline ukubangela ukwanda okuyingozi kwengcindezi yegazi. Imimoya ecacile efana ne-vodka noma i-gin ngokuvamile iyizinqumo eziphephe kakhulu uma ukhetha ukuphuza.

Xoxa nodokotela wakho ngemikhuba yakho yotshwala ukuze bakwazi ukukunikeza iseluleko esiqondene nawe. Bangase batusa ukugwema utshwala ngokuphelele uma uhlangabezana nemiphumela emibi ethile noma uthatha eminye imithi esebenzisana notshwala.